#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30542	uniprotkb:P08588	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335213|imex:IM-26957-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	-	-	-	figure legend:Figure 1A-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rigid:h+eBSRYzgPheAYCTtK//rihhp0c	false	myc tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30542	uniprotkb:P07550	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335221|imex:IM-26957-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	-	-	-	figure legend:Figure 1A-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rigid:dRdSG7HiISYYHu3z/la38MgQGpw	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30542	uniprotkb:P07550	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335229|imex:IM-26957-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	-	-	-	figure legend:Figure 1A-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rigid:dRdSG7HiISYYHu3z/la38MgQGpw	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30542	uniprotkb:P08588	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335237|imex:IM-26957-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	-	-	-	figure legend:Figure 1A-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rigid:h+eBSRYzgPheAYCTtK//rihhp0c	false	myc tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30542	uniprotkb:P08588	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335259|imex:IM-26957-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rigid:h+eBSRYzgPheAYCTtK//rihhp0c	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P30542	uniprotkb:P07550	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335268|imex:IM-26957-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rigid:dRdSG7HiISYYHu3z/la38MgQGpw	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P30542	uniprotkb:P08588	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335277|imex:IM-26957-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	-	-	-	figure legend:Figure 5-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-heart)|taxid:9606(Homo sapiens)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rigid:h+eBSRYzgPheAYCTtK//rihhp0c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30542	uniprotkb:P07550	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335282|imex:IM-26957-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	-	-	-	figure legend:Figure 5-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-heart)|taxid:9606(Homo sapiens)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rigid:dRdSG7HiISYYHu3z/la38MgQGpw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30542	uniprotkb:P08588	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335287|imex:IM-26957-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	-	-	-	figure legend:Figure 5-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-heart)|taxid:9606(Homo sapiens)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rigid:IHdl099LidmV/gTBzMM2jolahiU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30542	uniprotkb:P07550	intact:EBI-2903663|ensembl:ENSP00000308549|ensembl:ENSP00000338435|ensembl:ENSP00000356205|uniprotkb:A6NFY5|uniprotkb:A6NGP4|uniprotkb:A8K1L3|uniprotkb:B3KXQ4|uniprotkb:Q6FHK3|uniprotkb:Q8TAM8|uniprotkb:D2CGD0	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	psi-mi:aa1r_human(display_long)|uniprotkb:ADORA1(gene name)|psi-mi:ADORA1(display_short)	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chandrasekera et al. (2013)	pubmed:23291003|imex:IM-26957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335287|imex:IM-26957-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163485(gene)|ensembl:ENST00000309502(transcript)|ensembl:ENST00000337894(transcript)|ensembl:ENST00000367236(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044305"(calyx of Held)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30542|rcsb pdb:5N2S|rcsb pdb:5UEN|rcsb pdb:6D9H|reactome:R-HSA-417973|reactome:R-HSA-418594|refseq:NP_000665.1|refseq:NP_001041695.1	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	-	-	-	figure legend:Figure 5-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-heart)|taxid:9606(Homo sapiens)	-	2019/04/03	2019/04/17	rogid:3L0HPxo92ofTLzVTjNJXOjU+TLU9606	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rigid:IHdl099LidmV/gTBzMM2jolahiU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)