#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407608|imex:IM-27038-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 1A, Lane 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/05/01	2019/05/24	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407625|imex:IM-27038-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 1B, Lane 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/05/01	2019/05/24	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407621|imex:IM-27038-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 1A, Lane 2 +3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/05/01	2019/05/24	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407629|imex:IM-27038-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 1B, Lane 2 +3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/05/01	2019/05/24	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407742|imex:IM-27038-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 3, Supplementary figure 3|agonist:Apelin -13 peptide|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/05/01	2019/05/27	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	renilla luciferase protein tag:c-c	enhanced yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407758|imex:IM-27038-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Supplementary figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/01	2019/05/27	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	enhanced yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21407767|imex:IM-27038-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Supplementary figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/01	2019/05/27	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	renilla luciferase protein tag:c-c	enhanced yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21445326|imex:IM-27038-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 2D|agonist:Apelin-13, alone,  and  in presence of  Angiotensin II.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/01	2019/05/30	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21445317|imex:IM-27038-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 2C|agonist:Apelin-13, alone,  and  in presence of  Angiotensin II.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/01	2019/05/30	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21445348|imex:IM-27038-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/01	2019/05/30	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21445357|imex:IM-27038-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/01	2019/05/30	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P30556	uniprotkb:P35414	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21445377|imex:IM-27038-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	-	-	-	figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/01	2019/05/30	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35414	uniprotkb:P30556	intact:EBI-2875891|ensembl:ENSP00000257254|ensembl:ENSP00000475344	intact:EBI-6623016|uniprotkb:Q8TBK4|ensembl:ENSP00000273430|ensembl:ENSP00000385612|ensembl:ENSP00000418084|ensembl:ENSP00000418851|ensembl:ENSP00000419422|ensembl:ENSP00000419783|ensembl:ENSP00000385641|ensembl:ENSP00000398832|uniprotkb:Q13725	psi-mi:apj_human(display_long)|uniprotkb:APLNR(gene name)|psi-mi:APLNR(display_short)|uniprotkb:AGTRL1(gene name synonym)|uniprotkb:APJ(gene name synonym)|uniprotkb:Angiotensin receptor-like 1(gene name synonym)|uniprotkb:G-protein coupled receptor APJ(gene name synonym)|uniprotkb:G-protein coupled receptor HG11(gene name synonym)	psi-mi:agtr1_human(display_long)|uniprotkb:AGTR1(gene name)|psi-mi:AGTR1(display_short)|uniprotkb:AGTR1A(gene name synonym)|uniprotkb:AGTR1B(gene name synonym)|uniprotkb:AT2R1(gene name synonym)|uniprotkb:AT2R1B(gene name synonym)|uniprotkb:AT1AR(gene name synonym)|uniprotkb:AT1BR(gene name synonym)|uniprotkb:Angiotensin II type-1 receptor(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Siddiquee et al. (2013)	pubmed:22935142|imex:IM-27038	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21445386|imex:IM-27038-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134817(gene)|ensembl:ENST00000257254(transcript)|ensembl:ENST00000606794(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0001947"(heart looping)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0035904"(aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060182"(apelin receptor activity)|go:"GO:0060183"(apelin receptor signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903596"(regulation of gap junction assembly)|go:"GO:1904325"(positive regulation of inhibitory G protein-coupled receptor phosphorylation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003904(APJ receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35414|rcsb pdb:2LOT|rcsb pdb:2LOU|rcsb pdb:2LOV|rcsb pdb:2LOW|rcsb pdb:5VBL|rcsb pdb:6KNM|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_005152.1	refseq:NP_114038.4|refseq:NP_114438.2|ensembl:ENSG00000144891(gene)|ensembl:ENST00000349243(transcript)|ensembl:ENST00000402260(transcript)|ensembl:ENST00000404754(transcript)|ensembl:ENST00000461609(transcript)|ensembl:ENST00000474935(transcript)|ensembl:ENST00000475347(transcript)|ensembl:ENST00000497524(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001822"(kidney development)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|ensembl:ENST00000418473(transcript)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P30556|rcsb pdb:1ZV0|rcsb pdb:4YAY|rcsb pdb:4ZUD|rcsb pdb:6DO1|rcsb pdb:6OS0|rcsb pdb:6OS1|rcsb pdb:6OS2|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:0019229"(regulation of vasoconstriction)|refseq:NP_004826.5|refseq:NP_000676.1|refseq:NP_033611.1	-	-	-	figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/01	2019/05/30	rogid:OaKR4qnsU9jANK+HB2qQ4TlanpQ9606	rogid:hrgCoboCmBvuoZEj5YuPnL+KuEQ9606	rigid:Kj766BTDfRhJahVrDOmg04biw80	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)