#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75496	uniprotkb:P31274	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926448|imex:IM-27180-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	-	-	figure legend:Fig.1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/22	2019/07/24	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:wpwqbHQal6X2kdytDx8Ay889RuQ	false	glutathione s tranferase tag:n-n|sufficient binding region:151-170|sufficient binding region:171-190	sufficient binding region:138-209	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O75496	uniprotkb:P31274	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926466|pdbe:2lp0|imex:IM-27180-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	-	-	figure legend:Fig.1C, Fig.1D, Fig.2, Fig.S7B, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:29.7x10^-6 ~5.5(molar)	2019/07/22	2019/07/23	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:wpwqbHQal6X2kdytDx8Ay889RuQ	false	sufficient binding region:171-190|15n label:?-?|mutation increasing interaction strength:184-184|mutation decreasing interaction strength:177-179|mutation decreasing interaction strength:181-183|mutation decreasing interaction strength:186-188|mutation decreasing interaction strength:182-182,187-188,177-179	mutation decreasing interaction strength:234-234,245-245|sufficient binding region:177-260|15n label:?-?|mutation decreasing interaction strength:193-196	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75496	uniprotkb:P14653	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	intact:EBI-301331|ensembl:ENSP00000355140|uniprotkb:Q4VB03	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:hxb1_human(display_long)|uniprotkb:HOXB1(gene name)|psi-mi:HOXB1(display_short)|uniprotkb:HOX2I(gene name synonym)|uniprotkb:Homeobox protein Hox-2I(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926507|imex:IM-27180-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	refseq:NP_002135.2|ensembl:ENSG00000120094(gene)|ensembl:ENST00000239174(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007389"(pattern specification process)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021570"(rhombomere 4 development)|go:"GO:0021571"(rhombomere 5 development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021754"(facial nucleus development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:1B72|reactome:R-HSA-5617472|dip:DIP-6106N	-	-	-	figure legend:Fig.S7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:190.0x10^-6 ~20.0(molar)	2019/07/22	2019/07/23	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rogid:ufMo2889HT1Hrr4Mizej0e5Dwsc9606	rigid:pXxXR2B1+9IHhHspEf6Uxfu+Rk4	false	sufficient binding region:171-190	15n label:?-?|sufficient binding region:203-262	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28358	uniprotkb:O75496	intact:EBI-12690664|ensembl:ENSP00000249501|uniprotkb:Q6NT10	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	psi-mi:hxd10_human(display_long)|uniprotkb:HOXD10(gene name)|psi-mi:HOXD10(display_short)|uniprotkb:HOX4D(gene name synonym)|uniprotkb:HOX4E(gene name synonym)|uniprotkb:Homeobox protein Hox-4D(gene name synonym)|uniprotkb:Homeobox protein Hox-4E(gene name synonym)	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926534|imex:IM-27180-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000128710(gene)|ensembl:ENST00000249501(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0050905"(neuromuscular process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001356(Homeobox)|go:"GO:0005829"(cytosol)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007338"(single fertilization)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|refseq:NP_002139.2	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	-	-	-	figure legend:Fig.S7C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:42.9x10^-6 ~5.9(molar)	2019/07/22	2019/07/24	rogid:8Kl7Gkk7bhZ4MMgI9RXIcVdqbqo9606	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rigid:6glLiE7xQfw1/nPZGw1ETUl+Q+I	false	15n label:?-?|sufficient binding region:266-325	sufficient binding region:171-190	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28360	uniprotkb:O75496	intact:EBI-3919342|ensembl:ENSP00000372170|uniprotkb:Q96NY4|uniprotkb:A0SZU5|uniprotkb:A8K3M1	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	psi-mi:msx1_human(display_long)|uniprotkb:MSX1(gene name)|psi-mi:MSX1(display_short)|uniprotkb:HOX7(gene name synonym)|uniprotkb:Homeobox protein Hox-7(gene name synonym)|uniprotkb:Msh homeobox 1-like protein(gene name synonym)	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926545|imex:IM-27180-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|ensembl:ENSG00000163132(gene)|ensembl:ENST00000382723(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035880"(embryonic nail plate morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0090427"(activation of meiosis)|go:"GO:0030308"(negative regulation of cell growth)|refseq:NP_002439.2	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	-	-	-	figure legend:Fig.S7D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:263.6x10^-6 ~29.9(molar)	2019/07/22	2019/07/24	rogid:moD9wVPS7gbE9d0VPHu/atQijKs9606	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rigid:cA38qqZY7WlabPtQ3Fn0v4IH8rM	false	15n label:?-?|sufficient binding region:172-231	sufficient binding region:171-190	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26367	uniprotkb:O75496	intact:EBI-747278|uniprotkb:Q6N006|uniprotkb:Q99413|ensembl:ENSP00000241001|ensembl:ENSP00000368403|ensembl:ENSP00000368427|ensembl:ENSP00000490963|ensembl:ENSP00000491295|ensembl:ENSP00000492822|ensembl:ENSP00000495109	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	psi-mi:pax6_human(display_long)|uniprotkb:Oculorhombin(gene name synonym)|uniprotkb:Aniridia type II protein(gene name synonym)|uniprotkb:PAX6(gene name)|psi-mi:PAX6(display_short)|uniprotkb:AN2(gene name synonym)	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926556|imex:IM-27180-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000271.1|refseq:NP_001121084.1|refseq:NP_001595.2|refseq:NP_001297088.1|refseq:NP_001297090.1|ensembl:ENSG00000007372(gene)|refseq:NP_001245393.1|refseq:NP_001245394.1|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR001523(Paired box protein, N-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR036388|interpro:IPR043182|interpro:IPR043565|rcsb pdb:2CUE|rcsb pdb:6PAX|reactome:R-HSA-210745|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-5617472|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021778"(oligodendrocyte cell fate specification)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021905"(forebrain-midbrain boundary formation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021986"(habenula development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042593"(glucose homeostasis)|ensembl:ENST00000241001(transcript)|ensembl:ENST00000379109(transcript)|ensembl:ENST00000379132(transcript)|ensembl:ENST00000639916(transcript)|ensembl:ENST00000640287(transcript)|ensembl:ENST00000640610(transcript)|ensembl:ENST00000643871(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001654"(eye development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003322"(pancreatic A cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0009887"(animal organ morphogenesis)|dip:DIP-37436N	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	-	-	-	figure legend:Fig.S7E and Fig.S7J|comment:"We recorded 1000uM for the Kd of the interaction, however the authors specify this value as a lower estimate for the true Kd (>1000uM)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1000.0x10^-6(molar)	2019/07/22	2019/07/24	rogid:Fy8LCDCQ1ZwGv6PWDz/B/NTackM9606	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rigid:Xkq1fxCOzw8uRelZ5GZOdgHgmRM	false	15n label:?-?|sufficient binding region:210-273|mutation increasing interaction strength:252-252,263-263	sufficient binding region:171-190	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61371	uniprotkb:O75496	intact:EBI-3906896|uniprotkb:P47894|uniprotkb:P20663|ensembl:ENSP00000230658	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	psi-mi:isl1_human(display_long)|uniprotkb:ISL1(gene name)|psi-mi:ISL1(display_short)	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926568|imex:IM-27180-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002193.2|ensembl:ENSP00000230658|ensembl:ENSG00000016082(gene)|ensembl:ENST00000230658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048880"(sensory system development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P61371|reactome:R-HSA-400511|reactome:R-HSA-9010553	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	-	-	-	figure legend:Fig.S7F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:184.3x10^-6 ~30.4(molar)	2019/07/22	2019/07/24	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd09606	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rigid:jMfardZODSXrEs6sZ3XDvIclED8	false	15n label:?-?|sufficient binding region:180-244	sufficient binding region:171-190	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01860	uniprotkb:O75496	intact:EBI-475687|uniprotkb:P31359|uniprotkb:Q15167|uniprotkb:Q15168|uniprotkb:Q16422|uniprotkb:A6NCS1|uniprotkb:A6NLL8|uniprotkb:Q5STF3|uniprotkb:Q5STF4|ensembl:ENSP00000259915|ensembl:ENSP00000373016|ensembl:ENSP00000388842|ensembl:ENSP00000391681|ensembl:ENSP00000392877|ensembl:ENSP00000400047|ensembl:ENSP00000405041|uniprotkb:D2IYK4	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	psi-mi:po5f1_human(display_long)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:POU5F1(gene name)|psi-mi:POU5F1(display_short)|uniprotkb:OCT3(gene name synonym)|uniprotkb:OCT4(gene name synonym)|uniprotkb:OTF3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926579|imex:IM-27180-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272916.1|refseq:NP_002692.2|ensembl:ENSG00000204531(gene)|ensembl:ENSG00000206454(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0003723"(RNA binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|mint:Q01860|rcsb pdb:6T90|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-452723|ensembl:ENSG00000230336(gene)|ensembl:ENSG00000233911(gene)|ensembl:ENSG00000235068(gene)|ensembl:ENSG00000237582(gene)|ensembl:ENST00000259915(transcript)|ensembl:ENST00000383524(transcript)|ensembl:ENST00000429603(transcript)|ensembl:ENST00000433063(transcript)|ensembl:ENST00000434616(transcript)|ensembl:ENST00000437747(transcript)|ensembl:ENSG00000229094(gene)|ensembl:ENST00000454714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|dip:DIP-33440N	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	-	-	-	figure legend:Fig.S7G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:165.4x10^-6 ~25.7(molar)	2019/07/22	2019/07/24	rogid:eMEp6g1n+kU2YnuRprn2B79q7OM9606	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rigid:57AvylftqDC6HmbZjet2qQYnmLs	false	15n label:?-?|sufficient binding region:230-289	sufficient binding region:171-190	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95343	uniprotkb:O75496	intact:EBI-13644574|ensembl:ENSP00000260653|uniprotkb:D6W5A5|uniprotkb:Q53T42	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	psi-mi:six3_human(display_long)|uniprotkb:SIX3(gene name)|psi-mi:SIX3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926590|imex:IM-27180-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138083(gene)|ensembl:ENST00000260653(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021537"(telencephalon development)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_005404.1	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	-	-	-	figure legend:Fig.S7H|comment:"We recorded 1000uM for the Kd of the interaction, however the authors specify this value as a lower estimate for the true Kd (>1000uM)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1000.0x10^-6(molar)	2019/07/22	2019/07/24	rogid:v7PWpHcsHZVRgHfEQwkWNlv14489606	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rigid:XL50aevscVK6vLDsQoOibaV8dEo	false	15n label:?-?|sufficient binding region:206-265	sufficient binding region:171-190	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31274	uniprotkb:O75496	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	intact:EBI-371669|uniprotkb:Q9H1Z1|uniprotkb:B3KMM8|ensembl:ENSP00000230056|ensembl:ENSP00000348902|ensembl:ENSP00000477506	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:gemi_human(display_long)|uniprotkb:GMNN(gene name)|psi-mi:GMNN(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zhou et al. (2012)	pubmed:22615398|imex:IM-27180	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926484|imex:IM-27180-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	refseq:NP_056979.1|refseq:NP_001238918.1|refseq:NP_001238919.1|refseq:NP_001238920.1|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR022786|interpro:IPR029697|mint:O75496|rcsb pdb:1T6F|rcsb pdb:1UII|rcsb pdb:2LP0|rcsb pdb:2WVR|rcsb pdb:4BRY|reactome:R-HSA-68827|go:"GO:0009887"(animal organ morphogenesis)|reactome:R-HSA-68962|refseq:XP_005249216.1|ensembl:ENSG00000112312(gene)|ensembl:ENST00000230056(transcript)|ensembl:ENST00000356509(transcript)|ensembl:ENST00000620958(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|dip:DIP-31088N	-	-	-	figure legend:Fig.1E, Fig.S2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.3x10^-6 ~0.3(molar)	2019/07/22	2019/07/25	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rogid:4jWHqSy3+J1JqSU+kNTTYmeYjF49606	rigid:wpwqbHQal6X2kdytDx8Ay889RuQ	false	mutation decreasing interaction strength:193-196|sufficient binding region:177-260	sufficient binding region:171-190	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)