#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:28794"	uniprotkb:P11509	intact:EBI-21447270|chebi:"CHEBI:3906"|chebi:"CHEBI:41552"|chebi:"CHEBI:101256"|chebi:"CHEBI:23402"	intact:EBI-21447212|uniprotkb:Q4VAT9|uniprotkb:A7YAE5|uniprotkb:B2R7F6|uniprotkb:P00190|uniprotkb:P10890|uniprotkb:Q16803|uniprotkb:Q4VAU0|uniprotkb:Q4VAU1|uniprotkb:Q9H1Z7|uniprotkb:Q9UCU0|uniprotkb:Q9UK48|ensembl:ENSP00000301141	psi-mi:coumarin(display_short)|psi-mi:"CHEBI:28794"(display_long)|intact:1,2-Benzopyrone(synonym)|intact:"2-Propenoic acid, 3-(2-hydroxyphenyl)-, d-lactone"(synonym)|intact:"2-Propenoic acid, 3-(2-hydroxyphenyl)-, delta-lactone"(synonym)|intact:2H-1-Benzopyran-2-one(synonym)|intact:2H-benzo[b]pyran-2-one(synonym)|intact:5,6-Benzo-2-pyrone(synonym)|intact:Benzo-a-pyrone(synonym)|intact:Benzo-alpha-pyrone(synonym)|intact:cis-o-Coumarinic acid lactone(synonym)|intact:Coumarine(synonym)|intact:Coumarinic anhydride(synonym)|intact:Cumarin(synonym)|intact:o-hydroxycinnamic acid delta-lactone(synonym)|intact:o-Hydroxycinnamic acid lactone(synonym)|intact:Rattex(synonym)|intact:Tonka bean camphor(synonym)|intact:2H-chromen-2-one(iupac name)	psi-mi:cp2a6_human(display_long)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:CYPIIA6(gene name synonym)|uniprotkb:Coumarin 7-hydroxylase(gene name synonym)|uniprotkb:Cytochrome P450 IIA3(gene name synonym)|uniprotkb:"Cytochrome P450(I)"(gene name synonym)|uniprotkb:CYP2A6(gene name)|psi-mi:CYP2A6(display_short)|uniprotkb:CYP2A3(gene name synonym)	psi-mi:"MI:0966"(ultraviolet-visible spectroscopy)	Han et al. (2011)	pubmed:22382327|imex:IM-27060	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21447296|imex:IM-27060-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000753.3|ensembl:ENSG00000255974(gene)|ensembl:ENST00000301141(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008389"(coumarin 7-hydroxylase activity)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0009804"(coumarin metabolic process)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0042738"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046226"(coumarin catabolic process)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR008067(Cytochrome P450, E-class, group I, CYP2A-like)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1Z10|rcsb pdb:1Z11|rcsb pdb:2FDU|rcsb pdb:2FDV|rcsb pdb:2FDW|rcsb pdb:2FDY|rcsb pdb:3EBS|rcsb pdb:3T3Q|rcsb pdb:3T3R|rcsb pdb:4EJJ|rcsb pdb:4RUI|reactome:R-HSA-211981|reactome:R-HSA-211999	-	-	-	figure legend:Table 1, Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.5x10^-6 ~0.1(molar)	2019/06/04	2020/01/15	-	rogid:ZQuEiJtuAyL2MNnm5O+D30PW67k9606	-	false	-	mutation decreasing interaction strength:471-471|mutation decreasing interaction strength:485-485|mutation decreasing interaction strength:392-392|mutation decreasing interaction strength:438-438|his tag:c-c|mutation decreasing interaction strength:392-392,471-471	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:28794"	uniprotkb:P11509	intact:EBI-21447270|chebi:"CHEBI:3906"|chebi:"CHEBI:41552"|chebi:"CHEBI:101256"|chebi:"CHEBI:23402"	intact:EBI-21447212|uniprotkb:Q4VAT9|uniprotkb:A7YAE5|uniprotkb:B2R7F6|uniprotkb:P00190|uniprotkb:P10890|uniprotkb:Q16803|uniprotkb:Q4VAU0|uniprotkb:Q4VAU1|uniprotkb:Q9H1Z7|uniprotkb:Q9UCU0|uniprotkb:Q9UK48|ensembl:ENSP00000301141	psi-mi:coumarin(display_short)|psi-mi:"CHEBI:28794"(display_long)|intact:1,2-Benzopyrone(synonym)|intact:"2-Propenoic acid, 3-(2-hydroxyphenyl)-, d-lactone"(synonym)|intact:"2-Propenoic acid, 3-(2-hydroxyphenyl)-, delta-lactone"(synonym)|intact:2H-1-Benzopyran-2-one(synonym)|intact:2H-benzo[b]pyran-2-one(synonym)|intact:5,6-Benzo-2-pyrone(synonym)|intact:Benzo-a-pyrone(synonym)|intact:Benzo-alpha-pyrone(synonym)|intact:cis-o-Coumarinic acid lactone(synonym)|intact:Coumarine(synonym)|intact:Coumarinic anhydride(synonym)|intact:Cumarin(synonym)|intact:o-hydroxycinnamic acid delta-lactone(synonym)|intact:o-Hydroxycinnamic acid lactone(synonym)|intact:Rattex(synonym)|intact:Tonka bean camphor(synonym)|intact:2H-chromen-2-one(iupac name)	psi-mi:cp2a6_human(display_long)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:CYPIIA6(gene name synonym)|uniprotkb:Coumarin 7-hydroxylase(gene name synonym)|uniprotkb:Cytochrome P450 IIA3(gene name synonym)|uniprotkb:"Cytochrome P450(I)"(gene name synonym)|uniprotkb:CYP2A6(gene name)|psi-mi:CYP2A6(display_short)|uniprotkb:CYP2A3(gene name synonym)	psi-mi:"MI:1000"(hydroxylase assay)	Han et al. (2011)	pubmed:22382327|imex:IM-27060	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0210"(hydroxylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21447576|imex:IM-27060-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000753.3|ensembl:ENSG00000255974(gene)|ensembl:ENST00000301141(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008389"(coumarin 7-hydroxylase activity)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0009804"(coumarin metabolic process)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0042738"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046226"(coumarin catabolic process)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR008067(Cytochrome P450, E-class, group I, CYP2A-like)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1Z10|rcsb pdb:1Z11|rcsb pdb:2FDU|rcsb pdb:2FDV|rcsb pdb:2FDW|rcsb pdb:2FDY|rcsb pdb:3EBS|rcsb pdb:3T3Q|rcsb pdb:3T3R|rcsb pdb:4EJJ|rcsb pdb:4RUI|reactome:R-HSA-211981|reactome:R-HSA-211999	go:"GO:0008389"(coumarin 7-hydroxylase activity)|go:"GO:0009804"(coumarin metabolic process)	-	-	figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:7.6x10^-6 ~1.0(molar)	2019/06/04	2020/01/28	-	rogid:ZQuEiJtuAyL2MNnm5O+D30PW67k9606	-	false	-	mutation decreasing interaction rate:471-471|mutation decreasing interaction rate:392-392|mutation increasing interaction rate:485-485|his tag:c-c|mutation decreasing interaction rate:392-392,471-471|mutation increasing interaction rate:438-438	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18723"	uniprotkb:P11509	intact:EBI-10767161	intact:EBI-21447212|uniprotkb:Q4VAT9|uniprotkb:A7YAE5|uniprotkb:B2R7F6|uniprotkb:P00190|uniprotkb:P10890|uniprotkb:Q16803|uniprotkb:Q4VAU0|uniprotkb:Q4VAU1|uniprotkb:Q9H1Z7|uniprotkb:Q9UCU0|uniprotkb:Q9UK48|ensembl:ENSP00000301141	psi-mi:nicotine(display_short)|psi-mi:"CHEBI:18723"(display_long)|intact:"(+-)-nicotine"(synonym)|intact:"(+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine"(synonym)|intact:"(R,S)-nicotine"(synonym)|intact:"(RS)-nicotine"(synonym)|intact:Nicotin(synonym)|intact:Nikotin(synonym)|intact:"3-(1-methylpyrrolidin-2-yl)pyridine"(iupac name)	psi-mi:cp2a6_human(display_long)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:CYPIIA6(gene name synonym)|uniprotkb:Coumarin 7-hydroxylase(gene name synonym)|uniprotkb:Cytochrome P450 IIA3(gene name synonym)|uniprotkb:"Cytochrome P450(I)"(gene name synonym)|uniprotkb:CYP2A6(gene name)|psi-mi:CYP2A6(display_short)|uniprotkb:CYP2A3(gene name synonym)	psi-mi:"MI:0979"(oxidoreductase assay)	Han et al. (2011)	pubmed:22382327|imex:IM-27060	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055487|imex:IM-27060-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000753.3|ensembl:ENSG00000255974(gene)|ensembl:ENST00000301141(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008389"(coumarin 7-hydroxylase activity)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0009804"(coumarin metabolic process)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0042738"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046226"(coumarin catabolic process)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR008067(Cytochrome P450, E-class, group I, CYP2A-like)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1Z10|rcsb pdb:1Z11|rcsb pdb:2FDU|rcsb pdb:2FDV|rcsb pdb:2FDW|rcsb pdb:2FDY|rcsb pdb:3EBS|rcsb pdb:3T3Q|rcsb pdb:3T3R|rcsb pdb:4EJJ|rcsb pdb:4RUI|reactome:R-HSA-211981|reactome:R-HSA-211999	go:"GO:0018933"(nicotine metabolic process)|go:"GO:0018535"(nicotine dehydrogenase activity)	-	-	figure legend:Table 2, Figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:145.0x10^-6 ~39.0(molar)	2019/06/04	2020/01/28	-	rogid:ZQuEiJtuAyL2MNnm5O+D30PW67k9606	-	false	-	mutation decreasing interaction rate:471-471|mutation decreasing interaction rate:485-485|mutation decreasing interaction rate:392-392|mutation increasing interaction rate:392-392,471-471|mutation decreasing interaction rate:438-438|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)