#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P36956-PRO_0000314029	uniprotkb:P02545-1	intact:EBI-22057616	intact:EBI-351949|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:p02545-1(display_long)|uniprotkb:Lamin A(isoform synonym)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22057623|imex:IM-27410-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-948313(chain-parent)	intact:EBI-351935(lmna_human)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)	-	chain-seq-start:1|chain-seq-end:490	-	figure legend:Fig. 1d, 1e, 3b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/04	2019/10/09	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rigid:eXW1444rL4gA+jIrMpAA0DPVhZo	false	his tag:n-n|sufficient binding region:227-487	glutathione s tranferase tag:n-n|mutation with no effect:482-482|necessary binding region:607-656|sufficient binding region:389-572	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20700	uniprotkb:P36956-PRO_0000314029	intact:EBI-968218|ensembl:ENSP00000261366|uniprotkb:Q3SYN7|uniprotkb:Q96EI6|uniprotkb:B2R6J6	intact:EBI-22057616	psi-mi:lmnb1_human(display_long)|uniprotkb:LMNB1(gene name)|psi-mi:LMNB1(display_short)|uniprotkb:LMN2(gene name synonym)|uniprotkb:LMNB(gene name synonym)	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22057635|imex:IM-27410-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113368(gene)|ensembl:ENST00000261366(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P20700|rcsb pdb:2KPW|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3JT0|rcsb pdb:3TYY|rcsb pdb:3UMN|rcsb pdb:5VVX|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|reactome:R-HSA-2559584|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-4419969|reactome:R-HSA-8862803|reactome:R-HSA-8950505|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:NP_005564.1|dip:DIP-34897N	intact:EBI-948313(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:490	figure legend:Fig. 1d, 1e|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/04	2019/10/04	rogid:ZLv4OS5VSmn3sdXB9IP98YdQ+Iw9606	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rigid:V7IhqBDChYaZqqvZEY9/Nyvn5v8	false	sufficient binding region:391-586|glutathione s tranferase tag:n-n	his tag:n-n|sufficient binding region:227-487	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02545-1	uniprotkb:P36956-PRO_0000314029	intact:EBI-351949|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	intact:EBI-22057616	psi-mi:p02545-1(display_long)|uniprotkb:Lamin A(isoform synonym)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22078809|imex:IM-27410-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-351935(lmna_human)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)	intact:EBI-948313(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:490	figure legend:Fig. 1f|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:63.0x10^-9 ~19.0(molar)	2019/10/04	2019/11/11	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rigid:eXW1444rL4gA+jIrMpAA0DPVhZo	false	glutathione s tranferase tag:n-n|sufficient binding region:389-572	his tag:n-n|sufficient binding region:227-487	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36956-PRO_0000314029	uniprotkb:P02545-1	intact:EBI-22057616	intact:EBI-351949|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:p02545-1(display_long)|uniprotkb:Lamin A(isoform synonym)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22078871|imex:IM-27410-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-948313(chain-parent)	intact:EBI-351935(lmna_human)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)	go:"GO:0005654"(nucleoplasm)	chain-seq-start:1|chain-seq-end:490	-	figure legend:Fig. 2b|comment:"GFP tag of SREBP1 carries nucleolar localization sequence that targets the green fluorescent protein (GFP) into the granular component (GC) of nucleoli (pmid: 17179202)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/10/04	2019/10/09	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rigid:eXW1444rL4gA+jIrMpAA0DPVhZo	false	green fluorescent protein tag:?-?|sufficient binding region:227-487	flag tag:?-?|sufficient binding region:389-646	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P36956-PRO_0000314029	uniprotkb:P02545-1	intact:EBI-22057616	intact:EBI-351949|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:p02545-1(display_long)|uniprotkb:Lamin A(isoform synonym)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22083845|imex:IM-27410-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-948313(chain-parent)	intact:EBI-351935(lmna_human)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)	go:"GO:0005654"(nucleoplasm)	chain-seq-start:1|chain-seq-end:490	-	figure legend:Fig. 5b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/10/04	2019/10/09	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rigid:eXW1444rL4gA+jIrMpAA0DPVhZo	false	ha tag:?-?|sufficient binding region:227-487	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P36956-PRO_0000314029	uniprotkb:P02545-1	intact:EBI-22057616	intact:EBI-351949|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:p02545-1(display_long)|uniprotkb:Lamin A(isoform synonym)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22083919|imex:IM-27410-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-948313(chain-parent)	intact:EBI-351935(lmna_human)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)	go:"GO:0005654"(nucleoplasm)	chain-seq-start:1|chain-seq-end:490	-	figure legend:Fig. 6b-6d, 6f-6g, 7b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/10/04	2019/10/09	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rigid:eXW1444rL4gA+jIrMpAA0DPVhZo	false	ha tag:?-?|sufficient binding region:227-487	flag tag:?-?|mutation with no effect:482-482|mutation with no effect:647-647|necessary binding region:432-664	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P02545-6	uniprotkb:P36956-PRO_0000314029	intact:EBI-9034379|intact:EBI-8042626|intact:MINT-1408464|ensembl:ENSP00000357282	intact:EBI-22057616	psi-mi:p02545-6(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)|uniprotkb:Progerin(isoform synonym)	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22083980|imex:IM-27410-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-351935(isoform-parent)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000368299(transcript)	intact:EBI-948313(chain-parent)	go:"GO:0005654"(nucleoplasm)	isoform-comment:Disease-associated isoform. Polymorphism at codon 608 results in activation of a cryptic splice donor site within exon 11, resulting in a truncated protein product that lacks the site for endoproteolytic cleavage.	chain-seq-start:1|chain-seq-end:490	figure legend:Fig. 6h|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/10/04	2019/10/09	rogid:SnGZ06nvQ9x/vwBilYOuQGiWR7Q9606	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rigid:ZlAuRJ2o1dGFGw1zh2M2W1ncjRY	false	flag tag:?-?	ha tag:?-?|sufficient binding region:227-487	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P20700	uniprotkb:P36956-PRO_0000314029	intact:EBI-968218|ensembl:ENSP00000261366|uniprotkb:Q3SYN7|uniprotkb:Q96EI6|uniprotkb:B2R6J6	intact:EBI-22057616	psi-mi:lmnb1_human(display_long)|uniprotkb:LMNB1(gene name)|psi-mi:LMNB1(display_short)|uniprotkb:LMN2(gene name synonym)|uniprotkb:LMNB(gene name synonym)	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22084002|imex:IM-27410-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113368(gene)|ensembl:ENST00000261366(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P20700|rcsb pdb:2KPW|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3JT0|rcsb pdb:3TYY|rcsb pdb:3UMN|rcsb pdb:5VVX|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|reactome:R-HSA-2559584|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-4419969|reactome:R-HSA-8862803|reactome:R-HSA-8950505|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:NP_005564.1|dip:DIP-34897N	intact:EBI-948313(chain-parent)	go:"GO:0005654"(nucleoplasm)	-	chain-seq-start:1|chain-seq-end:490	figure legend:Fig. 6e|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/10/04	2019/10/09	rogid:ZLv4OS5VSmn3sdXB9IP98YdQ+Iw9606	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rigid:V7IhqBDChYaZqqvZEY9/Nyvn5v8	false	green fluorescent protein tag:?-?	ha tag:?-?|sufficient binding region:227-487	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P36956-PRO_0000314029	uniprotkb:P02545-1	intact:EBI-22057616	intact:EBI-351949|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:p02545-1(display_long)|uniprotkb:Lamin A(isoform synonym)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22083804|imex:IM-27410-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-948313(chain-parent)	intact:EBI-351935(lmna_human)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)	-	chain-seq-start:1|chain-seq-end:490	-	figure legend:Fig. 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/10/04	2019/10/09	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rigid:eXW1444rL4gA+jIrMpAA0DPVhZo	false	sufficient binding region:227-487|ha tag:?-?	flag tag:?-?|sufficient binding region:389-646|mutation with no effect:482-482|mutation with no effect:647-647	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P02545-6	uniprotkb:P36956-PRO_0000314029	intact:EBI-9034379|intact:EBI-8042626|intact:MINT-1408464|ensembl:ENSP00000357282	intact:EBI-22057616	psi-mi:p02545-6(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)|uniprotkb:Progerin(isoform synonym)	psi-mi:p36956-pro_0000314029(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Duband-Goulet et al. (2011)	pubmed:21993218|imex:IM-27410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22083824|imex:IM-27410-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-351935(isoform-parent)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000368299(transcript)	intact:EBI-948313(chain-parent)	-	isoform-comment:Disease-associated isoform. Polymorphism at codon 608 results in activation of a cryptic splice donor site within exon 11, resulting in a truncated protein product that lacks the site for endoproteolytic cleavage.	chain-seq-start:1|chain-seq-end:490	figure legend:Fig. 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/10/04	2019/10/09	rogid:SnGZ06nvQ9x/vwBilYOuQGiWR7Q9606	rogid:Y37QHvaKIKup55/YzyQbx/Y7WXQ9606	rigid:ZlAuRJ2o1dGFGw1zh2M2W1ncjRY	false	flag tag:?-?	sufficient binding region:227-487|ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)