#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:53412"	uniprotkb:P06909	intact:EBI-21991990	intact:EBI-8380956|uniprotkb:Q6NZK3|intact:MINT-1858780|ensembl:ENSMUSP00000066677	psi-mi:"poly(l-lysine) macromolecule"(display_short)|psi-mi:"CHEBI:53412"(display_long)|intact:"(S)-Poly(imino(2-amino-1-oxo-1,6-hexanediyl))"(synonym)|intact:E-Polylysine(synonym)|intact:PLL(synonym)|intact:"Poly(E-lysine)"(synonym)|intact:"poly(L-lysine)"(synonym)|intact:"poly[(S)-lysine]"(synonym)|intact:"poly{imino[(2S)-2-amino-1-oxohexane-1,6-diyl]}"(iupac name)	psi-mi:cfah_mouse(display_long)|uniprotkb:Cfh(gene name)|psi-mi:Cfh(display_short)|uniprotkb:Hf1(gene name synonym)|uniprotkb:Protein beta-1-H(gene name synonym)	psi-mi:"MI:0096"(pull down)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21991988|imex:IM-27324-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_034018.2|ensembl:ENSMUSG00000026365(gene)|ensembl:ENSMUST00000066859(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0001905"(activation of membrane attack complex)|go:"GO:0002021"(response to dietary excess)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007601"(visual perception)|go:"GO:0008201"(heparin binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010467"(gene expression)|go:"GO:0030424"(axon)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032835"(glomerulus development)|go:"GO:0034097"(response to cytokine)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051640"(organelle localization)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140053"(mitochondrial gene expression)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P06909|rcsb pdb:2YBY|reactome:R-MMU-977606	-	-	comment:mint|function:"Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway"	figure legend:Supplementary Table 1,  Supplementary Fig. 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	-	rogid:AC0IxswHG19xPmqLQikiHpBczAQ10090	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:53412"	uniprotkb:E9PV24	intact:EBI-21991990	intact:EBI-6252659|ensembl:ENSMUSP00000133117|intact:EBI-8314642|intact:MINT-1863401|uniprotkb:Q99K47	psi-mi:"poly(l-lysine) macromolecule"(display_short)|psi-mi:"CHEBI:53412"(display_long)|intact:"(S)-Poly(imino(2-amino-1-oxo-1,6-hexanediyl))"(synonym)|intact:E-Polylysine(synonym)|intact:PLL(synonym)|intact:"Poly(E-lysine)"(synonym)|intact:"poly(L-lysine)"(synonym)|intact:"poly[(S)-lysine]"(synonym)|intact:"poly{imino[(2S)-2-amino-1-oxohexane-1,6-diyl]}"(iupac name)	psi-mi:fiba_mouse(display_long)|uniprotkb:Fga(gene name)|psi-mi:Fga(display_short)	psi-mi:"MI:0096"(pull down)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21991988|imex:IM-27324-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_034326.1|ensembl:ENSMUSG00000028001(gene)|ensembl:ENSMUST00000166581(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072377"(blood coagulation, common pathway)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|go:"GO:0042730"(fibrinolysis)|interpro:IPR021996|interpro:IPR036056|interpro:IPR037579|mint:E9PV24|reactome:R-MMU-114608|reactome:R-MMU-140875|reactome:R-MMU-216083|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-5686938|reactome:R-MMU-8957275|interpro:IPR020837|refseq:NP_001104518.1	-	-	-	figure legend:Supplementary Table 1,  Supplementary Fig. 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	-	rogid:c9u+80j+sNgwjFuQ5vnHBVKgLCg10090	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:53412"	uniprotkb:Q8VCM7	intact:EBI-21991990	intact:EBI-6252682|ensembl:ENSMUSP00000037018|uniprotkb:Q8WUR3|uniprotkb:Q91ZP0	psi-mi:"poly(l-lysine) macromolecule"(display_short)|psi-mi:"CHEBI:53412"(display_long)|intact:"(S)-Poly(imino(2-amino-1-oxo-1,6-hexanediyl))"(synonym)|intact:E-Polylysine(synonym)|intact:PLL(synonym)|intact:"Poly(E-lysine)"(synonym)|intact:"poly(L-lysine)"(synonym)|intact:"poly[(S)-lysine]"(synonym)|intact:"poly{imino[(2S)-2-amino-1-oxohexane-1,6-diyl]}"(iupac name)	psi-mi:fibg_mouse(display_long)|uniprotkb:Fgg(gene name)|psi-mi:Fgg(display_short)	psi-mi:"MI:0096"(pull down)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21991988|imex:IM-27324-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000033860(gene)|ensembl:ENSMUST00000048486(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|interpro:IPR037581|mint:Q8VCM7|reactome:R-MMU-114608|reactome:R-MMU-140875|reactome:R-MMU-216083|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-5686938|reactome:R-MMU-8957275|refseq:NP_598623.1	-	-	-	figure legend:Supplementary Table 1,  Supplementary Fig. 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	-	rogid:AmOFe/GrPI4CGlyrFHBM1QHxYOk10090	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:53412"	uniprotkb:Q00623	intact:EBI-21991990	intact:EBI-1634106|uniprotkb:Q8BPD5|uniprotkb:O08855|uniprotkb:O09042|ensembl:ENSMUSP00000034588	psi-mi:"poly(l-lysine) macromolecule"(display_short)|psi-mi:"CHEBI:53412"(display_long)|intact:"(S)-Poly(imino(2-amino-1-oxo-1,6-hexanediyl))"(synonym)|intact:E-Polylysine(synonym)|intact:PLL(synonym)|intact:"Poly(E-lysine)"(synonym)|intact:"poly(L-lysine)"(synonym)|intact:"poly[(S)-lysine]"(synonym)|intact:"poly{imino[(2S)-2-amino-1-oxohexane-1,6-diyl]}"(iupac name)	psi-mi:apoa1_mouse(display_long)|uniprotkb:Apoa1(gene name)|psi-mi:Apoa1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21991988|imex:IM-27324-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_033822.2|ensembl:ENSMUSG00000032083(gene)|ensembl:ENSMUST00000034588(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:Q00623|rcsb pdb:2LEM|reactome:R-MMU-114608|reactome:R-MMU-1369062|reactome:R-MMU-2168880|reactome:R-MMU-3000471|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-8963896|reactome:R-MMU-8963901|reactome:R-MMU-8964011|reactome:R-MMU-8964058|reactome:R-MMU-9707616|reactome:R-MMU-975634	-	-	-	figure legend:Supplementary Table 1,  Supplementary Fig. 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	-	rogid:RFvdsVcof99jM6K/bEi1N1Vn9hE10090	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:53412"	uniprotkb:P01027	intact:EBI-21991990	intact:EBI-4281083|uniprotkb:Q80XP1|ensembl:ENSMUSP00000024988|uniprotkb:Q61370	psi-mi:"poly(l-lysine) macromolecule"(display_short)|psi-mi:"CHEBI:53412"(display_long)|intact:"(S)-Poly(imino(2-amino-1-oxo-1,6-hexanediyl))"(synonym)|intact:E-Polylysine(synonym)|intact:PLL(synonym)|intact:"Poly(E-lysine)"(synonym)|intact:"poly(L-lysine)"(synonym)|intact:"poly[(S)-lysine]"(synonym)|intact:"poly{imino[(2S)-2-amino-1-oxohexane-1,6-diyl]}"(iupac name)	psi-mi:co3_mouse(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:HSE-MSF(gene name synonym)	psi-mi:"MI:0096"(pull down)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21991988|imex:IM-27324-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000024164(gene)|ensembl:ENSMUST00000024988(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008289"(lipid binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01027|rcsb pdb:6XZU|reactome:R-MMU-173736|reactome:R-MMU-174577|reactome:R-MMU-198933|reactome:R-MMU-375276|reactome:R-MMU-381426|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-977606|refseq:NP_033908.2	-	-	-	figure legend:Supplementary Table 1,  Supplementary Fig. 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	-	rogid:VGFRYhKETrS9O7cyeJZyxBFgBL410090	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:53412"	uniprotkb:Q8R0I8	intact:EBI-21991990	intact:EBI-21992044	psi-mi:"poly(l-lysine) macromolecule"(display_short)|psi-mi:"CHEBI:53412"(display_long)|intact:"(S)-Poly(imino(2-amino-1-oxo-1,6-hexanediyl))"(synonym)|intact:E-Polylysine(synonym)|intact:PLL(synonym)|intact:"Poly(E-lysine)"(synonym)|intact:"poly(L-lysine)"(synonym)|intact:"poly[(S)-lysine]"(synonym)|intact:"poly{imino[(2S)-2-amino-1-oxohexane-1,6-diyl]}"(iupac name)	psi-mi:q8r0i8_mouse(display_long)|uniprotkb:Cfhr2(gene name)|psi-mi:Cfhr2(display_short)|uniprotkb:BC026782(gene name synonym)|uniprotkb:Cfh(gene name synonym)	psi-mi:"MI:0096"(pull down)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21991988|imex:IM-27324-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR035976|interpro:IPR000436(Sushi/SCR/CCP)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)	-	-	-	figure legend:Supplementary Table 1,  Supplementary Fig. 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	-	rogid:gM0Qmw4QpmppM67xwfyGW0fZZ0Y10090	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:53412"	uniprotkb:P14847	intact:EBI-21991990	intact:EBI-21992004|uniprotkb:E9PZ20|ensembl:ENSMUSP00000044665	psi-mi:"poly(l-lysine) macromolecule"(display_short)|psi-mi:"CHEBI:53412"(display_long)|intact:"(S)-Poly(imino(2-amino-1-oxo-1,6-hexanediyl))"(synonym)|intact:E-Polylysine(synonym)|intact:PLL(synonym)|intact:"Poly(E-lysine)"(synonym)|intact:"poly(L-lysine)"(synonym)|intact:"poly[(S)-lysine]"(synonym)|intact:"poly{imino[(2S)-2-amino-1-oxohexane-1,6-diyl]}"(iupac name)	psi-mi:crp_mouse(display_long)|uniprotkb:Crp(gene name)|psi-mi:Crp(display_short)|uniprotkb:Ptx1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21991988|imex:IM-27324-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_031794.3|ensembl:ENSMUSG00000037942(gene)|ensembl:ENSMUST00000038495(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042060"(wound healing)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|reactome:R-MMU-173623	-	-	-	figure legend:Supplementary Table 1,  Supplementary Fig. 2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	-	rogid:nFE1+6UiDsgZpaXgXe9aGJsI0zE10090	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:53412"	uniprotkb:P06909	intact:EBI-21991990	intact:EBI-8380956|uniprotkb:Q6NZK3|intact:MINT-1858780|ensembl:ENSMUSP00000066677	psi-mi:"poly(l-lysine) macromolecule"(display_short)|psi-mi:"CHEBI:53412"(display_long)|intact:"(S)-Poly(imino(2-amino-1-oxo-1,6-hexanediyl))"(synonym)|intact:E-Polylysine(synonym)|intact:PLL(synonym)|intact:"Poly(E-lysine)"(synonym)|intact:"poly(L-lysine)"(synonym)|intact:"poly[(S)-lysine]"(synonym)|intact:"poly{imino[(2S)-2-amino-1-oxohexane-1,6-diyl]}"(iupac name)	psi-mi:cfah_mouse(display_long)|uniprotkb:Cfh(gene name)|psi-mi:Cfh(display_short)|uniprotkb:Hf1(gene name synonym)|uniprotkb:Protein beta-1-H(gene name synonym)	psi-mi:"MI:0096"(pull down)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992067|imex:IM-27324-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_034018.2|ensembl:ENSMUSG00000026365(gene)|ensembl:ENSMUST00000066859(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0001905"(activation of membrane attack complex)|go:"GO:0002021"(response to dietary excess)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007601"(visual perception)|go:"GO:0008201"(heparin binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010467"(gene expression)|go:"GO:0030424"(axon)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032835"(glomerulus development)|go:"GO:0034097"(response to cytokine)|go:"GO:0035886"(vascular associated smooth muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051640"(organelle localization)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140053"(mitochondrial gene expression)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P06909|rcsb pdb:2YBY|reactome:R-MMU-977606	-	-	comment:mint|function:"Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway"	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:AC0IxswHG19xPmqLQikiHpBczAQ10090	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:53412"	uniprotkb:P08603	intact:EBI-21991990	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:"poly(l-lysine) macromolecule"(display_short)|psi-mi:"CHEBI:53412"(display_long)|intact:"(S)-Poly(imino(2-amino-1-oxo-1,6-hexanediyl))"(synonym)|intact:E-Polylysine(synonym)|intact:PLL(synonym)|intact:"Poly(E-lysine)"(synonym)|intact:"poly(L-lysine)"(synonym)|intact:"poly[(S)-lysine]"(synonym)|intact:"poly{imino[(2S)-2-amino-1-oxohexane-1,6-diyl]}"(iupac name)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992082|imex:IM-27324-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:39026"	uniprotkb:P08603	intact:EBI-21992105	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:low-density lipoprotein(display_short)|psi-mi:"CHEBI:39026"(display_long)|intact:beta-lipoproteins(synonym)|intact:LDL(synonym)|intact:low-density lipoproteins(synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992098|imex:IM-27324-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1C|comment:"Purified CFH bound in a calcium-independent manner to both MAA-modified low density lipoprotein (MAA-LDL) and MAA-modified bovine serum albumin (MAA-BSA)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P08603	uniprotkb:P02769	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992110|imex:IM-27324-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Figure 1C/D/E, 2B, supplementary Fig. 3/4B|comment:"Purified CFH bound in a calcium-independent manner to both MAA-modified low density lipoprotein (MAA-LDL) and MAA-modified bovine serum albumin (MAA-BSA)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.4x10^-8(molar)	2019/08/16	2019/09/18	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rigid:MR+NX4FYIwLUHwasVsyHcSmQqoI	false	mutation decreasing interaction strength:402-402	biological feature:?-?("CHEBI:75949")	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P02741	uniprotkb:P02769	intact:EBI-1395983|uniprotkb:A8K078|uniprotkb:Q08AK3|uniprotkb:Q8WW75|uniprotkb:D3DVD9|uniprotkb:D3DVE0|ensembl:ENSP00000255030	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:crp_human(display_long)|uniprotkb:CRP(gene name)|psi-mi:CRP(display_short)|uniprotkb:PTX1(gene name synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992117|imex:IM-27324-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000558.2|refseq:NP_001315986.1|refseq:NP_001315987.1|dip:DIP-39125N|ensembl:ENSG00000132693(gene)|ensembl:ENST00000255030(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008228"(opsonization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0033265"(choline binding)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:P02741|rcsb pdb:1B09|rcsb pdb:1CRV|rcsb pdb:1GNH|rcsb pdb:1LJ7|rcsb pdb:3L2Y|rcsb pdb:3PVN|rcsb pdb:3PVO|reactome:R-HSA-173623	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Figure 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	rogid:R7vKMSGKD4ETbUKVGL9IiL8jzjE9606	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rigid:jR97f/83pKQZzZY3ypnb+mV/yBQ	false	-	biological feature:?-?("CHEBI:55395")	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:39026"	uniprotkb:P02769	intact:EBI-21992105	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:low-density lipoprotein(display_short)|psi-mi:"CHEBI:39026"(display_long)|intact:beta-lipoproteins(synonym)|intact:LDL(synonym)|intact:low-density lipoproteins(synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992130|imex:IM-27324-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Figure 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	-	false	biological feature:?-?("CHEBI:75949")	biological feature:?-?("CHEBI:75949")	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P02769	uniprotkb:P08603	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992130|imex:IM-27324-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:39026"	uniprotkb:P02769	intact:EBI-21992105	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:low-density lipoprotein(display_short)|psi-mi:"CHEBI:39026"(display_long)|intact:beta-lipoproteins(synonym)|intact:LDL(synonym)|intact:low-density lipoproteins(synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992142|imex:IM-27324-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Figure 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	-	false	biological feature:?-?("CHEBI:566274")	biological feature:?-?("CHEBI:75949")	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P02769	uniprotkb:P08603	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992142|imex:IM-27324-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P02769	uniprotkb:P02769	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992153|imex:IM-27324-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Figure 1F|comment:Binding of CFH to coated MAA-BSA was competed by soluble MAA-BSA  in whole plasma.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rigid:MR+NX4FYIwLUHwasVsyHcSmQqoI	false	biological feature:?-?("CHEBI:75949")	biological feature:?-?("CHEBI:75949")	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P02769	uniprotkb:P08603	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992153|imex:IM-27324-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1F|comment:Binding of CFH to coated MAA-BSA was competed by soluble MAA-BSA  in whole plasma.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rigid:MR+NX4FYIwLUHwasVsyHcSmQqoI	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P08603	uniprotkb:P02769	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992228|imex:IM-27324-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606|interpro:IPR035976	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.4x10^-8(molar)	2019/08/16	2019/09/18	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rigid:MR+NX4FYIwLUHwasVsyHcSmQqoI	false	sufficient binding region:19..19-444..444|sufficient binding region:1046..1046-1230..1230|his tag:c-c|necessary binding region:387..387-444..444|necessary binding region:1170..1170-1230..1230(IPR035976)	biological feature:?-?("CHEBI:75949")	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:39026"	uniprotkb:P08603	intact:EBI-21992105	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:low-density lipoprotein(display_short)|psi-mi:"CHEBI:39026"(display_long)|intact:beta-lipoproteins(synonym)|intact:LDL(synonym)|intact:low-density lipoproteins(synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992253|imex:IM-27324-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 2C, Supplementary Fig. 9D|comment:Binding of plasma CFH to coated MDA-LDL in plasma of subjects either homozygous for the H402 risk allele , heterozygous for the H402 risk allele or homozygous for the Y402 allele.|comment:"Individuals with deletions of CFHR1 and CFHR3 were removed from this analysis, but this  did not alter the significance of the association of rs1061170 (Y402H mutation)  with decreased MDA binding."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/30	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:566274")	mutation decreasing interaction strength:402-402	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P08603	uniprotkb:P01024	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-905851|uniprotkb:A7E236|ensembl:ENSP00000245907	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:co3_human(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992363|imex:IM-27324-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	refseq:NP_000055.2|dip:DIP-35180N|ensembl:ENSG00000125730(gene)|ensembl:ENST00000245907(transcript)|go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001970"(positive regulation of activation of membrane attack complex)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0010866"(regulation of triglyceride biosynthetic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016322"(neuron remodeling)|go:"GO:0031715"(C5L2 anaphylatoxin chemotactic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035846"(oviduct epithelium development)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR035711|interpro:IPR035815|interpro:IPR036595|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|mint:P01024|rcsb pdb:1C3D|rcsb pdb:1GHQ|rcsb pdb:1W2S|rcsb pdb:2A73|rcsb pdb:2A74|rcsb pdb:2GOX|rcsb pdb:2I07|rcsb pdb:2ICE|rcsb pdb:2ICF|rcsb pdb:2NOJ|rcsb pdb:2QKI|rcsb pdb:2WII|rcsb pdb:2WIN|rcsb pdb:2WY7|rcsb pdb:2WY8|rcsb pdb:2XQW|rcsb pdb:2XWB|rcsb pdb:2XWJ|rcsb pdb:3D5R|rcsb pdb:3D5S|rcsb pdb:3G6J|rcsb pdb:3L3O|rcsb pdb:3L5N|rcsb pdb:3NMS|rcsb pdb:3OED|rcsb pdb:3OHX|rcsb pdb:3OXU|rcsb pdb:3RJ3|rcsb pdb:3T4A|rcsb pdb:4HW5|rcsb pdb:4HWJ|rcsb pdb:4I6O|rcsb pdb:4M76|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5FO7|rcsb pdb:5FO8|rcsb pdb:5FO9|rcsb pdb:5FOA|rcsb pdb:5FOB|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:6EHG|rcsb pdb:6RMT|rcsb pdb:6RMU|rcsb pdb:6RUR|rcsb pdb:6RUV|rcsb pdb:6S0B|rcsb pdb:6YO6|reactome:R-HSA-173736|reactome:R-HSA-174577|reactome:R-HSA-198933|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9660826|reactome:R-HSA-977606	-	-	-	figure legend:supplementary Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:6Axa89cCPpUXFsLnd7sCurZzLYI9606	rigid:KXm41TaVnrZ6VNFhwbfumpgLiy4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P08603	uniprotkb:P02769	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992375|imex:IM-27324-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Figure 1F, Supplementary Fig.5|comment:Binding of CFH to coated MAA-BSA was competed by soluble MAA-BSA  in whole plasma.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rigid:MR+NX4FYIwLUHwasVsyHcSmQqoI	false	-	biological feature:?-?("CHEBI:75949")	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:39026"	uniprotkb:P08603	intact:EBI-21992105	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:low-density lipoprotein(display_short)|psi-mi:"CHEBI:39026"(display_long)|intact:beta-lipoproteins(synonym)|intact:LDL(synonym)|intact:low-density lipoproteins(synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992175|imex:IM-27324-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:75949")|biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:39026"	uniprotkb:P08603	intact:EBI-21992105	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:low-density lipoprotein(display_short)|psi-mi:"CHEBI:39026"(display_long)|intact:beta-lipoproteins(synonym)|intact:LDL(synonym)|intact:low-density lipoproteins(synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992195|imex:IM-27324-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:39026"	uniprotkb:P08603	intact:EBI-21992105	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:low-density lipoprotein(display_short)|psi-mi:"CHEBI:39026"(display_long)|intact:beta-lipoproteins(synonym)|intact:LDL(synonym)|intact:low-density lipoproteins(synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992195|imex:IM-27324-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:75949")|biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:39026"	uniprotkb:P08603	intact:EBI-21992105	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:low-density lipoprotein(display_short)|psi-mi:"CHEBI:39026"(display_long)|intact:beta-lipoproteins(synonym)|intact:LDL(synonym)|intact:low-density lipoproteins(synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992206|imex:IM-27324-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:566274")	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:39026"	uniprotkb:P08603	intact:EBI-21992105	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:low-density lipoprotein(display_short)|psi-mi:"CHEBI:39026"(display_long)|intact:beta-lipoproteins(synonym)|intact:LDL(synonym)|intact:low-density lipoproteins(synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992206|imex:IM-27324-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:Figure 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:75949")|biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08603	uniprotkb:P02769	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992739|imex:IM-27324-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606|interpro:IPR035976	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Supplementary Figure 8|comment:"The protein \"FHL1\" is an isoform of CFH  (P08603-2) which has the same N-terminal sequence as the canonical isoform up to aa445, and with the addition of four C-terminal unique amino acids."|caution:"Supplementary figure 8 text and image text refer to the binding of MAA-BSA to CFH fragments. However the main text refers to \"Reciprocally, soluble MDA-LDL only bound to immobilized fragments containing either SCR7 or SCR20, respectively (Supplementary Fig. 8).\"  However the authors have confirmed that biotinylated  MAA-BSA was used."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.4x10^-8(molar)	2019/08/16	2019/08/30	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rigid:MR+NX4FYIwLUHwasVsyHcSmQqoI	false	necessary binding region:387..387-444..444|sufficient binding region:1046..1046-1230..1230(IPR035976)|his tag:c-c	biotin tag:?-?|biological feature:?-?("CHEBI:75949")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08603-2	uniprotkb:P02769	intact:EBI-12684810	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:p08603-2(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:FHL-1(isoform synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992769|imex:IM-27324-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1223708(isoform-parent)|uniprotkb:P08603-2(isoform-parent)|interpro:IPR035976	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Supplementary Figure 8i|comment:"The protein \"FHL1\" is an isoform of CFH  (P08603-2) which has the same N-terminal sequence as the canonical isoform up to aa445, and with the addition of four C-terminal unique amino acids."|caution:"Supplementary figure 8 text and image text refer to the binding of MAA-BSA to CFH fragments. However the main text refers to \"Reciprocally, soluble MDA-LDL only bound to immobilized fragments containing either SCR7 or SCR20, respectively (Supplementary Fig. 8).\"  However the authors have confirmed that biotinylated  MAA-BSA was used."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.4x10^-8(molar)	2019/08/16	2019/08/30	rogid:5z5TurtXwYSuzypYW+AWJDzcgso9606	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rigid:+SQpzqgSaUL44yx+LPGZenUWxAk	false	his tag:c-c	biotin tag:?-?|biological feature:?-?("CHEBI:75949")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18019"	uniprotkb:P08603	intact:EBI-21992283|chebi:"CHEBI:43950"|chebi:"CHEBI:6264"|chebi:"CHEBI:13135"|chebi:"CHEBI:21351"	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:l-lysine(display_short)|psi-mi:"CHEBI:18019"(display_long)|intact:"(S)-2,6-diaminohexanoic acid"(synonym)|intact:"(S)-alpha,epsilon-diaminocaproic acid"(synonym)|intact:"(S)-lysine"(synonym)|intact:6-ammonio-L-norleucine(synonym)|intact:K(synonym)|intact:L-2,6-Diaminocaproic acid(synonym)|intact:L-Lysin(synonym)|intact:L-Lysine(synonym)|intact:Lys(synonym)|intact:lysina(synonym)|intact:lysine(synonym)|intact:Lysine acid(synonym)|intact:lysinum(synonym)|intact:"(2S)-2,6-diaminohexanoic acid"(iupac name)|intact:L-lysine(iupac name)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992281|imex:IM-27324-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	go:"GO:0009986"(cell surface)	-	-	figure legend:3J|comment:CFH co-localized with MDA epitopes.|sample process:CFH co-localized with MDA epitopes|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/29	-	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	-	false	biological feature:?-?("CHEBI:566274")	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P02769	uniprotkb:P08603	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992333|imex:IM-27324-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:4A, Supplementary figure 12|comment:"C3b  is a complex  composed of the modified C3-alpha chain (a') (M.W. 105,000) and the intact C3-beta chain (M.W. 75,000). Factor I cleaves the a'  chain of the C3b complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/10/04	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rigid:fdkx9lKuqxhTvMRefmH/R45kw6c	false	biological feature:?-?("CHEBI:75949")	mutation decreasing interaction rate:402-402(rs1061170)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02769	uniprotkb:P05156	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-9352022|uniprotkb:O60442|ensembl:ENSP00000378130	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:cfai_human(display_long)|uniprotkb:CFI(gene name)|psi-mi:CFI(display_short)|uniprotkb:IF(gene name synonym)|uniprotkb:C3B/C4B inactivator(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992333|imex:IM-27324-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	refseq:NP_001317964.1|refseq:NP_000195.2|ensembl:ENSG00000205403(gene)|ensembl:ENST00000394634(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0016020"(membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR018114|interpro:IPR023415|interpro:IPR033116|interpro:IPR036055|interpro:IPR036058|interpro:IPR036772|interpro:IPR043504|mint:P05156|rcsb pdb:2XRC|rcsb pdb:5O32|reactome:R-HSA-977606	-	-	-	figure legend:4A, Supplementary figure 12|comment:"C3b  is a complex  composed of the modified C3-alpha chain (a') (M.W. 105,000) and the intact C3-beta chain (M.W. 75,000). Factor I cleaves the a'  chain of the C3b complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/10/04	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:2zm8YwMWNSX3vv6fLIJ3WZ6hrLc9606	rigid:fdkx9lKuqxhTvMRefmH/R45kw6c	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02769	uniprotkb:P01024-PRO_0000005911	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-12735725	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:p01024-pro_0000005911(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992333|imex:IM-27324-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	intact:EBI-905851(chain-parent)	-	-	chain-seq-start:749|chain-seq-end:1663	figure legend:4A, Supplementary figure 12|comment:"C3b  is a complex  composed of the modified C3-alpha chain (a') (M.W. 105,000) and the intact C3-beta chain (M.W. 75,000). Factor I cleaves the a'  chain of the C3b complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/10/04	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:PGQNhqtLcK90Rf1IY85ARmU6Jbs9606	rigid:fdkx9lKuqxhTvMRefmH/R45kw6c	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02769	uniprotkb:P08603	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992345|imex:IM-27324-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:4B|comment:"C3b  is a complex  composed of the modified C3-alpha chain (a') (M.W. 105,000) and the intact C3-beta chain (M.W. 75,000). Factor I cleaves the a'  chain of the C3b complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/10/04	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rigid:fdkx9lKuqxhTvMRefmH/R45kw6c	false	biological feature:?-?("CHEBI:75949")	sufficient binding region:1046..1046-1230..1230(IPR035976)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02769	uniprotkb:P08603	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992345|imex:IM-27324-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	-	-	-	figure legend:4B|comment:"C3b  is a complex  composed of the modified C3-alpha chain (a') (M.W. 105,000) and the intact C3-beta chain (M.W. 75,000). Factor I cleaves the a'  chain of the C3b complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/10/04	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rigid:fdkx9lKuqxhTvMRefmH/R45kw6c	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02769	uniprotkb:P05156	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-9352022|uniprotkb:O60442|ensembl:ENSP00000378130	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:cfai_human(display_long)|uniprotkb:CFI(gene name)|psi-mi:CFI(display_short)|uniprotkb:IF(gene name synonym)|uniprotkb:C3B/C4B inactivator(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992345|imex:IM-27324-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	refseq:NP_001317964.1|refseq:NP_000195.2|ensembl:ENSG00000205403(gene)|ensembl:ENST00000394634(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0016020"(membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR018114|interpro:IPR023415|interpro:IPR033116|interpro:IPR036055|interpro:IPR036058|interpro:IPR036772|interpro:IPR043504|mint:P05156|rcsb pdb:2XRC|rcsb pdb:5O32|reactome:R-HSA-977606	-	-	-	figure legend:4B|comment:"C3b  is a complex  composed of the modified C3-alpha chain (a') (M.W. 105,000) and the intact C3-beta chain (M.W. 75,000). Factor I cleaves the a'  chain of the C3b complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/10/04	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:2zm8YwMWNSX3vv6fLIJ3WZ6hrLc9606	rigid:fdkx9lKuqxhTvMRefmH/R45kw6c	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02769	uniprotkb:P01024-PRO_0000005911	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	intact:EBI-12735725	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:p01024-pro_0000005911(display_long)|uniprotkb:C3(gene name)|psi-mi:C3(display_short)|uniprotkb:CPAMD1(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992345|imex:IM-27324-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	intact:EBI-905851(chain-parent)	-	-	chain-seq-start:749|chain-seq-end:1663	figure legend:4B|comment:"C3b  is a complex  composed of the modified C3-alpha chain (a') (M.W. 105,000) and the intact C3-beta chain (M.W. 75,000). Factor I cleaves the a'  chain of the C3b complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/10/04	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rogid:PGQNhqtLcK90Rf1IY85ARmU6Jbs9606	rigid:fdkx9lKuqxhTvMRefmH/R45kw6c	false	biological feature:?-?("CHEBI:75949")	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08603	uniprotkb:P02769	intact:EBI-1223708|uniprotkb:A5PL14|uniprotkb:Q2TAZ5|uniprotkb:P78435|uniprotkb:Q14570|uniprotkb:Q38G77|uniprotkb:Q5TFM3|uniprotkb:Q8N708|uniprotkb:Q9NU86|ensembl:ENSP00000356399	intact:EBI-2296927|uniprotkb:A5PJX3|uniprotkb:O02787|uniprotkb:P04277|uniprotkb:Q3SZR2	psi-mi:cfah_human(display_long)|uniprotkb:CFH(gene name)|psi-mi:CFH(display_short)|uniprotkb:HF(gene name synonym)|uniprotkb:HF1(gene name synonym)|uniprotkb:HF2(gene name synonym)|uniprotkb:H factor 1(gene name synonym)	psi-mi:albu_bovin(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:BSA(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Weismann et al. (2011)	pubmed:21979047|imex:IM-27324	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21992698|imex:IM-27324-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000177.2|dip:DIP-38303N|ensembl:ENSG00000000971(gene)|ensembl:ENST00000367429(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR035976|mint:P08603|rcsb pdb:1FHC|rcsb pdb:1HAQ|rcsb pdb:1HCC|rcsb pdb:1HFH|rcsb pdb:1HFI|rcsb pdb:1KOV|rcsb pdb:2QFH|rcsb pdb:2RLP|rcsb pdb:2RLQ|rcsb pdb:2UWN|rcsb pdb:2V8E|rcsb pdb:2W80|rcsb pdb:2BZM|rcsb pdb:2G7I|rcsb pdb:2W81|rcsb pdb:2WII|rcsb pdb:2XQW|rcsb pdb:3GAU|rcsb pdb:3GAV|rcsb pdb:3GAW|rcsb pdb:3KXV|rcsb pdb:3KZJ|rcsb pdb:3OXU|rcsb pdb:3R62|rcsb pdb:3RJ3|rcsb pdb:3SW0|rcsb pdb:4AYD|rcsb pdb:4AYE|rcsb pdb:4AYI|rcsb pdb:4AYM|rcsb pdb:4B2R|rcsb pdb:4B2S|rcsb pdb:2IC4|rcsb pdb:2JGW|rcsb pdb:2JGX|rcsb pdb:4J38|rcsb pdb:4K12|rcsb pdb:4ONT|rcsb pdb:4ZH1|rcsb pdb:5NBQ|rcsb pdb:5O32|rcsb pdb:5O35|rcsb pdb:2KMS|rcsb pdb:2QFG|rcsb pdb:5WTB|rcsb pdb:6ATG|reactome:R-HSA-977606	rcsb pdb:4JK4|refseq:NP_851335.1|interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR021177|rcsb pdb:2L7U|rcsb pdb:3V03|rcsb pdb:4F5S|rcsb pdb:4OR0|rcsb pdb:6QS9|rcsb pdb:6RJV|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:1903981"(enterobactin binding)	-	-	-	figure legend:Supplementary fig.7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/09/18	rogid:1mjo+AJLIQnEsMFqsGsmUFbfUxk9606	rogid:J8N23Xjyoe+UM5phxwqJtC2a1+M9913	rigid:MR+NX4FYIwLUHwasVsyHcSmQqoI	false	-	biological feature:?-?("CHEBI:75949")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)