#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P08138 uniprotkb:Q96FE5 intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229 intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451 psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym) psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Bourikas et al. (2010) pubmed:20659559|imex:IM-27116 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-21022644|imex:IM-27116-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563 refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634 - - - figure legend:Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mo3.13)|taxid:9606(Human glial oligodendrocytes MO3.13) - 2019/01/23 2019/01/23 rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606 rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606 rigid:McCHucVbopxALBfNpqBWDxrzbhE false - ha tag:n-n|sufficient binding region:353-614 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)