#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P43694	intact:EBI-21454861	intact:EBI-7049352|uniprotkb:B7ZKZ4|ensembl:ENSP00000334458|ensembl:ENSP00000482268|ensembl:ENSP00000495511|uniprotkb:Q5IFM8|intact:MINT-3379484|uniprotkb:Q3MJ45|uniprotkb:B7ZKX0	ensembl:ENSG00000276490	psi-mi:gata4_human(display_long)|uniprotkb:GATA4(gene name)|psi-mi:GATA4(display_short)|uniprotkb:GATA-binding factor 4(gene name synonym)	psi-mi:gata-4_binding_region(display_short)|psi-mi:EBI-21454861(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Mwinyi et al. (2010)	pubmed:20206639|imex:IM-27092	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21454784|imex:IM-27092-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0318"(nucleic acid)	refseq:NP_001295022.1|refseq:XP_011542119.1|refseq:XP_011542120.1|ensembl:ENSG00000136574(gene)|ensembl:ENSG00000285109(gene)|ensembl:ENST00000335135(transcript)|ensembl:ENST00000622443(transcript)|ensembl:ENST00000647274(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007492"(endoderm development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0033189"(response to vitamin A)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR008013(GATA-type transcription activator, N-terminal)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016375(Transcription factor GATA-4/5/6)|interpro:IPR039355|mint:P43694|rcsb pdb:2M9W|reactome:R-HSA-2032785|reactome:R-HSA-400511|reactome:R-HSA-5578768|reactome:R-HSA-9690406|reactome:R-HSA-983231|refseq:XP_016868801.1|refseq:NP_002043.2|refseq:XP_005272442.1|refseq:XP_005272443.1|refseq:XP_006716311.1	-	-	function:"Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities"|comment:mint|function:Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5	genomic coord:"10:94762531-94762560"	figure legend:Fig. 4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/19	2019/06/19	rogid:lzfeBDLcKGZXrcnJzaVRQrJnfpE9606	-	-	false	-	mutation decreasing interaction strength:12-14|mutation decreasing interaction strength:18-20	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P43694	intact:EBI-21454861	intact:EBI-7049352|uniprotkb:B7ZKZ4|ensembl:ENSP00000334458|ensembl:ENSP00000482268|ensembl:ENSP00000495511|uniprotkb:Q5IFM8|intact:MINT-3379484|uniprotkb:Q3MJ45|uniprotkb:B7ZKX0	ensembl:ENSG00000276490	psi-mi:gata4_human(display_long)|uniprotkb:GATA4(gene name)|psi-mi:GATA4(display_short)|uniprotkb:GATA-binding factor 4(gene name synonym)	psi-mi:gata-4_binding_region(display_short)|psi-mi:EBI-21454861(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Mwinyi et al. (2010)	pubmed:20206639|imex:IM-27092	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21454877|imex:IM-27092-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0318"(nucleic acid)	refseq:NP_001295022.1|refseq:XP_011542119.1|refseq:XP_011542120.1|ensembl:ENSG00000136574(gene)|ensembl:ENSG00000285109(gene)|ensembl:ENST00000335135(transcript)|ensembl:ENST00000622443(transcript)|ensembl:ENST00000647274(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007492"(endoderm development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0033189"(response to vitamin A)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR008013(GATA-type transcription activator, N-terminal)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016375(Transcription factor GATA-4/5/6)|interpro:IPR039355|mint:P43694|rcsb pdb:2M9W|reactome:R-HSA-2032785|reactome:R-HSA-400511|reactome:R-HSA-5578768|reactome:R-HSA-9690406|reactome:R-HSA-983231|refseq:XP_016868801.1|refseq:NP_002043.2|refseq:XP_005272442.1|refseq:XP_005272443.1|refseq:XP_006716311.1	-	-	function:"Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities"|comment:mint|function:Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5	genomic coord:"10:94762531-94762560"	figure legend:Fig. 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/19	2019/06/19	rogid:lzfeBDLcKGZXrcnJzaVRQrJnfpE9606	-	-	false	-	mutation decreasing interaction strength:18-20|mutation decreasing interaction strength:12-14	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q92908	intact:EBI-21454861	intact:EBI-2869259|uniprotkb:P78327|uniprotkb:B0YJ17|intact:EBI-28985406|ensembl:ENSP00000269216|ensembl:ENSP00000462313	ensembl:ENSG00000276490	psi-mi:gata6_human(display_long)|uniprotkb:GATA6(gene name)|psi-mi:GATA6(display_short)|uniprotkb:GATA-binding factor 6(gene name synonym)	psi-mi:gata-4_binding_region(display_short)|psi-mi:EBI-21454861(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Mwinyi et al. (2010)	pubmed:20206639|imex:IM-27092	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21498712|imex:IM-27092-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0318"(nucleic acid)	refseq:NP_005248.2|ensembl:ENSP00000269216|ensembl:ENSP00000462313|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070848"(response to growth factor)|go:"GO:0071371"(cellular response to gonadotropin stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098773"(skin epidermis development)|go:"GO:0048645"(animal organ formation)|go:"GO:0110024"(positive regulation of cardiac muscle myoblast proliferation)|ensembl:ENSG00000141448(gene)|go:"GO:1904003"(negative regulation of sebum secreting cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR008013(GATA-type transcription activator, N-terminal)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR028437|interpro:IPR039355|mint:Q92908|reactome:R-HSA-5683826|reactome:R-HSA-983231|go:"GO:1901390"(positive regulation of transforming growth factor beta activation)|ensembl:ENST00000269216(transcript)|ensembl:ENST00000581694(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001949"(sebaceous gland cell differentiation)|go:"GO:0002759"(regulation of antimicrobial humoral response)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003309"(type B pancreatic cell differentiation)|go:"GO:0003310"(pancreatic A cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0007493"(endodermal cell fate determination)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032912"(negative regulation of transforming growth factor beta2 production)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)	-	-	-	genomic coord:"10:94762531-94762560"	figure legend:Fig. 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/06/19	2019/07/11	rogid:+pEu3biPLYjs3/QiV/Ozi1HR9iY9606	-	-	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P43694	ensembl:ENSG00000165841	intact:EBI-7049352|uniprotkb:B7ZKZ4|ensembl:ENSP00000334458|ensembl:ENSP00000482268|ensembl:ENSP00000495511|uniprotkb:Q5IFM8|intact:MINT-3379484|uniprotkb:Q3MJ45|uniprotkb:B7ZKX0	intact:EBI-21454903	psi-mi:gata4_human(display_long)|uniprotkb:GATA4(gene name)|psi-mi:GATA4(display_short)|uniprotkb:GATA-binding factor 4(gene name synonym)	uniprotkb:CYP2C19(gene name)|psi-mi:CYP2C19(display_short)|ensembl:cp2cj_human_gene(shortlabel)|psi-mi:ENSG00000165841(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Mwinyi et al. (2010)	pubmed:20206639|imex:IM-27092	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21454907|imex:IM-27092-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001295022.1|refseq:XP_011542119.1|refseq:XP_011542120.1|ensembl:ENSG00000136574(gene)|ensembl:ENSG00000285109(gene)|ensembl:ENST00000335135(transcript)|ensembl:ENST00000622443(transcript)|ensembl:ENST00000647274(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007492"(endoderm development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0033189"(response to vitamin A)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR008013(GATA-type transcription activator, N-terminal)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016375(Transcription factor GATA-4/5/6)|interpro:IPR039355|mint:P43694|rcsb pdb:2M9W|reactome:R-HSA-2032785|reactome:R-HSA-400511|reactome:R-HSA-5578768|reactome:R-HSA-9690406|reactome:R-HSA-983231|refseq:XP_016868801.1|refseq:NP_002043.2|refseq:XP_005272442.1|refseq:XP_005272443.1|refseq:XP_006716311.1	refseq:NP_000760.1	-	function:"Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities"|comment:mint|function:Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5	-	figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2019/06/19	2019/06/19	rogid:lzfeBDLcKGZXrcnJzaVRQrJnfpE9606	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)