#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P08908 uniprotkb:P47211 intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7 intact:EBI-6624741|ensembl:ENSP00000299727|uniprotkb:Q4VBL7 psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym) psi-mi:galr1_human(display_long)|uniprotkb:GALR1(gene name)|psi-mi:GALR1(display_short)|uniprotkb:GALNR(gene name synonym)|uniprotkb:GALNR1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Borroto-Escuela et al. (2010) pubmed:20171159|imex:IM-27039 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-21407810|imex:IM-27039-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2 ensembl:ENSG00000166573(gene)|ensembl:ENST00000299727(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051464"(positive regulation of cortisol secretion)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|interpro:IPR003906(Galanin 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001471.2 go:"GO:0005886"(plasma membrane) - - figure legend:Figure 1|agonist:"Galr2 (Galanin receptor type 2)."|comment:Superimpositions of images reveal a plasma membrane codistribution of 5-HT1A GFP2 -GalR1 YFP at 48 h, but not at 36h in the absence of GalR2.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/06 2019/05/27 rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606 rogid:2cyPncH8b79+lmM6piQTdEAS3h89606 rigid:Hbm/4uvz0+vLpJnkr4JQYKGlss8 false green fluorescent protein tag:c-c enhanced yellow fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P08908 uniprotkb:P47211 intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7 intact:EBI-6624741|ensembl:ENSP00000299727|uniprotkb:Q4VBL7 psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym) psi-mi:galr1_human(display_long)|uniprotkb:GALR1(gene name)|psi-mi:GALR1(display_short)|uniprotkb:GALNR(gene name synonym)|uniprotkb:GALNR1(gene name synonym) psi-mi:"MI:0055"(fluorescent resonance energy transfer) Borroto-Escuela et al. (2010) pubmed:20171159|imex:IM-27039 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-21407829|imex:IM-27039-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2 ensembl:ENSG00000166573(gene)|ensembl:ENST00000299727(transcript)|go:"GO:0004966"(galanin receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051464"(positive regulation of cortisol secretion)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000405(Galanin receptor)|interpro:IPR003906(Galanin 1 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|refseq:NP_001471.2 - - - figure legend:Figure 2|agonist:"Galr2 (Galanin receptor type 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/06 2019/05/27 rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606 rogid:2cyPncH8b79+lmM6piQTdEAS3h89606 rigid:Hbm/4uvz0+vLpJnkr4JQYKGlss8 false green fluorescent protein tag:c-c enhanced yellow fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)