#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6Y685	uniprotkb:P63058-1	intact:EBI-21349470|uniprotkb:Q05A66|uniprotkb:Q6Y686	intact:EBI-21349278|ensembl:ENSMUSP00000068281|uniprotkb:P15827-1	psi-mi:tacc1_mouse(display_long)|uniprotkb:Tacc1(gene name)|psi-mi:Tacc1(display_short)	psi-mi:p63058-1(display_long)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21349287|imex:IM-26969-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0005634"(nucleus)|refseq:NP_796063.3|refseq:NP_955355.1|interpro:IPR039915|interpro:IPR007707(Transforming acidic coiled-coil-containing)	intact:EBI-6935292(isoform-parent)|ensembl:ENSMUSG00000058756(gene)|ensembl:ENSMUST00000064187(transcript)	-	-	isoform-comment:Does not bind thyroid hormone T3.	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/04/25	2019/04/25	rogid:OxSKpsAOJBuATLuebszX+arhc6410090	rogid:NQpld9X5hOSWJSyhClyYt/u12AY10090	rigid:Llzk15ucvIB2DQ+ra0xi3Z+4Itw	false	sufficient binding region:487..490-770..774	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75410-10	uniprotkb:P63059-1	intact:EBI-21986506	intact:EBI-21350183|uniprotkb:P15827-1	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:p63059-1(display_long)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21350000|imex:IM-26969-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-624237(isoform-parent)	intact:EBI-21444089(isoform-parent)	-	isoform-comment:No experimental confirmation available.	isoform-comment:Does not bind thyroid hormone T3.	figure legend:Figure 2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/25	2019/08/15	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rogid:sHWPgmYoVVHk+9G4hf8Osc7QaSo10116	rigid:kQXno1REymv3V61C4YTMQCSgcB0	false	glutathione s tranferase tag:n-n	35s radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63059-2	uniprotkb:O75410-10	intact:EBI-21987107|ensembl:ENSRNOP00000072739|uniprotkb:P15827-2	intact:EBI-21986506	psi-mi:p63059-2(display_long)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:"MI:0096"(pull down)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21350008|imex:IM-26969-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000009066(gene)|ensembl:ENSRNOT00000087346(transcript)|intact:EBI-21444089(isoform-parent)	intact:EBI-624237(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Figure 2a|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/25	2019/08/15	rogid:Hiw8lubhNB18Zb9pIyRcP/8kYwQ10116	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rigid:iyL9giblLdH7ewnNZS+qnqNX8HM	false	35s radiolabel:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63059-2	uniprotkb:O75410-10	intact:EBI-21987107|ensembl:ENSRNOP00000072739|uniprotkb:P15827-2	intact:EBI-21986506	psi-mi:p63059-2(display_long)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21350143|imex:IM-26969-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000009066(gene)|ensembl:ENSRNOT00000087346(transcript)|intact:EBI-21444089(isoform-parent)	intact:EBI-624237(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Figures 2b, 2c and 3a|antagonist:Thyroid hormone, T3|comment:A truncated form of TRalpha1 was less affected by the presence of T3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/15	rogid:Hiw8lubhNB18Zb9pIyRcP/8kYwQ10116	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rigid:iyL9giblLdH7ewnNZS+qnqNX8HM	false	-	flag tag:?-?|mutation disrupting interaction strength:171-171,170-170	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75410-10	uniprotkb:P18113-1	intact:EBI-21986506	intact:EBI-21350165	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:p18113-1(display_long)|uniprotkb:Thrb(gene name)|psi-mi:Thrb(display_short)|uniprotkb:Erba2(gene name synonym)|uniprotkb:Nr1a2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group A member 2(gene name synonym)|uniprotkb:c-erbA-2(gene name synonym)|uniprotkb:c-erbA-beta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21350173|imex:IM-26969-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-624237(isoform-parent)	intact:EBI-15600415(isoform-parent)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 2b|antagonist:Thyroid hormone, T3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/15	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rogid:TmcsNeguwCSIsxUo01k2uAbVBc410116	rigid:7kJ9h96bzlFcetLpdANL+znC/oY	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75410-10	uniprotkb:P63059-1	intact:EBI-21986506	intact:EBI-21350183|uniprotkb:P15827-1	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:p63059-1(display_long)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21350192|imex:IM-26969-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-624237(isoform-parent)	intact:EBI-21444089(isoform-parent)	-	isoform-comment:No experimental confirmation available.	isoform-comment:Does not bind thyroid hormone T3.	figure legend:Figure 2b|comment:Thyroid hormone, T3,  was not able to inhibit the interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/15	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rogid:sHWPgmYoVVHk+9G4hf8Osc7QaSo10116	rigid:kQXno1REymv3V61C4YTMQCSgcB0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75410-10	uniprotkb:P11416	intact:EBI-21986506	intact:EBI-346736|uniprotkb:P22603|ensembl:ENSMUSP00000069744|ensembl:ENSMUSP00000103098|ensembl:ENSMUSP00000103099|ensembl:ENSMUSP00000129791	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:rara_mouse(display_long)|uniprotkb:Rara(gene name)|psi-mi:Rara(display_short)|uniprotkb:Nr1b1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21369089|imex:IM-26969-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-624237(isoform-parent)	refseq:NP_001169999.1|refseq:NP_001170773.1|refseq:NP_001170774.1|refseq:NP_033050.2|refseq:XP_006532655.1|refseq:XP_006532656.1|refseq:XP_017169842.1|dip:DIP-31480N|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060348"(bone development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|go:"GO:0030852"(regulation of granulocyte differentiation)|ensembl:ENSMUSG00000037992(gene)|ensembl:ENSMUST00000068133(transcript)|ensembl:ENSMUST00000107474(transcript)|ensembl:ENSMUST00000107475(transcript)|ensembl:ENSMUST00000164748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P11416|reactome:R-MMU-383280|reactome:R-MMU-4090294|reactome:R-MMU-5362517|reactome:R-MMU-9616222	-	isoform-comment:No experimental confirmation available.	-	figure legend:Additional file 2a|antagonist:"All-trans retinoic acid (5x10^-7 M)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/15	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rogid:Au9WAaW0hYj2SCVF3NjQMw0rGOw10090	rigid:XZA95P5NniQBporu7sj/RqYC1j0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P37238	uniprotkb:O75410-10	intact:EBI-5260705	intact:EBI-21986506	psi-mi:pparg_mouse(display_long)|uniprotkb:Pparg(gene name)|psi-mi:Pparg(display_short)|uniprotkb:Nr1c3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group C member 3(gene name synonym)	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21369096|imex:IM-26969-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011239554.1|refseq:NP_001295283.1|refseq:NP_001295281.1|refseq:NP_001120802.1|refseq:NP_035276.2|refseq:XP_006505806.1|refseq:XP_017176944.1|dip:DIP-60435N|reactome:R-MMU-381340|reactome:R-MMU-383280|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0032094"(response to food)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033993"(response to lipid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090278"(negative regulation of peptide hormone secretion)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001890"(placenta development)|go:"GO:0002021"(response to dietary excess)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000230"(negative regulation of pancreatic stellate cell proliferation)|go:"GO:2000272"(negative regulation of signaling receptor activity)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003074(Peroxisome proliferator-activated receptor)|interpro:IPR003077(Peroxisome proliferator-activated receptor, gamma)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR022590|interpro:IPR035500	intact:EBI-624237(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Additional file 2b|antagonist:"Rosiglitazon (10^-7 M)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/15	rogid:Np+uikZCzY6xfPCQ67/OHuDGh+010090	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rigid:Q9G8DMP4cl5aCdjGJ60r+hE1bFU	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75410-10	uniprotkb:P03372	intact:EBI-21986506	intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21369103|imex:IM-26969-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-624237(isoform-parent)	ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB	-	isoform-comment:No experimental confirmation available.	-	figure legend:Additional file 2c|antagonist:"Estradiol (10^-7 M)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/15	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606	rigid:RpZNLSz4HHwNlA94d5nzyDKtaAo	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P06537	uniprotkb:O75410-10	intact:EBI-492753|uniprotkb:Q61628|uniprotkb:Q61629|ensembl:ENSMUSP00000025300|ensembl:ENSMUSP00000095199|ensembl:ENSMUSP00000111229|ensembl:ENSMUSP00000111233|intact:EBI-26668912|uniprotkb:E9PUR6|uniprotkb:E0ZPU5|uniprotkb:Q06VW2|uniprotkb:Q3U126|uniprotkb:Q3U2M7|uniprotkb:E9PYV1	intact:EBI-21986506	psi-mi:gcr_mouse(display_long)|uniprotkb:Nuclear receptor subfamily 3 group C member 1(gene name synonym)|uniprotkb:Nr3c1(gene name)|psi-mi:Nr3c1(display_short)|uniprotkb:Grl(gene name synonym)|uniprotkb:Grl1(gene name synonym)	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21369121|imex:IM-26969-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024431(gene)|ensembl:ENSMUST00000025300(transcript)|ensembl:ENSMUST00000097592(transcript)|ensembl:ENSMUST00000115567(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0004883"(glucocorticoid receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|ensembl:ENSMUST00000115571(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|reactome:R-MMU-3371497|reactome:R-MMU-383280|reactome:R-MMU-4090294|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0031946"(regulation of glucocorticoid biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042562"(hormone binding)|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043197"(dendritic spine)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0048096"|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001409(Glucocorticoid receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06537|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|refseq:NP_032199.3|refseq:XP_006525721.1|refseq:XP_006525722.1|refseq:XP_006525723.1|refseq:XP_006525724.1|refseq:XP_006525725.1|refseq:XP_006525726.1|refseq:XP_006525727.1|refseq:XP_006525728.1|refseq:XP_006525729.1|refseq:XP_017173324.1|refseq:XP_017173325.1|refseq:XP_017173326.1|refseq:XP_017173327.1|dip:DIP-11N	intact:EBI-624237(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Additional file 2e|antagonist:"Dexamethasone (10^-7 M & 10^-6 M)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2021/11/30	rogid:BGeJbz2zNEPZBn4cdswdbgRBif410090	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rigid:LPXxH97KuXOpMd2r3T76WxpLyVs	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75410-9	uniprotkb:P63059-2	intact:EBI-21944703	intact:EBI-21987107|ensembl:ENSRNOP00000072739|uniprotkb:P15827-2	psi-mi:o75410-9(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-K(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:p63059-2(display_long)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21944681|imex:IM-26969-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-624237(isoform-parent)	ensembl:ENSRNOG00000009066(gene)|ensembl:ENSRNOT00000087346(transcript)|intact:EBI-21444089(isoform-parent)	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/15	rogid:KYMwSgnnKVIcwxVSzfUeJ3XQB4I9606	rogid:Hiw8lubhNB18Zb9pIyRcP/8kYwQ10116	rigid:AzxGX99ZRgKg1ONvU7b84zk0Lug	false	flag tag:?-?|mutation decreasing interaction strength:581-581,580-580	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75410-9	uniprotkb:P63059-1	intact:EBI-21944703	intact:EBI-21350183|uniprotkb:P15827-1	psi-mi:o75410-9(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-K(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:p63059-1(display_long)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21944758|imex:IM-26969-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-624237(isoform-parent)	intact:EBI-21444089(isoform-parent)	-	isoform-comment:No experimental confirmation available.	isoform-comment:Does not bind thyroid hormone T3.	figure legend:Figure 3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/15	rogid:KYMwSgnnKVIcwxVSzfUeJ3XQB4I9606	rogid:sHWPgmYoVVHk+9G4hf8Osc7QaSo10116	rigid:B8uzZr6Vad9Wq23qetbP4WUn7Mw	false	flag tag:?-?|mutation disrupting interaction strength:581-581,580-580	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P28700	uniprotkb:O75410-10	intact:EBI-346715|ensembl:ENSMUSP00000076491|ensembl:ENSMUSP00000133044	intact:EBI-21986506	psi-mi:rxra_mouse(display_long)|uniprotkb:Rxra(gene name)|psi-mi:Rxra(display_short)|uniprotkb:Nr2b1(gene name synonym)|uniprotkb:Retinoid X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group B member 1(gene name synonym)	psi-mi:o75410-10(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-J(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21988485|imex:IM-26969-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035435.1|ensembl:ENSMUSG00000015846(gene)|ensembl:ENSMUST00000077257(transcript)|ensembl:ENSMUST00000166775(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000003(Retinoid X receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021780|interpro:IPR035500|mint:P28700|rcsb pdb:1DKF|rcsb pdb:1XDK|rcsb pdb:3A9E|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-200425|reactome:R-MMU-204174|reactome:R-MMU-211976|reactome:R-MMU-381340|reactome:R-MMU-383280|reactome:R-MMU-400206|reactome:R-MMU-4090294|reactome:R-MMU-5362517|reactome:R-MMU-9029569|reactome:R-MMU-9616222|reactome:R-MMU-9623433|reactome:R-MMU-9707564	intact:EBI-624237(isoform-parent)	-	-	isoform-comment:No experimental confirmation available.	figure legend:Additional file 2d|antagonist:"9 cis Retinoic Acid (10^-7 M and 10^-6 M)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/20	rogid:AYPX54m7lVs5Ls6EzBlOC9GBNyI10090	rogid:YKGmZcxTw/2WO/oD6xWIxUMvNC49606	rigid:YtQfx6hujT/dhYMkXwplmXYR0b0	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11416	uniprotkb:Q6Y685	intact:EBI-346736|uniprotkb:P22603|ensembl:ENSMUSP00000069744|ensembl:ENSMUSP00000103098|ensembl:ENSMUSP00000103099|ensembl:ENSMUSP00000129791	intact:EBI-21349470|uniprotkb:Q05A66|uniprotkb:Q6Y686	psi-mi:rara_mouse(display_long)|uniprotkb:Rara(gene name)|psi-mi:Rara(display_short)|uniprotkb:Nr1b1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym)	psi-mi:tacc1_mouse(display_long)|uniprotkb:Tacc1(gene name)|psi-mi:Tacc1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21350256|imex:IM-26969-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001169999.1|refseq:NP_001170773.1|refseq:NP_001170774.1|refseq:NP_033050.2|refseq:XP_006532655.1|refseq:XP_006532656.1|refseq:XP_017169842.1|dip:DIP-31480N|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060348"(bone development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|go:"GO:0030852"(regulation of granulocyte differentiation)|ensembl:ENSMUSG00000037992(gene)|ensembl:ENSMUST00000068133(transcript)|ensembl:ENSMUST00000107474(transcript)|ensembl:ENSMUST00000107475(transcript)|ensembl:ENSMUST00000164748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P11416|reactome:R-MMU-383280|reactome:R-MMU-4090294|reactome:R-MMU-5362517|reactome:R-MMU-9616222	go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0005634"(nucleus)|refseq:NP_796063.3|refseq:NP_955355.1|interpro:IPR039915|interpro:IPR007707(Transforming acidic coiled-coil-containing)	go:"GO:0005634"(nucleus)	-	-	figure legend:Figure 4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-f9)|taxid:10090(Mus musculus)	-	2019/04/25	2019/04/26	rogid:Au9WAaW0hYj2SCVF3NjQMw0rGOw10090	rogid:OxSKpsAOJBuATLuebszX+arhc6410090	rigid:Mox2ssDdSazC9/gL0/zRDD0Fp4g	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6Y685-2	uniprotkb:P63058-1	intact:EBI-21986550|ensembl:ENSMUSP00000081560	intact:EBI-21349278|ensembl:ENSMUSP00000068281|uniprotkb:P15827-1	psi-mi:q6y685-2(display_long)|uniprotkb:Tacc1(gene name)|psi-mi:Tacc1(display_short)|uniprotkb:Short(isoform synonym)	psi-mi:p63058-1(display_long)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21369069|imex:IM-26969-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21349470(isoform-parent)|ensembl:ENSMUSG00000065954(gene)|ensembl:ENSMUST00000084512(transcript)	intact:EBI-6935292(isoform-parent)|ensembl:ENSMUSG00000058756(gene)|ensembl:ENSMUST00000064187(transcript)	-	-	isoform-comment:Does not bind thyroid hormone T3.	figure legend:Additional file 1|agonist:"Thyroid hormone (T3 10^-7M)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/04/25	2019/08/15	rogid:75lvwUnxNECdX8j4pXZZwV8InKU10090	rogid:NQpld9X5hOSWJSyhClyYt/u12AY10090	rigid:qSPhd1us6H1QvZ6c9IpasXU4U2I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6Y685-2	uniprotkb:P63058-2	intact:EBI-21986550|ensembl:ENSMUSP00000081560	intact:EBI-12518675|ensembl:ENSMUSP00000099428|uniprotkb:P15827-2	psi-mi:q6y685-2(display_long)|uniprotkb:Tacc1(gene name)|psi-mi:Tacc1(display_short)|uniprotkb:Short(isoform synonym)	psi-mi:p63058-2(display_long)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21369075|imex:IM-26969-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21349470(isoform-parent)|ensembl:ENSMUSG00000065954(gene)|ensembl:ENSMUST00000084512(transcript)	ensembl:ENSMUSG00000058756(gene)|ensembl:ENSMUST00000103139(transcript)|intact:EBI-6935292(isoform-parent)	-	-	-	figure legend:Additional file 1|antagonist:"Thyroid hormone (T3 10^-7M)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/04/25	2019/08/15	rogid:75lvwUnxNECdX8j4pXZZwV8InKU10090	rogid:Hiw8lubhNB18Zb9pIyRcP/8kYwQ10090	rigid:K7bde0R0Ssmb8jImIZ//2SVYxS0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-22051143	uniprotkb:O75410	-	intact:EBI-624237|uniprotkb:Q8IUJ3|uniprotkb:Q8IUJ4|uniprotkb:Q8IZG2|uniprotkb:Q8NEY7|uniprotkb:Q9UPP9|uniprotkb:B2RBD9|uniprotkb:Q6Y687|uniprotkb:Q86YG7|uniprotkb:Q8IUJ2|ensembl:ENSP00000321703|uniprotkb:D3DSX6|uniprotkb:B4E302	psi-mi:rara_chlae_protein(display_short)|psi-mi:EBI-22051143(display_long)	psi-mi:tacc1_human(display_long)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21396754|imex:IM-26969-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P10276(see-also)	ensembl:ENSG00000147526(gene)|ensembl:ENST00000317827(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030496"(midbody)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0051301"(cell division)|interpro:IPR007707(Transforming acidic coiled-coil-containing)|interpro:IPR039915|mint:O75410|go:"GO:0046966"(thyroid hormone receptor binding)|refseq:NP_001116296.1|refseq:NP_001139688.1|refseq:NP_006274.2|refseq:XP_005273682.1|refseq:XP_011542933.1|refseq:XP_011542934.1|refseq:XP_011542938.1|refseq:XP_016869261.1|refseq:XP_016869262.1|refseq:XP_016869263.1|refseq:XP_011542936.1|refseq:XP_011542939.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Additional file 3|comment:"UniProt does have RARA protein annotated for chlae; new interactor had been created with human RARA protein id as \"see-also\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/09/25	-	rogid:o/GBmp6rt7B1GgH4gdBNaN5VrSc9606	-	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O75410-9	uniprotkb:P63059-1	intact:EBI-21944703	intact:EBI-21350183|uniprotkb:P15827-1	psi-mi:o75410-9(display_long)|uniprotkb:Gastric cancer antigen Ga55(gene name synonym)|uniprotkb:Taxin-1(gene name synonym)|uniprotkb:TACC1-K(isoform synonym)|uniprotkb:TACC1(gene name)|psi-mi:TACC1(display_short)|uniprotkb:KIAA1103(gene name synonym)	psi-mi:p63059-1(display_long)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)|uniprotkb:Thra(gene name)|psi-mi:Thra(display_short)|uniprotkb:C-erba-alpha(gene name synonym)|uniprotkb:Nr1a1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Guyot et al. (2010)	pubmed:20078863|imex:IM-26969	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21944852|imex:IM-26969-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-624237(isoform-parent)	intact:EBI-21444089(isoform-parent)	-	isoform-comment:No experimental confirmation available.	isoform-comment:Does not bind thyroid hormone T3.	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/04/25	2019/08/15	rogid:KYMwSgnnKVIcwxVSzfUeJ3XQB4I9606	rogid:sHWPgmYoVVHk+9G4hf8Osc7QaSo10116	rigid:B8uzZr6Vad9Wq23qetbP4WUn7Mw	false	flag tag:?-?|mutation disrupting interaction strength:581-581,580-580	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)