#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O75462 uniprotkb:Q8NEV9 intact:EBI-15587902|ensembl:ENSP00000376188|uniprotkb:Q9UHH5 intact:EBI-15887997|ensembl:ENSP00000349365|uniprotkb:A0N0L2|uniprotkb:Q6P676 psi-mi:crlf1_human(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name) psi-mi:il27a_human(display_long)|uniprotkb:Interleukin-30(gene name synonym)|uniprotkb:p28(gene name synonym)|uniprotkb:IL27(gene name)|psi-mi:IL27(display_short)|uniprotkb:IL27A(gene name synonym)|uniprotkb:IL30(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Crabé et al. (2009) pubmed:19933857|imex:IM-27607 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25298096|imex:IM-27607-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000006016(gene)|ensembl:ENST00000392386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0097058"(CRLF-CLCF1 complex)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|interpro:IPR036179|reactome:R-HSA-6788467|reactome:R-HSA-9020956|refseq:NP_004741.1|dip:DIP-61205N ensembl:ENSG00000197272(gene)|ensembl:ENST00000356897(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0009617"(response to bacterium)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045523"(interleukin-27 receptor binding)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR026207|reactome:R-HSA-9020956|go:"GO:0045625"(regulation of T-helper 1 cell differentiation)|refseq:NP_663634.2|dip:DIP-59473N - - - figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2019/12/24 2019/12/31 rogid:JEffOc3DgEv/YxinygENbXbK3gQ9606 rogid:vKzcGLx7DjxDr0fXMfDa4v8TE+89606 rigid:T+1CivVHkJN+VR76SlgUFk8zmNY false flag tag:c-c tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O75462 uniprotkb:Q8NEV9 intact:EBI-15587902|ensembl:ENSP00000376188|uniprotkb:Q9UHH5 intact:EBI-15887997|ensembl:ENSP00000349365|uniprotkb:A0N0L2|uniprotkb:Q6P676 psi-mi:crlf1_human(display_long)|uniprotkb:CRLF1(gene name)|psi-mi:CRLF1(display_short)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:ZcytoR5(gene name synonym)|uniprotkb:UNQ288/PRO327(orf name) psi-mi:il27a_human(display_long)|uniprotkb:Interleukin-30(gene name synonym)|uniprotkb:p28(gene name synonym)|uniprotkb:IL27(gene name)|psi-mi:IL27(display_short)|uniprotkb:IL27A(gene name synonym)|uniprotkb:IL30(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Crabé et al. (2009) pubmed:19933857|imex:IM-27607 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25298104|imex:IM-27607-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000006016(gene)|ensembl:ENST00000392386(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0097058"(CRLF-CLCF1 complex)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|interpro:IPR036179|reactome:R-HSA-6788467|reactome:R-HSA-9020956|refseq:NP_004741.1|dip:DIP-61205N ensembl:ENSG00000197272(gene)|ensembl:ENST00000356897(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0009617"(response to bacterium)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045523"(interleukin-27 receptor binding)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR026207|reactome:R-HSA-9020956|go:"GO:0045625"(regulation of T-helper 1 cell differentiation)|refseq:NP_663634.2|dip:DIP-59473N - - - figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2019/12/24 2019/12/31 rogid:JEffOc3DgEv/YxinygENbXbK3gQ9606 rogid:vKzcGLx7DjxDr0fXMfDa4v8TE+89606 rigid:T+1CivVHkJN+VR76SlgUFk8zmNY false flag tag:c-c tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8K3I6 uniprotkb:Q9JM58 intact:EBI-3863005|ensembl:ENSMUSP00000054637 intact:EBI-8587091|ensembl:ENSMUSP00000008032|intact:MINT-8178437 psi-mi:il27a_mouse(display_long)|uniprotkb:Il27(gene name)|psi-mi:Il27(display_short)|uniprotkb:Il27a(gene name synonym)|uniprotkb:p28(gene name synonym) psi-mi:crlf1_mouse(display_long)|uniprotkb:Crlf1(gene name)|psi-mi:Crlf1(display_short)|uniprotkb:Crlm3(gene name synonym)|uniprotkb:Cytokine receptor-like molecule 3(gene name synonym)|uniprotkb:Cytokine-like factor 1(gene name synonym)|uniprotkb:Novel cytokine receptor 6(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Crabé et al. (2009) pubmed:19933857|imex:IM-27607 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25298121|imex:IM-27607-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_663611.1|ensembl:ENSMUST00000058429(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0009617"(response to bacterium)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045523"(interleukin-27 receptor binding)|go:"GO:0045625"(regulation of T-helper 1 cell differentiation)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR026207|reactome:R-MMU-9020956|ensembl:ENSMUSG00000044701(gene) ensembl:ENSMUSG00000007888(gene)|ensembl:ENSMUST00000008032(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0097058"(CRLF-CLCF1 complex)|go:"GO:2000672"(negative regulation of motor neuron apoptotic process)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015152(Erythropoietin receptor, ligand binding)|interpro:IPR036116|interpro:IPR036179|reactome:R-MMU-6788467|reactome:R-MMU-9020956|refseq:NP_061297.1 - - comment:mint figure legend:1D|agonist:"LPS:lipopolysaccharide -CHEBI:16412"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-dendritic cell)|taxid:10090(Mouse dendritic cell) - 2019/12/24 2019/12/31 rogid:e12TIBOkx+KRGoI0tVhFzfInB7410090 rogid:pU931JDWpYKzoJlXB+kpDF1t3rY10090 rigid:5JmQ+bNL9iL1OTInm+e+8M9BuEk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)