#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8TCY5-1 uniprotkb:Q01718 intact:EBI-21991233 intact:EBI-9537171|uniprotkb:A8K016|uniprotkb:Q3MI45|uniprotkb:Q504X6|ensembl:ENSP00000333821 psi-mi:q8tcy5-1(display_long)|uniprotkb:B27(gene name synonym)|uniprotkb:Fat cell-specific low molecular weight protein(gene name synonym)|uniprotkb:Fat tissue-specific low MW protein(gene name synonym)|uniprotkb:Alpha(isoform synonym)|uniprotkb:MRAP-alpha(isoform synonym)|uniprotkb:MRAP(gene name)|psi-mi:MRAP(display_short)|uniprotkb:C21orf61(gene name synonym)|uniprotkb:FALP(gene name synonym) psi-mi:acthr_human(display_long)|uniprotkb:MC2R(gene name)|psi-mi:MC2R(display_short)|uniprotkb:ACTHR(gene name synonym)|uniprotkb:Adrenocorticotropin receptor(gene name synonym)|uniprotkb:Melanocortin receptor 2(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Chan et al. (2009) pubmed:19151134|imex:IM-27316 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-21991243|imex:IM-27316-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9538727(isoform-parent) refseq:XP_016881270.1|refseq:NP_001278840.1|refseq:NP_000520.1|dip:DIP-29949N|ensembl:ENSG00000185231(gene)|ensembl:ENST00000327606(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004977"(melanocortin receptor activity)|go:"GO:0004978"(corticotropin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001168("Adrenocorticotrophin (ACTH) receptor")|interpro:IPR001671(Melanocortin/ACTH receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418555|reactome:R-HSA-5579031|reactome:R-HSA-9660821 go:"GO:0005886"(plasma membrane) - - figure legend:Figure 2b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos)|taxid:9534(Chlorocebus aethiops) - 2019/08/27 2019/08/27 rogid:Bk0P9TWrtnH9owEjN0BPz/6bvxk9606 rogid:8ws6S3uX+iCrWkXmZ05MErv+FSI9606 rigid:mOvNpJnur5/GXZ1cOvyAsV48cKo false flag tag:?-? ha tag:?-?|mutation disrupting interaction strength:129-129|mutation with no effect:278-278|mutation disrupting interaction strength:129-129,278-278 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q8TCY5-1 uniprotkb:Q01718 intact:EBI-21991233 intact:EBI-9537171|uniprotkb:A8K016|uniprotkb:Q3MI45|uniprotkb:Q504X6|ensembl:ENSP00000333821 psi-mi:q8tcy5-1(display_long)|uniprotkb:B27(gene name synonym)|uniprotkb:Fat cell-specific low molecular weight protein(gene name synonym)|uniprotkb:Fat tissue-specific low MW protein(gene name synonym)|uniprotkb:Alpha(isoform synonym)|uniprotkb:MRAP-alpha(isoform synonym)|uniprotkb:MRAP(gene name)|psi-mi:MRAP(display_short)|uniprotkb:C21orf61(gene name synonym)|uniprotkb:FALP(gene name synonym) psi-mi:acthr_human(display_long)|uniprotkb:MC2R(gene name)|psi-mi:MC2R(display_short)|uniprotkb:ACTHR(gene name synonym)|uniprotkb:Adrenocorticotropin receptor(gene name synonym)|uniprotkb:Melanocortin receptor 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chan et al. (2009) pubmed:19151134|imex:IM-27316 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21991272|imex:IM-27316-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9538727(isoform-parent) refseq:XP_016881270.1|refseq:NP_001278840.1|refseq:NP_000520.1|dip:DIP-29949N|ensembl:ENSG00000185231(gene)|ensembl:ENST00000327606(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004977"(melanocortin receptor activity)|go:"GO:0004978"(corticotropin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001168("Adrenocorticotrophin (ACTH) receptor")|interpro:IPR001671(Melanocortin/ACTH receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418555|reactome:R-HSA-5579031|reactome:R-HSA-9660821 - - - figure legend:Figure 2c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos)|taxid:9534(Chlorocebus aethiops) - 2019/08/27 2019/08/27 rogid:Bk0P9TWrtnH9owEjN0BPz/6bvxk9606 rogid:8ws6S3uX+iCrWkXmZ05MErv+FSI9606 rigid:mOvNpJnur5/GXZ1cOvyAsV48cKo false flag tag:?-? ha tag:?-?|mutation with no effect:129-129 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)