#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96RK4 uniprotkb:Q15154 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-741421|uniprotkb:A6NNN6|uniprotkb:B4DYD5|uniprotkb:E7ETA6|uniprotkb:E7EV56|ensembl:ENSP00000327077|uniprotkb:Q58F13|uniprotkb:Q6P1K7|uniprotkb:Q8NB85|uniprotkb:Q9BWC1|uniprotkb:Q9H4A2|intact:EBI-2563316|intact:EBI-16421643|intact:EBI-10961691 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:pcm1_human(display_long)|uniprotkb:PCM1(gene name)|psi-mi:PCM1(display_short) psi-mi:"MI:0676"(tandem affinity purification) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21454169|imex:IM-27089-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_006188.3|ensembl:ENSG00000078674(gene)|ensembl:ENST00000325083(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0035176"(social behavior)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR024138|interpro:IPR031446|mint:Q15154|rcsb pdb:6HYL|rcsb pdb:6HYM|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016020"(membrane)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034454"(microtubule anchoring at centrosome)|refseq:NP_001302437.1|dip:DIP-42189N - - - figure legend:Figure 1A, 2G/H, Supplementary figure 1|comment:"The subunit composition of the BBSome purified from cells without microtubules (+ nocodazole) was indistinguishable from the control."|comment:Alpha and beta tubulins were also detected, but the identity of the molecules found is not stated.|comment:When cells were depleted of BBIP10 by siRNA no BBSome subunits copurified with BBS4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/18 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:ktyZQ5ot9yYxZXSvWZjOxX/eVHA9606 rigid:9v4gMjj+2mxby98GvNUk/0QE4rM false lap tag:n-n - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RK4 uniprotkb:Q3SYG4 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0676"(tandem affinity purification) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21454169|imex:IM-27089-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Figure 1A, 2G/H, Supplementary figure 1|comment:"The subunit composition of the BBSome purified from cells without microtubules (+ nocodazole) was indistinguishable from the control."|comment:Alpha and beta tubulins were also detected, but the identity of the molecules found is not stated.|comment:When cells were depleted of BBIP10 by siRNA no BBSome subunits copurified with BBS4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/18 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rigid:9v4gMjj+2mxby98GvNUk/0QE4rM false lap tag:n-n - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RK4 uniprotkb:Q8TAM2 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892638|uniprotkb:Q86SY0|uniprotkb:Q86TV9|uniprotkb:Q86U26|uniprotkb:Q8NDH9|uniprotkb:Q96DG8|uniprotkb:A6NFG2|uniprotkb:B3KWA5|uniprotkb:Q67B97 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:ttc8_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:BBS8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21454169|imex:IM-27089-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0050893"(sensory processing)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR028796|interpro:IPR019734|refseq:NP_653197.2|refseq:NP_938051.1|refseq:NP_938052.1|reactome:R-HSA-5620922|refseq:NP_001275710.1|refseq:NP_001275711.1|refseq:NP_001275712.1|dip:DIP-60359N|refseq:XP_006720098.1|refseq:XP_006720100.1|refseq:XP_011534734.1 - - - figure legend:Figure 1A, 2G/H, Supplementary figure 1|comment:"The subunit composition of the BBSome purified from cells without microtubules (+ nocodazole) was indistinguishable from the control."|comment:Alpha and beta tubulins were also detected, but the identity of the molecules found is not stated.|comment:When cells were depleted of BBIP10 by siRNA no BBSome subunits copurified with BBS4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/18 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:m1hnsT8xqmD1F301kYJBTbo+Qd09606 rigid:9v4gMjj+2mxby98GvNUk/0QE4rM false lap tag:n-n - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RK4 uniprotkb:Q8IWZ6 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21454169|imex:IM-27089-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Figure 1A, 2G/H, Supplementary figure 1|comment:"The subunit composition of the BBSome purified from cells without microtubules (+ nocodazole) was indistinguishable from the control."|comment:Alpha and beta tubulins were also detected, but the identity of the molecules found is not stated.|comment:When cells were depleted of BBIP10 by siRNA no BBSome subunits copurified with BBS4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/18 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rigid:9v4gMjj+2mxby98GvNUk/0QE4rM false lap tag:n-n - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RK4 uniprotkb:Q8N3I7 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:"MI:0676"(tandem affinity purification) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21454169|imex:IM-27089-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) - - - figure legend:Figure 1A, 2G/H, Supplementary figure 1|comment:"The subunit composition of the BBSome purified from cells without microtubules (+ nocodazole) was indistinguishable from the control."|comment:Alpha and beta tubulins were also detected, but the identity of the molecules found is not stated.|comment:When cells were depleted of BBIP10 by siRNA no BBSome subunits copurified with BBS4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/18 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 rigid:9v4gMjj+2mxby98GvNUk/0QE4rM false lap tag:n-n - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RK4 uniprotkb:Q9BXC9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0676"(tandem affinity purification) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21454169|imex:IM-27089-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Figure 1A, 2G/H, Supplementary figure 1|comment:"The subunit composition of the BBSome purified from cells without microtubules (+ nocodazole) was indistinguishable from the control."|comment:Alpha and beta tubulins were also detected, but the identity of the molecules found is not stated.|comment:When cells were depleted of BBIP10 by siRNA no BBSome subunits copurified with BBS4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/18 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rigid:9v4gMjj+2mxby98GvNUk/0QE4rM false lap tag:n-n - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RK4 uniprotkb:Q8NFJ9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21454169|imex:IM-27089-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Figure 1A, 2G/H, Supplementary figure 1|comment:"The subunit composition of the BBSome purified from cells without microtubules (+ nocodazole) was indistinguishable from the control."|comment:Alpha and beta tubulins were also detected, but the identity of the molecules found is not stated.|comment:When cells were depleted of BBIP10 by siRNA no BBSome subunits copurified with BBS4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/18 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rigid:9v4gMjj+2mxby98GvNUk/0QE4rM false lap tag:n-n - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RK4 uniprotkb:A8MTZ0 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21454169|imex:IM-27089-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 - - - figure legend:Figure 1A, 2G/H, Supplementary figure 1|comment:"The subunit composition of the BBSome purified from cells without microtubules (+ nocodazole) was indistinguishable from the control."|comment:Alpha and beta tubulins were also detected, but the identity of the molecules found is not stated.|comment:When cells were depleted of BBIP10 by siRNA no BBSome subunits copurified with BBS4.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/18 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rigid:9v4gMjj+2mxby98GvNUk/0QE4rM false lap tag:n-n - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0817"(molecular weight estimation by silver staining)|psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0102"(sequence tag identification) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0676"(tandem affinity purification) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21453950|imex:IM-27089-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/17 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false - lap tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0029"(cosedimentation through density gradient) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21453972|imex:IM-27089-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Figure 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/17 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false - lap tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0071"(molecular sieving) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21453985|imex:IM-27089-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Figure 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/17 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Loktev et al. (2008) pubmed:19081074|imex:IM-27089 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21453999|imex:IM-27089-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 go:"GO:0034451"(centriolar satellite)|go:"GO:0005929"(cilium) - - figure legend:Figure 1E, Supplementary figure 9|comment:BBS4 remained localized to centriolar satellites in BBIP10-depleted cells.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2019/05/08 2019/06/17 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false - lap tag:n-n - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)