#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UBN7	uniprotkb:O60260	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jiang et al. (2008)	pubmed:19036992|imex:IM-27075	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21450997|imex:IM-27075-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:figure 3A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line)	-	2019/05/08	2019/06/11	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rigid:heVQVnWEjGNh5N5FU/bjKxcMafk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBN7	uniprotkb:O60260	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jiang et al. (2008)	pubmed:19036992|imex:IM-27075	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451008|imex:IM-27075-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:figure 3B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/08	2019/06/11	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rigid:heVQVnWEjGNh5N5FU/bjKxcMafk	false	flag tag:c-c	myc tag:n-n|sufficient binding region:217-310(IPR041170)|sufficient binding region:395-465(IPR041170)|sufficient binding region:77-237	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UBN7	uniprotkb:O60260	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jiang et al. (2008)	pubmed:19036992|imex:IM-27075	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451034|imex:IM-27075-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:figure 3C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/08	2019/06/11	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rigid:heVQVnWEjGNh5N5FU/bjKxcMafk	false	sufficient binding region:106-439(IPR037138)|sufficient binding region:440-840(IPR037138)|flag tag:c-c	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UBN7	uniprotkb:O60260	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jiang et al. (2008)	pubmed:19036992|imex:IM-27075	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451057|imex:IM-27075-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:figure 3D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/08	2019/06/11	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rigid:heVQVnWEjGNh5N5FU/bjKxcMafk	false	sufficient binding region:106-439(IPR037138)|sufficient binding region:440-840(IPR037138)|flag tag:c-c|sufficient binding region:106-439(IPR037138)	sufficient binding region:395-465(IPR041170)|myc tag:n-n|sufficient binding region:77-237|sufficient binding region:217-310(IPR041170)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UBN7	uniprotkb:O60260	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Jiang et al. (2008)	pubmed:19036992|imex:IM-27075	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451107|imex:IM-27075-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	-	-	-	figure legend:figure 3E|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/08	2019/06/11	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rigid:heVQVnWEjGNh5N5FU/bjKxcMafk	false	his tag:n-n|flag tag:c-c	sufficient binding region:395-465(IPR041170)|glutathione s tranferase tag:n-n|sufficient binding region:77-237|sufficient binding region:217-310(IPR041170)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60260	uniprotkb:Q9UBN7	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Jiang et al. (2008)	pubmed:19036992|imex:IM-27075	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451142|imex:IM-27075-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	-	-	-	figure legend:figure 3F|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/08	2019/06/11	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rigid:heVQVnWEjGNh5N5FU/bjKxcMafk	false	sufficient binding region:395-465(IPR041170)|glutathione s tranferase tag:n-n|sufficient binding region:77-237|sufficient binding region:217-310(IPR041170)	his tag:n-n|sufficient binding region:106-439(IPR037138)|sufficient binding region:440-840(IPR037138)|flag tag:c-c|sufficient binding region:106-439(IPR037138)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)