#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q969F8	uniprotkb:P01040	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-724303|ensembl:ENSP00000264474|uniprotkb:Q6IB90	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:cyta_human(display_long)|uniprotkb:Cystatin-AS(gene name synonym)|uniprotkb:Stefin-A(gene name synonym)|uniprotkb:CSTA(gene name)|psi-mi:CSTA(display_short)|uniprotkb:STF1(gene name synonym)|uniprotkb:STFA(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_005204.1|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001713(Proteinase inhibitor I25A, stefin A)|mint:P01040|rcsb pdb:1CYU|rcsb pdb:1CYV|rcsb pdb:1DVC|rcsb pdb:1DVD|rcsb pdb:1GD3|rcsb pdb:1GD4|rcsb pdb:1N9J|rcsb pdb:1NB3|rcsb pdb:1NB5|rcsb pdb:3K9M|rcsb pdb:3KFQ|interpro:IPR018073|rcsb pdb:3KSE|reactome:R-HSA-6809371|ensembl:ENSG00000121552(gene)|ensembl:ENST00000264474(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002020"(protease binding)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0045861"(negative regulation of proteolysis)	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:SzbpyWUHlOtItIvffzuwhcqFsDI9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:Q9BVC6	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-1057733|ensembl:ENSP00000227525|ensembl:ENSP00000443990	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:tm109_human(display_long)|uniprotkb:TMEM109(gene name)|psi-mi:TMEM109(display_short)|uniprotkb:Mitsugumin-23(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_076997.1|ensembl:ENSG00000110108(gene)|ensembl:ENST00000227525(transcript)|ensembl:ENST00000536171(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|interpro:IPR039492|mint:Q9BVC6	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:KsibbFWmzuiZPpo4GqJikbMMaMQ9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:Q71RG4	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-2820477|ensembl:ENSP00000444565|ensembl:ENSP00000466971|uniprotkb:Q9HAG3|uniprotkb:Q8NDI2|uniprotkb:Q9BPZ5|uniprotkb:B3KU81	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:tmub2_human(display_long)|uniprotkb:TMUB2(gene name)|psi-mi:TMUB2(display_short)|uniprotkb:FP2653(orf name)|uniprotkb:UNQ1897/PRO4343(orf name)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:XP_011523500.1|refseq:XP_011523503.1|refseq:XP_011523507.1|refseq:XP_011523509.1|refseq:XP_011523510.1|refseq:XP_011523511.1|refseq:XP_011523508.1|ensembl:ENSG00000168591(gene)|ensembl:ENST00000538716(transcript)|refseq:NP_001070142.1|refseq:NP_077012.2|refseq:NP_803190.2|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR040352|mint:Q71RG4|ensembl:ENST00000587989(transcript)|refseq:NP_001317164.1|refseq:XP_016880537.1|refseq:XP_016880538.1|refseq:XP_016880539.1|refseq:XP_016880540.1|dip:DIP-60896N	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:swCGysYjPDaY9/vYf73+1//kkl49606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:Q02413	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-1045757|intact:EBI-28968615|ensembl:ENSP00000257192|uniprotkb:B7Z845	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:dsg1_human(display_long)|uniprotkb:CDHF4(gene name synonym)|uniprotkb:Desmosomal glycoprotein 1(gene name synonym)|uniprotkb:Pemphigus foliaceus antigen(gene name synonym)|uniprotkb:DSG1(gene name)|psi-mi:DSG1(display_short)|uniprotkb:Cadherin family member 4(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	ensembl:ENSP00000257192|refseq:NP_001933.2|ensembl:ENSG00000134760(gene)|ensembl:ENST00000257192(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR009123(Desmoglein)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|mint:Q02413|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696270	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:CiRFIJ9IWOol9bQpLJPxH8JArtE9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:P31025	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-1052433|uniprotkb:Q5T8A1|ensembl:ENSP00000263598|ensembl:ENSP00000360846	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:lcn1_human(display_long)|uniprotkb:Tear prealbumin(gene name synonym)|uniprotkb:Tear lipocalin(gene name synonym)|uniprotkb:LCN1(gene name)|psi-mi:LCN1(display_short)|uniprotkb:VEGP(gene name synonym)|uniprotkb:von Ebner gland protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_002288.1|refseq:NP_001239547.1|refseq:NP_001239548.1|refseq:NP_001239546.1|ensembl:ENSG00000160349(gene)|ensembl:ENST00000263598(transcript)|ensembl:ENST00000371781(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002345(Lipocalin)|interpro:IPR002450(von Ebner's gland protein/ Bos/Can allergen)|interpro:IPR012674(Calycin)|mint:P31025|rcsb pdb:1XKI|rcsb pdb:3EYC|rcsb pdb:4QAF|rcsb pdb:5T43|reactome:R-HSA-804914	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:bpcDgVZMNuh6M1hEl3b8IncbuO49606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:P29508	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-359110|uniprotkb:Q53H28|uniprotkb:Q86VF3|uniprotkb:Q86W04|uniprotkb:Q8IWL4|uniprotkb:Q8IXI3|uniprotkb:Q9BYF8|uniprotkb:Q53YB5|uniprotkb:Q96J21|uniprotkb:B2RBT5|uniprotkb:A6NDM2|uniprotkb:B3W5Y6|ensembl:ENSP00000283752	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:spb3_human(display_long)|uniprotkb:SERPINB3(gene name)|psi-mi:SERPINB3(display_short)|uniprotkb:SCCA(gene name synonym)|uniprotkb:SCCA1(gene name synonym)|uniprotkb:Squamous cell carcinoma antigen 1(gene name synonym)|uniprotkb:Protein T4-A(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_008850.1|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0035425"(autocrine signaling)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0038001"(paracrine signaling)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P29508|rcsb pdb:2ZV6|rcsb pdb:4ZK0|rcsb pdb:4ZK3|reactome:R-HSA-6798695|ensembl:ENSG00000057149(gene)|ensembl:ENST00000283752(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:Q6rcSr7BU3XXRUX39SbdLT6Nm5s9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:Q9BVT8	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-11425701|uniprotkb:D3DX06|uniprotkb:Q53AQ2|ensembl:ENSP00000297533|ensembl:ENSP00000376565|ensembl:ENSP00000417519|ensembl:ENSP00000418709|ensembl:ENSP00000419214	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:tmub1_human(display_long)|uniprotkb:TMUB1(gene name)|psi-mi:TMUB1(display_short)|uniprotkb:C7orf21(gene name synonym)|uniprotkb:DULP(gene name synonym)|uniprotkb:HOPS(gene name synonym)|uniprotkb:Dendritic cell-derived ubiquitin-like protein(gene name synonym)|uniprotkb:Hepatocyte odd protein shuttling protein(gene name synonym)|uniprotkb:Ubiquitin-like protein SB144(gene name synonym)|uniprotkb:SB144(orf name)|uniprotkb:UNQ763/PRO1555(orf name)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_001129516.1|refseq:NP_113622.1|ensembl:ENSG00000164897(gene)|ensembl:ENST00000297533(transcript)|ensembl:ENST00000392818(transcript)|ensembl:ENST00000462940(transcript)|ensembl:ENST00000476627(transcript)|ensembl:ENST00000482202(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0055037"(recycling endosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR040352	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:n89Hgo8fzSg9u5u2upp7+Prodiw9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:Q9NWT6	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:Q6AW86	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-4395769|uniprotkb:B2RTZ6|uniprotkb:Q6ZMX8|uniprotkb:Q6ZS42|ensembl:ENSP00000337473|ensembl:ENSP00000438930	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:z324b_human(display_long)|uniprotkb:ZNF324B(gene name)|psi-mi:ZNF324B(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_997278.2|refseq:XP_005258972.1|refseq:XP_005258975.1|ensembl:ENSG00000249471(gene)|ensembl:ENST00000336614(transcript)|ensembl:ENST00000545523(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:By/NNc+tRtZ7igitb+gw4PLB2HE9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:Q9P0L0	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:Q9Y385	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-988826|uniprotkb:Q5W0N4|uniprotkb:Q9BZ32|uniprotkb:Q9NQL3|uniprotkb:Q9NY66|uniprotkb:Q9P011|uniprotkb:Q9P0S0|uniprotkb:Q9UF10|ensembl:ENSP00000451261|uniprotkb:A8K3F9|uniprotkb:Q53F25	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:ub2j1_human(display_long)|uniprotkb:Non-canonical ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:Yeast ubiquitin-conjugating enzyme UBC6 homolog E(gene name synonym)|uniprotkb:UBE2J1(gene name)|psi-mi:UBE2J1(display_short)|uniprotkb:NCUBE1(gene name synonym)|uniprotkb:CGI-76(orf name)|uniprotkb:HSPC153(orf name)|uniprotkb:HSPC205(orf name)|uniprotkb:E2 ubiquitin-conjugating enzyme J1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|reactome:R-HSA-983168|ensembl:ENSG00000198833(gene)|ensembl:ENST00000435041(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007286"(spermatid development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:NP_057105.2|dip:DIP-45598N	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:nc3+V3Qxy1ZDhTWgTPLakJukxPM9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:P11142	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:P07339	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-2115097|uniprotkb:Q6IB57|ensembl:ENSP00000236671	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:catd_human(display_long)|uniprotkb:CTSD(gene name)|psi-mi:CTSD(display_short)|uniprotkb:CPSD(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_001900.1|dip:DIP-43906N|ensembl:ENSG00000117984(gene)|ensembl:ENST00000236671(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070001"(aspartic-type peptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033144|mint:P07339|rcsb pdb:1LYA|rcsb pdb:1LYB|rcsb pdb:1LYW|rcsb pdb:4OBZ|rcsb pdb:4OC6|rcsb pdb:4OD9|reactome:R-HSA-1442490|reactome:R-HSA-2022377|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-9018519	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:M1qLQBlL2DSCZiAwIPee9Vza3dU9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:O95816	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:O75477	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-359299|uniprotkb:B0QZ42|uniprotkb:Q53HV0|ensembl:ENSP00000384900|ensembl:ENSP00000410964|intact:EBI-21351077|uniprotkb:D3DR65	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:erln1_human(display_long)|uniprotkb:KEO4(gene name synonym)|uniprotkb:ERLIN1(gene name)|psi-mi:ERLIN1(display_short)|uniprotkb:C10orf69(gene name synonym)|uniprotkb:KE04(gene name synonym)|uniprotkb:SPFH1(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 1(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1(gene name synonym)|uniprotkb:Protein KE04(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_001094096.1|refseq:NP_006450.2|ensembl:ENSG00000107566(gene)|ensembl:ENST00000407654(transcript)|ensembl:ENST00000421367(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O75477|reactome:R-HSA-382556|reactome:R-HSA-5678895|refseq:NP_001334786.1|refseq:NP_001334788.1|refseq:NP_001334789.1|refseq:NP_001334790.1	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:HycFhL5qL5GLmaIIc9NtTcBbu1M9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:Q9NQ66	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-3396023|uniprotkb:Q9NQH9|uniprotkb:Q8IV93|uniprotkb:Q9NTH4|uniprotkb:Q9BQW2|uniprotkb:Q9H8H5|uniprotkb:Q9H4H2|uniprotkb:Q17RQ6|uniprotkb:Q9NQ65|uniprotkb:Q5TFF7|uniprotkb:Q5TGC9|uniprotkb:Q9UM26|uniprotkb:O60325|uniprotkb:Q9UJP6|uniprotkb:D3DW12|uniprotkb:D3DW13|ensembl:ENSP00000338185	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:plcb1_human(display_long)|uniprotkb:PLCB1(gene name)|psi-mi:PLCB1(display_short)|uniprotkb:KIAA0581(gene name synonym)|uniprotkb:PLC-154(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-beta-1(gene name synonym)|uniprotkb:Phospholipase C-I(gene name synonym)|uniprotkb:Phospholipase C-beta-1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_056007.1|refseq:NP_877398.1|ensembl:ENSG00000182621(gene)|ensembl:ENST00000338037(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0080154"(regulation of fertilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099178"(regulation of retrograde trans-synaptic signaling by endocanabinoid)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000438"(negative regulation of monocyte extravasation)|go:"GO:2000560"(positive regulation of CD24 production)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR009535(Protein of unknown function DUF1154)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028400|interpro:IPR035892|interpro:IPR037862|interpro:IPR042531|reactome:R-HSA-112043|reactome:R-HSA-1855204|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418217|reactome:R-HSA-434316|reactome:R-HSA-500657|reactome:R-HSA-4086398	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:HMEga+JeiTN5mFTwOnsmuVqArts9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:P68104	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-352162|uniprotkb:P04719|uniprotkb:P04720|intact:EBI-2834776|intact:EBI-8011754|intact:MINT-4903558|uniprotkb:Q6IQ15|ensembl:ENSP00000330054|ensembl:ENSP00000339053|ensembl:ENSP00000339063|ensembl:ENSP00000348651|ensembl:ENSP00000392366|ensembl:ENSP00000479055|ensembl:ENSP00000503192|ensembl:ENSP00000503249|ensembl:ENSP00000503823|ensembl:ENSP00000504335|intact:EBI-16423274	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:ef1a1_human(display_long)|uniprotkb:EEF1A1(gene name)|psi-mi:EEF1A1(display_short)|uniprotkb:EEF1A(gene name synonym)|uniprotkb:EF1A(gene name synonym)|uniprotkb:LENG7(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 7(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282024|imex:IM-26917-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:XP_011533816.1|ensembl:ENSG00000156508(gene)|ensembl:ENST00000309268(transcript)|ensembl:ENST00000316292(transcript)|ensembl:ENST00000331523(transcript)|ensembl:ENST00000356303(transcript)|ensembl:ENST00000455918(transcript)|ensembl:ENST00000615060(transcript)|ensembl:ENST00000676710(transcript)|ensembl:ENST00000677236(transcript)|ensembl:ENST00000678508(transcript)|ensembl:ENST00000678702(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P68104|rcsb pdb:1SYW|rcsb pdb:3C5J|rcsb pdb:6ZMO|reactome:R-HSA-156842|reactome:R-HSA-156902|reactome:R-HSA-3371511|reactome:R-HSA-6798695|reactome:R-HSA-8876725|reactome:R-HSA-9613829|dip:DIP-31277N|refseq:NP_001393.1	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/05/28	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:d3REF87FDKboAjyvlJJEXtqhrcw9606	rigid:J3yPY7yAtpvjaQyY4dLrCjT8ftk	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969F8	uniprotkb:P50148	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-3909604|uniprotkb:Q6NT27|uniprotkb:Q92471|uniprotkb:O15108|uniprotkb:Q9BZB9|uniprotkb:Q13462|ensembl:ENSP00000286548	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:gnaq_human(display_long)|uniprotkb:GNAQ(gene name)|psi-mi:GNAQ(display_short)|uniprotkb:GAQ(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein alpha-q(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282286|imex:IM-26917-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_002063.2|ensembl:ENSG00000156052(gene)|ensembl:ENST00000286548(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P50148|rcsb pdb:6VU5|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|dip:DIP-41652N	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Figure 5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/03/18	2019/03/26	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:ExDRSmmaTXllLWSDrc79rkxxAqQ9606	rigid:3BUow5RwPc18LcF4wmmu9KvvD/A	false	glutathione s tranferase tag:n-n|mutation with no effect:148-148	his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q969F8	uniprotkb:P50148	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-3909604|uniprotkb:Q6NT27|uniprotkb:Q92471|uniprotkb:O15108|uniprotkb:Q9BZB9|uniprotkb:Q13462|ensembl:ENSP00000286548	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:gnaq_human(display_long)|uniprotkb:GNAQ(gene name)|psi-mi:GNAQ(display_short)|uniprotkb:GAQ(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein alpha-q(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282361|imex:IM-26917-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_002063.2|ensembl:ENSG00000156052(gene)|ensembl:ENST00000286548(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P50148|rcsb pdb:6VU5|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|dip:DIP-41652N	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Figure 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/03/26	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:ExDRSmmaTXllLWSDrc79rkxxAqQ9606	rigid:3BUow5RwPc18LcF4wmmu9KvvD/A	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969F8	uniprotkb:P30679	intact:EBI-8481408|uniprotkb:Q96QG0|intact:UNK-5533686|uniprotkb:A5D8U2|uniprotkb:B2RTV1|ensembl:ENSP00000234371	intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958	psi-mi:kissr_human(display_long)|uniprotkb:KISS1R(gene name)|psi-mi:KISS1R(display_short)|uniprotkb:AXOR12(gene name synonym)|uniprotkb:GPR54(gene name synonym)|uniprotkb:Kisspeptins receptor(gene name synonym)|uniprotkb:Metastin receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 54(gene name synonym)|uniprotkb:Hypogonadotropin-1(gene name synonym)|uniprotkb:G-protein coupled receptor OT7T175(gene name synonym)	psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282392|imex:IM-26917-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115940.2|ensembl:ENSG00000116014(gene)|ensembl:ENST00000234371(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008188"(neuropeptide receptor activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR008103(KiSS-1 peptide receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:Q969F8|reactome:R-HSA-375276|reactome:R-HSA-416476	refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122	-	comment:mint|function:"Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins"|function:"Defects in KISS1R are a cause of isolated hypogonadotropic hypogonadism (IHH) [MIM:146110]. Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)"	-	figure legend:Figure 5Bi|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/03/26	rogid:wKcLQu7qwtslB76sNpuDGLdMEEw9606	rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606	rigid:FAfQsvLC24bRxjz0PHW/0KNkH6o	false	ha tag:n-n|calmodulin binding protein tag:n-n|strep tag:n-n|mutation with no effect:148-148	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21279	uniprotkb:P62871	intact:EBI-771975|uniprotkb:Q6PFF5|ensembl:ENSMUSP00000025541	intact:EBI-357141|ensembl:ENSBTAP00000000259|ensembl:ENSBTAP00000042481|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:Q3MHF1	psi-mi:gnaq_mouse(display_long)|uniprotkb:Guanine nucleotide-binding protein alpha-q(gene name synonym)|uniprotkb:Gnaq(gene name)|psi-mi:Gnaq(display_short)	psi-mi:gbb1_bovin(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Wacker et al. (2008)	pubmed:18772143|imex:IM-26917	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21282654|imex:IM-26917-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032165.3|dip:DIP-606N|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045634"(regulation of melanocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P21279|rcsb pdb:2BCJ|rcsb pdb:2RGN|rcsb pdb:3AH8|rcsb pdb:3OHM|rcsb pdb:4EKC|rcsb pdb:4EKD|rcsb pdb:4GNK|rcsb pdb:4QJ3|rcsb pdb:4QJ4|rcsb pdb:4QJ5|rcsb pdb:5DO9|reactome:R-MMU-112043|reactome:R-MMU-202040|reactome:R-MMU-399997|reactome:R-MMU-416476|reactome:R-MMU-418592|reactome:R-MMU-428930|reactome:R-MMU-434316|reactome:R-MMU-456926|reactome:R-MMU-6814122|go:"GO:0044297"(cell body)|ensembl:ENSMUSG00000024639(gene)|ensembl:ENSMUST00000025541(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016020"(membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042711"(maternal behavior)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043267"(negative regulation of potassium ion transport)	ensembl:ENSBTAG00000000215(gene)|ensembl:ENSBTAT00000000259(transcript)|ensembl:ENSBTAT00000045065(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62871|rcsb pdb:1A0R|rcsb pdb:1B9X|rcsb pdb:1B9Y|rcsb pdb:1GG2|rcsb pdb:1GOT|rcsb pdb:1GP2|rcsb pdb:1OMW|rcsb pdb:1TBG|rcsb pdb:1XHM|rcsb pdb:2BCJ|rcsb pdb:2TRC|rcsb pdb:3AH8|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:3UZS|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:5KDO|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6B20|rcsb pdb:6C2Y|rcsb pdb:6OY9|rcsb pdb:6OYA|rcsb pdb:6PCV|rcsb pdb:6QNO|rcsb pdb:6U7C|rcsb pdb:7BZ2|rcsb pdb:7D68|rcsb pdb:7DHI|rcsb pdb:7DHR|rcsb pdb:7JJO|rcsb pdb:7O7F|refseq:NP_786971.2|dip:DIP-29227N|refseq:XP_010811610.1|refseq:XP_005217074.1	-	-	-	figure legend:Figure 6|agonist:P21146 -Bovine GRK2|comment:Stimulation with KP-10 causes a decrease in FRET between YFP and CFP. WT hGPR54 shows a robust decrease in FRET in response to KP-10, whereas L148S hGPR54 fails to respond.|antagonist:"Kisspeptin_10 (KP-10):-PRO_0000021548 (Q15726)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/03/18	2019/03/27	rogid:7HfYjIynxSexMzn1uUS6x4sfzbI10090	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9913	rigid:/YKR7e6T9wX3Iitv45qj7d9JAVg	false	cyan fluorescent protein tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)