#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43561	uniprotkb:Q14643	intact:EBI-1222766|uniprotkb:O43919|uniprotkb:B7WPI0|uniprotkb:C7C5T6|uniprotkb:G5E9K3|ensembl:ENSP00000354119	intact:EBI-465548|ensembl:ENSP00000497605|uniprotkb:Q14660|uniprotkb:Q99897|uniprotkb:E7EPX7|uniprotkb:E9PDE9	psi-mi:lat_human(display_long)|uniprotkb:LAT(gene name)|psi-mi:LAT(display_short)|uniprotkb:36 kDa phospho-tyrosine adapter protein(gene name synonym)|uniprotkb:p36-38(gene name synonym)	psi-mi:itpr1_human(display_long)|uniprotkb:ITPR1(gene name)|psi-mi:ITPR1(display_short)|uniprotkb:INSP3R1(gene name synonym)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	deSouza et al. (2007)	imex:IM-27419|pubmed:18056410	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-22080929|imex:IM-27419-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014987.1|refseq:NP_001014988.1|refseq:NP_001014989.2|refseq:NP_055202.1|dip:DIP-29231N|ensembl:ENSG00000213658(gene)|ensembl:ENST00000360872(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050863"(regulation of T cell activation)|interpro:IPR008359("Linker for activation of T cells (LAT)")|mint:O43561|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-5673001	ensembl:ENSG00000150995(gene)|ensembl:ENST00000649015(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-418457|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695|refseq:NP_001093422.2|refseq:NP_002213.5|refseq:XP_011531985.1|dip:DIP-29714N|refseq:NP_001161744.1	-	-	-	figure legend:fig.1b|comment:"In ZAP-70–defi cient  T cells, LAT did not coimmunoprecipitate with IP3R1 (Fig. 1 B),  which suggests that the association of IP3R1 with LAT is mediated  by phosphorylation of LAT by ZAP-70."|agonist:zap-70 P43403|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jurkat)|taxid:9606(Homo sapiens)	-	2019/10/08	2019/10/08	rogid:oBG4calUDTkuXSPcr3x08rFDj6s9606	rogid:54BRt783vU5D9fCHNO5uFJy1N7I9606	rigid:ouIehW3ZvJqzeMSmS6yFb5QnkrE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)