#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51141	uniprotkb:Q8TAA9	intact:EBI-1538407|uniprotkb:Q60868|uniprotkb:Q3U2D3|ensembl:ENSMUSP00000030948|ensembl:ENSMUSP00000133137	intact:EBI-682393|uniprotkb:Q86WG8|uniprotkb:Q8N559|uniprotkb:Q5T1D3|uniprotkb:Q5T1D4|ensembl:ENSP00000310800|ensembl:ENSP00000347672|ensembl:ENSP00000358522	psi-mi:dvl1_mouse(display_long)|uniprotkb:Dvl1(gene name)|psi-mi:Dvl1(display_short)|uniprotkb:Dvl(gene name synonym)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:vang1_human(display_long)|uniprotkb:Van Gogh-like protein 1(gene name synonym)|uniprotkb:Strabismus 2(gene name synonym)|uniprotkb:Loop-tail protein 2 homolog(gene name synonym)|uniprotkb:VANGL1(gene name)|psi-mi:VANGL1(display_short)|uniprotkb:STB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kibar et al. (2007)	pubmed:17409324|imex:IM-27253	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982823|imex:IM-27253-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034221.3|refseq:NP_001289271.1|dip:DIP-38263N|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048668"(collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060029"(convergent extension involved in organogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|rcsb pdb:1FSH|rcsb pdb:1MC7|rcsb pdb:2KAW|rcsb pdb:2MX6|rcsb pdb:3PZ8|reactome:R-MMU-201688|reactome:R-MMU-4086400|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5663220|ensembl:ENSMUSG00000029071(gene)|ensembl:ENSMUST00000030948(transcript)|ensembl:ENSMUST00000168552(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_001165882.1|refseq:NP_001165883.1|refseq:NP_620409.1|ensembl:ENSG00000173218(gene)|ensembl:ENST00000310260(transcript)|ensembl:ENST00000355485(transcript)|ensembl:ENST00000369509(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0043473"(pigmentation)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR009539(Strabismus)|mint:Q8TAA9|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9035034|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:Figure 2b|comment:"Interaction studied in the most stringent medium which supports the growth of diploid cells only if proteins interact (labeled –Ade/–His/–Leu/–Trp lacking adenine, histidine, leucine, and tryptophan) was curated"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/12	2019/08/12	rogid:m61iD63WqE333GDlyLU6Mlnq50o10090	rogid:TRLqwMf+W5eZcgW8gT5S1zM9VzU9606	rigid:VOs+44BaLF8RNBYT9C7Vk7Bog7Y	false	gal4 activation domain:?-?|sufficient binding region:1-404|ha tag:?-?	gal4 dna binding domain:?-?|mutation disrupting interaction strength:239-239|mutation disrupting interaction strength:259-259|mutation with no effect:274-274|mutation with no effect:328-328|mutation disrupting interaction strength:467-467|myc tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60838	uniprotkb:Q8TAA9	intact:EBI-641940|uniprotkb:Q7TN14|ensembl:ENSMUSP00000099635|ensembl:ENSMUSP00000140073|ensembl:ENSMUSP00000019362	intact:EBI-682393|uniprotkb:Q86WG8|uniprotkb:Q8N559|uniprotkb:Q5T1D3|uniprotkb:Q5T1D4|ensembl:ENSP00000310800|ensembl:ENSP00000347672|ensembl:ENSP00000358522	psi-mi:dvl2_mouse(display_long)|uniprotkb:Dvl2(gene name)|psi-mi:Dvl2(display_short)|uniprotkb:DSH homolog 2(gene name synonym)	psi-mi:vang1_human(display_long)|uniprotkb:Van Gogh-like protein 1(gene name synonym)|uniprotkb:Strabismus 2(gene name synonym)|uniprotkb:Loop-tail protein 2 homolog(gene name synonym)|uniprotkb:VANGL1(gene name)|psi-mi:VANGL1(display_short)|uniprotkb:STB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kibar et al. (2007)	pubmed:17409324|imex:IM-27253	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982874|imex:IM-27253-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031914.3|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q60838|rcsb pdb:3ML6|rcsb pdb:6VCC|reactome:R-MMU-201688|reactome:R-MMU-2028269|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5099900|reactome:R-MMU-5663220|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUST00000019362(transcript)|ensembl:ENSMUST00000102575(transcript)|ensembl:ENSMUST00000190940(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060029"(convergent extension involved in organogenesis)|ensembl:ENSMUSG00000020888(gene)|dip:DIP-29399N	refseq:NP_001165882.1|refseq:NP_001165883.1|refseq:NP_620409.1|ensembl:ENSG00000173218(gene)|ensembl:ENST00000310260(transcript)|ensembl:ENST00000355485(transcript)|ensembl:ENST00000369509(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0043473"(pigmentation)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR009539(Strabismus)|mint:Q8TAA9|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9035034|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:Figure 2b|comment:"Interaction studied in the most stringent medium which supports the growth of diploid cells only if proteins interact (labeled –Ade/–His/–Leu/–Trp lacking adenine, histidine, leucine, and tryptophan) was curated"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/12	2019/08/12	rogid:bFjXy0cGGbY8YE60qW3+0NLpqNs10090	rogid:TRLqwMf+W5eZcgW8gT5S1zM9VzU9606	rigid:PS4Cn9VxYtfZ38n+tfxUDAHyLC4	false	sufficient binding region:1-418|gal4 activation domain:?-?|ha tag:?-?	gal4 dna binding domain:?-?|mutation disrupting interaction strength:239-239|mutation disrupting interaction strength:259-259|mutation with no effect:274-274|mutation with no effect:328-328|mutation decreasing interaction strength:467-467|myc tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61062	uniprotkb:Q8TAA9	intact:EBI-1538450|uniprotkb:G5E820|ensembl:ENSMUSP00000003318	intact:EBI-682393|uniprotkb:Q86WG8|uniprotkb:Q8N559|uniprotkb:Q5T1D3|uniprotkb:Q5T1D4|ensembl:ENSP00000310800|ensembl:ENSP00000347672|ensembl:ENSP00000358522	psi-mi:dvl3_mouse(display_long)|uniprotkb:Dvl3(gene name)|psi-mi:Dvl3(display_short)|uniprotkb:DSH homolog 3(gene name synonym)	psi-mi:vang1_human(display_long)|uniprotkb:Van Gogh-like protein 1(gene name synonym)|uniprotkb:Strabismus 2(gene name synonym)|uniprotkb:Loop-tail protein 2 homolog(gene name synonym)|uniprotkb:VANGL1(gene name)|psi-mi:VANGL1(display_short)|uniprotkb:STB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kibar et al. (2007)	pubmed:17409324|imex:IM-27253	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21982904|imex:IM-27253-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031915.2|ensembl:ENSMUSG00000003233(gene)|ensembl:ENSMUST00000003318(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|reactome:R-MMU-201688|reactome:R-MMU-4086400|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5663220	refseq:NP_001165882.1|refseq:NP_001165883.1|refseq:NP_620409.1|ensembl:ENSG00000173218(gene)|ensembl:ENST00000310260(transcript)|ensembl:ENST00000355485(transcript)|ensembl:ENST00000369509(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0043473"(pigmentation)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR009539(Strabismus)|mint:Q8TAA9|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9035034|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273	-	-	-	figure legend:Figure 2b|comment:"Interaction studied in the most stringent medium which supports the growth of diploid cells only if proteins interact (labeled –Ade/–His/–Leu/–Trp lacking adenine, histidine, leucine, and tryptophan) was curated"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/08/12	2019/08/12	rogid:+l0INmdRADXIgkikNBGmdG3UfiI10090	rogid:TRLqwMf+W5eZcgW8gT5S1zM9VzU9606	rigid:823X97hymvU05fuCQw+8saDvPWA	false	sufficient binding region:1-395|gal4 activation domain:?-?|ha tag:?-?|necessary binding region:1-388	gal4 dna binding domain:?-?|mutation disrupting interaction strength:239-239|mutation disrupting interaction strength:259-259|mutation with no effect:274-274|mutation with no effect:328-328|mutation with no effect:467-467|myc tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)