#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08913	uniprotkb:P08913	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Small et al. (2006)	pubmed:16605244|imex:IM-26958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335347|imex:IM-26958-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	-	-	-	figure legend:Figure 2A/B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2020/01/08	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	rigid:b/bZ6/xPI+biPIt3w+7nGmcEQAY	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P18825	uniprotkb:P08913	intact:EBI-12015266|ensembl:ENSP00000386069|uniprotkb:P35369|uniprotkb:Q9HB49	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	psi-mi:ada2c_human(display_long)|uniprotkb:ADRA2C(gene name)|psi-mi:ADRA2C(display_short)|uniprotkb:ADRA2L2(gene name synonym)|uniprotkb:ADRA2RL2(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C4(gene name synonym)|uniprotkb:Alpha-2C adrenoreceptor(gene name synonym)	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Small et al. (2006)	pubmed:16605244|imex:IM-26958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335355|imex:IM-26958-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184160(gene)|ensembl:ENST00000330055(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070473"(negative regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000735(Adrenergic receptor, alpha-2C)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6KUW|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000674.2	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	-	-	-	figure legend:Figure 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2020/01/08	rogid:STsoo3CQ+z5o8GomYRF52kCRcPI9606	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	rigid:QpYD4VGR108SVNHDvzb3iaPquVU	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P18825	uniprotkb:P18825	intact:EBI-12015266|ensembl:ENSP00000386069|uniprotkb:P35369|uniprotkb:Q9HB49	intact:EBI-12015266|ensembl:ENSP00000386069|uniprotkb:P35369|uniprotkb:Q9HB49	psi-mi:ada2c_human(display_long)|uniprotkb:ADRA2C(gene name)|psi-mi:ADRA2C(display_short)|uniprotkb:ADRA2L2(gene name synonym)|uniprotkb:ADRA2RL2(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C4(gene name synonym)|uniprotkb:Alpha-2C adrenoreceptor(gene name synonym)	psi-mi:ada2c_human(display_long)|uniprotkb:ADRA2C(gene name)|psi-mi:ADRA2C(display_short)|uniprotkb:ADRA2L2(gene name synonym)|uniprotkb:ADRA2RL2(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C4(gene name synonym)|uniprotkb:Alpha-2C adrenoreceptor(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Small et al. (2006)	pubmed:16605244|imex:IM-26958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335363|imex:IM-26958-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184160(gene)|ensembl:ENST00000330055(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070473"(negative regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000735(Adrenergic receptor, alpha-2C)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6KUW|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000674.2	ensembl:ENSG00000184160(gene)|ensembl:ENST00000330055(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070473"(negative regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000735(Adrenergic receptor, alpha-2C)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6KUW|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000674.2	-	-	-	figure legend:Figure 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/07/03	rogid:STsoo3CQ+z5o8GomYRF52kCRcPI9606	rogid:STsoo3CQ+z5o8GomYRF52kCRcPI9606	rigid:XZCwbCNtUpoGQC4wtH+8w7nvFI4	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P18825	uniprotkb:P08913	intact:EBI-12015266|ensembl:ENSP00000386069|uniprotkb:P35369|uniprotkb:Q9HB49	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	psi-mi:ada2c_human(display_long)|uniprotkb:ADRA2C(gene name)|psi-mi:ADRA2C(display_short)|uniprotkb:ADRA2L2(gene name synonym)|uniprotkb:ADRA2RL2(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C4(gene name synonym)|uniprotkb:Alpha-2C adrenoreceptor(gene name synonym)	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Small et al. (2006)	pubmed:16605244|imex:IM-26958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335378|imex:IM-26958-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184160(gene)|ensembl:ENST00000330055(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070473"(negative regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000735(Adrenergic receptor, alpha-2C)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6KUW|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000674.2	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	-	-	-	figure legend:Figure 3 Lane 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2020/01/08	rogid:STsoo3CQ+z5o8GomYRF52kCRcPI9606	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	rigid:QpYD4VGR108SVNHDvzb3iaPquVU	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08913	uniprotkb:P08913	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Small et al. (2006)	pubmed:16605244|imex:IM-26958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335388|imex:IM-26958-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N	-	-	-	figure legend:Figure 3 Lane 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2020/01/08	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606	rigid:b/bZ6/xPI+biPIt3w+7nGmcEQAY	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P18825	uniprotkb:P18825	intact:EBI-12015266|ensembl:ENSP00000386069|uniprotkb:P35369|uniprotkb:Q9HB49	intact:EBI-12015266|ensembl:ENSP00000386069|uniprotkb:P35369|uniprotkb:Q9HB49	psi-mi:ada2c_human(display_long)|uniprotkb:ADRA2C(gene name)|psi-mi:ADRA2C(display_short)|uniprotkb:ADRA2L2(gene name synonym)|uniprotkb:ADRA2RL2(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C4(gene name synonym)|uniprotkb:Alpha-2C adrenoreceptor(gene name synonym)	psi-mi:ada2c_human(display_long)|uniprotkb:ADRA2C(gene name)|psi-mi:ADRA2C(display_short)|uniprotkb:ADRA2L2(gene name synonym)|uniprotkb:ADRA2RL2(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C4(gene name synonym)|uniprotkb:Alpha-2C adrenoreceptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Small et al. (2006)	pubmed:16605244|imex:IM-26958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21335396|imex:IM-26958-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000184160(gene)|ensembl:ENST00000330055(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070473"(negative regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000735(Adrenergic receptor, alpha-2C)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6KUW|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000674.2	ensembl:ENSG00000184160(gene)|ensembl:ENST00000330055(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0030168"(platelet activation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070473"(negative regulation of uterine smooth muscle contraction)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000735(Adrenergic receptor, alpha-2C)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6KUW|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000674.2	-	-	-	figure legend:Figure 3 Lane 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/04/03	2019/04/17	rogid:STsoo3CQ+z5o8GomYRF52kCRcPI9606	rogid:STsoo3CQ+z5o8GomYRF52kCRcPI9606	rigid:XZCwbCNtUpoGQC4wtH+8w7nvFI4	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)