#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97454	uniprotkb:Q62424	intact:EBI-7066475|ensembl:ENSMUSP00000065798|ensembl:ENSMUSP00000105500|ensembl:ENSMUSP00000105502|uniprotkb:P70341|intact:MINT-99279|uniprotkb:Q810K0	intact:EBI-925160|ensembl:ENSMUSP00000125221	psi-mi:smad5_mouse(display_long)|uniprotkb:Smad5(gene name)|psi-mi:Smad5(display_short)|uniprotkb:Madh5(gene name synonym)|uniprotkb:Msmad5(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)|uniprotkb:Dwarfin-C(gene name synonym)	psi-mi:hxa13_mouse(display_long)|uniprotkb:Hoxa13(gene name)|psi-mi:Hoxa13(display_short)|uniprotkb:Hox-1.10(gene name synonym)|uniprotkb:Homeobox protein Hox-1.10(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21229888|imex:IM-26891-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517180.1|refseq:XP_006517181.1|ensembl:ENSMUSG00000021540(gene)|ensembl:ENSMUST00000069557(transcript)|ensembl:ENSMUST00000109874(transcript)|ensembl:ENSMUST00000109876(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97454|rcsb pdb:5X6G|rcsb pdb:5X6H|rcsb pdb:5X6M|reactome:R-MMU-201451|refseq:NP_001157513.1|refseq:NP_032567.1|refseq:NP_001157514.1	refseq:NP_032290.1|ensembl:ENSMUSG00000038203(gene)|ensembl:ENSMUST00000147595(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060847"(endothelial cell fate specification)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|rcsb pdb:2LD5	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity). Required for angiogenesis"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:9+0xdGWH0UtFQl/ec5ybRhFyHXQ10090	rogid:/k6I7UlWa95HTqDWVlgZiYlrNs010090	rigid:0rmyElahGMec2XkFiv0i4wP5E7U	false	sufficient binding region:175-465|b42 activation domain:n-n	sufficient binding region:150-360|lexa dna binding domain:n-n	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60954	uniprotkb:Q62424	intact:EBI-445706|uniprotkb:B1ARH5|uniprotkb:Q60955|uniprotkb:Q8CIL0|uniprotkb:Q5SVC8|ensembl:ENSMUSP00000069277	intact:EBI-925160|ensembl:ENSMUSP00000125221	psi-mi:meis1_mouse(display_long)|uniprotkb:Myeloid ecotropic viral integration site 1(gene name synonym)|uniprotkb:Meis1(gene name)|psi-mi:Meis1(display_short)	psi-mi:hxa13_mouse(display_long)|uniprotkb:Hoxa13(gene name)|psi-mi:Hoxa13(display_short)|uniprotkb:Hox-1.10(gene name synonym)|uniprotkb:Homeobox protein Hox-1.10(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21229896|imex:IM-26891-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180200.1|refseq:NP_034919.1|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|mint:Q60954|ensembl:ENSMUSG00000020160(gene)|ensembl:ENSMUST00000068264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043565"(sequence-specific DNA binding)	refseq:NP_032290.1|ensembl:ENSMUSG00000038203(gene)|ensembl:ENSMUST00000147595(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060847"(endothelial cell fate specification)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|rcsb pdb:2LD5	-	-	-	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:RGSZw4Y6pNk7d/7zSj0rItFpMGc10090	rogid:/k6I7UlWa95HTqDWVlgZiYlrNs010090	rigid:+n4CLhIY2Suqi+La66xYik/0b4s	false	lexa dna binding domain:n-n	sufficient binding region:150-360|b42 activation domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70217	uniprotkb:Q60954	intact:EBI-925264|uniprotkb:Q2VPB0|uniprotkb:A2ASM5|uniprotkb:Q2VPB1|uniprotkb:Q64177|ensembl:ENSMUSP00000001872	intact:EBI-445706|uniprotkb:B1ARH5|uniprotkb:Q60955|uniprotkb:Q8CIL0|uniprotkb:Q5SVC8|ensembl:ENSMUSP00000069277	psi-mi:hxd13_mouse(display_long)|uniprotkb:Hoxd13(gene name)|psi-mi:Hoxd13(display_short)|uniprotkb:Hox-4.8(gene name synonym)|uniprotkb:Homeobox protein Hox-4.8(gene name synonym)	psi-mi:meis1_mouse(display_long)|uniprotkb:Myeloid ecotropic viral integration site 1(gene name synonym)|uniprotkb:Meis1(gene name)|psi-mi:Meis1(display_short)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21229903|imex:IM-26891-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032301.2|ensembl:ENSMUSG00000001819(gene)|ensembl:ENSMUST00000001872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007389"(pattern specification process)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030539"(male genitalia development)|go:"GO:0033574"(response to testosterone)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060602"(branch elongation of an epithelium)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|mint:P70217	refseq:NP_001180200.1|refseq:NP_034919.1|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|mint:Q60954|ensembl:ENSMUSG00000020160(gene)|ensembl:ENSMUST00000068264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043565"(sequence-specific DNA binding)	-	-	-	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:FWeR98eKeTKa8R6EG03n7Gelgi410090	rogid:RGSZw4Y6pNk7d/7zSj0rItFpMGc10090	rigid:5t3F7SYgZewIJtie6VmZj4H/CJI	false	sufficient binding region:1-312|b42 activation domain:n-n	lexa dna binding domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97454	uniprotkb:P70217	intact:EBI-7066475|ensembl:ENSMUSP00000065798|ensembl:ENSMUSP00000105500|ensembl:ENSMUSP00000105502|uniprotkb:P70341|intact:MINT-99279|uniprotkb:Q810K0	intact:EBI-925264|uniprotkb:Q2VPB0|uniprotkb:A2ASM5|uniprotkb:Q2VPB1|uniprotkb:Q64177|ensembl:ENSMUSP00000001872	psi-mi:smad5_mouse(display_long)|uniprotkb:Smad5(gene name)|psi-mi:Smad5(display_short)|uniprotkb:Madh5(gene name synonym)|uniprotkb:Msmad5(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)|uniprotkb:Dwarfin-C(gene name synonym)	psi-mi:hxd13_mouse(display_long)|uniprotkb:Hoxd13(gene name)|psi-mi:Hoxd13(display_short)|uniprotkb:Hox-4.8(gene name synonym)|uniprotkb:Homeobox protein Hox-4.8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21229909|imex:IM-26891-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517180.1|refseq:XP_006517181.1|ensembl:ENSMUSG00000021540(gene)|ensembl:ENSMUST00000069557(transcript)|ensembl:ENSMUST00000109874(transcript)|ensembl:ENSMUST00000109876(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97454|rcsb pdb:5X6G|rcsb pdb:5X6H|rcsb pdb:5X6M|reactome:R-MMU-201451|refseq:NP_001157513.1|refseq:NP_032567.1|refseq:NP_001157514.1	refseq:NP_032301.2|ensembl:ENSMUSG00000001819(gene)|ensembl:ENSMUST00000001872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007389"(pattern specification process)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030539"(male genitalia development)|go:"GO:0033574"(response to testosterone)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060602"(branch elongation of an epithelium)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|mint:P70217	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity). Required for angiogenesis"	-	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:9+0xdGWH0UtFQl/ec5ybRhFyHXQ10090	rogid:FWeR98eKeTKa8R6EG03n7Gelgi410090	rigid:jHMJqYFrcnTEtzRZAubPFsbk/sY	false	sufficient binding region:175-465|lexa dna binding domain:n-n	sufficient binding region:1-312|b42 activation domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60954	uniprotkb:P31311	intact:EBI-445706|uniprotkb:B1ARH5|uniprotkb:Q60955|uniprotkb:Q8CIL0|uniprotkb:Q5SVC8|ensembl:ENSMUSP00000069277	intact:EBI-445941|uniprotkb:Q3V026|ensembl:ENSMUSP00000040920	psi-mi:meis1_mouse(display_long)|uniprotkb:Myeloid ecotropic viral integration site 1(gene name synonym)|uniprotkb:Meis1(gene name)|psi-mi:Meis1(display_short)	psi-mi:hxa11_mouse(display_long)|uniprotkb:Hoxa11(gene name)|psi-mi:Hoxa11(display_short)|uniprotkb:Hox-1.9(gene name synonym)|uniprotkb:Hoxa-11(gene name synonym)|uniprotkb:Homeobox protein Hox-1.9(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21229917|imex:IM-26891-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180200.1|refseq:NP_034919.1|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|mint:Q60954|ensembl:ENSMUSG00000020160(gene)|ensembl:ENSMUST00000068264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043565"(sequence-specific DNA binding)	refseq:NP_034580.1|ensembl:ENSMUSG00000038210(gene)|ensembl:ENSMUST00000048026(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010720"(positive regulation of cell development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048589"(developmental growth)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060065"(uterus development)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060348"(bone development)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR021918	-	-	-	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:RGSZw4Y6pNk7d/7zSj0rItFpMGc10090	rogid:xmuaYwHq6mzn6Qbx/zJIcMkoNsk10090	rigid:fd+BkJW9qdhG1fwXLNW3uu2NrqI	false	lexa dna binding domain:n-n	sufficient binding region:1-281|b42 activation domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09631	uniprotkb:Q60954	intact:EBI-925334|uniprotkb:O70154|uniprotkb:O70155|ensembl:ENSMUSP00000046939	intact:EBI-445706|uniprotkb:B1ARH5|uniprotkb:Q60955|uniprotkb:Q8CIL0|uniprotkb:Q5SVC8|ensembl:ENSMUSP00000069277	psi-mi:hxa9_mouse(display_long)|uniprotkb:Hoxa9(gene name)|psi-mi:Hoxa9(display_short)|uniprotkb:Hox-1.7(gene name synonym)|uniprotkb:Hoxa-9(gene name synonym)|uniprotkb:Homeobox protein Hox-1.7(gene name synonym)	psi-mi:meis1_mouse(display_long)|uniprotkb:Myeloid ecotropic viral integration site 1(gene name synonym)|uniprotkb:Meis1(gene name)|psi-mi:Meis1(display_short)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21229923|imex:IM-26891-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034586.1|dip:DIP-35619N|ensembl:ENSMUSG00000038227(gene)|ensembl:ENSMUST00000048680(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0060065"(uterus development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:1PUF	refseq:NP_001180200.1|refseq:NP_034919.1|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|mint:Q60954|ensembl:ENSMUSG00000020160(gene)|ensembl:ENSMUST00000068264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043565"(sequence-specific DNA binding)	-	-	-	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:OjGwxaxJEuDgDykwUs76pvyWuvU10090	rogid:RGSZw4Y6pNk7d/7zSj0rItFpMGc10090	rigid:/roxqj9OokQca3Xjv60+m2IMwH4	false	sufficient binding region:1-245|b42 activation domain:n-n	lexa dna binding domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97454	uniprotkb:Q62424	intact:EBI-7066475|ensembl:ENSMUSP00000065798|ensembl:ENSMUSP00000105500|ensembl:ENSMUSP00000105502|uniprotkb:P70341|intact:MINT-99279|uniprotkb:Q810K0	intact:EBI-925160|ensembl:ENSMUSP00000125221	psi-mi:smad5_mouse(display_long)|uniprotkb:Smad5(gene name)|psi-mi:Smad5(display_short)|uniprotkb:Madh5(gene name synonym)|uniprotkb:Msmad5(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)|uniprotkb:Dwarfin-C(gene name synonym)	psi-mi:hxa13_mouse(display_long)|uniprotkb:Hoxa13(gene name)|psi-mi:Hoxa13(display_short)|uniprotkb:Hox-1.10(gene name synonym)|uniprotkb:Homeobox protein Hox-1.10(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21229946|imex:IM-26891-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517180.1|refseq:XP_006517181.1|ensembl:ENSMUSG00000021540(gene)|ensembl:ENSMUST00000069557(transcript)|ensembl:ENSMUST00000109874(transcript)|ensembl:ENSMUST00000109876(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97454|rcsb pdb:5X6G|rcsb pdb:5X6H|rcsb pdb:5X6M|reactome:R-MMU-201451|refseq:NP_001157513.1|refseq:NP_032567.1|refseq:NP_001157514.1	refseq:NP_032290.1|ensembl:ENSMUSG00000038203(gene)|ensembl:ENSMUST00000147595(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060847"(endothelial cell fate specification)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|rcsb pdb:2LD5	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity). Required for angiogenesis"	-	figure legend:Figure 2, Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:9+0xdGWH0UtFQl/ec5ybRhFyHXQ10090	rogid:/k6I7UlWa95HTqDWVlgZiYlrNs010090	rigid:0rmyElahGMec2XkFiv0i4wP5E7U	false	sufficient binding region:265-465|b42 activation domain:n-n	sufficient binding region:150-360|lexa dna binding domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97454	uniprotkb:Q62424	intact:EBI-7066475|ensembl:ENSMUSP00000065798|ensembl:ENSMUSP00000105500|ensembl:ENSMUSP00000105502|uniprotkb:P70341|intact:MINT-99279|uniprotkb:Q810K0	intact:EBI-925160|ensembl:ENSMUSP00000125221	psi-mi:smad5_mouse(display_long)|uniprotkb:Smad5(gene name)|psi-mi:Smad5(display_short)|uniprotkb:Madh5(gene name synonym)|uniprotkb:Msmad5(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)|uniprotkb:Dwarfin-C(gene name synonym)	psi-mi:hxa13_mouse(display_long)|uniprotkb:Hoxa13(gene name)|psi-mi:Hoxa13(display_short)|uniprotkb:Hox-1.10(gene name synonym)|uniprotkb:Homeobox protein Hox-1.10(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21229973|imex:IM-26891-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517180.1|refseq:XP_006517181.1|ensembl:ENSMUSG00000021540(gene)|ensembl:ENSMUST00000069557(transcript)|ensembl:ENSMUST00000109874(transcript)|ensembl:ENSMUST00000109876(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97454|rcsb pdb:5X6G|rcsb pdb:5X6H|rcsb pdb:5X6M|reactome:R-MMU-201451|refseq:NP_001157513.1|refseq:NP_032567.1|refseq:NP_001157514.1	refseq:NP_032290.1|ensembl:ENSMUSG00000038203(gene)|ensembl:ENSMUST00000147595(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060847"(endothelial cell fate specification)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|rcsb pdb:2LD5	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity). Required for angiogenesis"	-	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:9+0xdGWH0UtFQl/ec5ybRhFyHXQ10090	rogid:/k6I7UlWa95HTqDWVlgZiYlrNs010090	rigid:0rmyElahGMec2XkFiv0i4wP5E7U	false	sufficient binding region:175-465|lexa dna binding domain:n-n	sufficient binding region:150-360|b42 activation domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97454	uniprotkb:P70217	intact:EBI-7066475|ensembl:ENSMUSP00000065798|ensembl:ENSMUSP00000105500|ensembl:ENSMUSP00000105502|uniprotkb:P70341|intact:MINT-99279|uniprotkb:Q810K0	intact:EBI-925264|uniprotkb:Q2VPB0|uniprotkb:A2ASM5|uniprotkb:Q2VPB1|uniprotkb:Q64177|ensembl:ENSMUSP00000001872	psi-mi:smad5_mouse(display_long)|uniprotkb:Smad5(gene name)|psi-mi:Smad5(display_short)|uniprotkb:Madh5(gene name synonym)|uniprotkb:Msmad5(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)|uniprotkb:Dwarfin-C(gene name synonym)	psi-mi:hxd13_mouse(display_long)|uniprotkb:Hoxd13(gene name)|psi-mi:Hoxd13(display_short)|uniprotkb:Hox-4.8(gene name synonym)|uniprotkb:Homeobox protein Hox-4.8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21230008|imex:IM-26891-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517180.1|refseq:XP_006517181.1|ensembl:ENSMUSG00000021540(gene)|ensembl:ENSMUST00000069557(transcript)|ensembl:ENSMUST00000109874(transcript)|ensembl:ENSMUST00000109876(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97454|rcsb pdb:5X6G|rcsb pdb:5X6H|rcsb pdb:5X6M|reactome:R-MMU-201451|refseq:NP_001157513.1|refseq:NP_032567.1|refseq:NP_001157514.1	refseq:NP_032301.2|ensembl:ENSMUSG00000001819(gene)|ensembl:ENSMUST00000001872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007389"(pattern specification process)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030539"(male genitalia development)|go:"GO:0033574"(response to testosterone)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060602"(branch elongation of an epithelium)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|mint:P70217	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity). Required for angiogenesis"	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:9+0xdGWH0UtFQl/ec5ybRhFyHXQ10090	rogid:FWeR98eKeTKa8R6EG03n7Gelgi410090	rigid:jHMJqYFrcnTEtzRZAubPFsbk/sY	false	sufficient binding region:265-465|b42 activation domain:n-n	lexa dna binding domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70340	uniprotkb:Q62424	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	intact:EBI-925160|ensembl:ENSMUSP00000125221	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:hxa13_mouse(display_long)|uniprotkb:Hoxa13(gene name)|psi-mi:Hoxa13(display_short)|uniprotkb:Hox-1.10(gene name synonym)|uniprotkb:Homeobox protein Hox-1.10(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21230036|imex:IM-26891-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2	refseq:NP_032290.1|ensembl:ENSMUSG00000038203(gene)|ensembl:ENSMUST00000147595(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060847"(endothelial cell fate specification)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|rcsb pdb:2LD5	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	rogid:/k6I7UlWa95HTqDWVlgZiYlrNs010090	rigid:I47Eoqy/a9gEkv2OzfhEtEGM6gk	false	sufficient binding region:265-465|b42 activation domain:n-n	sufficient binding region:150-360|lexa dna binding domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70340	uniprotkb:P70217	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	intact:EBI-925264|uniprotkb:Q2VPB0|uniprotkb:A2ASM5|uniprotkb:Q2VPB1|uniprotkb:Q64177|ensembl:ENSMUSP00000001872	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:hxd13_mouse(display_long)|uniprotkb:Hoxd13(gene name)|psi-mi:Hoxd13(display_short)|uniprotkb:Hox-4.8(gene name synonym)|uniprotkb:Homeobox protein Hox-4.8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21230052|imex:IM-26891-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2	refseq:NP_032301.2|ensembl:ENSMUSG00000001819(gene)|ensembl:ENSMUST00000001872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007389"(pattern specification process)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030539"(male genitalia development)|go:"GO:0033574"(response to testosterone)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060602"(branch elongation of an epithelium)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|mint:P70217	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	rogid:FWeR98eKeTKa8R6EG03n7Gelgi410090	rigid:jY+p6dUSLF9FAnOmEhcZlEGn5go	false	sufficient binding region:265-465|b42 activation domain:n-n	lexa dna binding domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62432	uniprotkb:Q62424	intact:EBI-2337932|uniprotkb:Q6GU18|uniprotkb:Q6VP00|uniprotkb:Q9D8P6|ensembl:ENSMUSP00000025453|ensembl:ENSMUSP00000130115	intact:EBI-925160|ensembl:ENSMUSP00000125221	psi-mi:smad2_mouse(display_long)|uniprotkb:Smad2(gene name)|psi-mi:Smad2(display_short)|uniprotkb:Madh2(gene name synonym)|uniprotkb:Madr2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)	psi-mi:hxa13_mouse(display_long)|uniprotkb:Hoxa13(gene name)|psi-mi:Hoxa13(display_short)|uniprotkb:Hox-1.10(gene name synonym)|uniprotkb:Homeobox protein Hox-1.10(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21230058|imex:IM-26891-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034884.2|refseq:NP_001239410.1|refseq:NP_001297999.1|refseq:XP_006525762.1|refseq:XP_017173331.1|ensembl:ENSMUSG00000024563(gene)|ensembl:ENSMUST00000025453(transcript)|ensembl:ENSMUST00000168423(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q62432|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-9617828	refseq:NP_032290.1|ensembl:ENSMUSG00000038203(gene)|ensembl:ENSMUST00000147595(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060847"(endothelial cell fate specification)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|rcsb pdb:2LD5	-	-	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:PDNrM3U7qpRcHjSJIPv50FD2W7E10090	rogid:/k6I7UlWa95HTqDWVlgZiYlrNs010090	rigid:+g5nHF8ZEUuIMHYPxnJz4chPYyE	false	sufficient binding region:268-467|b42 activation domain:n-n	sufficient binding region:150-360|lexa dna binding domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70217	uniprotkb:Q62432	intact:EBI-925264|uniprotkb:Q2VPB0|uniprotkb:A2ASM5|uniprotkb:Q2VPB1|uniprotkb:Q64177|ensembl:ENSMUSP00000001872	intact:EBI-2337932|uniprotkb:Q6GU18|uniprotkb:Q6VP00|uniprotkb:Q9D8P6|ensembl:ENSMUSP00000025453|ensembl:ENSMUSP00000130115	psi-mi:hxd13_mouse(display_long)|uniprotkb:Hoxd13(gene name)|psi-mi:Hoxd13(display_short)|uniprotkb:Hox-4.8(gene name synonym)|uniprotkb:Homeobox protein Hox-4.8(gene name synonym)	psi-mi:smad2_mouse(display_long)|uniprotkb:Smad2(gene name)|psi-mi:Smad2(display_short)|uniprotkb:Madh2(gene name synonym)|uniprotkb:Madr2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Williams et al. (2004)	pubmed:16087734|imex:IM-26891	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21230068|imex:IM-26891-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032301.2|ensembl:ENSMUSG00000001819(gene)|ensembl:ENSMUST00000001872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007389"(pattern specification process)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030539"(male genitalia development)|go:"GO:0033574"(response to testosterone)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060602"(branch elongation of an epithelium)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR022067|mint:P70217	refseq:NP_034884.2|refseq:NP_001239410.1|refseq:NP_001297999.1|refseq:XP_006525762.1|refseq:XP_017173331.1|ensembl:ENSMUSG00000024563(gene)|ensembl:ENSMUST00000025453(transcript)|ensembl:ENSMUST00000168423(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q62432|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-9617828	-	-	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/03/06	2019/03/06	rogid:FWeR98eKeTKa8R6EG03n7Gelgi410090	rogid:PDNrM3U7qpRcHjSJIPv50FD2W7E10090	rigid:TBQfWnlvkqXimWIEXlSc8qbjRfE	false	lexa dna binding domain:n-n	sufficient binding region:268-467|b42 activation domain:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)