#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43918	uniprotkb:O43918	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Meloni et al. (2005)	pubmed:15712268|imex:IM-27396	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22055796|imex:IM-27396-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	-	-	-	figure legend:Table 2, Figure 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/10/02	2019/10/02	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rigid:C3bXsl1h9kuWQRjW7NsPjL467y4	false	sufficient binding region:1-524	mutation decreasing interaction strength:15-15|mutation decreasing interaction strength:16-16|mutation disrupting interaction strength:22-23|mutation disrupting interaction strength:77-77|mutation disrupting interaction strength:78-78	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)