#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99M75	uniprotkb:Q96FE5	intact:EBI-7370412|intact:MINT-243866|ensembl:ENSRNOP00000041517	intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451	psi-mi:rtn4r_rat(display_long)|uniprotkb:Rtn4r(gene name)|psi-mi:Rtn4r(display_short)|uniprotkb:Nogor(gene name synonym)|uniprotkb:Nogo receptor(gene name synonym)|uniprotkb:Nogo-66 receptor(gene name synonym)	psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mi et al. (2004)	pubmed:14966521|imex:IM-27117	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022534|imex:IM-27117-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620810|refseq:NP_446065.1|interpro:IPR032675|rcsb pdb:3KJ4|ensembl:ENSRNOG00000030920(gene)|ensembl:ENSRNOT00000051037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)	refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634	-	function:Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system|comment:mint	-	figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/23	2019/06/26	rogid:JNKz36jyj56yCZdDB3464B0mhgY10116	rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606	rigid:bfLOsVnk7Kar9QY/LRggW2Rae+I	false	sufficient binding region:27..27-447..447|fc-igg tag:?-?	his tag:c-c|alkaline phosphatase tag:c-c|sufficient binding region:34-532	-	-	psi-mi:"MI:0980"(tag visualisation by enzyme assay)	psi-mi:"MI:0980"(tag visualisation by enzyme assay)
uniprotkb:Q99M75	uniprotkb:Q99M75	intact:EBI-7370412|intact:MINT-243866|ensembl:ENSRNOP00000041517	intact:EBI-7370412|intact:MINT-243866|ensembl:ENSRNOP00000041517	psi-mi:rtn4r_rat(display_long)|uniprotkb:Rtn4r(gene name)|psi-mi:Rtn4r(display_short)|uniprotkb:Nogor(gene name synonym)|uniprotkb:Nogo receptor(gene name synonym)|uniprotkb:Nogo-66 receptor(gene name synonym)	psi-mi:rtn4r_rat(display_long)|uniprotkb:Rtn4r(gene name)|psi-mi:Rtn4r(display_short)|uniprotkb:Nogor(gene name synonym)|uniprotkb:Nogo receptor(gene name synonym)|uniprotkb:Nogo-66 receptor(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mi et al. (2004)	pubmed:14966521|imex:IM-27117	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21459022|imex:IM-27117-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620810|refseq:NP_446065.1|interpro:IPR032675|rcsb pdb:3KJ4|ensembl:ENSRNOG00000030920(gene)|ensembl:ENSRNOT00000051037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)	rgd:620810|refseq:NP_446065.1|interpro:IPR032675|rcsb pdb:3KJ4|ensembl:ENSRNOG00000030920(gene)|ensembl:ENSRNOT00000051037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)	-	function:Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system|comment:mint	function:Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system|comment:mint	figure legend:Fig. 3C|comment:Binding of LINGO1 to sNgR1 could be inhibited by up to 80% if excess sNgR1 was first added as a soluble competitor..|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/23	2019/06/26	rogid:JNKz36jyj56yCZdDB3464B0mhgY10116	rogid:JNKz36jyj56yCZdDB3464B0mhgY10116	rigid:bfLOsVnk7Kar9QY/LRggW2Rae+I	false	sufficient binding region:27..27-447..447|fc-igg tag:?-?	sufficient binding region:27..27-447..447|fc-igg tag:?-?	-	-	psi-mi:"MI:0980"(tag visualisation by enzyme assay)	psi-mi:"MI:0980"(tag visualisation by enzyme assay)
uniprotkb:Q99M75	uniprotkb:Q96FE5	intact:EBI-7370412|intact:MINT-243866|ensembl:ENSRNOP00000041517	intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451	psi-mi:rtn4r_rat(display_long)|uniprotkb:Rtn4r(gene name)|psi-mi:Rtn4r(display_short)|uniprotkb:Nogor(gene name synonym)|uniprotkb:Nogo receptor(gene name synonym)|uniprotkb:Nogo-66 receptor(gene name synonym)	psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mi et al. (2004)	pubmed:14966521|imex:IM-27117	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21459022|imex:IM-27117-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620810|refseq:NP_446065.1|interpro:IPR032675|rcsb pdb:3KJ4|ensembl:ENSRNOG00000030920(gene)|ensembl:ENSRNOT00000051037(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)	refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634	-	function:Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system|comment:mint	-	figure legend:Fig. 3C|comment:Binding of LINGO1 to sNgR1 could be inhibited by up to 80% if excess sNgR1 was first added as a soluble competitor..|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/23	2019/06/26	rogid:JNKz36jyj56yCZdDB3464B0mhgY10116	rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606	rigid:bfLOsVnk7Kar9QY/LRggW2Rae+I	false	sufficient binding region:27..27-447..447|fc-igg tag:?-?	his tag:c-c|alkaline phosphatase tag:c-c|sufficient binding region:34-532	-	-	psi-mi:"MI:0980"(tag visualisation by enzyme assay)	psi-mi:"MI:0980"(tag visualisation by enzyme assay)
uniprotkb:P08138	uniprotkb:Q9BZR6	intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229	intact:EBI-5240240|uniprotkb:D3DX28|ensembl:ENSP00000043402	psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:rtn4r_human(display_long)|uniprotkb:RTN4R(gene name)|psi-mi:RTN4R(display_short)|uniprotkb:NOGOR(gene name synonym)|uniprotkb:Nogo receptor(gene name synonym)|uniprotkb:Nogo-66 receptor(gene name synonym)|uniprotkb:UNQ330/PRO526(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mi et al. (2004)	pubmed:14966521|imex:IM-27117	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022556|imex:IM-27117-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563	refseq:NP_075380.1|ensembl:ENSG00000040608(gene)|ensembl:ENST00000043402(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|rcsb pdb:1OZN|rcsb pdb:1P8T|reactome:R-HSA-193634	-	-	-	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/01/23	2019/01/23	rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606	rogid:KzyySuqIDgFlEOepobQQBgItepQ9606	rigid:nXm6ShrREjkisN/n9xxzqIytxeM	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96FE5	uniprotkb:Q9BZR6	intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451	intact:EBI-5240240|uniprotkb:D3DX28|ensembl:ENSP00000043402	psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym)	psi-mi:rtn4r_human(display_long)|uniprotkb:RTN4R(gene name)|psi-mi:RTN4R(display_short)|uniprotkb:NOGOR(gene name synonym)|uniprotkb:Nogo receptor(gene name synonym)|uniprotkb:Nogo-66 receptor(gene name synonym)|uniprotkb:UNQ330/PRO526(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mi et al. (2004)	pubmed:14966521|imex:IM-27117	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022567|imex:IM-27117-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634	refseq:NP_075380.1|ensembl:ENSG00000040608(gene)|ensembl:ENST00000043402(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|rcsb pdb:1OZN|rcsb pdb:1P8T|reactome:R-HSA-193634	-	-	-	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/01/23	2019/01/23	rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606	rogid:KzyySuqIDgFlEOepobQQBgItepQ9606	rigid:LbLo+eqb0f9FrW1j0vezBGBr864	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96FE5	uniprotkb:P08138	intact:EBI-719955|uniprotkb:Q6VVG2|uniprotkb:Q6NUK3|uniprotkb:Q6UXM3|uniprotkb:Q6VVG0|uniprotkb:Q6VVG1|uniprotkb:Q8N3K5|uniprotkb:Q96K52|uniprotkb:D3DW80|ensembl:ENSP00000347451	intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229	psi-mi:ligo1_human(display_long)|uniprotkb:LERN1(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 6A(gene name synonym)|uniprotkb:Leucine-rich repeat neuronal protein 1(gene name synonym)|uniprotkb:UNQ201/PRO227(orf name)|uniprotkb:LINGO1(gene name)|psi-mi:LINGO1(display_short)|uniprotkb:LRRN6A(gene name synonym)|uniprotkb:Leucine-rich repeat and immunoglobulin domain-containing protein 1(gene name synonym)	psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mi et al. (2004)	pubmed:14966521|imex:IM-27117	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21022581|imex:IM-27117-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116197.4|refseq:NP_001288115.1|refseq:NP_001288116.1|refseq:NP_001288118.1|refseq:NP_001288120.1|refseq:NP_001288121.1|refseq:NP_001288123.1|refseq:NP_001288124.1|refseq:NP_001288126.1|refseq:NP_001288127.1|refseq:NP_001288128.1|refseq:NP_001288129.1|refseq:XP_011520420.1|refseq:XP_016878171.1|dip:DIP-60981N|ensembl:ENSG00000169783(gene)|ensembl:ENST00000355300(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q96FE5|rcsb pdb:2ID5|rcsb pdb:4OQT|reactome:R-HSA-193634	refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563	-	-	-	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2019/01/23	2019/06/26	rogid:Y6wLyY2T9DE19Yirc0l3YmZHdjA9606	rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606	rigid:McCHucVbopxALBfNpqBWDxrzbhE	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)