#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17891	uniprotkb:P22137	intact:EBI-4758|uniprotkb:D6VUV0|ensemblfungi:YGR167W	intact:EBI-4766|uniprotkb:D6VTU9|ensemblfungi:YGL206C	psi-mi:clc1_yeast(display_long)|uniprotkb:CLC1(gene name)|psi-mi:CLC1(display_short)|uniprotkb:YGR167W(locus name)	psi-mi:clh_yeast(display_long)|uniprotkb:CHC1(gene name)|psi-mi:CHC1(display_short)|uniprotkb:YGL206C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Pishvaee et al. (1997)	pubmed:9171338|imex:IM-26367	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16747190|imex:IM-26367-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003399|refseq:NP_011683.3|dip:DIP-2280N|mint:P17891|ensemblfungi:YGR167W(gene)|ensemblfungi:YGR167W_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR000996(Clathrin light chain)|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_011309.1|sgd:S000003174|dip:DIP-2279N|mint:P22137|ensemblfungi:YGL206C(gene)|ensemblfungi:YGL206C_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030479"(actin cortical patch)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0071439"(clathrin complex)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	-	crc64:622F3083DF2FE315	figure legend:Fig. 2A, Fig. 3A-D, Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2018/01/24	2018/01/24	rogid:NOTbXsJM337wAjSs35MLezndK5Q559292	rogid:SAN6H3nVFozXZyTiRLaljMcIKIA559292	rigid:HGbLwT85Ay8Rx1Z9uX8IJxPBqA8	false	-	mutation disrupting interaction strength:1553-1553,1331-1331,1347-1347,1590-1590|mutation disrupting interaction strength:1590-1590|mutation disrupting interaction strength:1347-1347,1553-1553,1590-1590|mutation disrupting interaction strength:1590-1590|mutation disrupting interaction strength:1590-1590,1331-1331,1347-1347|mutation with no effect:1553-1553,1347-1347,1331-1331|mutation with no effect:1331-1331,1347-1347|mutation with no effect:1347-1347,1553-1553|mutation disrupting interaction strength:1331-1331,1347-1347,1590-1590|mutation disrupting interaction strength:1553-1553,1590-1590	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17891	uniprotkb:P22137	intact:EBI-4758|uniprotkb:D6VUV0|ensemblfungi:YGR167W	intact:EBI-4766|uniprotkb:D6VTU9|ensemblfungi:YGL206C	psi-mi:clc1_yeast(display_long)|uniprotkb:CLC1(gene name)|psi-mi:CLC1(display_short)|uniprotkb:YGR167W(locus name)	psi-mi:clh_yeast(display_long)|uniprotkb:CHC1(gene name)|psi-mi:CHC1(display_short)|uniprotkb:YGL206C(locus name)	psi-mi:"MI:0071"(molecular sieving)	Pishvaee et al. (1997)	pubmed:9171338|imex:IM-26367	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16747340|imex:IM-26367-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003399|refseq:NP_011683.3|dip:DIP-2280N|mint:P17891|ensemblfungi:YGR167W(gene)|ensemblfungi:YGR167W_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR000996(Clathrin light chain)|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	refseq:NP_011309.1|sgd:S000003174|dip:DIP-2279N|mint:P22137|ensemblfungi:YGL206C(gene)|ensemblfungi:YGL206C_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030479"(actin cortical patch)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0071439"(clathrin complex)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|reactome:R-SCE-190873|reactome:R-SCE-196025|reactome:R-SCE-432720|reactome:R-SCE-437239|reactome:R-SCE-8856828|reactome:R-SCE-8866427|reactome:R-SCE-8964038	-	-	crc64:622F3083DF2FE315	figure legend:Fig. 2B, 3E, 3F, 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2018/01/24	2018/01/24	rogid:NOTbXsJM337wAjSs35MLezndK5Q559292	rogid:SAN6H3nVFozXZyTiRLaljMcIKIA559292	rigid:HGbLwT85Ay8Rx1Z9uX8IJxPBqA8	false	-	mutation disrupting interaction strength:1590-1590|mutation disrupting interaction strength:1331-1331,1347-1347,1590-1590|mutation disrupting interaction strength:1553-1553,1331-1331,1347-1347,1590-1590|mutation disrupting interaction strength:1590-1590|mutation with no effect:1553-1553,1347-1347,1331-1331|mutation with no effect:1331-1331,1347-1347	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)