#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P23979 uniprotkb:P23979 intact:EBI-11295097|uniprotkb:Q61225|uniprotkb:Q61226 intact:EBI-11295097|uniprotkb:Q61225|uniprotkb:Q61226 psi-mi:5ht3a_mouse(display_long)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym)|uniprotkb:Htr3a(gene name)|psi-mi:Htr3a(display_short)|uniprotkb:5ht3(gene name synonym)|uniprotkb:Htr3(gene name synonym) psi-mi:5ht3a_mouse(display_long)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym)|uniprotkb:Htr3a(gene name)|psi-mi:Htr3a(display_short)|uniprotkb:5ht3(gene name synonym)|uniprotkb:Htr3(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Polovinkin et al. (2018) imex:IM-26851|pubmed:30401839 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-21001644|imex:IM-26851-1|wwpdb:6HIN|emdb:EMD-0225|wwpdb:6HIS|emdb:EMD-0226|wwpdb:6HIO|wwpdb:6HIQ|emdb:EMD-0227|emdb:EMD-0228 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038589.2|reactome:R-MMU-112314|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR036734|rcsb pdb:4PIR|rcsb pdb:6BE1|rcsb pdb:6DG7|rcsb pdb:6DG8|rcsb pdb:6HIN|rcsb pdb:6HIO|rcsb pdb:6HIQ|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|rcsb pdb:6NP0|rcsb pdb:6Y1Z|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|dip:DIP-48769N refseq:NP_038589.2|reactome:R-MMU-112314|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR036734|rcsb pdb:4PIR|rcsb pdb:6BE1|rcsb pdb:6DG7|rcsb pdb:6DG8|rcsb pdb:6HIN|rcsb pdb:6HIO|rcsb pdb:6HIQ|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|rcsb pdb:6NP0|rcsb pdb:6Y1Z|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|dip:DIP-48769N - - - figure legend:Fig 1, Extended Data Figs. 1, 2, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/12/04 2018/12/17 rogid:EolA9Q/mKhQ++GWO3CFmvxI7PsI10090 rogid:EolA9Q/mKhQ++GWO3CFmvxI7PsI10090 rigid:62Oerb4yO1busbOOovKR6zz0jTA false binding-associated region:35-484 binding-associated region:35-484 5 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)