#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27732	uniprotkb:Q9QX74-7	intact:EBI-8072674|uniprotkb:Q63491|uniprotkb:Q63492|uniprotkb:Q62691|uniprotkb:Q01542|uniprotkb:O09024|intact:MINT-7965882|uniprotkb:O09022|uniprotkb:Q62815|uniprotkb:O09023	intact:EBI-20939146|ensembl:ENSRNOP00000065891	psi-mi:cac1d_rat(display_long)|uniprotkb:Cacna1d(gene name)|psi-mi:Cacna1d(display_short)|uniprotkb:Cach3(gene name synonym)|uniprotkb:Cacn4(gene name synonym)|uniprotkb:Cacnl1a2(gene name synonym)|uniprotkb:Cchl1a2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Rat brain class D(gene name synonym)	psi-mi:q9qx74-7(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:E(isoform synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ishida et al. (2018)	imex:IM-26875|pubmed:30058071	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20939155|imex:IM-26875-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70973|refseq:NP_058994.1|dip:DIP-60740N|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|reactome:R-RNO-422356	ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000075078(transcript)|intact:EBI-397902(isoform-parent)	-	comment:mint	isoform-comment:Contains 6 ANK repeats at positions 196-226, 230-259, 263-293, 297-326, 330-359, 363-393.	figure legend:Supp Figs. 4, 8|caution:The figure legend to Supp Fig. 8 suggests this experiment was performed using SNK3. The data has been mapped to SNK2 as described in the main text. Note that amino acid numberings for SNK2 in the text are given for the human protein, not rat.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.1x10^-4(molar)	2018/11/20	2018/11/21	rogid:npFTYbblHdrM/cNG4TqjJ/u9kd010116	rogid:Ypn+1DT0C4anx5y6f5X6RiPhg+E10116	rigid:vhG0pXLUU4XOtiqJ3QLTum8BDDA	false	sufficient binding region:1949-1962	sufficient binding region:527-586(IPR001452)|mutation:586-586|mutation:527-527|mutation decreasing interaction strength:558-558|mutation with no effect:558-558	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01668	uniprotkb:Q9BYB0-1	intact:EBI-9207771|ensembl:ENSP00000288133|uniprotkb:B0FYA3|uniprotkb:Q13916|uniprotkb:Q13931|uniprotkb:Q71UT1|uniprotkb:Q9UDC3	intact:EBI-20939234	psi-mi:cac1d_human(display_long)|uniprotkb:CACH3(gene name synonym)|uniprotkb:CACN4(gene name synonym)|uniprotkb:CACNL1A2(gene name synonym)|uniprotkb:CCHL1A2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:CACNA1D(gene name)|psi-mi:CACNA1D(display_short)	psi-mi:q9byb0-1(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)|uniprotkb:PSAP2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Ishida et al. (2018)	imex:IM-26875|pubmed:30058071	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20939182|imex:IM-26875-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000350061(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|ensembl:ENSG00000157388(gene)|refseq:NP_000711.1|refseq:NP_001122311.1|refseq:NP_001122312.1|dip:DIP-48998N|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:3LV3|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|reactome:R-HSA-9662360	intact:EBI-1752330(isoform-parent)	-	-	isoform-comment:Primarily expressed in neurons.	figure legend:Fig. 3, Supp Fig. 6, 11|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.5x10^-4(molar)	2018/11/20	2018/11/21	rogid:RaNoFcLUmQYrmTRy4Y3WKlHN3t49606	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rigid:QNRP8rmXelyvMj2JZZRzzpWF4IY	false	mutation disrupting interaction strength:1908-1908|mutation:1916-1916|sufficient binding region:1907-1922|sufficient binding region:1907-1912	sufficient binding region:471-530(IPR001452)|mutation:471-471|mutation with no effect:480-480	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01668	uniprotkb:Q9Y566-1	intact:EBI-9207771|ensembl:ENSP00000288133|uniprotkb:B0FYA3|uniprotkb:Q13916|uniprotkb:Q13931|uniprotkb:Q71UT1|uniprotkb:Q9UDC3	intact:EBI-20939173|ensembl:ENSP00000293441	psi-mi:cac1d_human(display_long)|uniprotkb:CACH3(gene name synonym)|uniprotkb:CACN4(gene name synonym)|uniprotkb:CACNL1A2(gene name synonym)|uniprotkb:CCHL1A2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:CACNA1D(gene name)|psi-mi:CACNA1D(display_short)	psi-mi:q9y566-1(display_long)|uniprotkb:Somatostatin receptor-interacting protein(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:SHANK1(gene name)|psi-mi:SHANK1(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Ishida et al. (2018)	imex:IM-26875|pubmed:30058071	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20939217|imex:IM-26875-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000350061(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|ensembl:ENSG00000157388(gene)|refseq:NP_000711.1|refseq:NP_001122311.1|refseq:NP_001122312.1|dip:DIP-48998N|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:3LV3|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|reactome:R-HSA-9662360	ensembl:ENSG00000161681(gene)|ensembl:ENST00000293441(transcript)|intact:EBI-3442234(isoform-parent)	-	-	-	figure legend:Fig. 4A, 4B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/20	2018/11/21	rogid:RaNoFcLUmQYrmTRy4Y3WKlHN3t49606	rogid:XhX+mw+sujJRnA6RoKA1QeVywBY9606	rigid:+YalnfWkcUlFqZmTYaokeXBArEw	false	sufficient binding region:1908-1920|mutation:1916-1916	sufficient binding region:554-613(IPR001452)|mutation:554-554|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27732	uniprotkb:Q9QX74-7	intact:EBI-8072674|uniprotkb:Q63491|uniprotkb:Q63492|uniprotkb:Q62691|uniprotkb:Q01542|uniprotkb:O09024|intact:MINT-7965882|uniprotkb:O09022|uniprotkb:Q62815|uniprotkb:O09023	intact:EBI-20939146|ensembl:ENSRNOP00000065891	psi-mi:cac1d_rat(display_long)|uniprotkb:Cacna1d(gene name)|psi-mi:Cacna1d(display_short)|uniprotkb:Cach3(gene name synonym)|uniprotkb:Cacn4(gene name synonym)|uniprotkb:Cacnl1a2(gene name synonym)|uniprotkb:Cchl1a2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Rat brain class D(gene name synonym)	psi-mi:q9qx74-7(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:GKAP/SAPAP-interacting protein(gene name synonym)|uniprotkb:Proline-rich synapse-associated protein 1(gene name synonym)|uniprotkb:SPANK-3(gene name synonym)|uniprotkb:E(isoform synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Ishida et al. (2018)	imex:IM-26875|pubmed:30058071	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20939203|imex:IM-26875-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70973|refseq:NP_058994.1|dip:DIP-60740N|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|reactome:R-RNO-422356	ensembl:ENSRNOG00000050206(gene)|ensembl:ENSRNOT00000075078(transcript)|intact:EBI-397902(isoform-parent)	-	comment:mint	isoform-comment:Contains 6 ANK repeats at positions 196-226, 230-259, 263-293, 297-326, 330-359, 363-393.	figure legend:Fig. 4A, 4B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/20	2018/11/21	rogid:npFTYbblHdrM/cNG4TqjJ/u9kd010116	rogid:Ypn+1DT0C4anx5y6f5X6RiPhg+E10116	rigid:vhG0pXLUU4XOtiqJ3QLTum8BDDA	false	sufficient binding region:1949-1962	mutation:586-586|sufficient binding region:527-586(IPR001452)|mutation:527-527|15n label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01668	uniprotkb:Q9BYB0-1	intact:EBI-9207771|ensembl:ENSP00000288133|uniprotkb:B0FYA3|uniprotkb:Q13916|uniprotkb:Q13931|uniprotkb:Q71UT1|uniprotkb:Q9UDC3	intact:EBI-20939234	psi-mi:cac1d_human(display_long)|uniprotkb:CACH3(gene name synonym)|uniprotkb:CACN4(gene name synonym)|uniprotkb:CACNL1A2(gene name synonym)|uniprotkb:CCHL1A2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:CACNA1D(gene name)|psi-mi:CACNA1D(display_short)	psi-mi:q9byb0-1(display_long)|uniprotkb:Proline-rich synapse-associated protein 2(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:SHANK3(gene name)|psi-mi:SHANK3(display_short)|uniprotkb:KIAA1650(gene name synonym)|uniprotkb:PROSAP2(gene name synonym)|uniprotkb:PSAP2(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Ishida et al. (2018)	imex:IM-26875|pubmed:30058071	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20939245|imex:IM-26875-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000350061(transcript)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0030018"(Z disc)|go:"GO:0030506"(ankyrin binding)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|ensembl:ENSG00000157388(gene)|refseq:NP_000711.1|refseq:NP_001122311.1|refseq:NP_001122312.1|dip:DIP-48998N|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:3LV3|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|reactome:R-HSA-9662360	intact:EBI-1752330(isoform-parent)	-	-	isoform-comment:Primarily expressed in neurons.	figure legend:Fig. 4B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/11/20	2018/11/21	rogid:RaNoFcLUmQYrmTRy4Y3WKlHN3t49606	rogid:lYflQon8u7cSZVzSr6IYNiWLZUY9606	rigid:QNRP8rmXelyvMj2JZZRzzpWF4IY	false	mutation:1916-1916|sufficient binding region:1908-1920	sufficient binding region:471-530(IPR001452)|mutation:471-471|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)