#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z0J1	uniprotkb:O00755	intact:EBI-20720091|ensembl:ENSMUSP00000030198|uniprotkb:B1AWM3	intact:EBI-727198|uniprotkb:Q9Y560|uniprotkb:Q96H90|ensembl:ENSP00000285018	psi-mi:reck_mouse(display_long)|uniprotkb:Reck(gene name)|psi-mi:Reck(display_short)	psi-mi:wnt7a_human(display_long)|uniprotkb:WNT7A(gene name)|psi-mi:WNT7A(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720089|imex:IM-26759-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028476(gene)|ensembl:ENSMUST00000030198(transcript)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007566"(embryo implantation)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904684"(negative regulation of metalloendopeptidase activity)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR039016|rcsb pdb:6WBH|rcsb pdb:6WBJ|reactome:R-MMU-163125|refseq:NP_057887.2	refseq:NP_004616.2|ensembl:ENSG00000154764(gene)|ensembl:ENST00000285018(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048864"(stem cell development)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904891"(positive regulation of excitatory synapse assembly)|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:4UZQ|reactome:R-HSA-3238698|reactome:R-HSA-373080|dip:DIP-61511N	-	-	-	figure legend:Fig 1d, Fig 2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/08/17	2018/08/17	rogid:nDyvbrg6Il7e5iWyT/2P15bPg8M10090	rogid:dydZ+HONRF0rd3v9Za9GTgBOlkU9606	rigid:ts1kVZNrJnoX4KVENwSvHzIvlCg	false	necessary binding region:225-272|ha tag:n-n|necessary binding region:301-347	v5 tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9EQD0	uniprotkb:O00755	intact:EBI-7938232|uniprotkb:G5E8F0|uniprotkb:Q8CHK9|uniprotkb:Q8BMR2|intact:MINT-1783095|uniprotkb:O08975|ensembl:ENSMUSP00000067783|ensembl:ENSMUSP00000111828	intact:EBI-727198|uniprotkb:Q9Y560|uniprotkb:Q96H90|ensembl:ENSP00000285018	psi-mi:fzd5_mouse(display_long)|uniprotkb:Fzd5(gene name)|psi-mi:Fzd5(display_short)	psi-mi:wnt7a_human(display_long)|uniprotkb:WNT7A(gene name)|psi-mi:WNT7A(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720120|imex:IM-26759-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036124.1|refseq:NP_073558.2|dip:DIP-41260N|ensembl:ENSMUSG00000045005(gene)|ensembl:ENSMUST00000063982(transcript)|ensembl:ENSMUST00000116133(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001944"(vasculature development)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR037441|reactome:R-MMU-4086398|reactome:R-MMU-4608870|reactome:R-MMU-4641262|reactome:R-MMU-4641263|reactome:R-MMU-5140745	refseq:NP_004616.2|ensembl:ENSG00000154764(gene)|ensembl:ENST00000285018(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048864"(stem cell development)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904891"(positive regulation of excitatory synapse assembly)|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:4UZQ|reactome:R-HSA-3238698|reactome:R-HSA-373080|dip:DIP-61511N	-	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4	-	figure legend:Fig 1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/08/17	2018/08/17	rogid:O3uI77ElZ4+6mCkb8gfIfqe6+jE10090	rogid:dydZ+HONRF0rd3v9Za9GTgBOlkU9606	rigid:rmTml+2ZRg4hzg00Oj+rohFqcSA	false	ha tag:n-n	v5 tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z0J1	uniprotkb:P56706	intact:EBI-20720091|ensembl:ENSMUSP00000030198|uniprotkb:B1AWM3	intact:EBI-3913589|uniprotkb:B8A596|uniprotkb:Q96Q12|ensembl:ENSP00000341032	psi-mi:reck_mouse(display_long)|uniprotkb:Reck(gene name)|psi-mi:Reck(display_short)	psi-mi:wnt7b_human(display_long)|uniprotkb:WNT7B(gene name)|psi-mi:WNT7B(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720233|imex:IM-26759-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028476(gene)|ensembl:ENSMUST00000030198(transcript)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007566"(embryo implantation)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904684"(negative regulation of metalloendopeptidase activity)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR039016|rcsb pdb:6WBH|rcsb pdb:6WBJ|reactome:R-MMU-163125|refseq:NP_057887.2	refseq:NP_478679.1|ensembl:ENSG00000188064(gene)|ensembl:ENST00000339464(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0021871"(forebrain regionalization)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030324"(lung development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032536"(regulation of cell projection size)|go:"GO:0042592"(homeostatic process)|go:"GO:0044237"(cellular metabolic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060482"(lobar bronchus development)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0060560"(developmental growth involved in morphogenesis)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072060"(outer medullary collecting duct development)|go:"GO:0072061"(inner medullary collecting duct development)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072207"(metanephric epithelium development)|go:"GO:0072236"(metanephric loop of Henle development)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-3238698|reactome:R-HSA-373080|go:"GO:0030182"(neuron differentiation)	-	-	-	figure legend:Fig 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/08/17	2018/08/20	rogid:nDyvbrg6Il7e5iWyT/2P15bPg8M10090	rogid:e1adNIubTXBMNKtYw+tAr+b6cJQ9606	rigid:N8BTUKP1B4Z0FzsGLkvOMdxJq5E	false	ha tag:n-n	v5 tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z0J1	uniprotkb:O00755	intact:EBI-20720091|ensembl:ENSMUSP00000030198|uniprotkb:B1AWM3	intact:EBI-727198|uniprotkb:Q9Y560|uniprotkb:Q96H90|ensembl:ENSP00000285018	psi-mi:reck_mouse(display_long)|uniprotkb:Reck(gene name)|psi-mi:Reck(display_short)	psi-mi:wnt7a_human(display_long)|uniprotkb:WNT7A(gene name)|psi-mi:WNT7A(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720249|imex:IM-26759-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028476(gene)|ensembl:ENSMUST00000030198(transcript)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007566"(embryo implantation)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904684"(negative regulation of metalloendopeptidase activity)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR039016|rcsb pdb:6WBH|rcsb pdb:6WBJ|reactome:R-MMU-163125|refseq:NP_057887.2	refseq:NP_004616.2|ensembl:ENSG00000154764(gene)|ensembl:ENST00000285018(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048864"(stem cell development)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904891"(positive regulation of excitatory synapse assembly)|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:4UZQ|reactome:R-HSA-3238698|reactome:R-HSA-373080|dip:DIP-61511N	-	-	-	figure legend:Fig 2e, 2f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/08/17	2018/08/20	rogid:nDyvbrg6Il7e5iWyT/2P15bPg8M10090	rogid:dydZ+HONRF0rd3v9Za9GTgBOlkU9606	rigid:ts1kVZNrJnoX4KVENwSvHzIvlCg	false	ha tag:n-n	v5 tag:c-c|necessary binding region:238-279|sufficient binding region:1-279	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z0J1	uniprotkb:O00755	intact:EBI-20720091|ensembl:ENSMUSP00000030198|uniprotkb:B1AWM3	intact:EBI-727198|uniprotkb:Q9Y560|uniprotkb:Q96H90|ensembl:ENSP00000285018	psi-mi:reck_mouse(display_long)|uniprotkb:Reck(gene name)|psi-mi:Reck(display_short)	psi-mi:wnt7a_human(display_long)|uniprotkb:WNT7A(gene name)|psi-mi:WNT7A(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720221|imex:IM-26759-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028476(gene)|ensembl:ENSMUST00000030198(transcript)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007566"(embryo implantation)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904684"(negative regulation of metalloendopeptidase activity)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR039016|rcsb pdb:6WBH|rcsb pdb:6WBJ|reactome:R-MMU-163125|refseq:NP_057887.2	refseq:NP_004616.2|ensembl:ENSG00000154764(gene)|ensembl:ENST00000285018(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048864"(stem cell development)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904891"(positive regulation of excitatory synapse assembly)|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:4UZQ|reactome:R-HSA-3238698|reactome:R-HSA-373080|dip:DIP-61511N	-	-	-	figure legend:Fig 1f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/17	2018/11/02	rogid:nDyvbrg6Il7e5iWyT/2P15bPg8M10090	rogid:dydZ+HONRF0rd3v9Za9GTgBOlkU9606	rigid:ts1kVZNrJnoX4KVENwSvHzIvlCg	false	ha tag:n-n	v5 tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z0J1	uniprotkb:O00755	intact:EBI-20720091|ensembl:ENSMUSP00000030198|uniprotkb:B1AWM3	intact:EBI-727198|uniprotkb:Q9Y560|uniprotkb:Q96H90|ensembl:ENSP00000285018	psi-mi:reck_mouse(display_long)|uniprotkb:Reck(gene name)|psi-mi:Reck(display_short)	psi-mi:wnt7a_human(display_long)|uniprotkb:WNT7A(gene name)|psi-mi:WNT7A(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720272|imex:IM-26759-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028476(gene)|ensembl:ENSMUST00000030198(transcript)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007566"(embryo implantation)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904684"(negative regulation of metalloendopeptidase activity)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR039016|rcsb pdb:6WBH|rcsb pdb:6WBJ|reactome:R-MMU-163125|refseq:NP_057887.2	refseq:NP_004616.2|ensembl:ENSG00000154764(gene)|ensembl:ENST00000285018(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048864"(stem cell development)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904891"(positive regulation of excitatory synapse assembly)|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:4UZQ|reactome:R-HSA-3238698|reactome:R-HSA-373080|dip:DIP-61511N	-	-	-	figure legend:Fig 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.0x10^-6(molar)	2018/08/17	2018/08/21	rogid:nDyvbrg6Il7e5iWyT/2P15bPg8M10090	rogid:dydZ+HONRF0rd3v9Za9GTgBOlkU9606	rigid:ts1kVZNrJnoX4KVENwSvHzIvlCg	false	ha tag:n-n|fc-igg1:c-c|binding-associated region:46-347	binding-associated region:238-266|mutation disrupting interaction strength:241-241,251-251,252-252,262-262	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z0J1	uniprotkb:P56706	intact:EBI-20720091|ensembl:ENSMUSP00000030198|uniprotkb:B1AWM3	intact:EBI-3913589|uniprotkb:B8A596|uniprotkb:Q96Q12|ensembl:ENSP00000341032	psi-mi:reck_mouse(display_long)|uniprotkb:Reck(gene name)|psi-mi:Reck(display_short)	psi-mi:wnt7b_human(display_long)|uniprotkb:WNT7B(gene name)|psi-mi:WNT7B(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720295|imex:IM-26759-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028476(gene)|ensembl:ENSMUST00000030198(transcript)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007566"(embryo implantation)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904684"(negative regulation of metalloendopeptidase activity)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR039016|rcsb pdb:6WBH|rcsb pdb:6WBJ|reactome:R-MMU-163125|refseq:NP_057887.2	refseq:NP_478679.1|ensembl:ENSG00000188064(gene)|ensembl:ENST00000339464(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0021871"(forebrain regionalization)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030324"(lung development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032536"(regulation of cell projection size)|go:"GO:0042592"(homeostatic process)|go:"GO:0044237"(cellular metabolic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060482"(lobar bronchus development)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0060560"(developmental growth involved in morphogenesis)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072060"(outer medullary collecting duct development)|go:"GO:0072061"(inner medullary collecting duct development)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072207"(metanephric epithelium development)|go:"GO:0072236"(metanephric loop of Henle development)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-3238698|reactome:R-HSA-373080|go:"GO:0030182"(neuron differentiation)	-	-	-	figure legend:Fig 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-6(molar)	2018/08/17	2018/08/21	rogid:nDyvbrg6Il7e5iWyT/2P15bPg8M10090	rogid:e1adNIubTXBMNKtYw+tAr+b6cJQ9606	rigid:N8BTUKP1B4Z0FzsGLkvOMdxJq5E	false	necessary binding region:301-347|ha tag:n-n|fc-igg1:c-c|binding-associated region:46-347|necessary binding region:225-275	binding-associated region:238-266	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z0J1	uniprotkb:P56706	intact:EBI-20720091|ensembl:ENSMUSP00000030198|uniprotkb:B1AWM3	intact:EBI-3913589|uniprotkb:B8A596|uniprotkb:Q96Q12|ensembl:ENSP00000341032	psi-mi:reck_mouse(display_long)|uniprotkb:Reck(gene name)|psi-mi:Reck(display_short)	psi-mi:wnt7b_human(display_long)|uniprotkb:WNT7B(gene name)|psi-mi:WNT7B(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720316|imex:IM-26759-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028476(gene)|ensembl:ENSMUST00000030198(transcript)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007566"(embryo implantation)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904684"(negative regulation of metalloendopeptidase activity)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR039016|rcsb pdb:6WBH|rcsb pdb:6WBJ|reactome:R-MMU-163125|refseq:NP_057887.2	refseq:NP_478679.1|ensembl:ENSG00000188064(gene)|ensembl:ENST00000339464(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0021871"(forebrain regionalization)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030324"(lung development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032536"(regulation of cell projection size)|go:"GO:0042592"(homeostatic process)|go:"GO:0044237"(cellular metabolic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060482"(lobar bronchus development)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0060560"(developmental growth involved in morphogenesis)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072060"(outer medullary collecting duct development)|go:"GO:0072061"(inner medullary collecting duct development)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072207"(metanephric epithelium development)|go:"GO:0072236"(metanephric loop of Henle development)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-3238698|reactome:R-HSA-373080|go:"GO:0030182"(neuron differentiation)	-	-	-	figure legend:Fig 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/17	2018/08/21	rogid:nDyvbrg6Il7e5iWyT/2P15bPg8M10090	rogid:e1adNIubTXBMNKtYw+tAr+b6cJQ9606	rigid:N8BTUKP1B4Z0FzsGLkvOMdxJq5E	false	mutation decreasing interaction strength:46-93|ha tag:n-n|fc-igg1:c-c|binding-associated region:46-347|mutation decreasing interaction strength:113-150|mutation decreasing interaction strength:160-206	binding-associated region:238-266	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z0J1	uniprotkb:P56706	intact:EBI-20720091|ensembl:ENSMUSP00000030198|uniprotkb:B1AWM3	intact:EBI-3913589|uniprotkb:B8A596|uniprotkb:Q96Q12|ensembl:ENSP00000341032	psi-mi:reck_mouse(display_long)|uniprotkb:Reck(gene name)|psi-mi:Reck(display_short)	psi-mi:wnt7b_human(display_long)|uniprotkb:WNT7B(gene name)|psi-mi:WNT7B(display_short)	psi-mi:"MI:0859"(force spectroscopy)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720341|imex:IM-26759-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028476(gene)|ensembl:ENSMUST00000030198(transcript)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007566"(embryo implantation)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0090210"(regulation of establishment of blood-brain barrier)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904684"(negative regulation of metalloendopeptidase activity)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|interpro:IPR039016|rcsb pdb:6WBH|rcsb pdb:6WBJ|reactome:R-MMU-163125|refseq:NP_057887.2	refseq:NP_478679.1|ensembl:ENSG00000188064(gene)|ensembl:ENST00000339464(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0021871"(forebrain regionalization)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030324"(lung development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032536"(regulation of cell projection size)|go:"GO:0042592"(homeostatic process)|go:"GO:0044237"(cellular metabolic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060482"(lobar bronchus development)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0060560"(developmental growth involved in morphogenesis)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072060"(outer medullary collecting duct development)|go:"GO:0072061"(inner medullary collecting duct development)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072207"(metanephric epithelium development)|go:"GO:0072236"(metanephric loop of Henle development)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-3238698|reactome:R-HSA-373080|go:"GO:0030182"(neuron differentiation)	-	-	-	figure legend:Fig 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.0x10^-6(molar)	2018/08/17	2018/08/21	rogid:nDyvbrg6Il7e5iWyT/2P15bPg8M10090	rogid:e1adNIubTXBMNKtYw+tAr+b6cJQ9606	rigid:N8BTUKP1B4Z0FzsGLkvOMdxJq5E	false	ha tag:n-n|fc-igg1:c-c|binding-associated region:46-347	binding-associated region:238-266	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51142	uniprotkb:A0A0U2ULT4	intact:EBI-6257503	intact:EBI-20720366	psi-mi:dvl2_xenla(display_long)|uniprotkb:dvl2(gene name)|psi-mi:dvl2(display_short)|uniprotkb:dsh(gene name synonym)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:Xdsh(gene name synonym)	psi-mi:a0a0u2ult4_danre(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720364|imex:IM-26759-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0022008"(neurogenesis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032053"(ciliary basal body organization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0045545"(syndecan binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0060026"(convergent extension)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060271"(cilium assembly)|go:"GO:0090630"(activation of GTPase activity)|rcsb pdb:1L6O|rcsb pdb:2F0A|rcsb pdb:3FY5|mint:P51142|refseq:NP_001084096.1|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR024580|interpro:IPR003351(Dishevelled protein)|interpro:IPR001158(DIX)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029071|interpro:IPR038207|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390	go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001305000.1|interpro:IPR017981|interpro:IPR036445|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000203(GPS)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675	-	-	-	figure legend:Fig 5J|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/08/17	2018/08/21	rogid:9sVQXQeFtWj/Vjbc/ABl3kHS5dE8355	rogid:g6z0Mc4W0sMGtFhZCJ2dlhNvoi07955	rigid:e7EIcgVpcXt7kEp+WNuljJezK9w	false	green fluorescent protein tag:c-c	flag tag:n-n|necessary binding region:81-213	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14641	uniprotkb:A0A0U2ULT4	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-20720366	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:a0a0u2ult4_danre(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720395|imex:IM-26759-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001305000.1|interpro:IPR017981|interpro:IPR036445|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000203(GPS)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675	-	-	-	figure legend:Fig S17|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/08/17	2018/08/21	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:g6z0Mc4W0sMGtFhZCJ2dlhNvoi07955	rigid:BRJpCt0Z/7KZFbdY+P+Lrb9UGzM	false	-	flag tag:n-n|necessary binding region:81-337	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P51142	uniprotkb:A0A0U2ULT4	intact:EBI-6257503	intact:EBI-20720366	psi-mi:dvl2_xenla(display_long)|uniprotkb:dvl2(gene name)|psi-mi:dvl2(display_short)|uniprotkb:dsh(gene name synonym)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:Xdsh(gene name synonym)	psi-mi:a0a0u2ult4_danre(display_long)	psi-mi:"MI:0096"(pull down)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720410|imex:IM-26759-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0022008"(neurogenesis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032053"(ciliary basal body organization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0045545"(syndecan binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0060026"(convergent extension)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060271"(cilium assembly)|go:"GO:0090630"(activation of GTPase activity)|rcsb pdb:1L6O|rcsb pdb:2F0A|rcsb pdb:3FY5|mint:P51142|refseq:NP_001084096.1|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR024580|interpro:IPR003351(Dishevelled protein)|interpro:IPR001158(DIX)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029071|interpro:IPR038207|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390	go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001305000.1|interpro:IPR017981|interpro:IPR036445|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000203(GPS)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675	-	-	-	figure legend:Fig S18|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/17	2018/11/06	rogid:9sVQXQeFtWj/Vjbc/ABl3kHS5dE8355	rogid:g6z0Mc4W0sMGtFhZCJ2dlhNvoi07955	rigid:e7EIcgVpcXt7kEp+WNuljJezK9w	false	35s radiolabel:?-?	binding-associated region:1058-1363|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70421	uniprotkb:A0A0U2ULT4	intact:EBI-8472411|uniprotkb:Q7TS82|uniprotkb:O08974|intact:MINT-1779162|ensembl:ENSMUSP00000058629	intact:EBI-20720366	psi-mi:fzd1_mouse(display_long)|uniprotkb:Fzd1(gene name)|psi-mi:Fzd1(display_short)	psi-mi:a0a0u2ult4_danre(display_long)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Eubelen et al. (2018)	pubmed:30026314|imex:IM-26759	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720423|imex:IM-26759-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067432.2|ensembl:ENSMUSG00000044674(gene)|ensembl:ENSMUST00000054294(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044339"(canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641262	go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|refseq:NP_001305000.1|interpro:IPR017981|interpro:IPR036445|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000203(GPS)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675	-	function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues|comment:mint	-	figure legend:Fig 6F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	-	2018/08/17	2018/08/21	rogid:84C8sHUGQrTVl/84BXOUZL7Rzq810090	rogid:g6z0Mc4W0sMGtFhZCJ2dlhNvoi07955	rigid:3z3/8WZQ5aMNwfen0a3urx6f1fY	false	c-venus:n-n	n-venus:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0867"(tag visualisation by fluorescence)|psi-mi:"MI:0396"(predetermined participant)