#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:W2SDE2	uniprotkb:W2SDE2	intact:EBI-20716966|ensemblfungi:ETN46053	intact:EBI-20716966|ensemblfungi:ETN46053	psi-mi:w2sde2_9euro(display_long)|uniprotkb:HMPREF1541_00236(orf name)	psi-mi:w2sde2_9euro(display_long)|uniprotkb:HMPREF1541_00236(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Baradaran et al. (2018)	pubmed:29995857|imex:IM-26794	taxid:1220924(Cyphellophora europaea CBS 101466)|taxid:1220924(Cyphellophora europaea CBS 101466)	taxid:1220924(Cyphellophora europaea CBS 101466)|taxid:1220924(Cyphellophora europaea CBS 101466)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20716963|wwpdb:6DNF|emdb:EMDB-7971|imex:IM-26794-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6DNF|ensemblfungi:ETN46053(transcript)|ensemblfungi:HMPREF1541_00236(gene)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0015292"(uniporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|refseq:XP_008710765.1|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055	rcsb pdb:6DNF|ensemblfungi:ETN46053(transcript)|ensemblfungi:HMPREF1541_00236(gene)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0015292"(uniporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|refseq:XP_008710765.1|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055	-	-	-	figure legend:Fig 1, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4922(picpa)|taxid:4922("Pichia pastoris (Yeast)")	-	2018/08/09	2018/08/09	rogid:DVuKMl9Kn0a5ApHB0Q3HbKKZueY1220924	rogid:DVuKMl9Kn0a5ApHB0Q3HbKKZueY1220924	rigid:oCV7T9gNrpPVJlYlsuPXyImjBfE	false	tag:c-c	tag:c-c	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:W2SDE2	uniprotkb:W2SDE2	intact:EBI-20716966|ensemblfungi:ETN46053	intact:EBI-20716966|ensemblfungi:ETN46053	psi-mi:w2sde2_9euro(display_long)|uniprotkb:HMPREF1541_00236(orf name)	psi-mi:w2sde2_9euro(display_long)|uniprotkb:HMPREF1541_00236(orf name)	psi-mi:"MI:0030"(cross-linking study)	Baradaran et al. (2018)	pubmed:29995857|imex:IM-26794	taxid:1220924(Cyphellophora europaea CBS 101466)|taxid:1220924(Cyphellophora europaea CBS 101466)	taxid:1220924(Cyphellophora europaea CBS 101466)|taxid:1220924(Cyphellophora europaea CBS 101466)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717897|imex:IM-26794-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6DNF|ensemblfungi:ETN46053(transcript)|ensemblfungi:HMPREF1541_00236(gene)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0015292"(uniporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|refseq:XP_008710765.1|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055	rcsb pdb:6DNF|ensemblfungi:ETN46053(transcript)|ensemblfungi:HMPREF1541_00236(gene)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0015292"(uniporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|refseq:XP_008710765.1|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055	-	-	-	figure legend:Extended Data Fig 2h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4922(picpa)|taxid:4922("Pichia pastoris (Yeast)")	-	2018/08/09	2018/08/13	rogid:DVuKMl9Kn0a5ApHB0Q3HbKKZueY1220924	rogid:DVuKMl9Kn0a5ApHB0Q3HbKKZueY1220924	rigid:oCV7T9gNrpPVJlYlsuPXyImjBfE	false	tag:c-c	tag:c-c	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08BI9	uniprotkb:Q08BI9	intact:EBI-20717912	intact:EBI-20717912	psi-mi:mcu_danre(display_long)|uniprotkb:mcu(gene name)|psi-mi:mcu(display_short)|uniprotkb:"zgc:153607"(orf name)	psi-mi:mcu_danre(display_long)|uniprotkb:mcu(gene name)|psi-mi:mcu(display_short)|uniprotkb:"zgc:153607"(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Baradaran et al. (2018)	pubmed:29995857|imex:IM-26794	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717938|imex:IM-26794-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-DRE-8949215|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:1990246"(uniplex complex)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007015"(actin filament organization)|refseq:NP_001070793.1|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|emdb:EMDB-7972(identity)	reactome:R-DRE-8949215|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:1990246"(uniplex complex)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007015"(actin filament organization)|refseq:NP_001070793.1|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|emdb:EMDB-7972(identity)	-	-	-	figure legend:Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2018/08/09	2018/08/13	rogid:6cgsuJQYuZTJmABsijYa+ecn0KM7955	rogid:6cgsuJQYuZTJmABsijYa+ecn0KM7955	rigid:LJdB+wDxRptDaw3/XV73zdurESc	false	tag:c-c	tag:c-c	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08BI9	uniprotkb:Q08BI9	intact:EBI-20717912	intact:EBI-20717912	psi-mi:mcu_danre(display_long)|uniprotkb:mcu(gene name)|psi-mi:mcu(display_short)|uniprotkb:"zgc:153607"(orf name)	psi-mi:mcu_danre(display_long)|uniprotkb:mcu(gene name)|psi-mi:mcu(display_short)|uniprotkb:"zgc:153607"(orf name)	psi-mi:"MI:0030"(cross-linking study)	Baradaran et al. (2018)	pubmed:29995857|imex:IM-26794	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717958|imex:IM-26794-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-DRE-8949215|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:1990246"(uniplex complex)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007015"(actin filament organization)|refseq:NP_001070793.1|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|emdb:EMDB-7972(identity)	reactome:R-DRE-8949215|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0015292"(uniporter activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0060027"(convergent extension involved in gastrulation)|go:"GO:1990246"(uniplex complex)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007015"(actin filament organization)|refseq:NP_001070793.1|interpro:IPR006769(Protein of unknown function DUF607)|interpro:IPR039055|emdb:EMDB-7972(identity)	-	-	-	figure legend:Fig 2J|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient)	-	2018/08/09	2018/08/13	rogid:6cgsuJQYuZTJmABsijYa+ecn0KM7955	rogid:6cgsuJQYuZTJmABsijYa+ecn0KM7955	rigid:LJdB+wDxRptDaw3/XV73zdurESc	false	tag:c-c	tag:c-c	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NE86-1	uniprotkb:Q8NE86-1	intact:EBI-15932889|ensembl:ENSP00000362144	intact:EBI-15932889|ensembl:ENSP00000362144	psi-mi:q8ne86-1(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:q8ne86-1(display_long)|uniprotkb:MCU(gene name)|psi-mi:MCU(display_short)|uniprotkb:C10orf42(gene name synonym)|uniprotkb:CCDC109A(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 109A(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Baradaran et al. (2018)	pubmed:29995857|imex:IM-26794	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717972|imex:IM-26794-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|intact:EBI-6552124(isoform-parent)	ensembl:ENSG00000156026(gene)|ensembl:ENST00000373053(transcript)|intact:EBI-6552124(isoform-parent)	-	-	-	figure legend:Extended Data Fig 2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/08/09	2018/08/13	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rogid:t2fSATmrk7IEC0nMpquAoPB3CHs9606	rigid:NxoAj0hdLRWvGCbJ+MFig91xhLA	false	tag:c-c|binding-associated region:67-351	tag:c-c|binding-associated region:67-351	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)