#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13635-1	uniprotkb:Q15465	intact:EBI-13635488|ensembl:ENSP00000332353	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	psi-mi:q13635-1(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)|uniprotkb:1B(isoform synonym)	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Gong et al. (2018)	pubmed:29954986|imex:IM-26753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20718544|wwpdb:6DMY|emdb:EMD-7968|imex:IM-26753-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8775406(isoform-parent)|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	-	-	-	figure legend:Fig. 1, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/14	2018/08/14	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rigid:zxC/clhQCdWjOGTZLZKjRS9EByU	false	flag tag:n-n|binding-associated region:1-1305|his tag:c-c	binding-associated region:24-197	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15465	uniprotkb:Q13635-1	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	intact:EBI-13635488|ensembl:ENSP00000332353	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:q13635-1(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)|uniprotkb:1B(isoform synonym)	psi-mi:"MI:0096"(pull down)	Gong et al. (2018)	pubmed:29954986|imex:IM-26753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20718511|imex:IM-26753-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	intact:EBI-8775406(isoform-parent)|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)	-	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/14	2018/08/14	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rigid:zxC/clhQCdWjOGTZLZKjRS9EByU	false	mutation disrupting interaction:153-153|maltose binding protein tag:n-n|binding-associated region:24-197|mutation disrupting interaction:44-44,45-45|mutation disrupting interaction:155-155|mutation disrupting interaction:177-177,178-178	flag tag:n-n|binding-associated region:1-1305|his tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15465	uniprotkb:Q13635-1	intact:EBI-11666886|uniprotkb:A4D247|uniprotkb:Q75MC9|ensembl:ENSP00000297261	intact:EBI-13635488|ensembl:ENSP00000332353	psi-mi:shh_human(display_long)|uniprotkb:Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains(gene name synonym)|uniprotkb:SHH(gene name)|psi-mi:SHH(display_short)|uniprotkb:HHG-1(gene name synonym)	psi-mi:q13635-1(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)|uniprotkb:1B(isoform synonym)	psi-mi:"MI:0096"(pull down)	Gong et al. (2018)	pubmed:29954986|imex:IM-26753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20718573|imex:IM-26753-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000184.1|go:"GO:0060738"(epithelial-mesenchymal signaling involved in prostate gland development)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0060782"(regulation of mesenchymal cell proliferation involved in prostate gland development)|go:"GO:0060783"(mesenchymal smoothened signaling pathway involved in prostate gland development)|go:"GO:0060840"(artery development)|go:"GO:1900175"(regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905327"(tracheoesophageal septum formation)|go:"GO:0061053"(somite development)|go:"GO:2000062"(negative regulation of ureter smooth muscle cell differentiation)|go:"GO:2000063"(positive regulation of ureter smooth muscle cell differentiation)|go:"GO:2000357"(negative regulation of kidney smooth muscle cell differentiation)|go:"GO:2000358"(positive regulation of kidney smooth muscle cell differentiation)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000320(Hedgehog amino-terminal signaling region)|interpro:IPR001657(Peptidase C46, hedgehog protein)|go:"GO:0061189"(positive regulation of sclerotome development)|interpro:IPR001767(Peptidase C46, hedgehog protein, hint region)|interpro:IPR003586(Hedgehog/intein hint domain, C-terminal)|interpro:IPR003587(Hedgehog/intein hint, N-terminal)|interpro:IPR006141(Intein splicing site)|interpro:IPR009045(Hedgehog/DD-peptidase, zinc-binding motif)|interpro:IPR036844|go:"GO:0062023"(collagen-containing extracellular matrix)|rcsb pdb:3HO5|rcsb pdb:3M1N|go:"GO:0071285"(cellular response to lithium ion)|rcsb pdb:3MXW|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEV|rcsb pdb:6PJV|rcsb pdb:6RMG|rcsb pdb:6RVD|rcsb pdb:7MHZ|reactome:R-HSA-373080|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5362798|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|reactome:R-HSA-5658034|ensembl:ENSG00000164690(gene)|ensembl:ENST00000297261(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005113"(patched binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007418"(ventral midline development)|go:"GO:0007507"(heart development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0014858"(positive regulation of skeletal muscle cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016015"(morphogen activity)|go:"GO:0016539"(intein-mediated protein splicing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0021513"(spinal cord dorsal/ventral patterning)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021930"(cerebellar granule cell precursor proliferation)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0030850"(prostate gland development)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043369"(CD4-positive or CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045121"(membrane raft)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046639"(negative regulation of alpha-beta T cell differentiation)|go:"GO:0048468"(cell development)|go:"GO:0048538"(thymus development)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048645"(animal organ formation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048839"(inner ear development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0048864"(stem cell development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060174"(limb bud formation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060458"(right lung development)|go:"GO:0060459"(left lung development)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060516"(primary prostatic bud elongation)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060685"(regulation of prostatic bud formation)|dip:DIP-61763N	intact:EBI-8775406(isoform-parent)|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/14	2018/08/14	rogid:OjyhApvp8xR4UewZ+aMxM5xuY7Q9606	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rigid:zxC/clhQCdWjOGTZLZKjRS9EByU	false	maltose binding protein tag:n-n|binding-associated region:24-197	mutation disrupting interaction:513-513|mutation disrupting interaction:282-282|flag tag:n-n|binding-associated region:1-1305|his tag:c-c|mutation disrupting interaction:282-282,500-500,504-504|mutation disrupting interaction:500-500,504-504|mutation disrupting interaction:509-509	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)