#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14867	uniprotkb:P18507-1	intact:EBI-6258308|ensembl:ENSP00000023897|ensembl:ENSP00000377517|ensembl:ENSP00000393097|ensembl:ENSP00000415441|ensembl:ENSP00000489738|ensembl:ENSP00000489839|ensembl:ENSP00000490320|ensembl:ENSP00000490804|uniprotkb:D3DQK6|uniprotkb:Q8N629	intact:EBI-15096916|ensembl:ENSP00000492125	psi-mi:gbra1_human(display_long)|uniprotkb:GABRA1(gene name)|psi-mi:GABRA1(display_short)|uniprotkb:"GABA(A) receptor subunit alpha-1"(gene name synonym)	psi-mi:p18507-1(display_long)|uniprotkb:GABRG2(gene name)|psi-mi:GABRG2(display_short)|uniprotkb:"GABA(A) receptor subunit gamma-2"(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Zhu et al. (2018)	imex:IM-26858|pubmed:29950725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720076|imex:IM-26858-1|wwpdb:6D6U|wwpdb:6D6T|emdb:EMD-7817|emdb:EMD-7816	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050809"(diazepam binding)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001390(Gamma-aminobutyric-acid A receptor, alpha subunit)|interpro:IPR005431(Gamma-aminobutyric-acid A receptor, alpha 1 subunit)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:6CDU|rcsb pdb:6D1S|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6HUG|rcsb pdb:6HUJ|rcsb pdb:6HUK|rcsb pdb:6HUO|rcsb pdb:6HUP|rcsb pdb:6I53|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|ensembl:ENSG00000022355(gene)|ensembl:ENST00000023897(transcript)|ensembl:ENST00000393943(transcript)|ensembl:ENST00000428797(transcript)|ensembl:ENST00000437025(transcript)|ensembl:ENST00000635880(transcript)|ensembl:ENST00000636573(transcript)|ensembl:ENST00000637827(transcript)|ensembl:ENST00000638112(transcript)|refseq:NP_000797.2|refseq:NP_001121115.1|refseq:NP_001121116.1|refseq:NP_001121117.1|refseq:NP_001121120.1	intact:EBI-9008430(isoform-parent)|ensembl:ENSG00000113327(gene)|ensembl:ENST00000639111(transcript)	-	-	-	figure legend:Extended Data Figure 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2018/08/16	2018/11/26	rogid:6wrRTf2MOYgoKk0RgswgfaI5d+c9606	rogid:CxZyFzov1aoSaBHrcHW7Lsv54h09606	rigid:iO6wdUoRHV382s6vY0vglmURqz4	false	binding-associated region:28-261,269-456	strep tag:n-n|binding-associated region:8-326|tag:n-n	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14867	uniprotkb:P47870-2	intact:EBI-6258308|ensembl:ENSP00000023897|ensembl:ENSP00000377517|ensembl:ENSP00000393097|ensembl:ENSP00000415441|ensembl:ENSP00000489738|ensembl:ENSP00000489839|ensembl:ENSP00000490320|ensembl:ENSP00000490804|uniprotkb:D3DQK6|uniprotkb:Q8N629	intact:EBI-20976695|ensembl:ENSP00000274547|ensembl:ENSP00000377531	psi-mi:gbra1_human(display_long)|uniprotkb:GABRA1(gene name)|psi-mi:GABRA1(display_short)|uniprotkb:"GABA(A) receptor subunit alpha-1"(gene name synonym)	psi-mi:p47870-2(display_long)|uniprotkb:"GABA(A) receptor subunit beta-2"(gene name synonym)|uniprotkb:Beta-2L(isoform synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:GABRB2(gene name)|psi-mi:GABRB2(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Zhu et al. (2018)	imex:IM-26858|pubmed:29950725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20720076|imex:IM-26858-1|wwpdb:6D6U|wwpdb:6D6T|emdb:EMD-7817|emdb:EMD-7816	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050809"(diazepam binding)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001390(Gamma-aminobutyric-acid A receptor, alpha subunit)|interpro:IPR005431(Gamma-aminobutyric-acid A receptor, alpha 1 subunit)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:6CDU|rcsb pdb:6D1S|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6HUG|rcsb pdb:6HUJ|rcsb pdb:6HUK|rcsb pdb:6HUO|rcsb pdb:6HUP|rcsb pdb:6I53|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|ensembl:ENSG00000022355(gene)|ensembl:ENST00000023897(transcript)|ensembl:ENST00000393943(transcript)|ensembl:ENST00000428797(transcript)|ensembl:ENST00000437025(transcript)|ensembl:ENST00000635880(transcript)|ensembl:ENST00000636573(transcript)|ensembl:ENST00000637827(transcript)|ensembl:ENST00000638112(transcript)|refseq:NP_000797.2|refseq:NP_001121115.1|refseq:NP_001121116.1|refseq:NP_001121117.1|refseq:NP_001121120.1	ensembl:ENSG00000145864(gene)|ensembl:ENST00000274547(transcript)|ensembl:ENST00000393959(transcript)|intact:EBI-6949072(isoform-parent)	-	-	-	figure legend:Extended Data Figure 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2018/08/16	2018/11/26	rogid:6wrRTf2MOYgoKk0RgswgfaI5d+c9606	rogid:E5RyMQHTXlCmzSgIHjnYK4Zlivc9606	rigid:iO6wdUoRHV382s6vY0vglmURqz4	false	binding-associated region:28-261,269-456	binding-associated region:25-331,486-512	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14867	uniprotkb:P47870	intact:EBI-6258308|ensembl:ENSP00000023897|ensembl:ENSP00000377517|ensembl:ENSP00000393097|ensembl:ENSP00000415441|ensembl:ENSP00000489738|ensembl:ENSP00000489839|ensembl:ENSP00000490320|ensembl:ENSP00000490804|uniprotkb:D3DQK6|uniprotkb:Q8N629	intact:EBI-6949072|ensembl:ENSP00000274547|ensembl:ENSP00000377531|intact:MINT-268409|uniprotkb:A8K1A0|uniprotkb:D1LYT1|uniprotkb:Q4FZB2|uniprotkb:Q16323|uniprotkb:D1LYT0|uniprotkb:A8K115	psi-mi:gbra1_human(display_long)|uniprotkb:GABRA1(gene name)|psi-mi:GABRA1(display_short)|uniprotkb:"GABA(A) receptor subunit alpha-1"(gene name synonym)	psi-mi:gbrb2_human(display_long)|uniprotkb:GABRB2(gene name)|psi-mi:GABRB2(display_short)|uniprotkb:"GABA(A) receptor subunit beta-2"(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Zhu et al. (2018)	imex:IM-26858|pubmed:29950725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20767704|imex:IM-26858-3|wwpdb:6D6U|wwpdb:6D6T|emdb:EMD-7817|emdb:EMD-7816	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050809"(diazepam binding)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001390(Gamma-aminobutyric-acid A receptor, alpha subunit)|interpro:IPR005431(Gamma-aminobutyric-acid A receptor, alpha 1 subunit)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:6CDU|rcsb pdb:6D1S|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6HUG|rcsb pdb:6HUJ|rcsb pdb:6HUK|rcsb pdb:6HUO|rcsb pdb:6HUP|rcsb pdb:6I53|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|ensembl:ENSG00000022355(gene)|ensembl:ENST00000023897(transcript)|ensembl:ENST00000393943(transcript)|ensembl:ENST00000428797(transcript)|ensembl:ENST00000437025(transcript)|ensembl:ENST00000635880(transcript)|ensembl:ENST00000636573(transcript)|ensembl:ENST00000637827(transcript)|ensembl:ENST00000638112(transcript)|refseq:NP_000797.2|refseq:NP_001121115.1|refseq:NP_001121116.1|refseq:NP_001121117.1|refseq:NP_001121120.1	ensembl:ENSG00000145864(gene)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060384"(innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0090102"(cochlea development)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR002289(Gamma-aminobutyric-acid A receptor, beta subunit)|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|ensembl:ENST00000274547(transcript)|ensembl:ENST00000393959(transcript)|go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|refseq:NP_068711.1|refseq:NP_000804.1	-	-	comment:mint|function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	figure legend:Extended Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2018/08/16	2018/11/25	rogid:6wrRTf2MOYgoKk0RgswgfaI5d+c9606	rogid:E5RyMQHTXlCmzSgIHjnYK4Zlivc9606	rigid:iO6wdUoRHV382s6vY0vglmURqz4	false	sufficient binding region:28-261,269-456	sufficient binding region:25-331,486-512	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P14867	uniprotkb:P18507	intact:EBI-6258308|ensembl:ENSP00000023897|ensembl:ENSP00000377517|ensembl:ENSP00000393097|ensembl:ENSP00000415441|ensembl:ENSP00000489738|ensembl:ENSP00000489839|ensembl:ENSP00000490320|ensembl:ENSP00000490804|uniprotkb:D3DQK6|uniprotkb:Q8N629	intact:EBI-9008430|uniprotkb:Q6GRL6|uniprotkb:Q6PCC3|uniprotkb:Q9UDB3|uniprotkb:F5HB82|uniprotkb:Q9UN15|ensembl:ENSP00000492125	psi-mi:gbra1_human(display_long)|uniprotkb:GABRA1(gene name)|psi-mi:GABRA1(display_short)|uniprotkb:"GABA(A) receptor subunit alpha-1"(gene name synonym)	psi-mi:gbrg2_human(display_long)|uniprotkb:GABRG2(gene name)|psi-mi:GABRG2(display_short)|uniprotkb:"GABA(A) receptor subunit gamma-2"(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Zhu et al. (2018)	imex:IM-26858|pubmed:29950725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20767704|imex:IM-26858-3|wwpdb:6D6U|wwpdb:6D6T|emdb:EMD-7817|emdb:EMD-7816	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050809"(diazepam binding)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001390(Gamma-aminobutyric-acid A receptor, alpha subunit)|interpro:IPR005431(Gamma-aminobutyric-acid A receptor, alpha 1 subunit)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:6CDU|rcsb pdb:6D1S|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6HUG|rcsb pdb:6HUJ|rcsb pdb:6HUK|rcsb pdb:6HUO|rcsb pdb:6HUP|rcsb pdb:6I53|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|ensembl:ENSG00000022355(gene)|ensembl:ENST00000023897(transcript)|ensembl:ENST00000393943(transcript)|ensembl:ENST00000428797(transcript)|ensembl:ENST00000437025(transcript)|ensembl:ENST00000635880(transcript)|ensembl:ENST00000636573(transcript)|ensembl:ENST00000637827(transcript)|ensembl:ENST00000638112(transcript)|refseq:NP_000797.2|refseq:NP_001121115.1|refseq:NP_001121116.1|refseq:NP_001121117.1|refseq:NP_001121120.1	refseq:NP_000807.2|refseq:NP_944493.2|refseq:NP_944494.1|rcsb pdb:6HUP|rcsb pdb:6I53|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|rcsb pdb:6HUO|ensembl:ENSG00000113327(gene)|ensembl:ENST00000639111(transcript)|go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008503"(benzodiazepine receptor activity)|go:"GO:0009791"(post-embryonic development)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030424"(axon)|go:"GO:0030534"(adult behavior)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR005437(Gamma-aminobutyric-acid A receptor, gamma subunit)|interpro:IPR005439(Gamma-aminobutyric-acid A receptor, gamma 2 subunit)|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6HUG|rcsb pdb:6HUJ|rcsb pdb:6HUK	-	-	-	figure legend:Extended Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2018/08/16	2018/11/25	rogid:6wrRTf2MOYgoKk0RgswgfaI5d+c9606	rogid:CxZyFzov1aoSaBHrcHW7Lsv54h09606	rigid:iO6wdUoRHV382s6vY0vglmURqz4	false	sufficient binding region:28-261,269-456	strep tag:n-n|sufficient binding region:8-326	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)