#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96LT7-1 uniprotkb:Q9HAD4 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679 psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938744|imex:IM-26682-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy) - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. - figure legend:Supp Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2018/11/19 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606 rigid:AZnm9hsaO7Nw36gMcN6XM2yQpvA false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-1 uniprotkb:Q8TEV9 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3 psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938744|imex:IM-26682-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062 - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. - figure legend:Supp Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2018/11/19 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606 rigid:AZnm9hsaO7Nw36gMcN6XM2yQpvA false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q86VY4 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-3436472|uniprotkb:B3KRF0|uniprotkb:Q9C0B3|ensembl:ENSP00000322802 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:tsyl5_human(display_long)|uniprotkb:TSPYL5(gene name)|psi-mi:TSPYL5(display_short)|uniprotkb:KIAA1750(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_277047.2|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0040008"(regulation of growth)|go:"GO:0042393"(histone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071480"(cellular response to gamma radiation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q86VY4|ensembl:ENSG00000180543(gene)|ensembl:ENST00000322128(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding) - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:Re2EBlbXEybC1/oghH+B067fNDM9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q8WXF1 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-1392258|uniprotkb:Q5JTQ3|uniprotkb:Q8NCZ9|uniprotkb:Q8WXE8|uniprotkb:Q9NV36|ensembl:ENSP00000343966|ensembl:ENSP00000481916 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:pspc1_human(display_long)|uniprotkb:PSPC1(gene name)|psi-mi:PSPC1(display_short)|uniprotkb:PSP1(gene name synonym)|uniprotkb:Paraspeckle protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:XP_006719907.1|refseq:NP_001035879.1|dip:DIP-39028N|refseq:XP_016876139.1|ensembl:ENSG00000121390(gene)|ensembl:ENST00000338910(transcript)|ensembl:ENST00000619300(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034522|interpro:IPR034523|interpro:IPR035979|mint:Q8WXF1|rcsb pdb:3SDE|rcsb pdb:5IFN|rcsb pdb:5WPA - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:voQ5zJMl7FYato9iDkUYfzZ3q/k9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q9BSF8 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-720180|uniprotkb:Q86WG1|ensembl:ENSP00000278174|uniprotkb:B7Z228 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:btbda_human(display_long)|uniprotkb:GMRP1(gene name synonym)|uniprotkb:Glucose metabolism-related protein 1(gene name synonym)|uniprotkb:BTBD10(gene name)|psi-mi:BTBD10(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_115696.2|refseq:NP_001284671.1|ensembl:ENSG00000148925(gene)|ensembl:ENST00000278174(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR039885|interpro:IPR039886|refseq:XP_016873897.1 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:AX5LXp9KHTw2ybKUKH9Mud6ge0E9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P04626 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:O15015 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-745608|uniprotkb:Q8IVD8|ensembl:ENSP00000300850 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:zn646_human(display_long)|uniprotkb:KIAA0296(gene name synonym)|uniprotkb:ZNF646(gene name)|psi-mi:ZNF646(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_055514.3|refseq:XP_011544292.1|ensembl:ENSG00000167395(gene)|ensembl:ENST00000300850(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:XP_005255767.1|refseq:XP_005255768.1 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:LLCOZY29R+2cHozH65lymJNIjRU9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q13610 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-1050630|uniprotkb:A8K3R6|ensembl:ENSP00000387365|uniprotkb:Q7Z3X9 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:pwp1_human(display_long)|uniprotkb:Keratinocyte protein IEF SSP 9502(gene name synonym)|uniprotkb:PWP1(gene name)|psi-mi:PWP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_008993.1|refseq:NP_001304892.1|ensembl:ENSG00000136045(gene)|ensembl:ENST00000412830(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006364"(rRNA processing)|go:"GO:0033140"(negative regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034773"(histone H4-K20 trimethylation)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990889"(H4K20me3 modified histone binding)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR044285|mint:Q13610 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:3LMa4f6IxjpvEoh2Hyu0hHKkY789606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P20290 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-1054687|uniprotkb:Q13893|uniprotkb:Q76M56|uniprotkb:A8K510|ensembl:ENSP00000369965 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:btf3_human(display_long)|uniprotkb:RNA polymerase B transcription factor 3(gene name synonym)|uniprotkb:BTF3(gene name)|psi-mi:BTF3(display_short)|uniprotkb:NACB(gene name synonym)|uniprotkb:OK/SW-cl.8(orf name)|uniprotkb:Nascent polypeptide-associated complex subunit beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001032726.1|refseq:NP_001198.2|ensembl:ENSG00000145741(gene)|ensembl:ENST00000380591(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0015031"(protein transport)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR038187|interpro:IPR039370|mint:P20290|rcsb pdb:3LKX|rcsb pdb:3MCB - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:TU7PtK2KVrzmdfaTdWcHloiRZYg9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:O15235 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-712205|ensembl:ENSP00000308845|ensembl:ENSP00000384579|ensembl:ENSP00000384952|ensembl:ENSP00000488926|ensembl:ENSP00000489374|ensembl:ENSP00000489467|uniprotkb:Q53X98 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:rt12_human(display_long)|uniprotkb:MT-RPS12(gene name synonym)|uniprotkb:MRPS12(gene name)|psi-mi:MRPS12(display_short)|uniprotkb:RPMS12(gene name synonym)|uniprotkb:RPSM12(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein uS12m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR005679(Ribosomal protein S12, bacterial-type)|interpro:IPR006032(Ribosomal protein S12/S23)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|go:"GO:0005840"(ribosome)|ensembl:ENSG00000128626(gene)|ensembl:ENSG00000283018(gene)|ensembl:ENST00000308018(transcript)|ensembl:ENST00000402029(transcript)|ensembl:ENST00000407800(transcript)|ensembl:ENST00000634246(transcript)|ensembl:ENST00000634400(transcript)|ensembl:ENST00000634704(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|refseq:NP_066930.1|refseq:NP_203526.1|refseq:NP_203527.1 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:FDGNbJ2YFbUR4eQ3AyFtC8trETo9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q9P086 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-394704|uniprotkb:Q6NS89|ensembl:ENSP00000293777 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:med11_human(display_long)|uniprotkb:Mediator complex subunit 11(gene name synonym)|uniprotkb:MED11(gene name)|psi-mi:MED11(display_short)|uniprotkb:HSPC296(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001291929.1|refseq:NP_001001683.1|ensembl:ENSG00000161920(gene)|ensembl:ENST00000293777(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR019404|mint:Q9P086|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340|go:"GO:0003712"(transcription coregulator activity) - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:y7SZi5hIo5aOatJSZi98Hqt082A9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P62891 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-8830744|uniprotkb:P02404|uniprotkb:Q9BYF2|uniprotkb:P39025|ensembl:ENSP00000355315 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:rl39_human(display_long)|uniprotkb:RPL39(gene name)|psi-mi:RPL39(display_short)|uniprotkb:Large ribosomal subunit protein eL39(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_000991.1|rcsb pdb:4V6X|ensembl:ENSG00000198918(gene)|ensembl:ENST00000361575(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR000077(Ribosomal protein L39e)|interpro:IPR020083|interpro:IPR023626|rcsb pdb:4UG0|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:AZus2dxwJsTxAOwnJ93E2yhasbo9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:O75935 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-347442|uniprotkb:A6NII7|uniprotkb:Q5T1I5|uniprotkb:Q5T1I7|uniprotkb:Q5T8G3|uniprotkb:Q9BPU8|uniprotkb:B2RBM5|ensembl:ENSP00000259632 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:dctn3_human(display_long)|uniprotkb:DCTN22(gene name synonym)|uniprotkb:DCTN3(gene name)|psi-mi:DCTN3(display_short)|uniprotkb:Dynactin complex subunit 22 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_009165.1|refseq:NP_077324.1|ensembl:ENSG00000137100(gene)|ensembl:ENST00000259632(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|interpro:IPR009991(Dynactin subunit p22)|mint:O75935|reactome:R-HSA-2132295|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-8854518|refseq:NP_001268354.1|refseq:NP_001268355.1 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:KPLiGDMa0KR/H31QtEdl2YiwYzk9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P62314 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-372177|uniprotkb:P13641|uniprotkb:B5BTZ1|ensembl:ENSP00000300413 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:smd1_human(display_long)|uniprotkb:SNRPD1(gene name)|psi-mi:SNRPD1(display_short)|uniprotkb:snRNP core protein D1(gene name synonym)|uniprotkb:Sm-D autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001278845.1|refseq:NP_008869.1|ensembl:ENSG00000167088(gene)|ensembl:ENST00000300413(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|go:"GO:0000243"(commitment complex)|interpro:IPR027141|interpro:IPR034102|mint:P62314|rcsb pdb:1B34|rcsb pdb:3CW1|rcsb pdb:3JCR|rcsb pdb:3PGW|rcsb pdb:4F7U|rcsb pdb:4PJO|go:"GO:0000245"(spliceosomal complex assembly)|rcsb pdb:4V98|rcsb pdb:4WZJ|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5XJL|rcsb pdb:5XJQ|go:"GO:0000387"(spliceosomal snRNP assembly)|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7B0Y|rcsb pdb:7DVQ|reactome:R-HSA-191859|reactome:R-HSA-72163|reactome:R-HSA-72165|dip:DIP-31207N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:bfXwsV+IOjDPCoOJOoMQgECyiII9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q9BWH6 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-1048085|uniprotkb:Q9H9I2|uniprotkb:Q9NSQ5|uniprotkb:Q9P2E4|uniprotkb:Q9UFS7|ensembl:ENSP00000306123 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:rpap1_human(display_long)|uniprotkb:RPAP1(gene name)|psi-mi:RPAP1(display_short)|uniprotkb:KIAA1403(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_056355.2|refseq:XP_005254354.1|ensembl:ENSG00000103932(gene)|ensembl:ENST00000304330(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006366"(transcription by RNA polymerase II)|interpro:IPR013929(RNA polymerase II-associated protein 1, C-terminal)|interpro:IPR013930(RNA polymerase II-associated protein 1, N-terminal)|interpro:IPR039913|mint:Q9BWH6 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:9vO/6r2beuU+WAmMIaz9ZVNLGQI9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q9H6T0 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-3941182|uniprotkb:Q8N6H8|uniprotkb:Q9H6I4|uniprotkb:Q8WZ15|ensembl:ENSP00000454554 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:esrp2_human(display_long)|uniprotkb:ESRP2(gene name)|psi-mi:ESRP2(display_short)|uniprotkb:RBM35B(gene name synonym)|uniprotkb:RNA-binding motif protein 35B(gene name synonym)|uniprotkb:RNA-binding protein 35B(gene name synonym)|uniprotkb:PP7059(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000103067(gene)|ensembl:ENST00000565858(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034431|interpro:IPR035979|interpro:IPR036397|reactome:R-HSA-6803529|refseq:NP_079215.2 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:0+erm7tj705S8/JL0j/2T3Y/tzw9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P26038 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-528768|ensembl:ENSP00000353408 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q14137 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-1050828|uniprotkb:Q969Z6|uniprotkb:Q96IS8|uniprotkb:Q9BSA7|uniprotkb:Q9BVM0|ensembl:ENSP00000455106|ensembl:ENSP00000495401|uniprotkb:Q96Q25 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:bop1_human(display_long)|uniprotkb:Block of proliferation 1 protein(gene name synonym)|uniprotkb:BOP1(gene name)|psi-mi:BOP1(display_short)|uniprotkb:KIAA0124(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_056016.1|ensembl:ENSG00000261236(gene)|ensembl:ENSG00000285301(gene)|ensembl:ENST00000569669(transcript)|ensembl:ENST00000642409(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070545"(PeBoW complex)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR012953(BOP1, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR028598|interpro:IPR036322|mint:Q14137|reactome:R-HSA-6791226 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:g2CwsRotXBvjvr+rSZSA0mKrVCY9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P63208 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q9BPZ7 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-749938|uniprotkb:Q00426|intact:EBI-1237531|uniprotkb:A8K1Z5|uniprotkb:B1AMA4|uniprotkb:Q5JSV5|uniprotkb:Q5JSV6|uniprotkb:Q5JSV9|uniprotkb:Q658R0|uniprotkb:Q699U1|uniprotkb:Q699U2|uniprotkb:Q699U3|uniprotkb:Q699U4|uniprotkb:Q6GVJ0|uniprotkb:Q6GVJ1|uniprotkb:Q6GVJ2|intact:EBI-1048293|uniprotkb:B7Z309|ensembl:ENSP00000265960|ensembl:ENSP00000362597 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:sin1_human(display_long)|uniprotkb:MIP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2-associated protein 1(gene name synonym)|uniprotkb:Stress-activated map kinase-interacting protein 1(gene name synonym)|uniprotkb:MAPKAP1(gene name)|psi-mi:MAPKAP1(display_short)|uniprotkb:SIN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001006618.1|refseq:NP_001006619.1|refseq:NP_001006620.1|refseq:NP_001006621.1|refseq:NP_001006622.1|refseq:NP_077022.1|refseq:XP_011517312.1|refseq:XP_016870615.1|dip:DIP-39480N|ensembl:ENSG00000119487(gene)|ensembl:ENST00000265960(transcript)|ensembl:ENST00000373498(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031932"(TORC2 complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031313|interpro:IPR031567|interpro:IPR032679|mint:Q9BPZ7|rcsb pdb:3VOQ|rcsb pdb:5ZCS|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5674400|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|reactome:R-HSA-6804757|refseq:XP_016870616.1 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:kIAa8HfqaJhvssnCDV2/8fj3JYA9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q9Y4Y9 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-373007|ensembl:ENSP00000410758 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:lsm5_human(display_long)|uniprotkb:LSM5(gene name)|psi-mi:LSM5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001124182.1|refseq:NP_001132971.1|refseq:NP_036454.1|dip:DIP-31162N|ensembl:ENSG00000106355(gene)|ensembl:ENST00000450169(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR033871|mint:Q9Y4Y9|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:EeF2r4qY+BFrZTyTCT+i4ccskf49606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P31942 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-711437|uniprotkb:Q9NPI4|uniprotkb:Q9UFU4|uniprotkb:Q9Y4J5|uniprotkb:Q9BSX1|uniprotkb:Q9NP53|uniprotkb:Q9NP96|uniprotkb:Q9NPA7|ensembl:ENSP00000265866|uniprotkb:A8K682|uniprotkb:B3KRE1 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:hnrh3_human(display_long)|uniprotkb:HNRNPH3(gene name)|psi-mi:HNRNPH3(display_short)|uniprotkb:HNRPH3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein 2H9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000096746(gene)|ensembl:ENST00000265866(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034969|interpro:IPR034970|interpro:IPR035979|mint:P31942|refseq:NP_036339.1|refseq:NP_067676.2|refseq:NP_001309363.1|refseq:NP_001309365.1|refseq:NP_001309366.1|refseq:NP_001309367.1|refseq:NP_001309368.1|refseq:NP_001309369.1|refseq:NP_001309370.1|refseq:NP_001309374.1|refseq:NP_001309375.1|refseq:NP_001309376.1|refseq:NP_001309377.1|refseq:NP_001309378.1|refseq:XP_016871657.1|refseq:XP_016871658.1 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:iJGBIhPXnQIIFQmgxWB1WjwVXSY9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:O14647 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-1210503|uniprotkb:C6G482|uniprotkb:Q96IP5|ensembl:ENSP00000377747 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:chd2_human(display_long)|uniprotkb:CHD2(gene name)|psi-mi:CHD2(display_short)|uniprotkb:ATP-dependent helicase CHD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001262.3|refseq:NP_001036037.1|interpro:IPR023780|interpro:IPR025260|interpro:IPR027417|interpro:IPR038718|interpro:IPR040793|mint:O14647|interpro:IPR023779|ensembl:ENSG00000173575(gene)|ensembl:ENST00000394196(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007517"(muscle organ development)|go:"GO:0042393"(histone binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like) - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:Vibq3UdOTD39yhVlCgkyhzxw1Zw9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q06455 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-743342|uniprotkb:O14784|uniprotkb:Q06456|uniprotkb:Q14873|uniprotkb:Q16239|uniprotkb:Q16346|uniprotkb:Q16347|uniprotkb:Q6IBL1|uniprotkb:Q92479|uniprotkb:Q9BRZ0|ensembl:ENSP00000265814|ensembl:ENSP00000428543|ensembl:ENSP00000481112|ensembl:ENSP00000481315|ensembl:ENSP00000481799|uniprotkb:B7Z4P4|uniprotkb:E7EPN4|uniprotkb:Q6NXH1|uniprotkb:Q7Z4J5 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:mtg8_human(display_long)|uniprotkb:Protein MTG8(gene name synonym)|uniprotkb:Protein ETO(gene name synonym)|uniprotkb:Eight twenty one protein(gene name synonym)|uniprotkb:Cyclin-D-related protein(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 2(gene name synonym)|uniprotkb:RUNX1T1(gene name)|psi-mi:RUNX1T1(display_short)|uniprotkb:AML1T1(gene name synonym)|uniprotkb:CBFA2T1(gene name synonym)|uniprotkb:CDR(gene name synonym)|uniprotkb:ETO(gene name synonym)|uniprotkb:MTG8(gene name synonym)|uniprotkb:ZMYND2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001185554.1|refseq:NP_001185555.1|refseq:NP_001185556.1|refseq:NP_001185557.1|refseq:NP_001185558.1|refseq:NP_001185559.1|refseq:NP_001185560.1|refseq:NP_001185561.1|refseq:NP_004340.1|refseq:NP_783552.1|refseq:NP_783553.1|refseq:NP_783554.1|ensembl:ENSG00000079102(gene)|ensembl:ENST00000265814(transcript)|ensembl:ENST00000523629(transcript)|ensembl:ENST00000613302(transcript)|ensembl:ENST00000614812(transcript)|ensembl:ENST00000617740(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR003894(TAFH/NHR1)|interpro:IPR013289(Eight-Twenty-One)|refseq:XP_011515653.1|refseq:XP_011515654.1|refseq:XP_011515655.1|interpro:IPR013290("Myeloid transforming gene on chromosome 8 (MTG8)")|interpro:IPR014896(NHR2-like)|interpro:IPR037249|mint:Q06455|rcsb pdb:1WQ6|rcsb pdb:2DJ8|rcsb pdb:2H7B|rcsb pdb:2KNH|rcsb pdb:2KYG|rcsb pdb:2OD1|rcsb pdb:2ODD|rcsb pdb:2PP4|rcsb pdb:4JOL|refseq:NP_001185563.1|refseq:NP_001185562.1|refseq:NP_001185608.1|refseq:XP_006716739.1|refseq:XP_016869420.1|refseq:XP_016869421.1|refseq:XP_016869422.1|refseq:XP_016869423.1|refseq:XP_016869424.1|refseq:XP_016869425.1|refseq:XP_016869426.1|dip:DIP-29401N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:SMomKOZSbtqhKiAkkUkabKbC8/09606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P62273 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-1054121|uniprotkb:P30054|uniprotkb:A8MZ73|ensembl:ENSP00000245458|ensembl:ENSP00000495033 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:rs29_human(display_long)|uniprotkb:RPS29(gene name)|psi-mi:RPS29(display_short)|uniprotkb:Small ribosomal subunit protein uS14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001023.1|refseq:NP_001025172.1|ensembl:ENSG00000213741(gene)|ensembl:ENST00000245458(transcript)|ensembl:ENST00000556230(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|interpro:IPR001209(Ribosomal protein S14)|interpro:IPR018271|interpro:IPR039744|interpro:IPR043140|mint:P62273|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:vMgvFs6gwidbpv837yH2u0sSIAU9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q8N184 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-749400|uniprotkb:Q6N044|uniprotkb:B3KX49|ensembl:ENSP00000441838|ensembl:ENSP00000507048 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:zn567_human(display_long)|uniprotkb:ZNF567(gene name)|psi-mi:ZNF567(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_689816.2|refseq:XP_011524886.1|refseq:NP_001287908.1|refseq:NP_001309840.1|refseq:NP_001309841.1|refseq:NP_001309842.1|refseq:NP_001309843.1|refseq:NP_001309844.1|refseq:NP_001309845.1|refseq:NP_001309846.1|refseq:NP_001309847.1|refseq:NP_001309848.1|refseq:NP_001309849.1|refseq:XP_016881906.1|refseq:XP_016881907.1|refseq:XP_016881909.1|refseq:XP_016881910.1|ensembl:ENSG00000189042(gene)|ensembl:ENST00000536254(transcript)|ensembl:ENST00000682579(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|mint:Q8N184|reactome:R-HSA-212436 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:c91XZ0kJYsZ9Vdq3wmM+0/VgyZE9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q96RE9 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-2826684|uniprotkb:B3KU35|uniprotkb:Q17RP3|uniprotkb:Q5H9N5|uniprotkb:A8MY91|uniprotkb:B4DU78|uniprotkb:Q06DQ3|ensembl:ENSP00000274599|uniprotkb:F5GWS1 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:zn300_human(display_long)|uniprotkb:ZNF300(gene name)|psi-mi:ZNF300(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001166302.1|refseq:NP_001166303.1|refseq:NP_443092.1|ensembl:ENSG00000145908(gene)|ensembl:ENST00000274599(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:38iNcXE1eJW5dyX9zAN46FoXT589606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q9P0L1 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-743851|uniprotkb:Q6WL09|uniprotkb:Q96FQ2|uniprotkb:A0PJV3|uniprotkb:A8K5H0|ensembl:ENSP00000273320|ensembl:ENSP00000395524|ensembl:ENSP00000485942|ensembl:ENSP00000485948 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:zksc7_human(display_long)|uniprotkb:ZKSCAN7(gene name)|psi-mi:ZKSCAN7(display_short)|uniprotkb:ZNF167(gene name synonym)|uniprotkb:ZNF448(gene name synonym)|uniprotkb:ZNF64(gene name synonym)|uniprotkb:Zinc finger protein 167(gene name synonym)|uniprotkb:Zinc finger protein 448(gene name synonym)|uniprotkb:Zinc finger protein 64(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_061121.2|refseq:NP_079445.1|refseq:NP_001275519.1|refseq:NP_001275520.1|refseq:NP_001275521.1|ensembl:ENST00000273320(transcript)|ensembl:ENST00000426540(transcript)|ensembl:ENST00000626497(transcript)|ensembl:ENST00000629379(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated box)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|interpro:IPR038269|reactome:R-HSA-212436|ensembl:ENSG00000196345(gene)|ensembl:ENSG00000281894(gene) - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:++VerbvttBGHtg/y0L504Fl9mU89606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P09496 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P05388 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-354101|uniprotkb:Q9BVK4|intact:EBI-8012155|intact:MINT-8395053|uniprotkb:Q3B7A4|ensembl:ENSP00000339027|ensembl:ENSP00000376299|ensembl:ENSP00000449328 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:rla0_human(display_long)|uniprotkb:RPLP0(gene name)|psi-mi:RPLP0(display_short)|uniprotkb:60S ribosomal protein L10E(gene name synonym)|uniprotkb:Large ribosomal subunit protein uL10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_000993.1|refseq:NP_444505.1|ensembl:ENSG00000089157(gene)|ensembl:ENST00000228306(transcript)|ensembl:ENST00000392514(transcript)|ensembl:ENST00000551150(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0098794"(postsynapse)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR030670|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:P05388|rcsb pdb:4V6W|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:6OLG|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-8950505|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:xv3QHqnXxvCd3BOIeHVkqEnSNNk9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P62987 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-357304|ensembl:ENSP00000388107|ensembl:ENSP00000396910|ensembl:ENSP00000470419|ensembl:ENSP00000470507|ensembl:ENSP00000471062|ensembl:ENSP00000471464|ensembl:ENSP00000471622|ensembl:ENSP00000472264|ensembl:ENSP00000472545|ensembl:ENSP00000473048|uniprotkb:P14793|uniprotkb:Q9BX98|uniprotkb:Q9UPK7|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:P62988|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:rl40_human(display_long)|uniprotkb:UBA52(gene name)|psi-mi:UBA52(display_short)|uniprotkb:UBCEP2(gene name synonym)|uniprotkb:CEP52(gene name synonym)|uniprotkb:Ubiquitin A-52 residue ribosomal protein fusion product 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000221983(gene)|ensembl:ENST00000430157(transcript)|ensembl:ENST00000442744(transcript)|ensembl:ENST00000595158(transcript)|rcsb pdb:2MBH|rcsb pdb:2MJB|rcsb pdb:2MUR|ensembl:ENST00000595683(transcript)|ensembl:ENST00000596273(transcript)|rcsb pdb:2N3U|rcsb pdb:2N3V|rcsb pdb:2N3W|rcsb pdb:2NBD|ensembl:ENST00000596304(transcript)|rcsb pdb:2NBE|rcsb pdb:2RSU|rcsb pdb:4HJK|ensembl:ENST00000597451(transcript)|ensembl:ENST00000598780(transcript)|rcsb pdb:4JIO|rcsb pdb:4P4H|rcsb pdb:4PIG|ensembl:ENST00000599551(transcript)|ensembl:ENST00000599595(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|rcsb pdb:4PIH|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017085"(response to insecticide)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR001975(Ribosomal protein L40e)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038587|mint:P62987|rcsb pdb:2LJ5|rcsb pdb:4PIJ|rcsb pdb:4RF0|rcsb pdb:4S1Z|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:4XKL|rcsb pdb:5AJ0|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5HPK|rcsb pdb:5HPL|rcsb pdb:5HPS|rcsb pdb:5HPT|rcsb pdb:5J26|rcsb pdb:5J8P|rcsb pdb:5JBV|rcsb pdb:5JBY|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:4RF1|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7AY1|rcsb pdb:7BHP|rcsb pdb:7M3Q|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|rcsb pdb:6Z6N|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-1799339|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-192823|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6791226|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-69231|reactome:R-HSA-8951664|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9633012|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-977225|reactome:R-HSA-983168|refseq:NP_001029102.1|refseq:NP_003324.1|refseq:NP_001307947.1|refseq:NP_001307948.1|refseq:NP_001307949.1|refseq:NP_001307946.1 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:x9O/Pbww4D28M1+hIj+p0xrUXgU9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:P35637 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q9Y446 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-2880227|ensembl:ENSP00000331678|uniprotkb:F8J390|uniprotkb:Q53EX8 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:pkp3_human(display_long)|uniprotkb:PKP3(gene name)|psi-mi:PKP3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000184363(gene)|ensembl:ENST00000331563(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006417"(regulation of translation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0001533"(cornified envelope)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028434|interpro:IPR028435|mint:Q9Y446|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|refseq:NP_001289958.1|refseq:NP_009114.1 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:zGNbdze5MA5Mnf8m9IWZsxAPjAQ9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q8IWZ3 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-359558|ensembl:ENSP00000354085|intact:EBI-948598|uniprotkb:A6NH85|uniprotkb:Q149P2|uniprotkb:Q8IWZ2|uniprotkb:Q8WY90|uniprotkb:Q96G77|uniprotkb:Q96GK0|uniprotkb:Q9H2U0|uniprotkb:Q9HA95|uniprotkb:Q9NWG4|uniprotkb:Q9UPR7 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:ankh1_human(display_long)|uniprotkb:Multiple ankyrin repeats single KH domain(gene name synonym)|uniprotkb:ANKHD1(gene name)|psi-mi:ANKHD1(display_short)|uniprotkb:HIV-1 Vpr-binding ankyrin repeat protein(gene name synonym)|uniprotkb:KIAA1085(gene name synonym)|uniprotkb:MASK(gene name synonym)|uniprotkb:VBARP(gene name synonym)|uniprotkb:PP2500(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000131503(gene)|ensembl:ENST00000360839(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|refseq:NP_001183959.1|refseq:NP_060217.1|refseq:NP_060448.1|refseq:NP_078944.2|refseq:NP_065741.3|ensembl:ENSP00000354085|ensembl:ENST00000394722|ensembl:ENSP00000378211|ensembl:ENST00000394723|ensembl:ENSP00000378212|ensembl:ENST00000616482|ensembl:ENSP00000478529|dip:DIP-36371N - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:yPjTR77ttPwAEMg8WHOzYJNcAhA9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-2 uniprotkb:Q9Y2P7 intact:EBI-16693673|ensembl:ENSP00000369331|ensembl:ENSP00000369333 intact:EBI-12223065|ensembl:ENSP00000282308|uniprotkb:B2RA92|uniprotkb:Q53Y85|uniprotkb:Q9BV71 psi-mi:q96lt7-2(display_long)|uniprotkb:"C9(SF)"(isoform synonym)|uniprotkb:C9-S(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:zn256_human(display_long)|uniprotkb:ZNF256(gene name)|psi-mi:ZNF256(display_short)|uniprotkb:BMZF3(gene name synonym)|uniprotkb:Bone marrow zinc finger 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938756|imex:IM-26682-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000379995(transcript)|ensembl:ENST00000379997(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000152454(gene)|ensembl:ENST00000282308(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436|refseq:XP_016881627.1|refseq:NP_005764.2 - - - figure legend:Supp. Table 1|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2019/07/08 rogid:ZDr8gR2UnsQmuc0gg8DT/ttGE+M9606 rogid:Mi1LTu+zHJYQ7vvMJV7YLVrtbus9606 rigid:lWM5srPjR7zbkp6gXhTjkRmJY68 false ha tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LT7-1 uniprotkb:Q9HAD4 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679 psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938806|imex:IM-26682-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy) - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. - figure legend:Supp Fig 1E, F|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2018/11/20 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606 rigid:AZnm9hsaO7Nw36gMcN6XM2yQpvA false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96LT7-1 uniprotkb:Q8TEV9 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3 psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938806|imex:IM-26682-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062 - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. - figure legend:Supp Fig 1E, F|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)") - 2018/11/19 2018/11/20 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606 rigid:AZnm9hsaO7Nw36gMcN6XM2yQpvA false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96LT7-1 uniprotkb:O75143 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 intact:EBI-2798775|ensembl:ENSP00000352500|ensembl:ENSP00000431974|uniprotkb:Q9BRL3|uniprotkb:Q9H8B0|uniprotkb:D3DQQ1|uniprotkb:D3DQQ2|uniprotkb:B4DFI4|uniprotkb:E9PQZ8|uniprotkb:Q53EN6|intact:EBI-28977728 psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:atg13_human(display_long)|uniprotkb:ATG13(gene name)|psi-mi:ATG13(display_short)|uniprotkb:KIAA0652(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938823|imex:IM-26682-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000175224(gene)|ensembl:ENST00000359513(transcript)|ensembl:ENST00000526508(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR018731|interpro:IPR036570|interpro:IPR040182|mint:O75143|refseq:NP_001333240.1|refseq:NP_001333241.1|refseq:NP_001333242.1|refseq:NP_001333243.1|refseq:NP_001333244.1|refseq:NP_001333245.1|refseq:NP_001333248.1|refseq:NP_001333249.1|refseq:NP_001333250.1|ensembl:ENSP00000352500|ensembl:ENST00000524625|ensembl:ENSP00000433543|ensembl:ENSP00000431974|ensembl:ENST00000528494|ensembl:ENSP00000432412|ensembl:ENST00000529655|ensembl:ENSP00000433756|ensembl:ENST00000530500|ensembl:ENSP00000434390|ensembl:ENST00000683050|ensembl:ENSP00000507809|refseq:NP_001333251.1|refseq:XP_011518795.1|refseq:XP_011518798.1|refseq:XP_011518801.1|refseq:NP_001136145.1|refseq:NP_001192048.1|refseq:NP_001192049.1|refseq:NP_001192050.1|refseq:NP_001192051.1|refseq:NP_055556.2|refseq:NP_001333271.1|refseq:XP_016874088.1|refseq:XP_016874092.1|refseq:XP_016874096.1|refseq:NP_001333252.1|refseq:NP_001333253.1|refseq:NP_001333254.1|refseq:NP_001333255.1|refseq:NP_001333256.1|refseq:NP_001333257.1|refseq:NP_001333258.1|refseq:NP_001333259.1|refseq:NP_001333260.1|refseq:NP_001333261.1|refseq:XP_006718459.1|refseq:XP_005253322.1|refseq:XP_005253323.1|refseq:XP_005253325.1|refseq:NP_001333273.1|refseq:NP_001333275.1|refseq:NP_001333277.1|refseq:NP_001333278.1|refseq:NP_001333279.1|refseq:NP_001333280.1|refseq:NP_001333281.1|refseq:NP_001333282.1|refseq:NP_001333283.1|dip:DIP-60540N|rcsb pdb:3WAO|rcsb pdb:3WAP|rcsb pdb:5C50|rcsb pdb:5XUY|rcsb pdb:5XV1|rcsb pdb:5XV3|rcsb pdb:5XV4|rcsb pdb:5XV6|rcsb pdb:6HYN|reactome:R-HSA-1632852|rcsb pdb:3WAN - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. - figure legend:Supp Fig 1H|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-motor_neuron)|taxid:9606(Human motor neuron) - 2018/11/19 2018/11/20 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rogid:xlABwrglkoQu3OSb/8yLTQVxN8o9606 rigid:DOFqR2hm8qNDyh6t+fEYaTtj//A false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96LT7-1 uniprotkb:O75385 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 intact:EBI-908831|uniprotkb:Q9UQ28|ensembl:ENSP00000324560 psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:ulk1_human(display_long)|uniprotkb:ULK1(gene name)|psi-mi:ULK1(display_short)|uniprotkb:KIAA0722(gene name synonym)|uniprotkb:Unc-51-like kinase 1(gene name synonym)|uniprotkb:Autophagy-related protein 1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938823|imex:IM-26682-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_003556.1|dip:DIP-35196N|ensembl:ENSG00000177169(gene)|ensembl:ENST00000321867(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044805"(late nucleophagy)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0051020"(GTPase binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0061709"(reticulophagy)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0097629"(extrinsic component of omegasome membrane)|go:"GO:0097632"(extrinsic component of phagophore assembly site membrane)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016237(Serine/threonine-protein kinase, Ulk1/Ulk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022708|mint:O75385|rcsb pdb:4WNO|rcsb pdb:4WNP|rcsb pdb:5CI7|rcsb pdb:6HYO|rcsb pdb:6MNH|rcsb pdb:6QAS|reactome:R-HSA-1632852|reactome:R-HSA-8854214|reactome:R-HSA-8876198|reactome:R-HSA-8934903 - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. - figure legend:Supp Fig 1H|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-motor_neuron)|taxid:9606(Human motor neuron) - 2018/11/19 2018/11/20 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rogid:Q27JsEOr//zWM8N4jycsZdzbALM9606 rigid:DOFqR2hm8qNDyh6t+fEYaTtj//A false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96LT7-1 uniprotkb:Q8TDY2 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 intact:EBI-1047793|uniprotkb:Q92601|uniprotkb:Q8WVU9|uniprotkb:Q86YR4|ensembl:ENSP00000025008 psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:rbcc1_human(display_long)|uniprotkb:RB1CC1(gene name)|psi-mi:RB1CC1(display_short)|uniprotkb:KIAA0203(gene name synonym)|uniprotkb:RBICC(gene name synonym)|uniprotkb:FAK family kinase-interacting protein of 200 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938823|imex:IM-26682-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_001077086.1|refseq:NP_055596.3|refseq:XP_011515945.1|refseq:XP_016869596.1|ensembl:ENSG00000023287(gene)|ensembl:ENST00000025008(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005764"(lysosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007049"(cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061709"(reticulophagy)|go:"GO:0061723"(glycophagy)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR019460|interpro:IPR040040|mint:Q8TDY2|rcsb pdb:6DCE|rcsb pdb:6GMA|rcsb pdb:7CZG|rcsb pdb:7CZM|rcsb pdb:7D0E|reactome:R-HSA-1632852|dip:DIP-45969N - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. - figure legend:Supp Fig 1H|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-motor_neuron)|taxid:9606(Human motor neuron) - 2018/11/19 2018/11/20 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rogid:3qWsqPCX1PTO00mfVMJejr7QLwU9606 rigid:DOFqR2hm8qNDyh6t+fEYaTtj//A false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96LT7-1 uniprotkb:Q9HAD4 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 intact:EBI-2819137|uniprotkb:Q8NDA7|uniprotkb:Q9NV62|uniprotkb:Q8IWG3|uniprotkb:Q7Z792|uniprotkb:Q8IXA9|uniprotkb:B4DT55|ensembl:ENSP00000296679 psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:wdr41_human(display_long)|uniprotkb:WDR41(gene name)|psi-mi:WDR41(display_short)|uniprotkb:MSTP048(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938823|imex:IM-26682-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) refseq:NP_060738.2|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040102|mint:Q9HAD4|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:6WHH|rcsb pdb:7MGE|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0010506"(regulation of autophagy)|ensembl:ENSG00000164253(gene)|ensembl:ENST00000296679(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy) - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. - figure legend:Supp Fig 1H|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-motor_neuron)|taxid:9606(Human motor neuron) - 2018/11/19 2018/11/20 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rogid:DrOZwpzvIfPWDIrWKfgEFDy3uPU9606 rigid:DOFqR2hm8qNDyh6t+fEYaTtj//A false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96LT7-1 uniprotkb:Q8TEV9 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3 psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938823|imex:IM-26682-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062 - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. - figure legend:Supp Fig 1H|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-motor_neuron)|taxid:9606(Human motor neuron) - 2018/11/19 2018/11/20 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606 rigid:DOFqR2hm8qNDyh6t+fEYaTtj//A false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TEV9 uniprotkb:Q96LT7-1 intact:EBI-2961718|ensembl:ENSP00000385025|ensembl:ENSP00000492062|uniprotkb:A5PKZ5|uniprotkb:Q3ZCN0|uniprotkb:Q6PJL3 intact:EBI-16693635|ensembl:ENSP00000369339|ensembl:ENSP00000482753 psi-mi:smcr8_human(display_long)|uniprotkb:SMCR8(gene name)|psi-mi:SMCR8(display_short)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym) psi-mi:q96lt7-1(display_long)|uniprotkb:"C9(LF)"(isoform synonym)|uniprotkb:C9-L(isoform synonym)|uniprotkb:C9orf72(gene name)|psi-mi:C9orf72(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2018) pubmed:29950492|imex:IM-26682 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20938833|imex:IM-26682-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176994(gene)|ensembl:ENSG00000283741(gene)|ensembl:ENST00000406438(transcript)|ensembl:ENST00000639332(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR037520|interpro:IPR037521|mint:Q8TEV9|rcsb pdb:6LT0|rcsb pdb:6V4U|rcsb pdb:7EL6|rcsb pdb:7MGE|refseq:NP_658988.2|ensembl:ENSP00000385025|ensembl:ENSP00000492062 ensembl:ENSG00000147894(gene)|ensembl:ENST00000380003(transcript)|ensembl:ENST00000619707(transcript)|intact:EBI-2961725(isoform-parent) - - isoform-comment:Encoded by 2 transcripts differing in the 5' non-coding region. figure legend:Supp Fig 1H|comment:Interaction observed in WDR41-/- cells|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-motor_neuron)|taxid:9606(Human motor neuron) - 2018/11/19 2018/11/28 rogid:w+qVoh0JXrz6HImAj8sYNYGklBg9606 rogid:dcsfVKdGP4UVSz0kfRMk/EocRcs9606 rigid:1v2bySI3IdYEQbx+lrOl1JSJ7to false - ha tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)