#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q80WG5 uniprotkb:Q80WG5 intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0 intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0 psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym) psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Deneka et al. (2018) imex:IM-26780|pubmed:29769723 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-20718008|emdb:EMD-4366|emdb:EMD-4367|emdb:EMD-4362|wwpdb:6G9L|wwpdb:6G9O|wwpdb:6G8Z|imex:IM-26780-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1|wwpdb:6G9L(identity)|wwpdb:6G9O(identity)|wwpdb:6G8Z(identity)|emdb:EMD-4366(identity)|emdb:EMD-4367(identity)|emdb:EMD-4362(identity) ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1|wwpdb:6G9L(identity)|wwpdb:6G9O(identity)|wwpdb:6G8Z(identity)|emdb:EMD-4366(identity)|emdb:EMD-4367(identity)|emdb:EMD-4362(identity) - - - figure legend:Fig 1a, b; Extended Data Fig 7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient) - 2018/08/13 2018/08/14 rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090 rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090 rigid:B2mpTpv6JyJAO/lPRKD5AaWLBBE false sufficient binding region:1-428 sufficient binding region:1-428 6 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8R502 uniprotkb:Q80WG5 intact:EBI-20718060|ensembl:ENSMUSP00000066015|uniprotkb:Q3TEP9|uniprotkb:Q8C296|uniprotkb:Q8R0N7|uniprotkb:Q8R3G5 intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0 psi-mi:lrc8c_mouse(display_long)|uniprotkb:Factor for adipocyte differentiation 158(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8C(gene name synonym)|uniprotkb:Lrrc8c(gene name)|psi-mi:Lrrc8c(display_short)|uniprotkb:Ad158(gene name synonym)|uniprotkb:Fad158(gene name synonym) psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Deneka et al. (2018) imex:IM-26780|pubmed:29769723 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-20718058|emdb:EMD-4361|imex:IM-26780-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000054720(gene)|ensembl:ENSMUST00000067924(transcript)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR032675|mint:Q8R502|reactome:R-MMU-5223345|go:"GO:0015734"(taurine transport)|refseq:NP_598658.1|refseq:XP_006534748.1|refseq:XP_017176062.1 ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1 - - - figure legend:Extended Data Fig 5f, Fig 1e, Extended Data Fig 7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient) - 2018/08/13 2018/08/14 rogid:3H5OySBpEv3c7ryGwyI1Ve3zOU010090 rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090 rigid:+6p+f0u2yEtQGEvTCmvptUobtr4 false - - 3 3 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q80WG5 uniprotkb:Q80WG5 intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0 intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0 psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym) psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Deneka et al. (2018) imex:IM-26780|pubmed:29769723 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-20718103|imex:IM-26780-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1 ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1 - - - figure legend:Extended Data Fig 2k-L|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient) - 2018/08/13 2018/08/14 rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090 rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090 rigid:B2mpTpv6JyJAO/lPRKD5AaWLBBE false sufficient binding region:1-428 sufficient binding region:1-428 6 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q80WG5 uniprotkb:Q80WG5 intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0 intact:EBI-20718010|ensembl:ENSMUSP00000092690|ensembl:ENSMUSP00000109284|ensembl:ENSMUSP00000139038|uniprotkb:A2AQZ0 psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym) psi-mi:lrc8a_mouse(display_long)|uniprotkb:Protein ebouriffe(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 8A(gene name synonym)|uniprotkb:Lrrc8a(gene name)|psi-mi:Lrrc8a(display_short)|uniprotkb:Lrrc8(gene name synonym) psi-mi:"MI:0104"(static light scattering) Deneka et al. (2018) imex:IM-26780|pubmed:29769723 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-20718121|imex:IM-26780-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1 ensembl:ENSMUSG00000099041(gene)|ensembl:ENSMUST00000095078(transcript)|ensembl:ENSMUST00000113654(transcript)|ensembl:ENSMUST00000139454(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002329"(pre-B cell differentiation)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0015734"(taurine transport)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034702"(ion channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140360"(cyclic-GMP-AMP transmembrane transporter activity)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|ensembl:ENSMUSG00000007476(gene)|interpro:IPR021040|interpro:IPR032675|mint:Q80WG5|rcsb pdb:6FNW|rcsb pdb:6G8Z|rcsb pdb:6G9L|rcsb pdb:6G9O|rcsb pdb:6NZW|rcsb pdb:6NZZ|rcsb pdb:6O00|rcsb pdb:7M17|rcsb pdb:7M19|reactome:R-MMU-5223345|refseq:NP_808393.1 - - - figure legend:Extended Data Fig 2L|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293s_gnti)|taxid:9606(HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient) - 2018/08/13 2018/08/14 rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090 rogid:a39hFvsEXuauN4cwEgT+rKHU3oo10090 rigid:B2mpTpv6JyJAO/lPRKD5AaWLBBE false sufficient binding region:1-428 sufficient binding region:1-428 6 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)