#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14332	uniprotkb:M4NKV9	intact:EBI-6254477|ensembl:ENSP00000323901|uniprotkb:Q0VG82	intact:EBI-20596828	psi-mi:fzd2_human(display_long)|uniprotkb:FZD2(gene name)|psi-mi:FZD2(display_short)|uniprotkb:FzE2(gene name synonym)	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20596877|imex:IM-28267-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180340(gene)|ensembl:ENST00000315323(transcript)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|interpro:IPR041778|rcsb pdb:6C0B|reactome:R-HSA-201681|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|reactome:R-HSA-5140745|refseq:NP_001457.1	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	-	-	-	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/06/28	rogid:xUZEXv3xJwlICF+75aayCbVPEpM9606	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rigid:5qAznzZ++pMkCqI0/JLiXerkxAQ	false	his tag:n-n|binding-associated region:24-156	binding-associated region:1285-1804(6C0B)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14332	uniprotkb:M4NKV9	intact:EBI-6254477|ensembl:ENSP00000323901|uniprotkb:Q0VG82	intact:EBI-20596828	psi-mi:fzd2_human(display_long)|uniprotkb:FZD2(gene name)|psi-mi:FZD2(display_short)|uniprotkb:FzE2(gene name synonym)	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:"MI:0969"(bio-layer interferometry)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20596916|imex:IM-28267-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180340(gene)|ensembl:ENST00000315323(transcript)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|interpro:IPR041778|rcsb pdb:6C0B|reactome:R-HSA-201681|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|reactome:R-HSA-5140745|refseq:NP_001457.1	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	-	-	-	figure legend:Figure S1, 4E, 4F, S7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.3x10^-8(molar)	2018/06/18	2020/08/13	rogid:xUZEXv3xJwlICF+75aayCbVPEpM9606	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rigid:5qAznzZ++pMkCqI0/JLiXerkxAQ	false	fc-igg tag:c-c|binding-associated region:29-168	binding-associated region:1285-1804|mutation decreasing interaction strength:1502-1502|mutation decreasing interaction strength:1510-1510,1512-1512|mutation decreasing interaction strength:1510-1510,1600-1600|mutation decreasing interaction strength:1434-1434|mutation disrupting interaction strength:1598-1598|mutation disrupting interaction strength:1598-1598|mutation disrupting interaction strength:1438-1438,1494-1494|mutation disrupting interaction strength:1434-1434,1438-1438,1494-1494|necessary binding region:1596-1601	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13467	uniprotkb:M4NKV9	intact:EBI-3913027|uniprotkb:Q53R22|intact:EBI-28987270|ensembl:ENSP00000354607|uniprotkb:A8K2X1|uniprotkb:B2RCZ1	intact:EBI-20596828	psi-mi:fzd5_human(display_long)|uniprotkb:FZD5(gene name)|psi-mi:FZD5(display_short)|uniprotkb:C2orf31(gene name synonym)|uniprotkb:FzE5(gene name synonym)	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:"MI:0969"(bio-layer interferometry)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20622487|imex:IM-28267-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003459.2|ensembl:ENSP00000354607|ensembl:ENSG00000163251(gene)|ensembl:ENST00000295417(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007416"(synapse assembly)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|go:"GO:0045202"(synapse)|interpro:IPR036790|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|interpro:IPR037441|rcsb pdb:5URY|rcsb pdb:5URZ|rcsb pdb:6O39|rcsb pdb:6WW2|go:"GO:0048471"(perinuclear region of cytoplasm)|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|reactome:R-HSA-4641263|reactome:R-HSA-5140745|reactome:R-HSA-5340588|go:"GO:0060061"(Spemann organizer formation)	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	-	-	-	figure legend:Figure 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/07/21	rogid:MoGzsWpiGoqv/NtqWfqL9ZmJXyA9606	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rigid:SAXoi7FF3KvNoZno4d8Z6DzvFME	false	his tag:c-c|binding-associated region:1-167|fc-igg tag:c-c	mutation decreasing interaction:1598-1598|ha tag:c-c|binding-associated region:1285-1804	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:M4NKV9	uniprotkb:Q14332	intact:EBI-20596828	intact:EBI-6254477|ensembl:ENSP00000323901|uniprotkb:Q0VG82	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:fzd2_human(display_long)|uniprotkb:FZD2(gene name)|psi-mi:FZD2(display_short)|uniprotkb:FzE2(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20622495|imex:IM-28267-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	ensembl:ENSG00000180340(gene)|ensembl:ENST00000315323(transcript)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|interpro:IPR041778|rcsb pdb:6C0B|reactome:R-HSA-201681|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|reactome:R-HSA-5140745|refseq:NP_001457.1	-	-	-	figure legend:Figure 4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2020/08/13	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rogid:xUZEXv3xJwlICF+75aayCbVPEpM9606	rigid:5qAznzZ++pMkCqI0/JLiXerkxAQ	false	ha tag:c-c|binding-associated region:1285-1804	fc-igg tag:c-c|binding-associated region:29-168	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56704	uniprotkb:Q14332	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	intact:EBI-6254477|ensembl:ENSP00000323901|uniprotkb:Q0VG82	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:fzd2_human(display_long)|uniprotkb:FZD2(gene name)|psi-mi:FZD2(display_short)|uniprotkb:FzE2(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20622694|imex:IM-28267-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	ensembl:ENSG00000180340(gene)|ensembl:ENST00000315323(transcript)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|interpro:IPR041778|rcsb pdb:6C0B|reactome:R-HSA-201681|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|reactome:R-HSA-5140745|refseq:NP_001457.1	-	-	-	figure legend:Figure 4E, Fig S7A, S7B, 4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2020/08/13	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	rogid:xUZEXv3xJwlICF+75aayCbVPEpM9606	rigid:zOZk3/kOzCCm/RJGDvbDXLhx9Jk	false	-	binding-associated region:29-168|fc-igg tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:M4NKV9	uniprotkb:Q9ULV1	intact:EBI-20596828	intact:EBI-2466380|ensembl:ENSP00000434034|uniprotkb:A8K9Q3|uniprotkb:Q14C97|uniprotkb:Q6S9E4	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:fzd4_human(display_long)|uniprotkb:FZD4(gene name)|psi-mi:FZD4(display_short)|uniprotkb:FzE4(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20638294|imex:IM-28267-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	reactome:R-HSA-8856828|reactome:R-HSA-8856825|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|ensembl:ENSG00000174804(gene)|ensembl:ENST00000531380(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|rcsb pdb:5BPB|rcsb pdb:5BPQ|rcsb pdb:5BQC|rcsb pdb:5BQE|rcsb pdb:5CL1|rcsb pdb:5CM4|rcsb pdb:5UWG|go:"GO:0060070"(canonical Wnt signaling pathway)|rcsb pdb:6BD4|rcsb pdb:6NE1|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5099900|reactome:R-HSA-5340588|refseq:NP_036325.2	-	-	-	figure legend:Fig S6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/07/19	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rogid:AMa+JdoYYdqHGs85YaqVNE+YGAY9606	rigid:+8rx4GXsZonB9mZ0MlcHDBFsoIk	false	ha tag:c-c|binding-associated region:1285-1804	binding-associated region:1-180|fc-igg tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:M4NKV9	uniprotkb:Q9H461	intact:EBI-20596828	intact:EBI-6254212|ensembl:ENSP00000363826	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:fzd8_human(display_long)|uniprotkb:FZD8(gene name)|psi-mi:FZD8(display_short)	psi-mi:"MI:0969"(bio-layer interferometry)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20638306|imex:IM-28267-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	ensembl:ENSG00000177283(gene)|ensembl:ENST00000374694(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:5UN5|rcsb pdb:5UN6|rcsb pdb:6NDZ|reactome:R-HSA-373080|reactome:R-HSA-4608870|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_114072.1	-	-	-	figure legend:Fig S6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/07/21	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rogid:4b66+WyB0ZsLi6KV5Rvcprf4jj49606	rigid:3G25VFjs2r20Q3gd753ClsFeo1E	false	binding-associated region:1285-1804|ha tag:c-c	binding-associated region:25-172|fc-igg tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:M4NKV9	uniprotkb:O00144	intact:EBI-20596828	intact:EBI-20638318|ensembl:ENSP00000345785	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:fzd9_human(display_long)|uniprotkb:FZD9(gene name)|psi-mi:FZD9(display_short)|uniprotkb:FZD3(gene name synonym)|uniprotkb:FzE6(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20638368|imex:IM-28267-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	ensembl:ENSG00000188763(gene)|ensembl:ENST00000344575(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007611"(learning or memory)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904394"(negative regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1990523"(bone regeneration)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|reactome:R-HSA-373080|refseq:NP_003499.1	-	-	-	figure legend:Fig S6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/07/19	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rogid:FhuOYWyfG8Sg1Aq3rGZLLZudbQA9606	rigid:bLi/C+yq1om3qTyA/0tjMoiDLTI	false	binding-associated region:1285-1804|ha tag:c-c	binding-associated region:23-185|fc-igg tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18177	uniprotkb:Q13467	intact:EBI-8536569|uniprotkb:M4NW36|intact:MINT-2634250	intact:EBI-3913027|uniprotkb:Q53R22|intact:EBI-28987270|ensembl:ENSP00000354607|uniprotkb:A8K2X1|uniprotkb:B2RCZ1	psi-mi:tcdb_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:toxB(gene name synonym)	psi-mi:fzd5_human(display_long)|uniprotkb:FZD5(gene name)|psi-mi:FZD5(display_short)|uniprotkb:C2orf31(gene name synonym)|uniprotkb:FzE5(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20638379|imex:IM-28267-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_009902069.1|interpro:IPR020974|interpro:IPR018337|interpro:IPR024772|interpro:IPR024769|interpro:IPR024770|interpro:IPR029044|interpro:IPR038383|mint:P18177|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0018243"(protein O-linked glycosylation via threonine)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035251"(UDP-glucosyltransferase activity)|go:"GO:0044083"(modulation by symbiont of host Rho protein signal transduction)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044174"(host cell endosome)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046527"(glucosyltransferase activity)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:2BVL|rcsb pdb:2BVM|rcsb pdb:4NC2|rcsb pdb:4NP4|rcsb pdb:5UQM|rcsb pdb:5UQN|rcsb pdb:5UQT|rcsb pdb:6AR6|rcsb pdb:6C0B|rcsb pdb:6OQ5|rcsb pdb:6OQ6|rcsb pdb:6OQ7|rcsb pdb:6OQ8|rcsb pdb:7ML7	refseq:NP_003459.2|ensembl:ENSP00000354607|ensembl:ENSG00000163251(gene)|ensembl:ENST00000295417(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007416"(synapse assembly)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|go:"GO:0045202"(synapse)|interpro:IPR036790|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|interpro:IPR037441|rcsb pdb:5URY|rcsb pdb:5URZ|rcsb pdb:6O39|rcsb pdb:6WW2|go:"GO:0048471"(perinuclear region of cytoplasm)|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|reactome:R-HSA-4641263|reactome:R-HSA-5140745|reactome:R-HSA-5340588|go:"GO:0060061"(Spemann organizer formation)	-	comment:mint|function:Cytotoxin	-	figure legend:Fig S6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/07/21	rogid:K4BbX+DMm7uUt0CrM1ONCFqaPwc1496	rogid:MoGzsWpiGoqv/NtqWfqL9ZmJXyA9606	rigid:s8WeHIfoobqhDmg0HUEmnyLJa2U	false	his tag:n-n	binding-associated region:1-167|his tag:c-c|fc-igg tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18177	uniprotkb:Q14332	intact:EBI-8536569|uniprotkb:M4NW36|intact:MINT-2634250	intact:EBI-6254477|ensembl:ENSP00000323901|uniprotkb:Q0VG82	psi-mi:tcdb_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:toxB(gene name synonym)	psi-mi:fzd2_human(display_long)|uniprotkb:FZD2(gene name)|psi-mi:FZD2(display_short)|uniprotkb:FzE2(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20638392|imex:IM-28267-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_009902069.1|interpro:IPR020974|interpro:IPR018337|interpro:IPR024772|interpro:IPR024769|interpro:IPR024770|interpro:IPR029044|interpro:IPR038383|mint:P18177|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0018243"(protein O-linked glycosylation via threonine)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035251"(UDP-glucosyltransferase activity)|go:"GO:0044083"(modulation by symbiont of host Rho protein signal transduction)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044174"(host cell endosome)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046527"(glucosyltransferase activity)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:2BVL|rcsb pdb:2BVM|rcsb pdb:4NC2|rcsb pdb:4NP4|rcsb pdb:5UQM|rcsb pdb:5UQN|rcsb pdb:5UQT|rcsb pdb:6AR6|rcsb pdb:6C0B|rcsb pdb:6OQ5|rcsb pdb:6OQ6|rcsb pdb:6OQ7|rcsb pdb:6OQ8|rcsb pdb:7ML7	ensembl:ENSG00000180340(gene)|ensembl:ENST00000315323(transcript)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|interpro:IPR041778|rcsb pdb:6C0B|reactome:R-HSA-201681|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|reactome:R-HSA-5140745|refseq:NP_001457.1	-	comment:mint|function:Cytotoxin	-	figure legend:Fig S7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2020/08/13	rogid:K4BbX+DMm7uUt0CrM1ONCFqaPwc1496	rogid:xUZEXv3xJwlICF+75aayCbVPEpM9606	rigid:S9wnd6JJiP/6kDZ3e72y4HByMTY	false	his tag:n-n	binding-associated region:29-168|fc-igg tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14332	uniprotkb:M4NKV9	intact:EBI-6254477|ensembl:ENSP00000323901|uniprotkb:Q0VG82	intact:EBI-20596828	psi-mi:fzd2_human(display_long)|uniprotkb:FZD2(gene name)|psi-mi:FZD2(display_short)|uniprotkb:FzE2(gene name synonym)	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:"MI:0096"(pull down)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20596893|wwpdb:6C0B|imex:IM-28267-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180340(gene)|ensembl:ENST00000315323(transcript)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|interpro:IPR041778|rcsb pdb:6C0B|reactome:R-HSA-201681|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|reactome:R-HSA-5140745|refseq:NP_001457.1	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	-	-	-	figure legend:Fig S3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/06/28	rogid:xUZEXv3xJwlICF+75aayCbVPEpM9606	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rigid:5qAznzZ++pMkCqI0/JLiXerkxAQ	false	his tag:n-n|binding-associated region:24-156	ha tag:c-c|binding-associated region:1285-1804|mutation disrupting interaction strength:1598-1598|mutation disrupting interaction strength:1598-1598|necessary binding region:1596-1601|mutation disrupting interaction strength:1438-1438,1494-1494|mutation disrupting interaction strength:1434-1434,1438-1438,1494-1494	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q13467	uniprotkb:M4NKV9	intact:EBI-3913027|uniprotkb:Q53R22|intact:EBI-28987270|ensembl:ENSP00000354607|uniprotkb:A8K2X1|uniprotkb:B2RCZ1	intact:EBI-20596828	psi-mi:fzd5_human(display_long)|uniprotkb:FZD5(gene name)|psi-mi:FZD5(display_short)|uniprotkb:C2orf31(gene name synonym)|uniprotkb:FzE5(gene name synonym)	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:"MI:0096"(pull down)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20597926|imex:IM-28267-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003459.2|ensembl:ENSP00000354607|ensembl:ENSG00000163251(gene)|ensembl:ENST00000295417(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007416"(synapse assembly)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|go:"GO:0045202"(synapse)|interpro:IPR036790|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|interpro:IPR037441|rcsb pdb:5URY|rcsb pdb:5URZ|rcsb pdb:6O39|rcsb pdb:6WW2|go:"GO:0048471"(perinuclear region of cytoplasm)|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|reactome:R-HSA-4641263|reactome:R-HSA-5140745|reactome:R-HSA-5340588|go:"GO:0060061"(Spemann organizer formation)	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	-	-	-	figure legend:Figure 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/07/21	rogid:MoGzsWpiGoqv/NtqWfqL9ZmJXyA9606	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rigid:SAXoi7FF3KvNoZno4d8Z6DzvFME	false	his tag:c-c|binding-associated region:1-167|fc-igg tag:c-c	ha tag:c-c	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13467	uniprotkb:P56704	intact:EBI-3913027|uniprotkb:Q53R22|intact:EBI-28987270|ensembl:ENSP00000354607|uniprotkb:A8K2X1|uniprotkb:B2RCZ1	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	psi-mi:fzd5_human(display_long)|uniprotkb:FZD5(gene name)|psi-mi:FZD5(display_short)|uniprotkb:C2orf31(gene name synonym)|uniprotkb:FzE5(gene name synonym)	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:"MI:0096"(pull down)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20620246|wwpdb:6C0B|imex:IM-28267-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003459.2|ensembl:ENSP00000354607|ensembl:ENSG00000163251(gene)|ensembl:ENST00000295417(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007416"(synapse assembly)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|go:"GO:0045202"(synapse)|interpro:IPR036790|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|interpro:IPR037441|rcsb pdb:5URY|rcsb pdb:5URZ|rcsb pdb:6O39|rcsb pdb:6WW2|go:"GO:0048471"(perinuclear region of cytoplasm)|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|reactome:R-HSA-4641263|reactome:R-HSA-5140745|reactome:R-HSA-5340588|go:"GO:0060061"(Spemann organizer formation)	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	-	-	-	figure legend:Figure 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/07/26	rogid:MoGzsWpiGoqv/NtqWfqL9ZmJXyA9606	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	rigid:hNAHiZWNumP/z1tyY0gVFRdkjLk	false	his tag:c-c|binding-associated region:1-180|fc-igg tag:c-c	-	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13467	uniprotkb:M4NKV9	intact:EBI-3913027|uniprotkb:Q53R22|intact:EBI-28987270|ensembl:ENSP00000354607|uniprotkb:A8K2X1|uniprotkb:B2RCZ1	intact:EBI-20596828	psi-mi:fzd5_human(display_long)|uniprotkb:FZD5(gene name)|psi-mi:FZD5(display_short)|uniprotkb:C2orf31(gene name synonym)|uniprotkb:FzE5(gene name synonym)	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:"MI:0096"(pull down)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20620246|wwpdb:6C0B|imex:IM-28267-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003459.2|ensembl:ENSP00000354607|ensembl:ENSG00000163251(gene)|ensembl:ENST00000295417(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007416"(synapse assembly)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|go:"GO:0045202"(synapse)|interpro:IPR036790|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|interpro:IPR037441|rcsb pdb:5URY|rcsb pdb:5URZ|rcsb pdb:6O39|rcsb pdb:6WW2|go:"GO:0048471"(perinuclear region of cytoplasm)|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|reactome:R-HSA-4641263|reactome:R-HSA-5140745|reactome:R-HSA-5340588|go:"GO:0060061"(Spemann organizer formation)	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	-	-	-	figure legend:Figure 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/07/26	rogid:MoGzsWpiGoqv/NtqWfqL9ZmJXyA9606	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rigid:hNAHiZWNumP/z1tyY0gVFRdkjLk	false	his tag:c-c|binding-associated region:1-180|fc-igg tag:c-c	binding-associated region:1285-1804|ha tag:c-c	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q14332	uniprotkb:M4NKV9	intact:EBI-6254477|ensembl:ENSP00000323901|uniprotkb:Q0VG82	intact:EBI-20596828	psi-mi:fzd2_human(display_long)|uniprotkb:FZD2(gene name)|psi-mi:FZD2(display_short)|uniprotkb:FzE2(gene name synonym)	psi-mi:m4nkv9_clodi(display_long)|uniprotkb:tcdB(gene name)|psi-mi:tcdB(display_short)|uniprotkb:SAMEA1531904_03703(orf name)	psi-mi:"MI:0096"(pull down)	Chen et al. (2018)	pubmed:29748286|imex:IM-28267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1496(clodi)|taxid:1496(Clostridium difficile)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20638999|imex:IM-28267-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180340(gene)|ensembl:ENST00000315323(transcript)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060022"(hard palate development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026550|interpro:IPR036790|interpro:IPR041778|rcsb pdb:6C0B|reactome:R-HSA-201681|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4608870|reactome:R-HSA-4641262|reactome:R-HSA-5140745|refseq:NP_001457.1	refseq:WP_003426838.1|interpro:IPR018337|interpro:IPR020974|interpro:IPR038383|interpro:IPR029044|interpro:IPR024770|interpro:IPR024772|interpro:IPR024769|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0090729"(toxin activity)|rcsb pdb:6OQ5|rcsb pdb:6OQ7	-	-	-	figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/18	2018/07/21	rogid:xUZEXv3xJwlICF+75aayCbVPEpM9606	rogid:9gud/OIj33uLwj0LHaIxUAhMo641496	rigid:5qAznzZ++pMkCqI0/JLiXerkxAQ	false	his tag:n-n|binding-associated region:24-156	ha tag:c-c|sufficient binding region:1285-1804|necessary binding region:1285-1429	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0396"(predetermined participant)