#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19156	uniprotkb:P18434	intact:EBI-8803609	intact:EBI-9009115|ensembl:ENSSSCP00000010209|ensembl:ENSSSCP00015002694|ensembl:ENSSSCP00025015510|ensembl:ENSSSCP00030004910|ensembl:ENSSSCP00035017407|ensembl:ENSSSCP00040011090|ensembl:ENSSSCP00045041137|ensembl:ENSSSCP00045041168|ensembl:ENSSSCP00050020855|ensembl:ENSSSCP00050020860|ensembl:ENSSSCP00055046428|ensembl:ENSSSCP00055046442|ensembl:ENSSSCP00060022633|ensembl:ENSSSCP00060022636|ensembl:ENSSSCP00065048656|ensembl:ENSSSCP00065048668|ensembl:ENSSSCP00070021829	psi-mi:atp4a_pig(display_long)|uniprotkb:ATP4A(gene name)|psi-mi:ATP4A(display_short)|uniprotkb:"Gastric H(+)/K(+) ATPase subunit alpha"(gene name synonym)|uniprotkb:Proton pump(gene name synonym)	psi-mi:atp4b_pig(display_long)|uniprotkb:ATP4B(gene name)|psi-mi:ATP4B(display_short)|uniprotkb:"Gastric H(+)/K(+) ATPase subunit beta"(gene name synonym)|uniprotkb:Proton pump beta chain(gene name synonym)|uniprotkb:gp60-90(gene name synonym)	psi-mi:"MI:0096"(pull down)	Abe et al. (2018)	pubmed:29618813|imex:IM-26797	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20644891|wwpdb:5LYU|wwpdb:5YLV|imex:IM-26797-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:5YLV|rcsb pdb:6JXH|rcsb pdb:6JXI|rcsb pdb:6JXJ|rcsb pdb:6JXK|rcsb pdb:5YLU|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0008900"("P-type potassium:proton transporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030955"(potassium ion binding)|rcsb pdb:1IWC|rcsb pdb:1IWF|rcsb pdb:2XZB|rcsb pdb:2YN9|rcsb pdb:3IXZ|rcsb pdb:4UX1|rcsb pdb:4UX2|rcsb pdb:5Y0B|interpro:IPR044492|interpro:IPR023214|mint:P19156|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR023299|interpro:IPR015127(Gastric H+/K+-ATPase, N terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR018303|interpro:IPR023298|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_999456.1|interpro:IPR036412	refseq:XP_005653896.1|refseq:NP_001001258.1|ensembl:ENSSSCG00035032852(gene)|ensembl:ENSSSCG00040019363(gene)|ensembl:ENSSSCG00045034353(gene)|ensembl:ENSSSCG00050037103(gene)|ensembl:ENSSSCG00055029233(gene)|ensembl:ENSSSCG00060039283(gene)|ensembl:ENSSSCG00065078438(gene)|ensembl:ENSSSCG00070013475(gene)|ensembl:ENSSSCT00000010481(transcript)|ensembl:ENSSSCT00015006532(transcript)|ensembl:ENSSSCT00025037061(transcript)|ensembl:ENSSSCT00030011096(transcript)|ensembl:ENSSSCT00035043522(transcript)|ensembl:ENSSSCT00040026224(transcript)|ensembl:ENSSSCT00045058795(transcript)|ensembl:ENSSSCT00045058834(transcript)|ensembl:ENSSSCT00050049928(transcript)|ensembl:ENSSSCT00050049935(transcript)|ensembl:ENSSSCT00055058033(transcript)|ensembl:ENSSSCT00055058052(transcript)|ensembl:ENSSSCT00060053134(transcript)|ensembl:ENSSSCT00060053141(transcript)|ensembl:ENSSSCT00065108712(transcript)|ensembl:ENSSSCT00065108726(transcript)|ensembl:ENSSSCT00070026294(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|ensembl:ENSSSCG00000009561(gene)|ensembl:ENSSSCG00015004859(gene)|ensembl:ENSSSCG00025027365(gene)|ensembl:ENSSSCG00030008180(gene)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|interpro:IPR038702|rcsb pdb:2XZB|rcsb pdb:2YN9|rcsb pdb:3IXZ|rcsb pdb:4UX1|rcsb pdb:4UX2|rcsb pdb:5Y0B|rcsb pdb:5YLU|rcsb pdb:5YLV|rcsb pdb:6JXH|rcsb pdb:6JXI|rcsb pdb:6JXJ|rcsb pdb:6JXK|reactome:R-SSC-936837	-	-	-	figure legend:Extended Data Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2018/07/23	2018/07/26	rogid:m8bA8B+lPl4xS0JRPay8bHtcPnc9823	rogid:QMrke8SbB+IWycJcwDFiKwaKkfA9823	rigid:Gp42nVPAn1FSNHINdsCGCkF7NCs	false	binding-associated region:48-c	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P19156	uniprotkb:P18434	intact:EBI-8803609	intact:EBI-9009115|ensembl:ENSSSCP00000010209|ensembl:ENSSSCP00015002694|ensembl:ENSSSCP00025015510|ensembl:ENSSSCP00030004910|ensembl:ENSSSCP00035017407|ensembl:ENSSSCP00040011090|ensembl:ENSSSCP00045041137|ensembl:ENSSSCP00045041168|ensembl:ENSSSCP00050020855|ensembl:ENSSSCP00050020860|ensembl:ENSSSCP00055046428|ensembl:ENSSSCP00055046442|ensembl:ENSSSCP00060022633|ensembl:ENSSSCP00060022636|ensembl:ENSSSCP00065048656|ensembl:ENSSSCP00065048668|ensembl:ENSSSCP00070021829	psi-mi:atp4a_pig(display_long)|uniprotkb:ATP4A(gene name)|psi-mi:ATP4A(display_short)|uniprotkb:"Gastric H(+)/K(+) ATPase subunit alpha"(gene name synonym)|uniprotkb:Proton pump(gene name synonym)	psi-mi:atp4b_pig(display_long)|uniprotkb:ATP4B(gene name)|psi-mi:ATP4B(display_short)|uniprotkb:"Gastric H(+)/K(+) ATPase subunit beta"(gene name synonym)|uniprotkb:Proton pump beta chain(gene name synonym)|uniprotkb:gp60-90(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Abe et al. (2018)	pubmed:29618813|imex:IM-26797	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20650961|wwpdb:5YLU|wwpdb:5YLV|imex:IM-26797-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:5YLV|rcsb pdb:6JXH|rcsb pdb:6JXI|rcsb pdb:6JXJ|rcsb pdb:6JXK|rcsb pdb:5YLU|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0008900"("P-type potassium:proton transporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030955"(potassium ion binding)|rcsb pdb:1IWC|rcsb pdb:1IWF|rcsb pdb:2XZB|rcsb pdb:2YN9|rcsb pdb:3IXZ|rcsb pdb:4UX1|rcsb pdb:4UX2|rcsb pdb:5Y0B|interpro:IPR044492|interpro:IPR023214|mint:P19156|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR023299|interpro:IPR015127(Gastric H+/K+-ATPase, N terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR018303|interpro:IPR023298|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_999456.1|interpro:IPR036412	refseq:XP_005653896.1|refseq:NP_001001258.1|ensembl:ENSSSCG00035032852(gene)|ensembl:ENSSSCG00040019363(gene)|ensembl:ENSSSCG00045034353(gene)|ensembl:ENSSSCG00050037103(gene)|ensembl:ENSSSCG00055029233(gene)|ensembl:ENSSSCG00060039283(gene)|ensembl:ENSSSCG00065078438(gene)|ensembl:ENSSSCG00070013475(gene)|ensembl:ENSSSCT00000010481(transcript)|ensembl:ENSSSCT00015006532(transcript)|ensembl:ENSSSCT00025037061(transcript)|ensembl:ENSSSCT00030011096(transcript)|ensembl:ENSSSCT00035043522(transcript)|ensembl:ENSSSCT00040026224(transcript)|ensembl:ENSSSCT00045058795(transcript)|ensembl:ENSSSCT00045058834(transcript)|ensembl:ENSSSCT00050049928(transcript)|ensembl:ENSSSCT00050049935(transcript)|ensembl:ENSSSCT00055058033(transcript)|ensembl:ENSSSCT00055058052(transcript)|ensembl:ENSSSCT00060053134(transcript)|ensembl:ENSSSCT00060053141(transcript)|ensembl:ENSSSCT00065108712(transcript)|ensembl:ENSSSCT00065108726(transcript)|ensembl:ENSSSCT00070026294(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|ensembl:ENSSSCG00000009561(gene)|ensembl:ENSSSCG00015004859(gene)|ensembl:ENSSSCG00025027365(gene)|ensembl:ENSSSCG00030008180(gene)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|interpro:IPR038702|rcsb pdb:2XZB|rcsb pdb:2YN9|rcsb pdb:3IXZ|rcsb pdb:4UX1|rcsb pdb:4UX2|rcsb pdb:5Y0B|rcsb pdb:5YLU|rcsb pdb:5YLV|rcsb pdb:6JXH|rcsb pdb:6JXI|rcsb pdb:6JXJ|rcsb pdb:6JXK|reactome:R-SSC-936837	-	-	-	figure legend:Extended Data Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293s)|taxid:9606(Human 293S cell line)	-	2018/07/23	2018/07/26	rogid:m8bA8B+lPl4xS0JRPay8bHtcPnc9823	rogid:QMrke8SbB+IWycJcwDFiKwaKkfA9823	rigid:Gp42nVPAn1FSNHINdsCGCkF7NCs	false	binding-associated region:48-c	-	1	1	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)