#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49768	uniprotkb:Q9NZC2	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2017)	pubmed:29611543|imex:IM-26853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20770901|imex:IM-26853-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	-	-	figure legend:Fig. 1A, 1D, 1E|comment:Confirmation that PSEN1 was cleaved into chains was by molecular weight in addition to antibody staining.|comment:Inhibition of gamma- secretase activity did not affect PS1/TREM2 co-precipitation|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/10/09	2018/10/10	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:fSgjEPDY9l/GGrC/2rm1ZzVTn1c	false	sufficient binding region:1-298|sufficient binding region:299-467|mutation with no effect:385-385	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49768	uniprotkb:Q9NZC2	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhao et al. (2017)	pubmed:29611543|imex:IM-26853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20770914|imex:IM-26853-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	-	-	figure legend:Fig. 1B|comment:Confirmation that PSEN1 was cleaved into chains was by molecular weight in addition to antibody staining.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/10/09	2019/01/21	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:R2F3fW6mhjPxtvy04NbYA/8gHnI	false	sufficient binding region:1-298|sufficient binding region:299-467	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49768	uniprotkb:Q92542	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	intact:EBI-998440|uniprotkb:Q86VV5|uniprotkb:Q5T207|ensembl:ENSP00000294785|uniprotkb:Q5T208	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:nica_human(display_long)|uniprotkb:NCSTN(gene name)|psi-mi:NCSTN(display_short)|uniprotkb:KIAA0253(gene name synonym)|uniprotkb:UNQ1874/PRO4317(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhao et al. (2017)	pubmed:29611543|imex:IM-26853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20770914|imex:IM-26853-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|rcsb pdb:6LQG|reactome:R-HSA-977225|ensembl:ENSG00000162736(gene)|ensembl:ENST00000294785(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:Q92542|rcsb pdb:2N7Q|rcsb pdb:2N7R|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|refseq:NP_056146.1|refseq:NP_001277113.1|refseq:NP_001277115.1|dip:DIP-36336N	-	-	-	figure legend:Fig. 1B|comment:Confirmation that PSEN1 was cleaved into chains was by molecular weight in addition to antibody staining.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/10/09	2019/01/21	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	rogid:Lf6xGDVDkOQXMUuG3Yn0tayAjF89606	rigid:R2F3fW6mhjPxtvy04NbYA/8gHnI	false	sufficient binding region:1-298|sufficient binding region:299-467	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P57716	uniprotkb:Q99NH8	intact:EBI-998934|uniprotkb:E9QLZ6|uniprotkb:Q8VE20|ensembl:ENSMUSP00000003550	intact:EBI-15982016|ensembl:ENSMUSP00000024791|uniprotkb:Q8CGK4|uniprotkb:Q8CIA6|uniprotkb:Q99NH9|uniprotkb:Q9JL34	psi-mi:nica_mouse(display_long)|uniprotkb:Ncstn(gene name)|psi-mi:Ncstn(display_short)	psi-mi:trem2_mouse(display_long)|uniprotkb:Trem2(gene name)|psi-mi:Trem2(display_short)|uniprotkb:Trem2a(gene name synonym)|uniprotkb:Trem2b(gene name synonym)|uniprotkb:Trem2c(gene name synonym)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhao et al. (2017)	pubmed:29611543|imex:IM-26853	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20770946|imex:IM-26853-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067620.3|ensembl:ENSMUSG00000003458(gene)|ensembl:ENSMUST00000003550(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045202"(synapse)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0070997"(neuron death)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:P57716|reactome:R-MMU-1251985|reactome:R-MMU-193692|reactome:R-MMU-205043|reactome:R-MMU-3928665|reactome:R-MMU-6798695|reactome:R-MMU-9013507|reactome:R-MMU-9017802|go:"GO:0008233"(peptidase activity)|dip:DIP-36334N	ensembl:ENSMUSG00000023992(gene)|ensembl:ENSMUST00000024791(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-2172127|reactome:R-MMU-2424491|reactome:R-MMU-416700|refseq:NP_001259007.1|refseq:NP_112544.1|dip:DIP-59896N	-	-	-	figure legend:Fig. 1C|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bv2)|taxid:10090(Mouse BV2 glioma cells)	-	2018/10/09	2019/01/21	rogid:l0mFGFYhwC38vnSRAy9oQuroZ8010090	rogid:GryhnogotbUPy3+Xd/ty/3ibKZ010090	rigid:939ABfNXf3wT05BJkNeFeJUvFfc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49768	uniprotkb:Q9NZC2	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhao et al. (2017)	pubmed:29611543|imex:IM-26853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20770973|imex:IM-26853-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	-	-	figure legend:Fig. 1G|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/10/09	2018/10/10	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:fSgjEPDY9l/GGrC/2rm1ZzVTn1c	false	-	glutathione s tranferase tag:c-c|necessary binding region:175-195	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49768	uniprotkb:Q9NZC2	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhao et al. (2017)	pubmed:29611543|imex:IM-26853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20771001|imex:IM-26853-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	go:"GO:0005794"(Golgi apparatus)	-	-	figure legend:Fig. 2A-2C|comment:Confirmation that PSEN1 was cleaved into chains was by molecular weight in addition to antibody staining.|comment:Inhibition of gamma- secretase activity did not affect PS1/TREM2 co-precipitation|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/10/09	2018/10/10	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:fSgjEPDY9l/GGrC/2rm1ZzVTn1c	false	-	mutation with no effect:66-66|myc tag:c-c|mutation with no effect:47-47|mutation with no effect:96-96	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P49768	uniprotkb:Q9NZC2	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhao et al. (2017)	pubmed:29611543|imex:IM-26853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20771032|imex:IM-26853-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	-	-	figure legend:Fig. 2D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/10/09	2019/01/21	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:R2F3fW6mhjPxtvy04NbYA/8gHnI	false	-	mutation decreasing interaction strength:66-66|myc tag:c-c|mutation with no effect:47-47|mutation with no effect:96-96	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49768	uniprotkb:Q92542	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	intact:EBI-998440|uniprotkb:Q86VV5|uniprotkb:Q5T207|ensembl:ENSP00000294785|uniprotkb:Q5T208	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:nica_human(display_long)|uniprotkb:NCSTN(gene name)|psi-mi:NCSTN(display_short)|uniprotkb:KIAA0253(gene name synonym)|uniprotkb:UNQ1874/PRO4317(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhao et al. (2017)	pubmed:29611543|imex:IM-26853	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20771032|imex:IM-26853-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|rcsb pdb:6LQG|reactome:R-HSA-977225|ensembl:ENSG00000162736(gene)|ensembl:ENST00000294785(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:Q92542|rcsb pdb:2N7Q|rcsb pdb:2N7R|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|refseq:NP_056146.1|refseq:NP_001277113.1|refseq:NP_001277115.1|dip:DIP-36336N	-	-	-	figure legend:Fig. 2D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/10/09	2019/01/21	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	rogid:Lf6xGDVDkOQXMUuG3Yn0tayAjF89606	rigid:R2F3fW6mhjPxtvy04NbYA/8gHnI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)