#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A0A062UZ78	uniprotkb:A0A062UZ78	intact:EBI-20596003|ensemblbacteria:KCZ72241	intact:EBI-20596003|ensemblbacteria:KCZ72241	psi-mi:a0a062uz78_9eury(display_long)|uniprotkb:ANME2D_01646(orf name)	psi-mi:a0a062uz78_9eury(display_long)|uniprotkb:ANME2D_01646(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Dong et al. (2018)	pubmed:29590073|imex:IM-26714	taxid:1392998(Candidatus Methanoperedens nitroreducens)|taxid:1392998(Candidatus Methanoperedens nitroreducens)	taxid:1392998(Candidatus Methanoperedens nitroreducens)|taxid:1392998(Candidatus Methanoperedens nitroreducens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20596015|wwpdb:6BXM|wwpdb:6BXN|wwpdb:6BXO|imex:IM-26714-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035435|interpro:IPR022428|refseq:WP_048090324.1|rcsb pdb:6BXM|rcsb pdb:6BXN|rcsb pdb:6BXO|interpro:IPR016435(Diphthamide synthesis, DHP1)|ensemblbacteria:ANME2D_01646(gene)|ensemblbacteria:KCZ72241(transcript)|go:"GO:0017183"(peptidyl-diphthamide biosynthetic process from peptidyl-histidine)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0090560"("2-(3-amino-3-carboxypropyl)histidine synthase activity")|interpro:IPR042263|interpro:IPR042264|interpro:IPR042265	interpro:IPR035435|interpro:IPR022428|refseq:WP_048090324.1|rcsb pdb:6BXM|rcsb pdb:6BXN|rcsb pdb:6BXO|interpro:IPR016435(Diphthamide synthesis, DHP1)|ensemblbacteria:ANME2D_01646(gene)|ensemblbacteria:KCZ72241(transcript)|go:"GO:0017183"(peptidyl-diphthamide biosynthetic process from peptidyl-histidine)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0090560"("2-(3-amino-3-carboxypropyl)histidine synthase activity")|interpro:IPR042263|interpro:IPR042264|interpro:IPR042265	-	-	-	figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/26	2018/06/27	rogid:litb53542JJUskwNqCVDY34Ywss1392998	rogid:litb53542JJUskwNqCVDY34Ywss1392998	rigid:gdtbKpKOoQ3yapJjMTUH23CQOjs	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O58832	uniprotkb:O58832	intact:EBI-20595984|ensemblbacteria:BAA30204	intact:EBI-20595984|ensemblbacteria:BAA30204	psi-mi:dph2_pyrho(display_long)|uniprotkb:Diphthamide biosynthesis protein Dph2(gene name synonym)|uniprotkb:"S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase"(gene name synonym)|uniprotkb:PH1105(locus name)|uniprotkb:dph2(gene name)|psi-mi:dph2(display_short)	psi-mi:dph2_pyrho(display_long)|uniprotkb:Diphthamide biosynthesis protein Dph2(gene name synonym)|uniprotkb:"S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase"(gene name synonym)|uniprotkb:PH1105(locus name)|uniprotkb:dph2(gene name)|psi-mi:dph2(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Dong et al. (2018)	pubmed:29590073|imex:IM-26714	taxid:70601(pyrho)|taxid:70601(Pyrococcus horikoshii)	taxid:70601(pyrho)|taxid:70601(Pyrococcus horikoshii)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20596100|wwpdb:6BXK|wwpdb:6BXL|imex:IM-26714-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_010885188.1|rcsb pdb:3LZC|rcsb pdb:3LZD|rcsb pdb:6BXK|rcsb pdb:6BXL|interpro:IPR016435(Diphthamide synthesis, DHP1)|interpro:IPR035435|interpro:IPR022428|ensemblbacteria:BAA30204(gene)|ensemblbacteria:BAA30204(transcript)|go:"GO:0016765"("transferase activity, transferring alkyl or aryl (other than methyl) groups")|go:"GO:0017183"(peptidyl-diphthamide biosynthetic process from peptidyl-histidine)|go:"GO:0046872"(metal ion binding)|go:"GO:0050843"(S-adenosylmethionine catabolic process)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0090560"("2-(3-amino-3-carboxypropyl)histidine synthase activity")|interpro:IPR042263|interpro:IPR042264|interpro:IPR042265	refseq:WP_010885188.1|rcsb pdb:3LZC|rcsb pdb:3LZD|rcsb pdb:6BXK|rcsb pdb:6BXL|interpro:IPR016435(Diphthamide synthesis, DHP1)|interpro:IPR035435|interpro:IPR022428|ensemblbacteria:BAA30204(gene)|ensemblbacteria:BAA30204(transcript)|go:"GO:0016765"("transferase activity, transferring alkyl or aryl (other than methyl) groups")|go:"GO:0017183"(peptidyl-diphthamide biosynthetic process from peptidyl-histidine)|go:"GO:0046872"(metal ion binding)|go:"GO:0050843"(S-adenosylmethionine catabolic process)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0090560"("2-(3-amino-3-carboxypropyl)histidine synthase activity")|interpro:IPR042263|interpro:IPR042264|interpro:IPR042265	-	-	-	figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/06/26	2018/06/27	rogid:HXfxThIchKrVVzV7YVsKrK/T14o70601	rogid:HXfxThIchKrVVzV7YVsKrK/T14o70601	rigid:SB1uLcvWuR/oqv+s9L4H8RTIXQw	false	his tag:n-n	his tag:n-n	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)