#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14793	uniprotkb:O14793	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Cotton et al. (2018)	imex:IM-26649|pubmed:29330193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717236|wwpdb:5NXS|wwpdb:5NTU|imex:IM-26649-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	-	comment:mint|comment:homomint	comment:mint|comment:homomint	figure legend:Figure 3A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2018/08/09	2018/08/09	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rigid:LiAlOshFQwkJwyd8vozaBBzC3is	false	mutation:319-319,320-320,217-217,218-218,220-220|binding-associated region:19-375	mutation:319-319,320-320,217-217,218-218,220-220|binding-associated region:19-375	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14793	uniprotkb:O14793	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Cotton et al. (2018)	imex:IM-26649|pubmed:29330193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717146|imex:IM-26649-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	-	comment:mint|comment:homomint	comment:mint|comment:homomint	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/09	2018/08/09	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rigid:LiAlOshFQwkJwyd8vozaBBzC3is	false	binding-associated region:19-375|his tag:n-n	binding-associated region:19-375|his tag:n-n	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14793-PRO_0000033951	uniprotkb:O14793-PRO_0000033950	intact:EBI-20717179	intact:EBI-20717185	psi-mi:o14793-pro_0000033951(display_long)|uniprotkb:Myostatin(gene name synonym)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)	psi-mi:o14793-pro_0000033950(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Cotton et al. (2018)	imex:IM-26649|pubmed:29330193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717191|imex:IM-26649-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8542977(chain-parent)	intact:EBI-8542977(chain-parent)|uniprotkb:O14793(chain-parent)	-	chain-seq-start:267|chain-seq-end:375	chain-seq-start:24|chain-seq-end:266	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/09	2022/01/21	rogid:uprLlEiN9D8BkF6QGU9Wi3ATGag9606	rogid:ijwcxTXx3HYJaKONdJNIxN0X3P09606	rigid:YlNftn9LH0jX0fBWFxZ+zp6CNWM	false	-	his tag:n-n	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14793	uniprotkb:O14793	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:"MI:0104"(static light scattering)	Cotton et al. (2018)	imex:IM-26649|pubmed:29330193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717159|imex:IM-26649-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	-	comment:mint|comment:homomint	comment:mint|comment:homomint	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/09	2018/08/09	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rigid:LiAlOshFQwkJwyd8vozaBBzC3is	false	binding-associated region:19-375|his tag:n-n	binding-associated region:19-375|his tag:n-n	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14793-PRO_0000033951	uniprotkb:O14793-PRO_0000033950	intact:EBI-20717179	intact:EBI-20717185	psi-mi:o14793-pro_0000033951(display_long)|uniprotkb:Myostatin(gene name synonym)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)	psi-mi:o14793-pro_0000033950(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:"MI:0104"(static light scattering)	Cotton et al. (2018)	imex:IM-26649|pubmed:29330193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717204|imex:IM-26649-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8542977(chain-parent)	intact:EBI-8542977(chain-parent)|uniprotkb:O14793(chain-parent)	-	chain-seq-start:267|chain-seq-end:375	chain-seq-start:24|chain-seq-end:266	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/09	2022/01/21	rogid:uprLlEiN9D8BkF6QGU9Wi3ATGag9606	rogid:ijwcxTXx3HYJaKONdJNIxN0X3P09606	rigid:YlNftn9LH0jX0fBWFxZ+zp6CNWM	false	-	his tag:n-n	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14793	uniprotkb:O14793	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	intact:EBI-8542977|uniprotkb:A1C2J7|intact:MINT-7914825|uniprotkb:Q6B0H2|uniprotkb:A1C2K0|ensembl:ENSP00000260950	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:gdf8_human(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Cotton et al. (2018)	imex:IM-26649|pubmed:29330193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0195"(covalent binding)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717172|imex:IM-26649-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	refseq:NP_005250.1|ensembl:ENSG00000138379(gene)|ensembl:ENST00000260950(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:5F3B|rcsb pdb:5F3H|rcsb pdb:5NTU|rcsb pdb:5NXS|rcsb pdb:6UMX|reactome:R-HSA-9617828	-	comment:mint|comment:homomint	comment:mint|comment:homomint	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/09	2018/08/09	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rogid:ezevGAU8nzCISaZvzi5qmWYx5Jg9606	rigid:LiAlOshFQwkJwyd8vozaBBzC3is	false	binding-associated region:19-375|his tag:n-n	binding-associated region:19-375|his tag:n-n	2	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14793-PRO_0000033951	uniprotkb:O14793-PRO_0000033951	intact:EBI-20717179	intact:EBI-20717179	psi-mi:o14793-pro_0000033951(display_long)|uniprotkb:Myostatin(gene name synonym)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)	psi-mi:o14793-pro_0000033951(display_long)|uniprotkb:Myostatin(gene name synonym)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Cotton et al. (2018)	imex:IM-26649|pubmed:29330193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717220|imex:IM-26649-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8542977(chain-parent)	intact:EBI-8542977(chain-parent)	-	chain-seq-start:267|chain-seq-end:375	chain-seq-start:267|chain-seq-end:375	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/09	2018/08/09	rogid:uprLlEiN9D8BkF6QGU9Wi3ATGag9606	rogid:uprLlEiN9D8BkF6QGU9Wi3ATGag9606	rigid:eB0hygwt2Z5hzfVxqCveCgwVpoo	false	-	-	2	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:O14793-PRO_0000033951	uniprotkb:O14793-PRO_0000033950	intact:EBI-20717179	intact:EBI-20717185	psi-mi:o14793-pro_0000033951(display_long)|uniprotkb:Myostatin(gene name synonym)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)	psi-mi:o14793-pro_0000033950(display_long)|uniprotkb:MSTN(gene name)|psi-mi:MSTN(display_short)|uniprotkb:GDF8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Cotton et al. (2018)	imex:IM-26649|pubmed:29330193	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20717311|imex:IM-26649-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8542977(chain-parent)	intact:EBI-8542977(chain-parent)|uniprotkb:O14793(chain-parent)	-	chain-seq-start:267|chain-seq-end:375	chain-seq-start:24|chain-seq-end:266	figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/08/09	2022/01/21	rogid:uprLlEiN9D8BkF6QGU9Wi3ATGag9606	rogid:ijwcxTXx3HYJaKONdJNIxN0X3P09606	rigid:YlNftn9LH0jX0fBWFxZ+zp6CNWM	false	-	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)