#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00206	uniprotkb:P24821	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16824996|imex:IM-26347-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	-	-	-	figure legend:Figure 1F-1,2C, 4, Supp Table 4|comment:Mutant 4 exhibited a slight reduction in binding to TLR4, however mutant 5 showed a significant reduction in the affinity for TLR4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:58.0x10^-9(molar)	2018/02/27	2018/03/02	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rigid:z4lCg0M1F1PBC5XM+UDlzP9Geic	false	sufficient binding region:24-631|his tag:c-c(IPR032675)	sufficient binding region:1973-2201(IPR002181)|his tag:?-?|mutation decreasing interaction strength:2096-2096,2098-2098|mutation decreasing interaction strength:2100-2100,2102-2102|mutation decreasing interaction strength:2096-2096,2098-2098,2102-2102,2100-2100|mutation decreasing interaction strength:2197-2198,2199-2201|mutation disrupting interaction strength:2199-2201,2197-2198,2096-2096,2098-2098,2100-2100,2102-2102|mutation decreasing interaction strength:2130-2130,2133-2133,2135-2135|mutation decreasing interaction strength:2130-2130,2133-2133,2135-2135,2096-2096,2098-2098,2100-2100,2102-2102	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:Q92752	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-3956837|uniprotkb:C9J563|uniprotkb:Q15568|uniprotkb:Q5R3G0|ensembl:ENSP00000263525|ensembl:ENSP00000356646	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:tenr_human(display_long)|uniprotkb:TNR(gene name)|psi-mi:TNR(display_short)|uniprotkb:Janusin(gene name synonym)|uniprotkb:Restrictin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825013|imex:IM-26347-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	ensembl:ENSG00000116147(gene)|ensembl:ENST00000263525(transcript)|ensembl:ENST00000367674(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0009986"(cell surface)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0045121"(membrane raft)|go:"GO:0048692"(negative regulation of axon extension involved in regeneration)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0008306"(associative learning)|go:"GO:0072534"(perineuronal net)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR033079|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|reactome:R-HSA-3000178|refseq:NP_003276.3|refseq:XP_016857707.1|refseq:XP_016857708.1	-	-	-	figure legend:Figure 1F-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:51.0x10^-9(molar)	2018/02/27	2018/03/02	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:PUp2ahH21aI8L9e9+EKujEOmWlo9606	rigid:NszuHMRBGYxEDvpCJihFSCZzNnU	false	sufficient binding region:24-631|his tag:c-c(IPR032675)	sufficient binding region:1128-1358(IPR002181)|his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:Q9UQP3	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-13640827|ensembl:ENSP00000239462|uniprotkb:A0A0A6YY94|uniprotkb:B9EGP3|uniprotkb:Q5R360	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:tenn_human(display_long)|uniprotkb:TNW(gene name synonym)|uniprotkb:Tenascin-W(gene name synonym)|uniprotkb:TNN(gene name)|psi-mi:TNN(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825031|imex:IM-26347-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	ensembl:ENSG00000120332(gene)|ensembl:ENST00000239462(transcript)|go:"GO:0002076"(osteoblast development)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0097442"(CA3 pyramidal cell dendrite)|go:"GO:1905240"(negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation)|go:"GO:1990026"(hippocampal mossy fiber expansion)|go:"GO:1990138"(neuron projection extension)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|reactome:R-HSA-3000178|refseq:NP_071376.1	-	-	-	figure legend:Figure 1F-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:58.0x10^-9(molar)	2018/02/27	2018/03/02	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:Vs4Px3N3yr3PK2/8j6Xsu8SokMM9606	rigid:kIhSE1U7YoP+2SOX/DfSpoTzMDA	false	sufficient binding region:24-631|his tag:c-c(IPR032675)	sufficient binding region:1062-1299(IPR002181)|his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24821	uniprotkb:P24821	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825047|imex:IM-26347-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	-	-	-	figure legend:Figure 2C-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/02	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rigid:z4lCg0M1F1PBC5XM+UDlzP9Geic	false	sufficient binding region:1973-2201(IPR002181)|his tag:?-?	sufficient binding region:2071-2100	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24821	uniprotkb:O00206	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825047|imex:IM-26347-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	-	-	-	figure legend:Figure 2C-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/02	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rigid:z4lCg0M1F1PBC5XM+UDlzP9Geic	false	sufficient binding region:1973-2201(IPR002181)|his tag:?-?	sufficient binding region:24-631|his tag:c-c(IPR032675)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24821	uniprotkb:P24821	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825065|imex:IM-26347-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	-	-	-	figure legend:Figure 2C-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/02	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rigid:z4lCg0M1F1PBC5XM+UDlzP9Geic	false	sufficient binding region:1973-2201(IPR002181)|his tag:?-?	sufficient binding region:2096-2124	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24821	uniprotkb:O00206	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825065|imex:IM-26347-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	-	-	-	figure legend:Figure 2C-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/02	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rigid:z4lCg0M1F1PBC5XM+UDlzP9Geic	false	sufficient binding region:1973-2201(IPR002181)|his tag:?-?	sufficient binding region:24-631|his tag:c-c(IPR032675)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24821	uniprotkb:P24821	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825083|imex:IM-26347-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	-	-	-	figure legend:Figure 2C-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/02	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rigid:z4lCg0M1F1PBC5XM+UDlzP9Geic	false	sufficient binding region:1973-2201(IPR002181)|his tag:?-?	sufficient binding region:2120-2148	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P24821	uniprotkb:O00206	intact:EBI-9979894|uniprotkb:C9IYT7|uniprotkb:C9J575|uniprotkb:C9J6D9|uniprotkb:C9J848|uniprotkb:Q14583|uniprotkb:Q15567|uniprotkb:Q5T7S3|ensembl:ENSP00000265131	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	psi-mi:tena_human(display_long)|uniprotkb:TNC(gene name)|psi-mi:TNC(display_short)|uniprotkb:HXB(gene name synonym)|uniprotkb:Cytotactin(gene name synonym)|uniprotkb:GMEM(gene name synonym)|uniprotkb:GP 150-225(gene name synonym)|uniprotkb:Glioma-associated-extracellular matrix antigen(gene name synonym)|uniprotkb:Hexabrachion(gene name synonym)|uniprotkb:JI(gene name synonym)|uniprotkb:Myotendinous antigen(gene name synonym)|uniprotkb:Neuronectin(gene name synonym)|uniprotkb:Tenascin-C(gene name synonym)	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825083|imex:IM-26347-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002151.2|refseq:XP_005252029.1|refseq:XP_005252031.1|refseq:XP_005252032.1|go:"GO:0005604"(basement membrane)|go:"GO:0005614"(interstitial matrix)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016020"(membrane)|go:"GO:0042060"(wound healing)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0005576"(extracellular region)|ensembl:ENSG00000041982(gene)|ensembl:ENST00000350763(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005201"(extracellular matrix structural constituent)|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-3000170|interpro:IPR036056|interpro:IPR036116|interpro:IPR041161|mint:P24821|rcsb pdb:1TEN|rcsb pdb:2RB8|rcsb pdb:2RBL|rcsb pdb:5R5T|rcsb pdb:5R5U|rcsb pdb:5R5V|rcsb pdb:5R5W|rcsb pdb:5R5X|rcsb pdb:5R5Y|rcsb pdb:5R5Z|rcsb pdb:5R60|rcsb pdb:5R61|rcsb pdb:5R62|rcsb pdb:5R63|interpro:IPR033078|rcsb pdb:6BRB|rcsb pdb:6QNV|reactome:R-HSA-216083|go:"GO:0045471"(response to ethanol)|interpro:IPR013111(EGF, extracellular)|go:"GO:0045545"(syndecan binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0060447"(bud outgrowth involved in lung branching)|go:"GO:0060739"(mesenchymal-epithelial cell signaling involved in prostate gland development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0071799"(cellular response to prostaglandin D stimulus)|go:"GO:0098966"(perisynaptic extracellular matrix)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|refseq:XP_011516931.1	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	-	-	-	figure legend:Figure 2C-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/02/27	2018/03/02	rogid:3V4KLLvsAFOCtJqiGfwPSQkK69g9606	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rigid:z4lCg0M1F1PBC5XM+UDlzP9Geic	false	sufficient binding region:1973-2201(IPR002181)|his tag:?-?	sufficient binding region:24-631|his tag:c-c(IPR032675)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:P02679-2	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-11063263|ensembl:ENSP00000384860	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:p02679-2(display_long)|uniprotkb:FGG(gene name)|psi-mi:FGG(display_short)|uniprotkb:PRO2061(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825156|imex:IM-26347-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	ensembl:ENSG00000171557(gene)|ensembl:ENST00000404648(transcript)|intact:EBI-1034422(isoform-parent)|uniprotkb:P02679-2(isoform-parent)	-	-	-	figure legend:Figure 7E|comment:Fibrinogen gamma chain was found to be isoform 2 by blast and translation of primers.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:121.0x10^-9(molar)	2018/02/27	2018/03/05	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:VDXP6tRKJU7MclA+YqWMjCkSJFI9606	rigid:4sc0bSgh4AoeUq+tzRm8Ceow5LE	false	sufficient binding region:24-631|his tag:c-c(IPR032675)	sufficient binding region:170-437(IPR002181)|his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O00206	uniprotkb:O00602	intact:EBI-528701|uniprotkb:Q9UK78|uniprotkb:Q9UM57|uniprotkb:A8K1Y8|uniprotkb:A9XLP9|uniprotkb:A9XLQ0|uniprotkb:A9XLQ1|uniprotkb:B4E194|uniprotkb:Q5VZI8|uniprotkb:Q5VZI9|uniprotkb:D1CS53|uniprotkb:D1CS52|ensembl:ENSP00000363089	intact:EBI-5282479|uniprotkb:Q5VYV5|uniprotkb:Q92596|ensembl:ENSP00000360871	psi-mi:tlr4_human(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:fcn1_human(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Zuliani-Alvarez et al. (2017)	pubmed:29150600|imex:IM-26347	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16825174|imex:IM-26347-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612564.1|refseq:NP_003257.1|refseq:NP_612567.1|dip:DIP-34769N|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|mint:O00206|rcsb pdb:2Z62|rcsb pdb:2Z63|rcsb pdb:2Z65|rcsb pdb:2Z66|rcsb pdb:3FXI|rcsb pdb:3UL7|rcsb pdb:3UL8|rcsb pdb:3UL9|rcsb pdb:3ULA|rcsb pdb:4G8A|rcsb pdb:5NAM|rcsb pdb:5NAO|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163|ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001726"(ruffle)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016046"(detection of fungus)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)	refseq:NP_001994.2|ensembl:ENSG00000085265(gene)|ensembl:ENST00000371806(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:O00602|rcsb pdb:2D39|rcsb pdb:2JHH|rcsb pdb:2JHI|rcsb pdb:2JHK|rcsb pdb:2JHL|rcsb pdb:2JHM|rcsb pdb:2WNP|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-6798695	-	-	-	figure legend:Figure 7E-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:248.0x10^-9(molar)	2018/02/27	2018/03/05	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:7qu36ZaWgX+GyX+QUbGj0RGrp4U9606	rigid:8u4RLv/zCU5S35e3Mf5LLi2zKw4	false	sufficient binding region:24-631|his tag:c-c(IPR032675)	sufficient binding region:109-326(IPR002181)|his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)