#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9R016 uniprotkb:Q3UP24 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20622027|wwpdb:6B5B|emdb:EMD-7055|imex:IM-27002-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/07/20 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n green fluorescent protein tag:n-n|mutation:79-79,83-83 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0410"(3D electron microscopy) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20622027|wwpdb:6B5B|emdb:EMD-7055|imex:IM-27002-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/07/20 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n myc tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R016 uniprotkb:Q3UP24 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20622048|imex:IM-27002-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Fig S7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20622048|imex:IM-27002-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Fig S7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n binding-associated region:441-475|ha tag:n-n|mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638589|imex:IM-27002-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Fig2B|comment:Mutation Asn107Ala;Ser108Ala decreased the ability of NAIP5 to bind flagellin proteins but had no effect on interaction with NLRC4 Mutation Trp841Ala;Phe842Ala decreased the ability of NAIP5 to bind the N-65 flagellin protein but had no effect on interaction with the C-35 protein or NLRC4 Mutation Gln843Ala;Phe844Ala decreased the ability of NAIP5 to bind the N-65 and C-35 flagellin proteins but had no effect on interaction with NLRC4 Mutation Leu848Ala;Trp849Ala decreased the ability of NAIP5 to bind flagellin proteins but had no effect on interaction with NLRC4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n|mutation with no effect:32-34|mutation with no effect:837-838|mutation with no effect:839-840 binding-associated region:1-65|green fluorescent protein tag:c-c|mutation disrupting interaction:31-33 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R016 uniprotkb:Q3UP24 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638589|imex:IM-27002-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Fig2B|comment:Mutation Asn107Ala;Ser108Ala decreased the ability of NAIP5 to bind flagellin proteins but had no effect on interaction with NLRC4 Mutation Trp841Ala;Phe842Ala decreased the ability of NAIP5 to bind the N-65 flagellin protein but had no effect on interaction with the C-35 protein or NLRC4 Mutation Gln843Ala;Phe844Ala decreased the ability of NAIP5 to bind the N-65 and C-35 flagellin proteins but had no effect on interaction with NLRC4 Mutation Leu848Ala;Trp849Ala decreased the ability of NAIP5 to bind flagellin proteins but had no effect on interaction with NLRC4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n|mutation with no effect:32-34|mutation with no effect:837-838|mutation with no effect:839-840 - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638589|imex:IM-27002-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Fig2B|comment:Mutation Asn107Ala;Ser108Ala decreased the ability of NAIP5 to bind flagellin proteins but had no effect on interaction with NLRC4 Mutation Trp841Ala;Phe842Ala decreased the ability of NAIP5 to bind the N-65 flagellin protein but had no effect on interaction with the C-35 protein or NLRC4 Mutation Gln843Ala;Phe844Ala decreased the ability of NAIP5 to bind the N-65 and C-35 flagellin proteins but had no effect on interaction with NLRC4 Mutation Leu848Ala;Trp849Ala decreased the ability of NAIP5 to bind flagellin proteins but had no effect on interaction with NLRC4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n|mutation with no effect:32-34|mutation with no effect:837-838|mutation with no effect:839-840 sufficient binding region:441-475|green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5ZVV0 uniprotkb:Q5ZVV0 intact:EBI-20622011|ensemblbacteria:AAU27422 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638886|imex:IM-27002-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Supp Fig 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/07/20 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false sufficient binding region:441-475|green fluorescent protein tag:n-n|flag tag:n-n green fluorescent protein tag:c-c|binding-associated region:1-65 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5ZVV0 uniprotkb:Q3UP24 intact:EBI-20622011|ensemblbacteria:AAU27422 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638886|imex:IM-27002-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Supp Fig 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/07/20 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false sufficient binding region:441-475|green fluorescent protein tag:n-n|flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5ZVV0 uniprotkb:Q9R016 intact:EBI-20622011|ensemblbacteria:AAU27422 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638886|imex:IM-27002-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 - - - figure legend:Supp Fig 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/07/20 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false sufficient binding region:441-475|green fluorescent protein tag:n-n|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R016 uniprotkb:Q3UP24 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638906|imex:IM-27002-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Supp Fig 9A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/07/20 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638906|imex:IM-27002-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Supp Fig 9A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/07/20 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n mutation disrupting interaction:470-470,472-472,473-473|sufficient binding region:441-475|green fluorescent protein tag:65-440 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638932|imex:IM-27002-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Supp. Fig 9A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/12 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n green fluorescent protein tag:n-n|binding-associated region:1-65|mutation disrupting interaction:32-32,31-31,33-33 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R016 uniprotkb:Q3UP24 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638932|imex:IM-27002-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Supp. Fig 9A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/12 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638932|imex:IM-27002-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Supp. Fig 9A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/12 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n mutation disrupting interaction:470-470,472-472,473-473|sufficient binding region:441-475|green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3UP24 uniprotkb:Q9R016 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20638960|imex:IM-27002-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 - - - figure legend:Fig 2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rigid:R9fGjgZ0oGOSQSlwxxlRtvYjH9w false green fluorescent protein tag:n-n flag tag:n-n|mutation decreasing interaction strength:847-847|mutation with no effect:974-975|mutation with no effect:626-627 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9JIB6 uniprotkb:Q3UP24 intact:EBI-15944303|ensembl:ENSMUSP00000041766|ensembl:ENSMUSP00000112867|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81704|uniprotkb:Q8CH68 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1f_mouse(display_long)|uniprotkb:Naip6(gene name)|psi-mi:Naip6(display_short)|uniprotkb:Birc1f(gene name synonym)|uniprotkb:Naip-rs4(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 6(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638968|imex:IM-27002-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078942(gene)|ensembl:ENSMUST00000042220(transcript)|ensembl:ENSMUST00000118574(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|dip:DIP-59149N|refseq:NP_035001.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Fig S9B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:+eKDBpreLg6AApayzJ3cjQcdoEw10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:DMcfVmT/vc7okjabFTimzLxn//U false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9JIB6 uniprotkb:Q5ZVV0 intact:EBI-15944303|ensembl:ENSMUSP00000041766|ensembl:ENSMUSP00000112867|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81704|uniprotkb:Q8CH68 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1f_mouse(display_long)|uniprotkb:Naip6(gene name)|psi-mi:Naip6(display_short)|uniprotkb:Birc1f(gene name synonym)|uniprotkb:Naip-rs4(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 6(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20638968|imex:IM-27002-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078942(gene)|ensembl:ENSMUST00000042220(transcript)|ensembl:ENSMUST00000118574(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|dip:DIP-59149N|refseq:NP_035001.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Fig S9B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:+eKDBpreLg6AApayzJ3cjQcdoEw10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:DMcfVmT/vc7okjabFTimzLxn//U false flag tag:n-n green fluorescent protein tag:65-440|binding-associated region:1-65,441-475 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9JIB6 uniprotkb:Q5ZVV0 intact:EBI-15944303|ensembl:ENSMUSP00000041766|ensembl:ENSMUSP00000112867|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81704|uniprotkb:Q8CH68 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1f_mouse(display_long)|uniprotkb:Naip6(gene name)|psi-mi:Naip6(display_short)|uniprotkb:Birc1f(gene name synonym)|uniprotkb:Naip-rs4(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 6(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716371|imex:IM-27002-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078942(gene)|ensembl:ENSMUST00000042220(transcript)|ensembl:ENSMUST00000118574(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|dip:DIP-59149N|refseq:NP_035001.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Fig S9B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:+eKDBpreLg6AApayzJ3cjQcdoEw10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:DMcfVmT/vc7okjabFTimzLxn//U false flag tag:n-n sufficient binding region:1-65|green fluorescent protein tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9JIB6 uniprotkb:Q3UP24 intact:EBI-15944303|ensembl:ENSMUSP00000041766|ensembl:ENSMUSP00000112867|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81704|uniprotkb:Q8CH68 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1f_mouse(display_long)|uniprotkb:Naip6(gene name)|psi-mi:Naip6(display_short)|uniprotkb:Birc1f(gene name synonym)|uniprotkb:Naip-rs4(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 6(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716371|imex:IM-27002-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078942(gene)|ensembl:ENSMUST00000042220(transcript)|ensembl:ENSMUST00000118574(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|dip:DIP-59149N|refseq:NP_035001.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Fig S9B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:+eKDBpreLg6AApayzJ3cjQcdoEw10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:DMcfVmT/vc7okjabFTimzLxn//U false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9JIB6 uniprotkb:Q5ZVV0 intact:EBI-15944303|ensembl:ENSMUSP00000041766|ensembl:ENSMUSP00000112867|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81704|uniprotkb:Q8CH68 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1f_mouse(display_long)|uniprotkb:Naip6(gene name)|psi-mi:Naip6(display_short)|uniprotkb:Birc1f(gene name synonym)|uniprotkb:Naip-rs4(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 6(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716371|imex:IM-27002-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078942(gene)|ensembl:ENSMUST00000042220(transcript)|ensembl:ENSMUST00000118574(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|dip:DIP-59149N|refseq:NP_035001.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Fig S9B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:+eKDBpreLg6AApayzJ3cjQcdoEw10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:DMcfVmT/vc7okjabFTimzLxn//U false flag tag:n-n green fluorescent protein tag:n-n|sufficient binding region:441-475|mutation disrupting interaction:473-473,472-472,470-470 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QUK4 uniprotkb:P41785 intact:EBI-15944068|ensembl:ENSMUSP00000070827|ensembl:ENSMUSP00000113890|uniprotkb:A9C470|uniprotkb:O09124|uniprotkb:Q9R030 intact:EBI-15880089|ensemblbacteria:AAL21752 psi-mi:bir1b_mouse(display_long)|uniprotkb:Naip2(gene name)|psi-mi:Naip2(display_short)|uniprotkb:Birc1b(gene name synonym)|uniprotkb:Naip-rs6(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 2(gene name synonym) psi-mi:prgj_salty(display_long)|uniprotkb:prgJ(gene name)|psi-mi:prgJ(display_short)|uniprotkb:STM2872(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:99287(salty)|taxid:99287(Salmonella typhimurium) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716422|imex:IM-27002-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078945(gene)|ensembl:ENSMUST00000067975(transcript)|ensembl:ENSMUST00000117913(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0046872"(metal ion binding)|dip:DIP-59160N|refseq:NP_001119654.1|refseq:NP_035002.2 ensemblbacteria:AAL21752(transcript)|ensemblbacteria:STM2872(gene)|go:"GO:0015031"(protein transport)|rcsb pdb:6PEP|rcsb pdb:6Q15|rcsb pdb:6Q16|rcsb pdb:7AGX|rcsb pdb:7AH9|rcsb pdb:7AHI|reactome:R-HSA-844623|refseq:NP_461793.1|refseq:WP_000020431.1|dip:DIP-59556N - - crc64:7AC04EF792D72598 figure legend:Fig S9C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:ABA+SvqyqCEVHGRgvxA0iSaZpng10090 rogid:CCDXFTTW8zNCRoWDvrQOveU7E5g99287 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false flag tag:n-n binding-associated region:1-63,64-101|green fluorescent protein tag:63-64 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QUK4 uniprotkb:Q3UP24 intact:EBI-15944068|ensembl:ENSMUSP00000070827|ensembl:ENSMUSP00000113890|uniprotkb:A9C470|uniprotkb:O09124|uniprotkb:Q9R030 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1b_mouse(display_long)|uniprotkb:Naip2(gene name)|psi-mi:Naip2(display_short)|uniprotkb:Birc1b(gene name synonym)|uniprotkb:Naip-rs6(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 2(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716422|imex:IM-27002-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078945(gene)|ensembl:ENSMUST00000067975(transcript)|ensembl:ENSMUST00000117913(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0046872"(metal ion binding)|dip:DIP-59160N|refseq:NP_001119654.1|refseq:NP_035002.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Fig S9C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:ABA+SvqyqCEVHGRgvxA0iSaZpng10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QUK4 uniprotkb:P41785 intact:EBI-15944068|ensembl:ENSMUSP00000070827|ensembl:ENSMUSP00000113890|uniprotkb:A9C470|uniprotkb:O09124|uniprotkb:Q9R030 intact:EBI-15880089|ensemblbacteria:AAL21752 psi-mi:bir1b_mouse(display_long)|uniprotkb:Naip2(gene name)|psi-mi:Naip2(display_short)|uniprotkb:Birc1b(gene name synonym)|uniprotkb:Naip-rs6(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 2(gene name synonym) psi-mi:prgj_salty(display_long)|uniprotkb:prgJ(gene name)|psi-mi:prgJ(display_short)|uniprotkb:STM2872(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:99287(salty)|taxid:99287(Salmonella typhimurium) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716456|imex:IM-27002-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078945(gene)|ensembl:ENSMUST00000067975(transcript)|ensembl:ENSMUST00000117913(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0046872"(metal ion binding)|dip:DIP-59160N|refseq:NP_001119654.1|refseq:NP_035002.2 ensemblbacteria:AAL21752(transcript)|ensemblbacteria:STM2872(gene)|go:"GO:0015031"(protein transport)|rcsb pdb:6PEP|rcsb pdb:6Q15|rcsb pdb:6Q16|rcsb pdb:7AGX|rcsb pdb:7AH9|rcsb pdb:7AHI|reactome:R-HSA-844623|refseq:NP_461793.1|refseq:WP_000020431.1|dip:DIP-59556N - - crc64:7AC04EF792D72598 figure legend:Fig S9C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:ABA+SvqyqCEVHGRgvxA0iSaZpng10090 rogid:CCDXFTTW8zNCRoWDvrQOveU7E5g99287 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false flag tag:n-n ha tag:n-n|mcherry fluorescent protein tag:n-n|sufficient binding region:64-101|mutation disrupting interaction:98-101 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QUK4 uniprotkb:P41785 intact:EBI-15944068|ensembl:ENSMUSP00000070827|ensembl:ENSMUSP00000113890|uniprotkb:A9C470|uniprotkb:O09124|uniprotkb:Q9R030 intact:EBI-15880089|ensemblbacteria:AAL21752 psi-mi:bir1b_mouse(display_long)|uniprotkb:Naip2(gene name)|psi-mi:Naip2(display_short)|uniprotkb:Birc1b(gene name synonym)|uniprotkb:Naip-rs6(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 2(gene name synonym) psi-mi:prgj_salty(display_long)|uniprotkb:prgJ(gene name)|psi-mi:prgJ(display_short)|uniprotkb:STM2872(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:99287(salty)|taxid:99287(Salmonella typhimurium) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716456|imex:IM-27002-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078945(gene)|ensembl:ENSMUST00000067975(transcript)|ensembl:ENSMUST00000117913(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0046872"(metal ion binding)|dip:DIP-59160N|refseq:NP_001119654.1|refseq:NP_035002.2 ensemblbacteria:AAL21752(transcript)|ensemblbacteria:STM2872(gene)|go:"GO:0015031"(protein transport)|rcsb pdb:6PEP|rcsb pdb:6Q15|rcsb pdb:6Q16|rcsb pdb:7AGX|rcsb pdb:7AH9|rcsb pdb:7AHI|reactome:R-HSA-844623|refseq:NP_461793.1|refseq:WP_000020431.1|dip:DIP-59556N - - crc64:7AC04EF792D72598 figure legend:Fig S9C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:ABA+SvqyqCEVHGRgvxA0iSaZpng10090 rogid:CCDXFTTW8zNCRoWDvrQOveU7E5g99287 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false flag tag:n-n sufficient binding region:1-63|green fluorescent protein tag:c-c|mutation disrupting interaction:33-33,34-34 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9QUK4 uniprotkb:Q3UP24 intact:EBI-15944068|ensembl:ENSMUSP00000070827|ensembl:ENSMUSP00000113890|uniprotkb:A9C470|uniprotkb:O09124|uniprotkb:Q9R030 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1b_mouse(display_long)|uniprotkb:Naip2(gene name)|psi-mi:Naip2(display_short)|uniprotkb:Birc1b(gene name synonym)|uniprotkb:Naip-rs6(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 2(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716456|imex:IM-27002-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000078945(gene)|ensembl:ENSMUST00000067975(transcript)|ensembl:ENSMUST00000117913(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0046872"(metal ion binding)|dip:DIP-59160N|refseq:NP_001119654.1|refseq:NP_035002.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Fig S9C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/07 rogid:ABA+SvqyqCEVHGRgvxA0iSaZpng10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3UP24 uniprotkb:P41785 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 intact:EBI-15880089|ensemblbacteria:AAL21752 psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:prgj_salty(display_long)|uniprotkb:prgJ(gene name)|psi-mi:prgJ(display_short)|uniprotkb:STM2872(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:99287(salty)|taxid:99287(Salmonella typhimurium) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716532|imex:IM-27002-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 ensemblbacteria:AAL21752(transcript)|ensemblbacteria:STM2872(gene)|go:"GO:0015031"(protein transport)|rcsb pdb:6PEP|rcsb pdb:6Q15|rcsb pdb:6Q16|rcsb pdb:7AGX|rcsb pdb:7AH9|rcsb pdb:7AHI|reactome:R-HSA-844623|refseq:NP_461793.1|refseq:WP_000020431.1|dip:DIP-59556N - - crc64:7AC04EF792D72598 figure legend:Fig S9D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/12 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rogid:CCDXFTTW8zNCRoWDvrQOveU7E5g99287 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false - flag tag:n-n|mcherry fluorescent protein tag:n-n|sufficient binding region:64-101 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3UP24 uniprotkb:P41785 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 intact:EBI-15880089|ensemblbacteria:AAL21752 psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:prgj_salty(display_long)|uniprotkb:prgJ(gene name)|psi-mi:prgJ(display_short)|uniprotkb:STM2872(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:99287(salty)|taxid:99287(Salmonella typhimurium) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716532|imex:IM-27002-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 ensemblbacteria:AAL21752(transcript)|ensemblbacteria:STM2872(gene)|go:"GO:0015031"(protein transport)|rcsb pdb:6PEP|rcsb pdb:6Q15|rcsb pdb:6Q16|rcsb pdb:7AGX|rcsb pdb:7AH9|rcsb pdb:7AHI|reactome:R-HSA-844623|refseq:NP_461793.1|refseq:WP_000020431.1|dip:DIP-59556N - - crc64:7AC04EF792D72598 figure legend:Fig S9D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/12 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rogid:CCDXFTTW8zNCRoWDvrQOveU7E5g99287 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false - sufficient binding region:1-63|green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3UP24 uniprotkb:Q9QUK4 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 intact:EBI-15944068|ensembl:ENSMUSP00000070827|ensembl:ENSMUSP00000113890|uniprotkb:A9C470|uniprotkb:O09124|uniprotkb:Q9R030 psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:bir1b_mouse(display_long)|uniprotkb:Naip2(gene name)|psi-mi:Naip2(display_short)|uniprotkb:Birc1b(gene name synonym)|uniprotkb:Naip-rs6(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716532|imex:IM-27002-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 ensembl:ENSMUSG00000078945(gene)|ensembl:ENSMUST00000067975(transcript)|ensembl:ENSMUST00000117913(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0046872"(metal ion binding)|dip:DIP-59160N|refseq:NP_001119654.1|refseq:NP_035002.2 - - - figure legend:Fig S9D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/12 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rogid:ABA+SvqyqCEVHGRgvxA0iSaZpng10090 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false - flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P41785 uniprotkb:P41785 intact:EBI-15880089|ensemblbacteria:AAL21752 intact:EBI-15880089|ensemblbacteria:AAL21752 psi-mi:prgj_salty(display_long)|uniprotkb:prgJ(gene name)|psi-mi:prgJ(display_short)|uniprotkb:STM2872(locus name) psi-mi:prgj_salty(display_long)|uniprotkb:prgJ(gene name)|psi-mi:prgJ(display_short)|uniprotkb:STM2872(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:99287(salty)|taxid:99287(Salmonella typhimurium) taxid:99287(salty)|taxid:99287(Salmonella typhimurium) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716571|imex:IM-27002-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAL21752(transcript)|ensemblbacteria:STM2872(gene)|go:"GO:0015031"(protein transport)|rcsb pdb:6PEP|rcsb pdb:6Q15|rcsb pdb:6Q16|rcsb pdb:7AGX|rcsb pdb:7AH9|rcsb pdb:7AHI|reactome:R-HSA-844623|refseq:NP_461793.1|refseq:WP_000020431.1|dip:DIP-59556N ensemblbacteria:AAL21752(transcript)|ensemblbacteria:STM2872(gene)|go:"GO:0015031"(protein transport)|rcsb pdb:6PEP|rcsb pdb:6Q15|rcsb pdb:6Q16|rcsb pdb:7AGX|rcsb pdb:7AH9|rcsb pdb:7AHI|reactome:R-HSA-844623|refseq:NP_461793.1|refseq:WP_000020431.1|dip:DIP-59556N - crc64:7AC04EF792D72598 crc64:7AC04EF792D72598 figure legend:Fig S9D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/12 rogid:CCDXFTTW8zNCRoWDvrQOveU7E5g99287 rogid:CCDXFTTW8zNCRoWDvrQOveU7E5g99287 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false flag tag:n-n|mcherry fluorescent protein tag:n-n|sufficient binding region:64-101 green fluorescent protein tag:c-c|sufficient binding region:1-63 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P41785 uniprotkb:Q9QUK4 intact:EBI-15880089|ensemblbacteria:AAL21752 intact:EBI-15944068|ensembl:ENSMUSP00000070827|ensembl:ENSMUSP00000113890|uniprotkb:A9C470|uniprotkb:O09124|uniprotkb:Q9R030 psi-mi:prgj_salty(display_long)|uniprotkb:prgJ(gene name)|psi-mi:prgJ(display_short)|uniprotkb:STM2872(locus name) psi-mi:bir1b_mouse(display_long)|uniprotkb:Naip2(gene name)|psi-mi:Naip2(display_short)|uniprotkb:Birc1b(gene name synonym)|uniprotkb:Naip-rs6(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:99287(salty)|taxid:99287(Salmonella typhimurium) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716571|imex:IM-27002-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAL21752(transcript)|ensemblbacteria:STM2872(gene)|go:"GO:0015031"(protein transport)|rcsb pdb:6PEP|rcsb pdb:6Q15|rcsb pdb:6Q16|rcsb pdb:7AGX|rcsb pdb:7AH9|rcsb pdb:7AHI|reactome:R-HSA-844623|refseq:NP_461793.1|refseq:WP_000020431.1|dip:DIP-59556N ensembl:ENSMUSG00000078945(gene)|ensembl:ENSMUST00000067975(transcript)|ensembl:ENSMUST00000117913(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070269"(pyroptosis)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|go:"GO:0046872"(metal ion binding)|dip:DIP-59160N|refseq:NP_001119654.1|refseq:NP_035002.2 - crc64:7AC04EF792D72598 - figure legend:Fig S9D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/12 rogid:CCDXFTTW8zNCRoWDvrQOveU7E5g99287 rogid:ABA+SvqyqCEVHGRgvxA0iSaZpng10090 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false flag tag:n-n|mcherry fluorescent protein tag:n-n|sufficient binding region:64-101 ha tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P41785 uniprotkb:Q3UP24 intact:EBI-15880089|ensemblbacteria:AAL21752 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:prgj_salty(display_long)|uniprotkb:prgJ(gene name)|psi-mi:prgJ(display_short)|uniprotkb:STM2872(locus name) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:99287(salty)|taxid:99287(Salmonella typhimurium) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20716571|imex:IM-27002-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAL21752(transcript)|ensemblbacteria:STM2872(gene)|go:"GO:0015031"(protein transport)|rcsb pdb:6PEP|rcsb pdb:6Q15|rcsb pdb:6Q16|rcsb pdb:7AGX|rcsb pdb:7AH9|rcsb pdb:7AHI|reactome:R-HSA-844623|refseq:NP_461793.1|refseq:WP_000020431.1|dip:DIP-59556N interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - crc64:7AC04EF792D72598 - figure legend:Fig S9D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/12 rogid:CCDXFTTW8zNCRoWDvrQOveU7E5g99287 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:JeyjUh1SB/4NEroM/aNCB82xRVs false flag tag:n-n|mcherry fluorescent protein tag:n-n|sufficient binding region:64-101 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R016 uniprotkb:Q3UP24 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20717824|imex:IM-27002-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Fig 2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/13 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n|mutation decreasing interaction:837-838|mutation decreasing interaction:839-840|mutation decreasing interaction:841-842|mutation decreasing interaction:843-844|mutation decreasing interaction:847-847|mutation decreasing interaction:848-849|mutation decreasing interaction:1329-1330|mutation decreasing interaction:1360-1360,1362-1363|mutation decreasing interaction:974-975|mutation decreasing interaction:626-627 - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-20717824|imex:IM-27002-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Fig 2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2018/08/13 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n|mutation decreasing interaction:837-838|mutation decreasing interaction:839-840|mutation decreasing interaction:841-842|mutation decreasing interaction:843-844|mutation decreasing interaction:847-847|mutation decreasing interaction:848-849|mutation decreasing interaction:1329-1330|mutation decreasing interaction:1360-1360,1362-1363|mutation decreasing interaction:974-975|mutation decreasing interaction:626-627 myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3UP24 uniprotkb:Q9R016 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-21400227|imex:IM-27002-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 - - - figure legend:Supp Fig 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rigid:R9fGjgZ0oGOSQSlwxxlRtvYjH9w false mutation disrupting interaction strength:125-125|mutation disrupting interaction strength:127-127|mutation decreasing interaction strength:349-349|mutation disrupting interaction strength:116-116|mutation decreasing interaction strength:118-118|mutation:79-79,83-83,288-288|mutation disrupting interaction strength:124-124|green fluorescent protein tag:n-n|mutation disrupting interaction strength:120-120|mutation decreasing interaction strength:123-123 flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-21400426|imex:IM-27002-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Supp Fig 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n mutation with no effect:12-12|green fluorescent protein tag:c-c|binding-associated region:1-65|mutation with no effect:18-18|mutation with no effect:25-25|mutation with no effect:32-32 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R016 uniprotkb:Q3UP24 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-16006652|ensembl:ENSMUSP00000059637|uniprotkb:Q3TAU8 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:nlrc4_mouse(display_long)|uniprotkb:Nlrc4(gene name)|psi-mi:Nlrc4(display_short)|uniprotkb:Card12(gene name synonym)|uniprotkb:Ipaf(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-21400426|imex:IM-27002-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:3JBL|rcsb pdb:4KXF|rcsb pdb:5AJ2|rcsb pdb:6B5B|interpro:IPR007111(NACHT nucleoside triphosphatase)|ensembl:ENSMUSG00000039193(gene)|ensembl:ENSMUST00000052124(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|refseq:NP_001028539.1|refseq:XP_006524409.1|refseq:XP_017172979.1|refseq:XP_017172980.1 - - - figure legend:Supp Fig 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:EwJUZJSasbk43tsDLlfJqxC2oec10090 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R016 uniprotkb:Q5ZVV0 intact:EBI-15944130|ensembl:ENSMUSP00000058611|uniprotkb:Q8CGT2|uniprotkb:O09121|uniprotkb:O09122|uniprotkb:P81703|uniprotkb:Q9R029 intact:EBI-20622011|ensemblbacteria:AAU27422 psi-mi:bir1e_mouse(display_long)|uniprotkb:Naip5(gene name)|psi-mi:Naip5(display_short)|uniprotkb:Birc1e(gene name synonym)|uniprotkb:Naip-rs3(gene name synonym)|uniprotkb:Neuronal apoptosis inhibitory protein 5(gene name synonym) psi-mi:q5zvv0_legph(display_long)|uniprotkb:fliC(gene name)|psi-mi:fliC(display_short)|uniprotkb:lpg1340(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tenthorey et al. (2017) pubmed:29146805|imex:IM-27002 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:272624(legph)|taxid:272624(Legionella pneumophila subsp. pneumophila) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-21400426|imex:IM-27002-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000071203(gene)|ensembl:ENSMUST00000049789(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR028789|interpro:IPR032675|interpro:IPR040535|interpro:IPR041075|rcsb pdb:5YUD|rcsb pdb:6B5B|refseq:XP_011242930.1|refseq:XP_017170904.1|dip:DIP-59148N|refseq:NP_035000.2 refseq:WP_010947070.1|refseq:YP_095369.1|rcsb pdb:6B5B|interpro:IPR001492(Flagellin, N-terminal)|interpro:IPR001029(Flagellin, C-terminal)|interpro:IPR010810(Flagellin hook IN)|ensemblbacteria:AAU27422(transcript)|ensemblbacteria:lpg1340(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009288"(bacterial-type flagellum)|go:"GO:0071973"(bacterial-type flagellum-dependent cell motility)|interpro:IPR042187 - - - figure legend:Supp Fig 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/12 2019/05/09 rogid:yNnApOdrkulKaMVJOTBVq+0lB3E10090 rogid:JkItvkDkHWsmAw4dYQoroyaSIr8272624 rigid:+lTuYUZpScAiJt4HLgSoFMr0WAo false flag tag:n-n sufficient binding region:441-475|green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)