#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P61006	uniprotkb:Q8TDZ2	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-7153876|ensembl:ENSP00000351664|uniprotkb:Q9H7I0|intact:MINT-1343875|uniprotkb:Q8IVS9|uniprotkb:Q7Z633|uniprotkb:Q9HAA1|uniprotkb:Q9UFF7|uniprotkb:B7Z3R5|uniprotkb:Q9H6X6|uniprotkb:E1P5F0|uniprotkb:Q96G47	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:mica1_human(display_long)|uniprotkb:MICAL1(gene name)|psi-mi:MICAL1(display_short)|uniprotkb:MICAL(gene name synonym)|uniprotkb:NICAL(gene name synonym)|uniprotkb:Molecule interacting with CasL protein 1(gene name synonym)|uniprotkb:NEDD9-interacting protein with calponin homology and LIM domains(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001273542.1|ensembl:ENSG00000135596(gene)|ensembl:ENST00000358807(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019417"(sulfur oxidation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0071949"(FAD binding)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:1990026"(hippocampal mossy fiber expansion)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR002938(Monooxygenase, FAD-binding)|interpro:IPR022735|interpro:IPR029937|interpro:IPR036188|interpro:IPR036872|mint:Q8TDZ2|rcsb pdb:1WYL|rcsb pdb:2CO8|rcsb pdb:2DK9|rcsb pdb:5LE0|rcsb pdb:5LPN|rcsb pdb:6KU0|reactome:R-HSA-983231|refseq:NP_001152763.1|refseq:NP_073602.3|ensembl:ENST00000358577|ensembl:ENSP00000351385|ensembl:ENSP00000351664|ensembl:ENST00000630715|ensembl:ENSP00000486901	-	-	comment:mint|comment:homomint|function:May be a cytoskeletal regulator that connects NEDD9 to intermediate filaments	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:BmwvLz7V3mW/K2zKwAZISU01Eog9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q14964	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-3048577|ensembl:ENSP00000322594|uniprotkb:A8KAA4|uniprotkb:Q8N6W2	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:rb39a_human(display_long)|uniprotkb:RAB39A(gene name)|psi-mi:RAB39A(display_short)|uniprotkb:RAB39(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000179331(gene)|ensembl:ENST00000320578(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041818|reactome:R-HSA-6811438|reactome:R-HSA-8873719|reactome:R-HSA-8876198|refseq:NP_059986.1|dip:DIP-60521N	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:jpkNU7VaaBLmc8P2kLuNq++1T2I9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8N3D4	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2834588|uniprotkb:Q8TB89|uniprotkb:Q9H7M7|ensembl:ENSP00000312671	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:eh1l1_human(display_long)|uniprotkb:EHBP1L1(gene name)|psi-mi:EHBP1L1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000173442(gene)|ensembl:ENST00000309295(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR019448|interpro:IPR022735|interpro:IPR029928|interpro:IPR036872|refseq:NP_001092879.1	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:A49ma5uVQHbpAMd99czZVg2Kkfw9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q7RTP6	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2555582|uniprotkb:E9PEF0|uniprotkb:Q5U4P4|uniprotkb:Q6ICK4|uniprotkb:Q9P2I3|intact:EBI-2558651|uniprotkb:O94909|uniprotkb:Q96DF2|ensembl:ENSP00000416015|uniprotkb:B2RXJ5	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:mica3_human(display_long)|uniprotkb:KIAA0819(gene name synonym)|uniprotkb:KIAA1364(gene name synonym)|uniprotkb:MICAL3(gene name)|psi-mi:MICAL3(display_short)|uniprotkb:Molecule interacting with CasL protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001116203.1|refseq:NP_056056.2|go:"GO:0007049"(cell cycle)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042995"(cell projection)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0071949"(FAD binding)|go:"GO:0090543"(Flemming body)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR002938(Monooxygenase, FAD-binding)|interpro:IPR022735|interpro:IPR029941|interpro:IPR036188|interpro:IPR036872|rcsb pdb:2D88|rcsb pdb:5SZG|rcsb pdb:6ICI|go:"GO:0007010"(cytoskeleton organization)|ensembl:ENSG00000243156(gene)|ensembl:ENST00000441493(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006887"(exocytosis)|refseq:NP_001129476.1|refseq:XP_005261319.1	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:Ve1WEQHry/REv1IzmmnyGGYd5No9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:P47224	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-713992|uniprotkb:Q92992|ensembl:ENSP00000356231|uniprotkb:B2R4P4	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:mss4_human(display_long)|uniprotkb:Rab-interacting factor(gene name synonym)|uniprotkb:RABIF(gene name)|psi-mi:RABIF(display_short)|uniprotkb:MSS4(gene name synonym)|uniprotkb:RASGRF3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000183155(gene)|ensembl:ENST00000367262(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0061025"(membrane fusion)|interpro:IPR007515(Mss4)|interpro:IPR011057(Mss4-like)|interpro:IPR011323(Mss4/translationally controlled tumour-associated TCTP)|mint:P47224|rcsb pdb:1FWQ|rcsb pdb:2FU5|refseq:NP_002862.2	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:BDlOz1AZhYAV6xVZZu0ZLb58po49606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8IY33	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2555563|uniprotkb:Q7Z655|uniprotkb:Q7RTP4|uniprotkb:Q8TEQ4|uniprotkb:Q9H5F9|uniprotkb:D3YTD2|ensembl:ENSP00000297508	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:milk2_human(display_long)|uniprotkb:MICALL2(gene name)|psi-mi:MICALL2(display_short)|uniprotkb:JRAB(gene name synonym)|uniprotkb:Junctional Rab13-binding protein(gene name synonym)|uniprotkb:Molecule interacting with CasL-like 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_891554.1|ensembl:ENSG00000164877(gene)|ensembl:ENST00000297508(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031005"(filamin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042805"(actinin binding)|go:"GO:0043005"(neuron projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|go:"GO:0032456"(endocytic recycling)	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:d9MLMRVjjQDtZwHGP1IA0pu9KlA9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8N3F8	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding)	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8NDI1	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2689720|uniprotkb:Q9NWI9|uniprotkb:Q6QNV2|uniprotkb:Q6NX72|uniprotkb:Q53TV6|uniprotkb:Q6PIT3|uniprotkb:Q53TG7|uniprotkb:Q580X2|uniprotkb:O94977|ensembl:ENSP00000263991	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:ehbp1_human(display_long)|uniprotkb:KIAA0903(gene name synonym)|uniprotkb:NACSIN(gene name synonym)|uniprotkb:EHBP1(gene name)|psi-mi:EHBP1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSP00000263991|ensembl:ENST00000405015|ensembl:ENSP00000384143|ensembl:ENST00000405289|ensembl:ENSP00000385524|ensembl:ENST00000431489|ensembl:ENSP00000403783|refseq:XP_011531015.1|refseq:XP_011531016.1|refseq:XP_011531017.1|refseq:NP_001136086.1|refseq:NP_001136087.1|refseq:NP_001136088.1|refseq:NP_056067.2|refseq:XP_016859136.1|refseq:XP_016859137.1|refseq:XP_016859138.1|refseq:XP_005264282.1|refseq:XP_005264283.1|refseq:XP_005264284.1|refseq:XP_016859132.1|refseq:XP_016859133.1|refseq:XP_016859140.1|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:2D89|rcsb pdb:6ZSH|ensembl:ENSG00000115504(gene)|ensembl:ENST00000263991(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR019448|interpro:IPR022735|interpro:IPR029944|interpro:IPR036872	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:sDcegXBYi8eQp7KReaysxBy3Ogc9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q15057	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-4401196|uniprotkb:A8K2V4|uniprotkb:Q8N5Z8|uniprotkb:Q9UQR3|ensembl:ENSP00000324287	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:acap2_human(display_long)|uniprotkb:ACAP2(gene name)|psi-mi:ACAP2(display_short)|uniprotkb:CENTB2(gene name synonym)|uniprotkb:KIAA0041(gene name synonym)|uniprotkb:Centaurin-beta-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_036419.3|ensembl:ENSG00000114331(gene)|ensembl:ENST00000326793(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030029"(actin filament-based process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0046872"(metal ion binding)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|rcsb pdb:6IF3	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:VHSpT12NSofZq3m02WlQNqj1IAQ9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:P31150	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-946999|uniprotkb:P50394|uniprotkb:Q7Z2G6|uniprotkb:Q7Z2G9|uniprotkb:Q7Z2H5|uniprotkb:Q7Z2I6|uniprotkb:Q6FG50|ensembl:ENSP00000394071	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:gdia_human(display_long)|uniprotkb:GDI1(gene name)|psi-mi:GDI1(display_short)|uniprotkb:OPHN2(gene name synonym)|uniprotkb:RABGDIA(gene name synonym)|uniprotkb:XAP4(gene name synonym)|uniprotkb:Guanosine diphosphate dissociation inhibitor 1(gene name synonym)|uniprotkb:Oligophrenin-2(gene name synonym)|uniprotkb:Protein XAP-4(gene name synonym)|uniprotkb:GDIL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001484.1|ensembl:ENSG00000203879(gene)|ensembl:ENST00000447750(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P31150|reactome:R-HSA-8876198	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:bE8RgEdzf7V/T+hWdGJkM9WM0yI9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8IVH8	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:P32019	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-10963917|uniprotkb:Q5VSH0|uniprotkb:Q86YE1|uniprotkb:Q5VSG9|uniprotkb:Q658Q5|uniprotkb:Q5VSH1|uniprotkb:C9J6U5|uniprotkb:Q6PD53|uniprotkb:Q6P6D4|ensembl:ENSP00000362114|ensembl:ENSP00000362117	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:i5p2_human(display_long)|uniprotkb:INPP5B(gene name)|psi-mi:INPP5B(display_short)|uniprotkb:75 kDa inositol polyphosphate-5-phosphatase(gene name synonym)|uniprotkb:OCRL2(gene name synonym)|uniprotkb:Phosphoinositide 5-phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001284363.1|refseq:NP_005531.2|ensembl:ENSG00000204084(gene)|ensembl:ENST00000373023(transcript)|ensembl:ENST00000373026(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0070613"(regulation of protein processing)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031896|interpro:IPR036691|interpro:IPR037793|rcsb pdb:3MTC|rcsb pdb:3N9V|rcsb pdb:4CML|rcsb pdb:5A7I|rcsb pdb:5A7J|reactome:R-HSA-1855183|reactome:R-HSA-1855204	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:0JIiNz1Bp56ZqscGeMQUXu8w4Fc9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q0IIM8	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-11837915|uniprotkb:B9A6K5|uniprotkb:B9A6K6|uniprotkb:Q5JRB7|uniprotkb:Q6ZVX5|uniprotkb:Q9NXE3|ensembl:ENSP00000349781	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:tbc8b_human(display_long)|uniprotkb:TBC1D8B(gene name)|psi-mi:TBC1D8B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_060222.2|refseq:NP_942582.1|ensembl:ENSG00000133138(gene)|ensembl:ENST00000357242(transcript)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004182(GRAM)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|interpro:IPR036012|interpro:IPR036015|reactome:R-HSA-432722	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:NWulX/MojVGvrZd5TQw+AJjfRoU9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:O60271	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-1023301|uniprotkb:O60905|uniprotkb:Q3KQU8|uniprotkb:Q3MKM7|uniprotkb:Q86WC7|uniprotkb:Q86WC8|uniprotkb:Q8IZX7|uniprotkb:Q96II0|uniprotkb:Q9H811|uniprotkb:A8MSX0|uniprotkb:B4DHH2|uniprotkb:A6H8U5|intact:EBI-2560890|ensembl:ENSP00000262013	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:jip4_human(display_long)|uniprotkb:JNK-associated leucine-zipper protein(gene name synonym)|uniprotkb:Sperm-associated antigen 9(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 4(gene name synonym)|uniprotkb:Human lung cancer oncogene 6 protein(gene name synonym)|uniprotkb:Proliferation-inducing protein 6(gene name synonym)|uniprotkb:Sperm-specific protein(gene name synonym)|uniprotkb:Sperm surface protein(gene name synonym)|uniprotkb:Protein highly expressed in testis(gene name synonym)|uniprotkb:Sunday driver 1(gene name synonym)|uniprotkb:Cancer/testis antigen 89(gene name synonym)|uniprotkb:HLC6(orf name)|uniprotkb:SPAG9(gene name)|psi-mi:SPAG9(display_short)|uniprotkb:HSS(gene name synonym)|uniprotkb:KIAA0516(gene name synonym)|uniprotkb:MAPK8IP4(gene name synonym)|uniprotkb:SYD1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001123999.1|refseq:NP_001238900.1|refseq:NP_001124000.1|refseq:NP_003962.3|ensembl:ENSG00000008294(gene)|ensembl:ENST00000262013(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032418"(lysosome localization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903860"(negative regulation of dendrite extension)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019143|interpro:IPR032486|interpro:IPR034743|interpro:IPR034744|interpro:IPR036322|interpro:IPR039911|mint:O60271|rcsb pdb:2W83|reactome:R-HSA-525793	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:UsItS/q6arsUKVnp+hGuBZE3P809606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q01968	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q969X0	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-717552|ensembl:ENSP00000280571	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:ripl2_human(display_long)|uniprotkb:Rab-interacting lysosomal protein-like 2(gene name synonym)|uniprotkb:p40phox-binding protein(gene name synonym)|uniprotkb:RILPL2(gene name)|psi-mi:RILPL2(display_short)|uniprotkb:RLP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_659495.1|ensembl:ENSG00000150977(gene)|ensembl:ENST00000280571(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:7LWB	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:Sp67YMUXLQ+A9uXKbUW5orzJ/GQ9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:P50395	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-1049143|uniprotkb:O43928|uniprotkb:Q9UQM6|ensembl:ENSP00000369538|uniprotkb:Q5SX88	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:gdib_human(display_long)|uniprotkb:Guanosine diphosphate dissociation inhibitor 2(gene name synonym)|uniprotkb:GDI2(gene name)|psi-mi:GDI2(display_short)|uniprotkb:RABGDIB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000057608(gene)|ensembl:ENST00000380191(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0034774"(secretory granule lumen)|refseq:NP_001108628.1|refseq:NP_001485.2|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P50395|reactome:R-HSA-6798695|reactome:R-HSA-8876198|dip:DIP-50593N	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:KTUS915xP+QA9QFU2aZSyS+Hkgc9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q66K14	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2688824|uniprotkb:O75163|uniprotkb:D3DWQ6|uniprotkb:Q96H49|uniprotkb:Q6MZI2|uniprotkb:Q53EY0|uniprotkb:D3DWQ5|ensembl:ENSP00000349291|ensembl:ENSP00000491373|ensembl:ENSP00000491970	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:tbc9b_human(display_long)|uniprotkb:KIAA0676(gene name synonym)|uniprotkb:TBC1D9B(gene name)|psi-mi:TBC1D9B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_055858.2|refseq:NP_942568.2|ensembl:ENSG00000197226(gene)|ensembl:ENSG00000284400(gene)|ensembl:ENST00000356834(transcript)|ensembl:ENST00000639361(transcript)|ensembl:ENST00000639711(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004182(GRAM)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|interpro:IPR036014|interpro:IPR036017|mint:Q66K14	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:DdCLCQa69pLYH6eIKdazflUwAKY9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:A4D1P6	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-718046|uniprotkb:A6NK54|uniprotkb:C9JMI4|uniprotkb:Q6FI65|uniprotkb:Q6MZQ1|uniprotkb:Q6P4I1|uniprotkb:Q96AE5|uniprotkb:Q96G63|uniprotkb:Q9H062|uniprotkb:Q9H9B6|uniprotkb:Q9NVG7|uniprotkb:Q9NZY6|ensembl:ENSP00000346466	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:wdr91_human(display_long)|uniprotkb:WDR91(gene name)|psi-mi:WDR91(display_short)|uniprotkb:HSPC049(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_054868.3|ensembl:ENSG00000105875(gene)|ensembl:ENST00000354475(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:1903362"(regulation of cellular protein catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039724|rcsb pdb:6VYC|reactome:R-HSA-9013148	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:Lcc2+uMzFIgd+WP1QGrWhAf4Bgw9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q562E7	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-5235360|uniprotkb:Q24JP6|uniprotkb:Q8N277|uniprotkb:Q8N3F3|uniprotkb:B3KW16|uniprotkb:B3KXU1|uniprotkb:B7Z579|uniprotkb:E9PHG7|uniprotkb:Q8TEL1|ensembl:ENSP00000386609	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:wdr81_human(display_long)|uniprotkb:WDR81(gene name)|psi-mi:WDR81(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006330|imex:IM-27029-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:XP_011521953.1|refseq:NP_001157145.1|refseq:NP_001157281.1|refseq:NP_001157283.1|refseq:NP_689561.2|ensembl:ENSG00000167716(gene)|ensembl:ENST00000409644(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0035973"(aggrephagy)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR036372|reactome:R-HSA-9013148|go:"GO:0045022"(early endosome to late endosome transport)	-	-	-	figure legend:Fig. 3A|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/23	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:WZMmbrspcu0HwOC1iuqrGa4NA2s9606	rigid:kU2Qde2BMh6tyRmixkCqX+tGffw	false	ha tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P55258	uniprotkb:Q9JJC6	intact:EBI-398411|uniprotkb:Q8VCF6|ensembl:ENSMUSP00000003121	intact:EBI-8320724|uniprotkb:Q80WV8|intact:MINT-4129976|ensembl:ENSMUSP00000050014	psi-mi:rab8a_mouse(display_long)|uniprotkb:Rab8a(gene name)|psi-mi:Rab8a(display_short)|uniprotkb:Mel(gene name synonym)|uniprotkb:Rab8(gene name synonym)|uniprotkb:Oncogene c-mel(gene name synonym)	psi-mi:ripl1_mouse(display_long)|uniprotkb:MNCb-2440(orf name)|uniprotkb:Rilpl1(gene name)|psi-mi:Rilpl1(display_short)|uniprotkb:Rab-interacting lysosomal-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006637|imex:IM-27029-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075615.2|dip:DIP-31053N|ensembl:ENSMUSG00000003037(gene)|ensembl:ENSMUST00000003121(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097546"(ciliary base)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P55258|rcsb pdb:2FU5|reactome:R-MMU-2565942|reactome:R-MMU-5620912|reactome:R-MMU-5620916|reactome:R-MMU-8854214|reactome:R-MMU-8873719|reactome:R-MMU-8876198|go:"GO:0098978"(glutamatergic synapse)	refseq:NP_067405.1|ensembl:ENSMUSG00000029392(gene)|ensembl:ENSMUST00000062153(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR019143|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|mint:Q9JJC6	-	-	comment:mint|function:Does not regulate lysosomal morphology and distribution	comment:Cells were transfected with LRRK Arg1441Cys. Levels of precipitated prey proteins were reduced when cells were treated with the selective LRRK2 inhibitor MLi-2|antagonist:"MLi-2 (CHEBI:132484)"|figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2018/12/14	2018/12/17	rogid:SE+1h+U6C8cAN2UTBIDapsUt4zA10090	rogid:61WiGzawdgig/og5CxZhZImRvAs10090	rigid:SOfYX3wPx6ehX4izFpe3blJYsAo	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P55258	uniprotkb:Q99LE1	intact:EBI-398411|uniprotkb:Q8VCF6|ensembl:ENSMUSP00000003121	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	psi-mi:rab8a_mouse(display_long)|uniprotkb:Rab8a(gene name)|psi-mi:Rab8a(display_short)|uniprotkb:Mel(gene name synonym)|uniprotkb:Rab8(gene name synonym)|uniprotkb:Oncogene c-mel(gene name synonym)	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006637|imex:IM-27029-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075615.2|dip:DIP-31053N|ensembl:ENSMUSG00000003037(gene)|ensembl:ENSMUST00000003121(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097546"(ciliary base)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P55258|rcsb pdb:2FU5|reactome:R-MMU-2565942|reactome:R-MMU-5620912|reactome:R-MMU-5620916|reactome:R-MMU-8854214|reactome:R-MMU-8873719|reactome:R-MMU-8876198|go:"GO:0098978"(glutamatergic synapse)	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	-	-	-	comment:Cells were transfected with LRRK Arg1441Cys. Levels of precipitated prey proteins were reduced when cells were treated with the selective LRRK2 inhibitor MLi-2|antagonist:"MLi-2 (CHEBI:132484)"|figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2018/12/14	2018/12/17	rogid:SE+1h+U6C8cAN2UTBIDapsUt4zA10090	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	rigid:SOfYX3wPx6ehX4izFpe3blJYsAo	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5EBL4	uniprotkb:P61006	intact:EBI-2797110|uniprotkb:Q66K36|uniprotkb:Q8N1M0|ensembl:ENSP00000366070	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:ripl1_human(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 1(gene name synonym)|uniprotkb:RILPL1(gene name)|psi-mi:RILPL1(display_short)|uniprotkb:RLP1(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006652|imex:IM-27029-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306172.1|refseq:NP_001306173.1|refseq:NP_001306231.1|refseq:NP_847884.2|ensembl:ENSG00000188026(gene)|ensembl:ENST00000376874(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR019143|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	comment:Interaction required active LRRK2 to be expressed in the cells|figure legend:Fig. 3D, 3F|antagonist:"MLI-2 (CHEBI:132484)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/14	2018/12/17	rogid:svCxG6aZws8OxMJdln0pj3rmqps9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rigid:6YnOHJEdUseATPb2ushnSxdOBo4	false	green fluorescent protein tag:?-?|mutation disrupting interaction strength:291-291|mutation disrupting interaction strength:293-293|mutation disrupting interaction strength:310-310	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q969X0	uniprotkb:P61006	intact:EBI-717552|ensembl:ENSP00000280571	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:ripl2_human(display_long)|uniprotkb:Rab-interacting lysosomal protein-like 2(gene name synonym)|uniprotkb:p40phox-binding protein(gene name synonym)|uniprotkb:RILPL2(gene name)|psi-mi:RILPL2(display_short)|uniprotkb:RLP2(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006661|imex:IM-27029-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659495.1|ensembl:ENSG00000150977(gene)|ensembl:ENST00000280571(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:7LWB	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	comment:Interaction required active LRRK2 to be expressed in the cells|figure legend:Fig. 3D, 3F|antagonist:"MLI-2 (CHEBI:132484)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/14	2018/12/17	rogid:Sp67YMUXLQ+A9uXKbUW5orzJ/GQ9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rigid:neRFKTcrm5z4kKMaXroZX0bS3p0	false	green fluorescent protein tag:?-?|mutation disrupting interaction strength:130-130|mutation disrupting interaction strength:132-132|mutation disrupting interaction strength:149-149	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5EBL4	uniprotkb:Q6IQ22	intact:EBI-2797110|uniprotkb:Q66K36|uniprotkb:Q8N1M0|ensembl:ENSP00000366070	intact:EBI-4289591|uniprotkb:A6NEF5|uniprotkb:Q4KMQ3	psi-mi:ripl1_human(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 1(gene name synonym)|uniprotkb:RILPL1(gene name)|psi-mi:RILPL1(display_short)|uniprotkb:RLP1(gene name synonym)	psi-mi:rab12_human(display_long)|uniprotkb:RAB12(gene name)|psi-mi:RAB12(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006689|imex:IM-27029-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306172.1|refseq:NP_001306173.1|refseq:NP_001306231.1|refseq:NP_847884.2|ensembl:ENSG00000188026(gene)|ensembl:ENST00000376874(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR019143|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744	refseq:NP_001020471.2|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|rcsb pdb:2IL1|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072659"(protein localization to plasma membrane)|reactome:R-HSA-8873719|interpro:IPR027417|reactome:R-HSA-8876198|interpro:IPR041830	-	-	-	comment:Constitutively active LRRK2 was expressed in the cells|figure legend:Fig. 3G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/14	2018/12/17	rogid:svCxG6aZws8OxMJdln0pj3rmqps9606	rogid:g+NgQCwasQQEIrQJlkzs8EQh8449606	rigid:CQjGhYTYSYlb7uWfjKsnlY2bvJk	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5EBL4	uniprotkb:P61026	intact:EBI-2797110|uniprotkb:Q66K36|uniprotkb:Q8N1M0|ensembl:ENSP00000366070	intact:EBI-726075|uniprotkb:O88386|uniprotkb:Q6IA52|uniprotkb:Q9D7X6|uniprotkb:Q9H0T3|uniprotkb:D6W538|ensembl:ENSP00000264710	psi-mi:ripl1_human(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 1(gene name synonym)|uniprotkb:RILPL1(gene name)|psi-mi:RILPL1(display_short)|uniprotkb:RLP1(gene name synonym)	psi-mi:rab10_human(display_long)|uniprotkb:RAB10(gene name)|psi-mi:RAB10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006689|imex:IM-27029-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306172.1|refseq:NP_001306173.1|refseq:NP_001306231.1|refseq:NP_847884.2|ensembl:ENSG00000188026(gene)|ensembl:ENST00000376874(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR019143|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744	refseq:NP_057215.3|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:5LPN|rcsb pdb:5SZJ|reactome:R-HSA-1445148|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000084733(gene)|ensembl:ENST00000264710(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)	-	-	-	comment:Constitutively active LRRK2 was expressed in the cells|figure legend:Fig. 3G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/14	2018/12/17	rogid:svCxG6aZws8OxMJdln0pj3rmqps9606	rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE9606	rigid:CQjGhYTYSYlb7uWfjKsnlY2bvJk	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5EBL4	uniprotkb:P61006	intact:EBI-2797110|uniprotkb:Q66K36|uniprotkb:Q8N1M0|ensembl:ENSP00000366070	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:ripl1_human(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 1(gene name synonym)|uniprotkb:RILPL1(gene name)|psi-mi:RILPL1(display_short)|uniprotkb:RLP1(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006689|imex:IM-27029-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306172.1|refseq:NP_001306173.1|refseq:NP_001306231.1|refseq:NP_847884.2|ensembl:ENSG00000188026(gene)|ensembl:ENST00000376874(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR019143|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	comment:Constitutively active LRRK2 was expressed in the cells|figure legend:Fig. 3G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/14	2018/12/17	rogid:svCxG6aZws8OxMJdln0pj3rmqps9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rigid:CQjGhYTYSYlb7uWfjKsnlY2bvJk	false	green fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969X0	uniprotkb:Q6IQ22	intact:EBI-717552|ensembl:ENSP00000280571	intact:EBI-4289591|uniprotkb:A6NEF5|uniprotkb:Q4KMQ3	psi-mi:ripl2_human(display_long)|uniprotkb:Rab-interacting lysosomal protein-like 2(gene name synonym)|uniprotkb:p40phox-binding protein(gene name synonym)|uniprotkb:RILPL2(gene name)|psi-mi:RILPL2(display_short)|uniprotkb:RLP2(gene name synonym)	psi-mi:rab12_human(display_long)|uniprotkb:RAB12(gene name)|psi-mi:RAB12(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006706|imex:IM-27029-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659495.1|ensembl:ENSG00000150977(gene)|ensembl:ENST00000280571(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:7LWB	refseq:NP_001020471.2|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|rcsb pdb:2IL1|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009306"(protein secretion)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072659"(protein localization to plasma membrane)|reactome:R-HSA-8873719|interpro:IPR027417|reactome:R-HSA-8876198|interpro:IPR041830	-	-	-	comment:Constitutively active LRRK2 was expressed in the cells|figure legend:Fig. 3H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/14	2018/12/17	rogid:Sp67YMUXLQ+A9uXKbUW5orzJ/GQ9606	rogid:g+NgQCwasQQEIrQJlkzs8EQh8449606	rigid:Acu2pvXOuea6Fd9CMaijMba/O4k	false	green fluorescent protein tag:?-?|mutation disrupting interaction strength:130-130|mutation disrupting interaction strength:132-132|mutation disrupting interaction strength:149-149	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969X0	uniprotkb:P61026	intact:EBI-717552|ensembl:ENSP00000280571	intact:EBI-726075|uniprotkb:O88386|uniprotkb:Q6IA52|uniprotkb:Q9D7X6|uniprotkb:Q9H0T3|uniprotkb:D6W538|ensembl:ENSP00000264710	psi-mi:ripl2_human(display_long)|uniprotkb:Rab-interacting lysosomal protein-like 2(gene name synonym)|uniprotkb:p40phox-binding protein(gene name synonym)|uniprotkb:RILPL2(gene name)|psi-mi:RILPL2(display_short)|uniprotkb:RLP2(gene name synonym)	psi-mi:rab10_human(display_long)|uniprotkb:RAB10(gene name)|psi-mi:RAB10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006706|imex:IM-27029-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659495.1|ensembl:ENSG00000150977(gene)|ensembl:ENST00000280571(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:7LWB	refseq:NP_057215.3|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:5LPN|rcsb pdb:5SZJ|reactome:R-HSA-1445148|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|ensembl:ENSG00000084733(gene)|ensembl:ENST00000264710(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)	-	-	-	comment:Constitutively active LRRK2 was expressed in the cells|figure legend:Fig. 3H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/14	2018/12/17	rogid:Sp67YMUXLQ+A9uXKbUW5orzJ/GQ9606	rogid:ZbfLtWtXl3z6/MYyhiZp6P1Y5tE9606	rigid:Acu2pvXOuea6Fd9CMaijMba/O4k	false	green fluorescent protein tag:?-?|mutation disrupting interaction strength:130-130|mutation disrupting interaction strength:132-132|mutation disrupting interaction strength:149-149	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q969X0	uniprotkb:P61006	intact:EBI-717552|ensembl:ENSP00000280571	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:ripl2_human(display_long)|uniprotkb:Rab-interacting lysosomal protein-like 2(gene name synonym)|uniprotkb:p40phox-binding protein(gene name synonym)|uniprotkb:RILPL2(gene name)|psi-mi:RILPL2(display_short)|uniprotkb:RLP2(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006706|imex:IM-27029-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659495.1|ensembl:ENSG00000150977(gene)|ensembl:ENST00000280571(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:7LWB	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	comment:Constitutively active LRRK2 was expressed in the cells|figure legend:Fig. 3H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/12/14	2018/12/17	rogid:Sp67YMUXLQ+A9uXKbUW5orzJ/GQ9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rigid:Acu2pvXOuea6Fd9CMaijMba/O4k	false	green fluorescent protein tag:?-?|mutation disrupting interaction strength:130-130|mutation disrupting interaction strength:132-132|mutation disrupting interaction strength:149-149	ha tag:?-?	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8TDZ2	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-7153876|ensembl:ENSP00000351664|uniprotkb:Q9H7I0|intact:MINT-1343875|uniprotkb:Q8IVS9|uniprotkb:Q7Z633|uniprotkb:Q9HAA1|uniprotkb:Q9UFF7|uniprotkb:B7Z3R5|uniprotkb:Q9H6X6|uniprotkb:E1P5F0|uniprotkb:Q96G47	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:mica1_human(display_long)|uniprotkb:MICAL1(gene name)|psi-mi:MICAL1(display_short)|uniprotkb:MICAL(gene name synonym)|uniprotkb:NICAL(gene name synonym)|uniprotkb:Molecule interacting with CasL protein 1(gene name synonym)|uniprotkb:NEDD9-interacting protein with calponin homology and LIM domains(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001273542.1|ensembl:ENSG00000135596(gene)|ensembl:ENST00000358807(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019417"(sulfur oxidation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0071949"(FAD binding)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:1990026"(hippocampal mossy fiber expansion)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR002938(Monooxygenase, FAD-binding)|interpro:IPR022735|interpro:IPR029937|interpro:IPR036188|interpro:IPR036872|mint:Q8TDZ2|rcsb pdb:1WYL|rcsb pdb:2CO8|rcsb pdb:2DK9|rcsb pdb:5LE0|rcsb pdb:5LPN|rcsb pdb:6KU0|reactome:R-HSA-983231|refseq:NP_001152763.1|refseq:NP_073602.3|ensembl:ENST00000358577|ensembl:ENSP00000351385|ensembl:ENSP00000351664|ensembl:ENST00000630715|ensembl:ENSP00000486901	-	-	comment:mint|comment:homomint|function:May be a cytoskeletal regulator that connects NEDD9 to intermediate filaments	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:BmwvLz7V3mW/K2zKwAZISU01Eog9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q14964	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-3048577|ensembl:ENSP00000322594|uniprotkb:A8KAA4|uniprotkb:Q8N6W2	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:rb39a_human(display_long)|uniprotkb:RAB39A(gene name)|psi-mi:RAB39A(display_short)|uniprotkb:RAB39(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000179331(gene)|ensembl:ENST00000320578(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041818|reactome:R-HSA-6811438|reactome:R-HSA-8873719|reactome:R-HSA-8876198|refseq:NP_059986.1|dip:DIP-60521N	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:jpkNU7VaaBLmc8P2kLuNq++1T2I9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:P31150	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-946999|uniprotkb:P50394|uniprotkb:Q7Z2G6|uniprotkb:Q7Z2G9|uniprotkb:Q7Z2H5|uniprotkb:Q7Z2I6|uniprotkb:Q6FG50|ensembl:ENSP00000394071	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:gdia_human(display_long)|uniprotkb:GDI1(gene name)|psi-mi:GDI1(display_short)|uniprotkb:OPHN2(gene name synonym)|uniprotkb:RABGDIA(gene name synonym)|uniprotkb:XAP4(gene name synonym)|uniprotkb:Guanosine diphosphate dissociation inhibitor 1(gene name synonym)|uniprotkb:Oligophrenin-2(gene name synonym)|uniprotkb:Protein XAP-4(gene name synonym)|uniprotkb:GDIL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001484.1|ensembl:ENSG00000203879(gene)|ensembl:ENST00000447750(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P31150|reactome:R-HSA-8876198	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:bE8RgEdzf7V/T+hWdGJkM9WM0yI9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8NDI1	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2689720|uniprotkb:Q9NWI9|uniprotkb:Q6QNV2|uniprotkb:Q6NX72|uniprotkb:Q53TV6|uniprotkb:Q6PIT3|uniprotkb:Q53TG7|uniprotkb:Q580X2|uniprotkb:O94977|ensembl:ENSP00000263991	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:ehbp1_human(display_long)|uniprotkb:KIAA0903(gene name synonym)|uniprotkb:NACSIN(gene name synonym)|uniprotkb:EHBP1(gene name)|psi-mi:EHBP1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSP00000263991|ensembl:ENST00000405015|ensembl:ENSP00000384143|ensembl:ENST00000405289|ensembl:ENSP00000385524|ensembl:ENST00000431489|ensembl:ENSP00000403783|refseq:XP_011531015.1|refseq:XP_011531016.1|refseq:XP_011531017.1|refseq:NP_001136086.1|refseq:NP_001136087.1|refseq:NP_001136088.1|refseq:NP_056067.2|refseq:XP_016859136.1|refseq:XP_016859137.1|refseq:XP_016859138.1|refseq:XP_005264282.1|refseq:XP_005264283.1|refseq:XP_005264284.1|refseq:XP_016859132.1|refseq:XP_016859133.1|refseq:XP_016859140.1|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:2D89|rcsb pdb:6ZSH|ensembl:ENSG00000115504(gene)|ensembl:ENST00000263991(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR019448|interpro:IPR022735|interpro:IPR029944|interpro:IPR036872	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:sDcegXBYi8eQp7KReaysxBy3Ogc9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q66K14	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2688824|uniprotkb:O75163|uniprotkb:D3DWQ6|uniprotkb:Q96H49|uniprotkb:Q6MZI2|uniprotkb:Q53EY0|uniprotkb:D3DWQ5|ensembl:ENSP00000349291|ensembl:ENSP00000491373|ensembl:ENSP00000491970	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:tbc9b_human(display_long)|uniprotkb:KIAA0676(gene name synonym)|uniprotkb:TBC1D9B(gene name)|psi-mi:TBC1D9B(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_055858.2|refseq:NP_942568.2|ensembl:ENSG00000197226(gene)|ensembl:ENSG00000284400(gene)|ensembl:ENST00000356834(transcript)|ensembl:ENST00000639361(transcript)|ensembl:ENST00000639711(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004182(GRAM)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|interpro:IPR036014|interpro:IPR036017|mint:Q66K14	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:DdCLCQa69pLYH6eIKdazflUwAKY9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q0IIM8	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-11837915|uniprotkb:B9A6K5|uniprotkb:B9A6K6|uniprotkb:Q5JRB7|uniprotkb:Q6ZVX5|uniprotkb:Q9NXE3|ensembl:ENSP00000349781	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:tbc8b_human(display_long)|uniprotkb:TBC1D8B(gene name)|psi-mi:TBC1D8B(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_060222.2|refseq:NP_942582.1|ensembl:ENSG00000133138(gene)|ensembl:ENST00000357242(transcript)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004182(GRAM)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|interpro:IPR036012|interpro:IPR036015|reactome:R-HSA-432722	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:NWulX/MojVGvrZd5TQw+AJjfRoU9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q96C24	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-747142|uniprotkb:Q5H9J3|uniprotkb:Q5JPG8|uniprotkb:Q8N9P4|uniprotkb:Q9H4R0|uniprotkb:Q9H4R1|ensembl:ENSP00000263033|ensembl:ENSP00000276141|ensembl:ENSP00000362080	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:sytl4_human(display_long)|uniprotkb:Exophilin-2(gene name synonym)|uniprotkb:Granuphilin(gene name synonym)|uniprotkb:SYTL4(gene name)|psi-mi:SYTL4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001123368.1|refseq:NP_001167539.1|refseq:NP_542775.2|refseq:XP_011529370.1|ensembl:ENSP00000263033|ensembl:ENSP00000276141|ensembl:ENST00000372981|ensembl:ENSP00000362072|ensembl:ENSP00000362080|refseq:XP_005262286.1|go:"GO:0032418"(lysosome localization)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028694|interpro:IPR035892|interpro:IPR037303|interpro:IPR041282|interpro:IPR043567|interpro:IPR044134|rcsb pdb:2CSZ|rcsb pdb:3FDW|rcsb pdb:5X6T|reactome:R-HSA-114608|go:"GO:0031267"(small GTPase binding)|ensembl:ENSG00000102362(gene)|ensembl:ENST00000263033(transcript)|ensembl:ENST00000276141(transcript)|ensembl:ENST00000372989(transcript)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031092"(platelet alpha granule membrane)|refseq:XP_016885460.1	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:mL6mjIGzdpbem45EAZ6WE8I5nsE9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q7RTP6	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2555582|uniprotkb:E9PEF0|uniprotkb:Q5U4P4|uniprotkb:Q6ICK4|uniprotkb:Q9P2I3|intact:EBI-2558651|uniprotkb:O94909|uniprotkb:Q96DF2|ensembl:ENSP00000416015|uniprotkb:B2RXJ5	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:mica3_human(display_long)|uniprotkb:KIAA0819(gene name synonym)|uniprotkb:KIAA1364(gene name synonym)|uniprotkb:MICAL3(gene name)|psi-mi:MICAL3(display_short)|uniprotkb:Molecule interacting with CasL protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001116203.1|refseq:NP_056056.2|go:"GO:0007049"(cell cycle)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042995"(cell projection)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0071949"(FAD binding)|go:"GO:0090543"(Flemming body)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR002938(Monooxygenase, FAD-binding)|interpro:IPR022735|interpro:IPR029941|interpro:IPR036188|interpro:IPR036872|rcsb pdb:2D88|rcsb pdb:5SZG|rcsb pdb:6ICI|go:"GO:0007010"(cytoskeleton organization)|ensembl:ENSG00000243156(gene)|ensembl:ENST00000441493(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006887"(exocytosis)|refseq:NP_001129476.1|refseq:XP_005261319.1	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:Ve1WEQHry/REv1IzmmnyGGYd5No9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8IVH8	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:O60271	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-1023301|uniprotkb:O60905|uniprotkb:Q3KQU8|uniprotkb:Q3MKM7|uniprotkb:Q86WC7|uniprotkb:Q86WC8|uniprotkb:Q8IZX7|uniprotkb:Q96II0|uniprotkb:Q9H811|uniprotkb:A8MSX0|uniprotkb:B4DHH2|uniprotkb:A6H8U5|intact:EBI-2560890|ensembl:ENSP00000262013	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:jip4_human(display_long)|uniprotkb:JNK-associated leucine-zipper protein(gene name synonym)|uniprotkb:Sperm-associated antigen 9(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 4(gene name synonym)|uniprotkb:Human lung cancer oncogene 6 protein(gene name synonym)|uniprotkb:Proliferation-inducing protein 6(gene name synonym)|uniprotkb:Sperm-specific protein(gene name synonym)|uniprotkb:Sperm surface protein(gene name synonym)|uniprotkb:Protein highly expressed in testis(gene name synonym)|uniprotkb:Sunday driver 1(gene name synonym)|uniprotkb:Cancer/testis antigen 89(gene name synonym)|uniprotkb:HLC6(orf name)|uniprotkb:SPAG9(gene name)|psi-mi:SPAG9(display_short)|uniprotkb:HSS(gene name synonym)|uniprotkb:KIAA0516(gene name synonym)|uniprotkb:MAPK8IP4(gene name synonym)|uniprotkb:SYD1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001123999.1|refseq:NP_001238900.1|refseq:NP_001124000.1|refseq:NP_003962.3|ensembl:ENSG00000008294(gene)|ensembl:ENST00000262013(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032418"(lysosome localization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903860"(negative regulation of dendrite extension)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019143|interpro:IPR032486|interpro:IPR034743|interpro:IPR034744|interpro:IPR036322|interpro:IPR039911|mint:O60271|rcsb pdb:2W83|reactome:R-HSA-525793	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:UsItS/q6arsUKVnp+hGuBZE3P809606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8N3F8	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-1056885|uniprotkb:Q5TI16|uniprotkb:Q7RTP5|uniprotkb:Q8N3N8|uniprotkb:Q9BVL9|uniprotkb:Q9BY92|uniprotkb:Q9UH43|uniprotkb:Q9UH44|uniprotkb:Q9UH45|ensembl:ENSP00000215957	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:milk1_human(display_long)|uniprotkb:MICALL1(gene name)|psi-mi:MICALL1(display_short)|uniprotkb:KIAA1668(gene name synonym)|uniprotkb:MIRAB13(gene name synonym)|uniprotkb:Molecule interacting with Rab13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_203744.1|ensembl:ENSP00000215957|ensembl:ENSG00000100139(gene)|ensembl:ENST00000215957(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032458"(slow endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|mint:Q8N3F8|rcsb pdb:2KSP|go:"GO:0045296"(cadherin binding)	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:G64P9EtjEfLIVLYkb+w3vCWaT0w9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q01968	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:P47224	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-713992|uniprotkb:Q92992|ensembl:ENSP00000356231|uniprotkb:B2R4P4	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:mss4_human(display_long)|uniprotkb:Rab-interacting factor(gene name synonym)|uniprotkb:RABIF(gene name)|psi-mi:RABIF(display_short)|uniprotkb:MSS4(gene name synonym)|uniprotkb:RASGRF3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000183155(gene)|ensembl:ENST00000367262(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0061025"(membrane fusion)|interpro:IPR007515(Mss4)|interpro:IPR011057(Mss4-like)|interpro:IPR011323(Mss4/translationally controlled tumour-associated TCTP)|mint:P47224|rcsb pdb:1FWQ|rcsb pdb:2FU5|refseq:NP_002862.2	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:BDlOz1AZhYAV6xVZZu0ZLb58po49606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8IY33	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2555563|uniprotkb:Q7Z655|uniprotkb:Q7RTP4|uniprotkb:Q8TEQ4|uniprotkb:Q9H5F9|uniprotkb:D3YTD2|ensembl:ENSP00000297508	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:milk2_human(display_long)|uniprotkb:MICALL2(gene name)|psi-mi:MICALL2(display_short)|uniprotkb:JRAB(gene name synonym)|uniprotkb:Junctional Rab13-binding protein(gene name synonym)|uniprotkb:Molecule interacting with CasL-like 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_891554.1|ensembl:ENSG00000164877(gene)|ensembl:ENST00000297508(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031005"(filamin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042805"(actinin binding)|go:"GO:0043005"(neuron projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR022735|interpro:IPR028563|interpro:IPR036872|go:"GO:0032456"(endocytic recycling)	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:d9MLMRVjjQDtZwHGP1IA0pu9KlA9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:P50395	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-1049143|uniprotkb:O43928|uniprotkb:Q9UQM6|ensembl:ENSP00000369538|uniprotkb:Q5SX88	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:gdib_human(display_long)|uniprotkb:Guanosine diphosphate dissociation inhibitor 2(gene name synonym)|uniprotkb:GDI2(gene name)|psi-mi:GDI2(display_short)|uniprotkb:RABGDIB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000057608(gene)|ensembl:ENST00000380191(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0034774"(secretory granule lumen)|refseq:NP_001108628.1|refseq:NP_001485.2|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P50395|reactome:R-HSA-6798695|reactome:R-HSA-8876198|dip:DIP-50593N	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:KTUS915xP+QA9QFU2aZSyS+Hkgc9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q562E7	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-5235360|uniprotkb:Q24JP6|uniprotkb:Q8N277|uniprotkb:Q8N3F3|uniprotkb:B3KW16|uniprotkb:B3KXU1|uniprotkb:B7Z579|uniprotkb:E9PHG7|uniprotkb:Q8TEL1|ensembl:ENSP00000386609	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:wdr81_human(display_long)|uniprotkb:WDR81(gene name)|psi-mi:WDR81(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:XP_011521953.1|refseq:NP_001157145.1|refseq:NP_001157281.1|refseq:NP_001157283.1|refseq:NP_689561.2|ensembl:ENSG00000167716(gene)|ensembl:ENST00000409644(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0035973"(aggrephagy)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR036372|reactome:R-HSA-9013148|go:"GO:0045022"(early endosome to late endosome transport)	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:WZMmbrspcu0HwOC1iuqrGa4NA2s9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:A4D1P6	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-718046|uniprotkb:A6NK54|uniprotkb:C9JMI4|uniprotkb:Q6FI65|uniprotkb:Q6MZQ1|uniprotkb:Q6P4I1|uniprotkb:Q96AE5|uniprotkb:Q96G63|uniprotkb:Q9H062|uniprotkb:Q9H9B6|uniprotkb:Q9NVG7|uniprotkb:Q9NZY6|ensembl:ENSP00000346466	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:wdr91_human(display_long)|uniprotkb:WDR91(gene name)|psi-mi:WDR91(display_short)|uniprotkb:HSPC049(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_054868.3|ensembl:ENSG00000105875(gene)|ensembl:ENST00000354475(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:1903362"(regulation of cellular protein catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039724|rcsb pdb:6VYC|reactome:R-HSA-9013148	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:Lcc2+uMzFIgd+WP1QGrWhAf4Bgw9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q969X0	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-717552|ensembl:ENSP00000280571	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:ripl2_human(display_long)|uniprotkb:Rab-interacting lysosomal protein-like 2(gene name synonym)|uniprotkb:p40phox-binding protein(gene name synonym)|uniprotkb:RILPL2(gene name)|psi-mi:RILPL2(display_short)|uniprotkb:RLP2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_659495.1|ensembl:ENSG00000150977(gene)|ensembl:ENST00000280571(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:7LWB	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:Sp67YMUXLQ+A9uXKbUW5orzJ/GQ9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P61006	uniprotkb:Q8N3D4	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-2834588|uniprotkb:Q8TB89|uniprotkb:Q9H7M7|ensembl:ENSP00000312671	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:eh1l1_human(display_long)|uniprotkb:EHBP1L1(gene name)|psi-mi:EHBP1L1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steger et al. (2017)	pubmed:29125462|imex:IM-27029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21006606|imex:IM-27029-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000173442(gene)|ensembl:ENST00000309295(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR019448|interpro:IPR022735|interpro:IPR029928|interpro:IPR036872|refseq:NP_001092879.1	-	-	-	figure legend:Fig. 3B|caution:This complex represents a subset of proteins binding to RAB8A in this experiment. Only those proteins identified by the author could be listed.|comment:ROC-COR domain LRRK2-R1441G mutant, which confers strong intracellular kinase activity, was expressed in these cells.|comment:"LRRK2 kinase activity inhibited by HG-10-102-01 (CHEBI:132509)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2018/12/14	2019/05/21	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:A49ma5uVQHbpAMd99czZVg2Kkfw9606	rigid:WNcqKbQUmsCNDNzmKjKFLTq8+o0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)