#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96RK4 uniprotkb:A8MTZ0 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20944740|imex:IM-26519-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 - - - figure legend:Supplementary Data 1, Fig. S6C|comment:"Three additional mutations in BBS18 (p.Ser93Ala, p.Ser93Lys, p.Ser93Glu) with no effect over the interaction were reported in the article. These mutations have been removed from the entry because they fall in a C-terminal serine that does not feature in the UniProt reference sequence."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/22 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false lexa dna binding domain:c-c|sufficient binding region:269-519 mutation with no effect:81-81|mutation with no effect:82-82|mutation with no effect:84-84|mutation with no effect:85-85|mutation with no effect:86-86|mutation with no effect:87-87|mutation with no effect:88-88|mutation with no effect:89-89|mutation with no effect:90-90|mutation with no effect:91-91|mutation with no effect:92-92|mutation with no effect:1-1|mutation with no effect:2-2|mutation with no effect:4-4|mutation with no effect:5-5|mutation with no effect:6-6|mutation with no effect:8-8|mutation with no effect:9-9|mutation with no effect:10-10|mutation with no effect:11-11|mutation with no effect:12-12|mutation with no effect:13-13|mutation with no effect:15-15|mutation with no effect:16-16|mutation with no effect:17-17|mutation with no effect:18-18|mutation with no effect:19-19|mutation with no effect:20-20|mutation with no effect:21-21|mutation with no effect:22-22|mutation with no effect:23-23|mutation with no effect:24-24|mutation with no effect:25-25|mutation with no effect:26-26|mutation with no effect:28-28|mutation with no effect:29-29|mutation with no effect:30-30|mutation with no effect:31-31|mutation disrupting interaction strength:32-32|mutation with no effect:33-33|mutation with no effect:34-34|mutation with no effect:35-35|mutation with no effect:37-37|mutation with no effect:38-38|mutation with no effect:39-39|mutation with no effect:40-40|mutation with no effect:41-41|mutation with no effect:42-42|mutation with no effect:43-43|mutation with no effect:44-44|mutation with no effect:45-45|mutation with no effect:46-46|mutation with no effect:47-47|mutation with no effect:48-48|mutation with no effect:49-49|mutation with no effect:50-50|mutation with no effect:51-51|mutation with no effect:53-53|mutation with no effect:55-55|mutation with no effect:56-56|mutation with no effect:57-57|mutation with no effect:58-58|mutation with no effect:60-60|mutation with no effect:61-61|mutation with no effect:62-62|mutation with no effect:63-63|mutation with no effect:64-64|mutation with no effect:66-66|mutation with no effect:67-67|mutation with no effect:69-69|mutation with no effect:70-70|mutation with no effect:71-71|mutation with no effect:72-72|mutation with no effect:73-73|mutation with no effect:74-74|mutation with no effect:75-75|mutation with no effect:76-76|mutation with no effect:77-77|mutation with no effect:78-78|mutation with no effect:79-79|mutation with no effect:80-80|mutation with no effect:81-81|mutation with no effect:82-82|mutation with no effect:83-83|mutation with no effect:84-84|mutation with no effect:86-86|mutation with no effect:87-87|mutation with no effect:88-88|mutation with no effect:89-89|mutation with no effect:90-90|mutation with no effect:91-91|mutation with no effect:92-92|mutation with no effect:1-1|mutation with no effect:2-2|mutation with no effect:3-3|mutation with no effect:4-4|mutation with no effect:5-5|mutation with no effect:6-6|mutation with no effect:7-7|mutation with no effect:8-8|mutation with no effect:9-9|mutation with no effect:11-11|mutation with no effect:12-12|mutation with no effect:13-13|mutation with no effect:14-14|mutation with no effect:15-15|mutation with no effect:16-16|mutation with no effect:17-17|mutation with no effect:18-18|mutation with no effect:19-19|mutation with no effect:20-20|mutation with no effect:21-21|mutation with no effect:22-22|mutation with no effect:23-23|mutation with no effect:24-24|mutation with no effect:26-26|mutation with no effect:27-27|mutation with no effect:28-28|mutation with no effect:29-29|mutation with no effect:30-30|mutation with no effect:31-31|mutation with no effect:33-33|mutation with no effect:34-34|mutation with no effect:35-35|mutation with no effect:36-36|mutation with no effect:37-37|mutation with no effect:38-38|mutation with no effect:39-39|mutation with no effect:40-40|mutation with no effect:41-41|mutation with no effect:42-42|mutation with no effect:44-44|mutation with no effect:45-45|mutation with no effect:46-46|mutation with no effect:47-47|mutation with no effect:48-48|mutation with no effect:49-49|mutation with no effect:50-50|mutation with no effect:51-51|mutation with no effect:52-52|mutation with no effect:53-53|mutation with no effect:54-54|mutation with no effect:55-55|mutation with no effect:56-56|mutation with no effect:57-57|mutation with no effect:58-58|mutation with no effect:59-59|mutation with no effect:60-60|mutation with no effect:61-61|mutation with no effect:62-62|mutation with no effect:63-63|mutation with no effect:65-65|mutation with no effect:66-66|mutation with no effect:68-68|mutation with no effect:69-69|mutation with no effect:70-70|mutation with no effect:71-71|mutation with no effect:72-72|mutation with no effect:73-73|mutation with no effect:74-74|mutation with no effect:75-75|mutation with no effect:76-76|mutation with no effect:77-77|mutation with no effect:78-78|mutation with no effect:79-79|mutation with no effect:80-80|mutation with no effect:82-82|mutation with no effect:83-83|mutation with no effect:85-85|mutation with no effect:86-86|mutation with no effect:87-87|mutation with no effect:88-88|mutation with no effect:89-89|mutation with no effect:90-90|mutation with no effect:91-91|mutation with no effect:92-92|mutation disrupting interaction strength:34-34|mutation disrupting interaction strength:72-72|mutation disrupting interaction strength:29-29|mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:56-56|mutation disrupting interaction strength:34-34|mutation disrupting interaction strength:52-52|mutation disrupting interaction strength:14-14|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:34-34|mutation disrupting interaction strength:36-36|mutation disrupting interaction strength:34-34|mutation disrupting interaction strength:35-35|mutation disrupting interaction strength:47-47|mutation disrupting interaction strength:57-57|mutation disrupting interaction strength:71-71|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:30-30|mutation disrupting interaction strength:35-35|mutation disrupting interaction strength:51-51|mutation disrupting interaction strength:62-62|mutation disrupting interaction strength:67-67|mutation disrupting interaction strength:35-35|mutation disrupting interaction strength:54-54|mutation disrupting interaction strength:70-70|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:36-36|mutation disrupting interaction strength:52-52|mutation disrupting interaction strength:54-54|gal4 activation domain:c-c|mutation with no effect:1-1|mutation with no effect:2-2|mutation with no effect:3-3|mutation with no effect:7-7|mutation with no effect:8-8|mutation with no effect:9-9|mutation with no effect:10-10|mutation with no effect:11-11|mutation with no effect:12-12|mutation with no effect:13-13|mutation with no effect:14-14|mutation with no effect:15-15|mutation with no effect:16-16|mutation with no effect:17-17|mutation with no effect:18-18|mutation with no effect:19-19|mutation with no effect:20-20|mutation with no effect:21-21|mutation with no effect:22-22|mutation with no effect:23-23|mutation with no effect:25-25|mutation with no effect:26-26|mutation with no effect:27-27|mutation with no effect:28-28|mutation with no effect:29-29|mutation with no effect:30-30|mutation with no effect:31-31|mutation with no effect:32-32|mutation with no effect:33-33|mutation disrupting interaction strength:34-34|mutation with no effect:35-35|mutation with no effect:36-36|mutation with no effect:37-37|mutation with no effect:38-38|mutation with no effect:39-39|mutation with no effect:40-40|mutation with no effect:41-41|mutation with no effect:42-42|mutation with no effect:43-43|mutation with no effect:44-44|mutation with no effect:45-45|mutation with no effect:46-46|mutation with no effect:47-47|mutation with no effect:48-48|mutation with no effect:49-49|mutation with no effect:50-50|mutation with no effect:51-51|mutation with no effect:52-52|mutation with no effect:53-53|mutation with no effect:54-54|mutation with no effect:55-55|mutation with no effect:56-56|mutation with no effect:57-57|mutation with no effect:58-58|mutation with no effect:59-59|mutation with no effect:60-60|mutation with no effect:61-61|mutation with no effect:62-62|mutation with no effect:63-63|mutation with no effect:64-64|mutation with no effect:65-65|mutation with no effect:66-66|mutation disrupting interaction strength:67-67|mutation with no effect:68-68|mutation with no effect:69-69|mutation with no effect:70-70|mutation with no effect:71-71|mutation with no effect:74-74|mutation with no effect:75-75|mutation with no effect:76-76|mutation with no effect:77-77|mutation with no effect:78-78|mutation with no effect:79-79|mutation with no effect:80-80 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:Q8NFJ9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20945599|imex:IM-26519-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Supplementary Data 1, Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/22 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rigid:v4O059J1ifzUKCNAa0cdUdhWfOA false gal4 activation domain:n-n|sufficient binding region:407-887 lexa dna binding domain:n-n|mutation with no effect:413-413|mutation with no effect:414-414|mutation with no effect:415-415|mutation with no effect:416-416|mutation with no effect:417-417|mutation with no effect:418-418|mutation with no effect:419-419|mutation with no effect:421-421|mutation with no effect:423-423|mutation with no effect:424-424|mutation with no effect:425-425|mutation with no effect:426-426|mutation with no effect:427-427|mutation with no effect:428-428|mutation with no effect:429-429|mutation with no effect:430-430|mutation with no effect:431-431|mutation with no effect:432-432|mutation with no effect:433-433|mutation with no effect:434-434|mutation with no effect:435-435|mutation disrupting interaction strength:436-436|mutation with no effect:437-437|mutation with no effect:438-438|mutation with no effect:439-439|mutation with no effect:440-440|mutation with no effect:441-441|mutation with no effect:442-442|mutation with no effect:443-443|mutation with no effect:445-445|mutation with no effect:446-446|mutation with no effect:448-448|mutation with no effect:449-449|mutation with no effect:450-450|mutation with no effect:452-452|mutation with no effect:453-453|mutation with no effect:454-454|mutation with no effect:455-455|mutation with no effect:456-456|mutation with no effect:457-457|mutation with no effect:458-458|mutation with no effect:459-459|mutation with no effect:460-460|mutation with no effect:461-461|mutation with no effect:462-462|mutation with no effect:465-465|mutation with no effect:467-467|mutation with no effect:468-468|mutation with no effect:469-469|mutation with no effect:471-471|mutation with no effect:472-472|mutation with no effect:473-473|mutation with no effect:474-474|mutation with no effect:475-475|mutation with no effect:476-476|mutation with no effect:477-477|mutation with no effect:478-478|mutation with no effect:479-479|mutation with no effect:480-480|mutation with no effect:481-481|mutation with no effect:483-483|mutation with no effect:484-484|mutation with no effect:485-485|mutation with no effect:486-486|mutation with no effect:487-487|mutation with no effect:488-488|mutation with no effect:489-489|mutation with no effect:491-491|mutation with no effect:492-492|mutation with no effect:493-493|mutation with no effect:494-494|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation with no effect:499-499|mutation with no effect:500-500|mutation disrupting interaction strength:501-501|mutation with no effect:502-502|mutation with no effect:503-503|mutation with no effect:504-504|mutation with no effect:505-505|mutation with no effect:506-506|mutation with no effect:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:511-511|mutation with no effect:512-512|mutation with no effect:513-513|mutation with no effect:514-514|mutation with no effect:515-515|mutation disrupting interaction strength:516-516|mutation with no effect:517-517|mutation with no effect:518-518|mutation with no effect:519-519|mutation with no effect:520-520|mutation with no effect:521-521|mutation with no effect:522-522|mutation disrupting interaction strength:523-523|mutation disrupting interaction strength:524-524|mutation with no effect:525-525|mutation with no effect:527-527|mutation disrupting interaction strength:528-528|mutation with no effect:529-529|mutation disrupting interaction strength:530-530|mutation with no effect:531-531|mutation with no effect:532-532|mutation with no effect:534-534|mutation with no effect:535-535|mutation with no effect:536-536|mutation with no effect:537-537|mutation with no effect:538-538|mutation disrupting interaction strength:539-539|mutation with no effect:540-540|mutation with no effect:541-541|mutation with no effect:542-542|mutation with no effect:543-543|mutation with no effect:544-544|mutation with no effect:545-545|mutation with no effect:546-546|mutation with no effect:547-547|mutation with no effect:548-548|mutation with no effect:549-549|mutation with no effect:550-550|mutation with no effect:551-551|mutation with no effect:552-552|mutation with no effect:553-553|mutation with no effect:554-554|mutation with no effect:555-555|mutation with no effect:556-556|mutation with no effect:557-557|mutation with no effect:558-558|mutation with no effect:559-559|mutation with no effect:560-560|mutation with no effect:561-561|mutation with no effect:562-562|mutation with no effect:563-563|mutation disrupting interaction strength:564-564|mutation with no effect:565-565|mutation with no effect:566-566|mutation with no effect:567-567|mutation disrupting interaction strength:568-568|mutation with no effect:569-569|mutation with no effect:570-570|mutation with no effect:571-571|mutation with no effect:572-572|mutation with no effect:573-573|mutation with no effect:574-574|mutation with no effect:576-576|mutation with no effect:577-577|mutation with no effect:578-578|mutation with no effect:579-579|mutation with no effect:581-581|mutation with no effect:582-582|mutation with no effect:583-583|mutation with no effect:584-584|mutation with no effect:585-585|mutation with no effect:586-586|mutation with no effect:587-587|mutation with no effect:588-588|mutation with no effect:589-589|mutation with no effect:590-590|mutation with 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with no effect:482-482|mutation with no effect:483-483|mutation with no effect:485-485|mutation disrupting interaction strength:486-486|mutation with no effect:487-487|mutation with no effect:488-488|mutation with no effect:489-489|mutation with no effect:490-490|mutation with no effect:491-491|mutation with no effect:492-492|mutation with no effect:493-493|mutation with no effect:494-494|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation disrupting interaction strength:499-499|mutation with no effect:500-500|mutation disrupting interaction strength:501-501|mutation with no effect:502-502|mutation disrupting interaction strength:503-503|mutation with no effect:504-504|mutation disrupting interaction strength:505-505|mutation with no effect:506-506|mutation disrupting interaction strength:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:511-511|mutation with no effect:512-512|mutation with no effect:513-513|mutation with no effect:514-514|mutation with no effect:515-515|mutation with no effect:516-516|mutation disrupting interaction strength:517-517|mutation with no effect:518-518|mutation disrupting interaction strength:519-519|mutation with no effect:520-520|mutation disrupting interaction strength:521-521|mutation with no effect:522-522|mutation disrupting interaction strength:523-523|mutation with no effect:524-524|mutation with no effect:526-526|mutation with no effect:527-527|mutation disrupting interaction strength:528-528|mutation with no effect:529-529|mutation disrupting interaction strength:530-530|mutation with no effect:531-531|mutation with no effect:532-532|mutation with no effect:533-533|mutation with no effect:534-534|mutation with no effect:535-535|mutation with no effect:536-536|mutation disrupting interaction strength:537-537|mutation with no effect:538-538|mutation disrupting interaction strength:539-539|mutation disrupting interaction strength:540-540|mutation with no effect:541-541|mutation with no effect:542-542|mutation with no effect:543-543|mutation with no effect:544-544|mutation with no effect:545-545|mutation disrupting interaction strength:546-546|mutation with no effect:547-547|mutation disrupting interaction strength:548-548|mutation with no effect:550-550|mutation with no effect:551-551|mutation disrupting interaction strength:552-552|mutation disrupting interaction strength:554-554|mutation with no effect:555-555|mutation with no effect:556-556|mutation with no effect:557-557|mutation with no effect:558-558|mutation with no effect:559-559|mutation with no effect:560-560|mutation with no effect:561-561|mutation with no effect:562-562|mutation with no effect:563-563|mutation disrupting interaction strength:564-564|mutation with no effect:565-565|mutation disrupting interaction strength:566-566|mutation with no effect:567-567|mutation disrupting interaction strength:568-568|mutation disrupting interaction strength:569-569|mutation with no effect:570-570|mutation with no effect:572-572|mutation with no effect:573-573|mutation with no effect:574-574|mutation with no effect:575-575|mutation with no effect:576-576|mutation with no effect:577-577|mutation with no effect:578-578|mutation with no effect:579-579|mutation with no effect:580-580|mutation with no effect:581-581|mutation with no effect:582-582|mutation with no effect:583-583|mutation with no effect:584-584|mutation with no effect:585-585|mutation with no effect:586-586|mutation with no effect:587-587|mutation with no effect:589-589|mutation with no effect:590-590|mutation with no effect:591-591|mutation with no effect:592-592|mutation with no effect:593-593|mutation disrupting interaction strength:452-452|mutation disrupting interaction strength:528-528|mutation disrupting interaction strength:530-530|mutation disrupting interaction strength:471-471|mutation disrupting interaction strength:432-432|mutation disrupting interaction strength:435-435|mutation disrupting interaction strength:509-509|mutation disrupting interaction strength:538-538|mutation disrupting interaction strength:430-430|mutation disrupting interaction strength:530-530|mutation disrupting interaction strength:505-505|mutation disrupting interaction strength:518-518|mutation disrupting interaction strength:527-527|mutation disrupting interaction strength:530-530|mutation disrupting interaction strength:530-530|mutation disrupting interaction strength:586-586|mutation disrupting interaction strength:459-459|mutation disrupting interaction strength:530-530|mutation disrupting interaction strength:530-530|sufficient binding region:413-593 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWZ6-2 uniprotkb:Q9BXC9 intact:EBI-20947190 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:q8iwz62(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:sBBS2L1(isoform synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20947198|imex:IM-26519-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q8IWZ6-2(isoform-parent) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/22 rogid:uWaBZJekKTwYu9wwslWw1euimf09606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rigid:lZNR3pCW99hKG1lQMBTuS1BnvqY false gal4 activation domain:n-n|sufficient binding region:326-672 mutation with no effect:712-712|mutation with no effect:713-713|mutation with no effect:714-714|mutation with no effect:715-715|mutation with no effect:716-716|mutation with no effect:717-717|mutation with no effect:718-718|mutation with no effect:719-719|mutation with no effect:720-720|mutation with no effect:721-721|mutation disrupting interaction strength:402-402|mutation disrupting interaction strength:457-457|mutation disrupting interaction strength:561-561|mutation disrupting interaction strength:635-635|mutation disrupting interaction strength:670-670|mutation disrupting interaction strength:376-376|mutation disrupting interaction strength:440-440|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:538-538|mutation disrupting interaction strength:636-636|mutation disrupting interaction strength:555-555|mutation disrupting interaction strength:564-564|mutation disrupting interaction strength:468-468|mutation disrupting interaction strength:472-472|mutation disrupting interaction strength:518-518|mutation disrupting interaction strength:574-574|mutation disrupting interaction strength:679-679|mutation disrupting interaction strength:461-461|mutation disrupting interaction strength:469-469|mutation disrupting interaction strength:493-493|mutation disrupting interaction strength:360-360|mutation disrupting interaction strength:384-384|mutation disrupting interaction strength:487-487|mutation disrupting interaction strength:484-484|mutation disrupting interaction strength:377-377|mutation disrupting interaction strength:412-412|mutation disrupting interaction strength:441-441|mutation disrupting interaction strength:487-487|mutation disrupting interaction strength:488-488|mutation disrupting interaction strength:499-499|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:538-538|mutation disrupting interaction strength:552-552|mutation disrupting interaction strength:564-564|mutation disrupting interaction strength:688-688|mutation disrupting interaction strength:408-408|mutation disrupting interaction strength:469-469|mutation disrupting interaction strength:484-484|mutation disrupting interaction strength:485-485|mutation disrupting interaction strength:501-501|mutation disrupting interaction strength:504-504|mutation disrupting interaction strength:544-544|mutation disrupting interaction strength:637-637|mutation disrupting interaction strength:464-464|mutation disrupting interaction strength:676-676|lexa dna binding domain:c-c|mutation with no effect:325-325|mutation with no effect:326-326|mutation with no effect:327-327|mutation with no effect:328-328|mutation with no effect:329-329|mutation with no effect:330-330|mutation with no effect:331-331|mutation with no effect:332-332|mutation with no effect:334-334|mutation with no effect:335-335|mutation with no effect:336-336|mutation with no effect:337-337|mutation with no effect:338-338|mutation with no effect:339-339|mutation with no effect:340-340|mutation with no effect:341-341|mutation with no effect:342-342|mutation with no effect:343-343|mutation with no effect:344-344|mutation with no effect:345-345|mutation with no effect:346-346|mutation with no effect:347-347|mutation with no effect:348-348|mutation with no effect:349-349|mutation with no effect:350-350|mutation with no effect:351-351|mutation with no effect:352-352|mutation with no effect:353-353|mutation with no effect:354-354|mutation with no effect:355-355|mutation with no effect:356-356|mutation with no effect:357-357|mutation with no effect:358-358|mutation with no effect:360-360|mutation with no 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with no effect:396-396|mutation with no effect:397-397|mutation with no effect:399-399|mutation with no effect:400-400|mutation with no effect:401-401|mutation disrupting interaction strength:402-402|mutation with no effect:403-403|mutation with no effect:404-404|mutation with no effect:405-405|mutation with no effect:406-406|mutation with no effect:407-407|mutation with no effect:408-408|mutation with no effect:409-409|mutation with no effect:410-410|mutation with no effect:411-411|mutation with no effect:412-412|mutation with no effect:413-413|mutation with no effect:415-415|mutation with no effect:416-416|mutation with no effect:417-417|mutation with no effect:418-418|mutation with no effect:420-420|mutation with no effect:421-421|mutation with no effect:422-422|mutation with no effect:423-423|mutation with no effect:424-424|mutation with no effect:425-425|mutation with no effect:426-426|mutation with no effect:427-427|mutation with no effect:428-428|mutation with no effect:429-429|mutation with no effect:430-430|mutation with no effect:431-431|mutation with no effect:432-432|mutation with no effect:433-433|mutation with no effect:434-434|mutation with no effect:435-435|mutation with no effect:436-436|mutation with no effect:437-437|mutation with no effect:438-438|mutation with no effect:439-439|mutation disrupting interaction strength:440-440|mutation with no effect:441-441|mutation with no effect:442-442|mutation with no effect:443-443|mutation with no effect:444-444|mutation disrupting interaction strength:445-445|mutation with no effect:446-446|mutation with no effect:447-447|mutation with no effect:448-448|mutation with no effect:449-449|mutation with no effect:450-450|mutation with no effect:451-451|mutation with no effect:452-452|mutation with no effect:453-453|mutation with no effect:454-454|mutation with no effect:455-455|mutation with no effect:456-456|mutation with no effect:457-457|mutation with no effect:458-458|mutation with no 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effect:489-489|mutation with no effect:490-490|mutation with no effect:491-491|mutation with no effect:492-492|mutation with no effect:493-493|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation disrupting interaction strength:499-499|mutation with no effect:500-500|mutation disrupting interaction strength:501-501|mutation with no effect:502-502|mutation with no effect:503-503|mutation with no effect:504-504|mutation with no effect:506-506|mutation with no effect:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:511-511|mutation with no effect:512-512|mutation disrupting interaction strength:513-513|mutation with no effect:514-514|mutation with no effect:515-515|mutation with no effect:516-516|mutation with no effect:517-517|mutation with no effect:518-518|mutation disrupting interaction strength:519-519|mutation with no effect:520-520|mutation with no effect:521-521|mutation with no effect:523-523|mutation with no effect:524-524|mutation with no effect:525-525|mutation with no effect:526-526|mutation with no effect:527-527|mutation with no effect:528-528|mutation with no effect:529-529|mutation with no effect:530-530|mutation with no effect:531-531|mutation with no effect:532-532|mutation disrupting interaction strength:533-533|mutation with no effect:534-534|mutation with no effect:535-535|mutation with no effect:536-536|mutation with no effect:537-537|mutation with no effect:538-538|mutation with no effect:539-539|mutation with no effect:540-540|mutation with no effect:541-541|mutation with no effect:542-542|mutation with no effect:543-543|mutation disrupting interaction strength:544-544|mutation with no effect:545-545|mutation with no effect:546-546|mutation disrupting interaction strength:547-547|mutation with no effect:548-548|mutation with no effect:549-549|mutation with no effect:550-550|mutation with no effect:551-551|mutation with no effect:552-552|mutation with no effect:554-554|mutation with no effect:555-555|mutation with no effect:556-556|mutation with no effect:557-557|mutation with no effect:558-558|mutation with no effect:559-559|mutation with no effect:560-560|mutation with no effect:561-561|mutation with no effect:562-562|mutation with no effect:563-563|mutation with no effect:564-564|mutation with no effect:565-565|mutation with no effect:566-566|mutation with no effect:567-567|mutation disrupting interaction strength:568-568|mutation with no effect:569-569|mutation with no effect:570-570|mutation with no effect:571-571|mutation with no effect:572-572|mutation with no effect:573-573|mutation with no effect:574-574|mutation with no effect:575-575|mutation with no effect:576-576|mutation with no effect:577-577|mutation with no effect:579-579|mutation with no effect:580-580|mutation with no effect:581-581|mutation with no effect:582-582|mutation with no effect:584-584|mutation with no effect:585-585|mutation with no effect:586-586|mutation with no effect:587-587|mutation with no effect:588-588|mutation with no effect:589-589|mutation with no effect:590-590|mutation with no effect:593-593|mutation with no effect:594-594|mutation with no effect:595-595|mutation with no effect:596-596|mutation with no effect:597-597|mutation with no effect:598-598|mutation with no effect:599-599|mutation with no effect:600-600|mutation with no effect:601-601|mutation with no effect:603-603|mutation with no effect:604-604|mutation disrupting interaction strength:605-605|mutation with no effect:606-606|mutation with no effect:607-607|mutation with no effect:608-608|mutation with no effect:609-609|mutation with no effect:610-610|mutation with no effect:611-611|mutation with no effect:612-612|mutation with no effect:613-613|mutation with no effect:614-614|mutation with no effect:615-615|mutation with no effect:616-616|mutation with no effect:617-617|mutation with no effect:618-618|mutation with no effect:619-619|mutation with no effect:620-620|mutation with no effect:621-621|mutation with no effect:622-622|mutation with no effect:623-623|mutation with no effect:624-624|mutation with no effect:625-625|mutation with no effect:626-626|mutation with no effect:627-627|mutation with no effect:628-628|mutation with no effect:630-630|mutation with no effect:631-631|mutation with no effect:632-632|mutation with no effect:633-633|mutation with no effect:634-634|mutation with no effect:635-635|mutation with no effect:636-636|mutation with no effect:637-637|mutation with no effect:638-638|mutation with no effect:639-639|mutation with no effect:640-640|mutation with no effect:641-641|mutation with no effect:642-642|mutation with no effect:643-643|mutation disrupting interaction strength:644-644|mutation with no effect:645-645|mutation disrupting interaction strength:647-647|mutation with no effect:648-648|mutation with no effect:649-649|mutation with no effect:650-650|mutation with no effect:651-651|mutation with no effect:652-652|mutation with no effect:653-653|mutation with no effect:654-654|mutation with no effect:655-655|mutation with no effect:656-656|mutation with no effect:657-657|mutation with no effect:658-658|mutation with no effect:659-659|mutation with no effect:660-660|mutation with no effect:661-661|mutation with no effect:662-662|mutation with no effect:663-663|mutation with no effect:664-664|mutation with no effect:665-665|mutation with no effect:666-666|mutation with no effect:668-668|mutation with no effect:669-669|mutation with no effect:670-670|mutation disrupting interaction strength:671-671|mutation with no effect:672-672|mutation with no effect:673-673|mutation with no effect:674-674|mutation with no effect:675-675|mutation with no effect:676-676|mutation with no effect:677-677|mutation with no effect:678-678|mutation disrupting interaction strength:679-679|mutation with no effect:680-680|mutation with no effect:681-681|mutation with no effect:682-682|mutation with no effect:683-683|mutation with no effect:684-684|mutation disrupting interaction strength:685-685|mutation disrupting interaction strength:686-686|mutation with no effect:687-687|mutation disrupting interaction strength:688-688|mutation with no effect:689-689|mutation with no effect:690-690|mutation with no effect:691-691|mutation with no effect:692-692|mutation with no effect:693-693|mutation with no effect:694-694|mutation with no effect:695-695|mutation with no effect:696-696|mutation with no effect:697-697|mutation with no effect:698-698|mutation with no effect:699-699|mutation with no effect:700-700|mutation with no effect:701-701|mutation with no effect:702-702|mutation with no effect:703-703|mutation with no effect:704-704|mutation with no effect:705-705|mutation with no effect:706-706|mutation with no effect:707-707|mutation with no effect:708-708|mutation with no effect:709-709|mutation with no effect:710-710|mutation with no effect:711-711|sufficient binding region:325-721 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:Q8N3I7 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20953065|imex:IM-26519-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) - - - figure legend:Supplementary Data 1, Fig. S7|comment:"Three additional mutations in BBS5 (p.Ser342Lys, p.Ser342Ala, p.Ser342Glu) with no effect over the interaction were reported in the article. These mutations have been removed from the entry because they fall in a C-terminal serine that does not feature in the UniProt reference sequence."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/22 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 rigid:TYiegKicFt188nDOwkN78GhbNGg false lexa dna binding domain:c-c mutation with no effect:213-213|mutation with no effect:214-214|mutation with no effect:215-215|mutation with no effect:216-216|mutation with no effect:217-217|mutation with no effect:218-218|mutation with no effect:219-219|mutation with no effect:220-220|mutation with no effect:221-221|mutation disrupting interaction strength:222-222|mutation with no effect:224-224|mutation with no effect:225-225|mutation with no effect:226-226|mutation with no effect:227-227|mutation with no effect:228-228|mutation with no effect:229-229|mutation with no effect:230-230|mutation with no effect:231-231|mutation with no effect:232-232|mutation with no effect:233-233|mutation with no effect:234-234|mutation with no effect:235-235|mutation disrupting interaction strength:236-236|mutation with no effect:237-237|mutation with no effect:238-238|mutation with no effect:239-239|mutation with no effect:240-240|mutation with no effect:242-242|mutation with no effect:243-243|mutation with no effect:244-244|mutation with no effect:246-246|mutation with no effect:247-247|mutation with no effect:248-248|mutation with no effect:250-250|mutation with no effect:251-251|mutation with no effect:252-252|mutation with no effect:253-253|mutation with no effect:254-254|mutation with no effect:255-255|mutation with no effect:256-256|mutation with no effect:257-257|mutation with no effect:258-258|mutation with no effect:259-259|mutation with no effect:260-260|mutation with no effect:261-261|mutation with no effect:262-262|mutation with no effect:263-263|mutation with no effect:264-264|mutation with no effect:265-265|mutation with no effect:266-266|mutation with no effect:267-267|mutation with no effect:269-269|mutation with no effect:272-272|mutation with no effect:273-273|mutation with no effect:274-274|mutation with no effect:275-275|mutation with no effect:276-276|mutation with no effect:278-278|mutation with no effect:279-279|mutation with no effect:280-280|mutation with no effect:281-281|mutation with no effect:283-283|mutation with no effect:284-284|mutation with no effect:285-285|mutation with no effect:286-286|mutation with no effect:287-287|mutation with no effect:288-288|mutation with no effect:290-290|mutation with no effect:291-291|mutation with no effect:292-292|mutation with no effect:293-293|mutation with no effect:294-294|mutation with no effect:295-295|mutation with no effect:296-296|mutation with no effect:297-297|mutation with no effect:298-298|mutation with no effect:299-299|mutation with no effect:300-300|mutation with no effect:301-301|mutation with no effect:302-302|mutation with no effect:303-303|mutation with no effect:304-304|mutation with no effect:305-305|mutation with no effect:306-306|mutation with no effect:307-307|mutation with no effect:308-308|mutation with no effect:309-309|mutation with no effect:310-310|mutation with no effect:311-311|mutation with no effect:312-312|mutation with no effect:314-314|mutation with no effect:315-315|mutation with no effect:316-316|mutation with no effect:317-317|mutation with no effect:320-320|mutation with no effect:321-321|mutation with no effect:322-322|mutation disrupting interaction strength:323-323|mutation with no effect:324-324|mutation with no effect:326-326|mutation with no effect:327-327|mutation with no effect:328-328|mutation with no effect:329-329|mutation with no effect:330-330|mutation disrupting interaction strength:331-331|mutation with no effect:332-332|mutation with no effect:333-333|mutation with no effect:334-334|mutation with no effect:335-335|mutation with no effect:336-336|mutation with no effect:337-337|mutation with no effect:339-339|mutation with no effect:340-340|mutation with no effect:341-341|mutation disrupting interaction strength:217-217|mutation disrupting interaction strength:55-55|mutation disrupting interaction strength:61-61|mutation disrupting interaction strength:123-123|mutation disrupting interaction strength:32-32|mutation disrupting interaction strength:56-56|mutation disrupting interaction strength:80-80|mutation disrupting interaction strength:104-104|mutation disrupting interaction strength:133-133|mutation disrupting interaction strength:247-247|mutation disrupting interaction strength:15-15|mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:238-238|mutation disrupting interaction strength:30-30|mutation disrupting interaction strength:17-17|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:178-178|mutation disrupting interaction strength:16-16|mutation disrupting interaction strength:48-48|mutation disrupting interaction strength:72-72|mutation disrupting interaction strength:229-229|mutation disrupting interaction strength:331-331|mutation disrupting interaction strength:76-76|mutation disrupting interaction strength:145-145|mutation disrupting interaction strength:11-11|gal4 activation domain:c-c|mutation with no effect:1-1|mutation with no effect:2-2|mutation with no effect:3-3|mutation with no effect:4-4|mutation with no effect:5-5|mutation with no effect:7-7|mutation with no effect:8-8|mutation with no effect:9-9|mutation with no effect:10-10|mutation disrupting interaction strength:11-11|mutation with no effect:12-12|mutation disrupting interaction strength:13-13|mutation with no effect:14-14|mutation disrupting interaction strength:15-15|mutation with no effect:16-16|mutation disrupting interaction strength:17-17|mutation with no effect:18-18|mutation disrupting interaction strength:20-20|mutation with no effect:21-21|mutation disrupting interaction strength:22-22|mutation with no effect:23-23|mutation with no effect:24-24|mutation with no effect:25-25|mutation with no effect:26-26|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:28-28|mutation disrupting interaction strength:29-29|mutation with no effect:30-30|mutation disrupting interaction strength:31-31|mutation with no effect:32-32|mutation with no effect:33-33|mutation with no effect:34-34|mutation with no effect:35-35|mutation with no effect:36-36|mutation with no effect:37-37|mutation with no effect:38-38|mutation with no effect:39-39|mutation with no effect:40-40|mutation with no effect:41-41|mutation with no effect:42-42|mutation with no effect:43-43|mutation with no effect:44-44|mutation with no effect:45-45|mutation with no effect:46-46|mutation with no effect:47-47|mutation with no effect:48-48|mutation with no effect:49-49|mutation disrupting interaction strength:50-50|mutation with no effect:51-51|mutation with no effect:52-52|mutation with no effect:53-53|mutation with no effect:54-54|mutation disrupting interaction strength:55-55|mutation disrupting interaction strength:56-56|mutation with no effect:57-57|mutation with no effect:58-58|mutation with no effect:59-59|mutation with no effect:60-60|mutation with no effect:61-61|mutation with no effect:62-62|mutation with no effect:64-64|mutation with no effect:65-65|mutation with no effect:66-66|mutation with no effect:67-67|mutation disrupting interaction strength:68-68|mutation with no effect:69-69|mutation with no effect:70-70|mutation with no effect:71-71|mutation with no effect:72-72|mutation with no effect:73-73|mutation with no effect:74-74|mutation with no effect:75-75|mutation with no effect:76-76|mutation with no effect:77-77|mutation with no effect:78-78|mutation with no effect:79-79|mutation disrupting interaction strength:80-80|mutation with no effect:81-81|mutation with no effect:82-82|mutation disrupting interaction strength:83-83|mutation with no effect:85-85|mutation with no effect:86-86|mutation with no effect:87-87|mutation with no effect:88-88|mutation with no effect:89-89|mutation with no effect:90-90|mutation with no effect:91-91|mutation with no effect:92-92|mutation with no effect:93-93|mutation with no effect:95-95|mutation with no effect:96-96|mutation with no effect:97-97|mutation with no effect:98-98|mutation with no effect:99-99|mutation with no effect:100-100|mutation with no effect:101-101|mutation with no effect:102-102|mutation with no effect:103-103|mutation with no effect:104-104|mutation with no effect:105-105|mutation with no effect:106-106|mutation with no effect:107-107|mutation with no effect:108-108|mutation with no effect:109-109|mutation with no effect:110-110|mutation with no effect:111-111|mutation with no effect:112-112|mutation with no effect:113-113|mutation with no effect:114-114|mutation with no effect:115-115|mutation with no effect:116-116|mutation with no effect:117-117|mutation with no effect:118-118|mutation with no effect:119-119|mutation with no effect:120-120|mutation with no effect:121-121|mutation with no effect:122-122|mutation with no effect:123-123|mutation with no effect:124-124|mutation with no effect:125-125|mutation with no effect:127-127|mutation with no effect:128-128|mutation with no effect:129-129|mutation with no effect:131-131|mutation with no effect:132-132|mutation with no effect:133-133|mutation with no effect:134-134|mutation with no effect:135-135|mutation with no effect:136-136|mutation with no effect:137-137|mutation with no effect:138-138|mutation with no effect:139-139|mutation with no effect:140-140|mutation with no effect:141-141|mutation with no effect:142-142|mutation with no effect:143-143|mutation with no effect:144-144|mutation with no effect:146-146|mutation with no effect:147-147|mutation with no effect:148-148|mutation with no effect:149-149|mutation with no effect:150-150|mutation with no effect:151-151|mutation with no effect:152-152|mutation with no effect:153-153|mutation with no effect:154-154|mutation with no effect:155-155|mutation with no effect:156-156|mutation with no effect:157-157|mutation with no effect:158-158|mutation with no effect:159-159|mutation with no effect:160-160|mutation with no effect:161-161|mutation with no effect:162-162|mutation with no effect:163-163|mutation with no effect:164-164|mutation with no effect:165-165|mutation with no effect:166-166|mutation with no effect:167-167|mutation with no effect:168-168|mutation with no effect:169-169|mutation with no effect:170-170|mutation with no effect:171-171|mutation with no effect:172-172|mutation with no effect:173-173|mutation with no effect:174-174|mutation with no effect:175-175|mutation with no effect:176-176|mutation with no effect:177-177|mutation with no effect:178-178|mutation with no effect:179-179|mutation with no effect:180-180|mutation with no effect:181-181|mutation with no effect:182-182|mutation with no effect:183-183|mutation with no effect:184-184|mutation with no effect:185-185|mutation with no effect:186-186|mutation with no effect:187-187|mutation with no effect:188-188|mutation with no effect:189-189|mutation with no effect:190-190|mutation with no effect:192-192|mutation with no effect:193-193|mutation with no effect:194-194|mutation with no effect:195-195|mutation with no effect:196-196|mutation with no effect:197-197|mutation with no effect:198-198|mutation with no effect:199-199|mutation with no effect:200-200|mutation with no effect:201-201|mutation with no effect:202-202|mutation with no effect:203-203|mutation with no effect:204-204|mutation with no effect:205-205|mutation with no effect:206-206|mutation with no effect:207-207|mutation with no effect:208-208|mutation with no effect:209-209|mutation with no effect:210-210|mutation with no effect:211-211|mutation with no effect:212-212|mutation with no effect:213-213|mutation with no effect:214-214|mutation with no effect:215-215|mutation with no effect:216-216|mutation with no effect:217-217|mutation with no effect:218-218|mutation with no effect:220-220|mutation with no effect:221-221|mutation with no effect:222-222|mutation with no effect:223-223|mutation with no effect:224-224|mutation with no effect:225-225|mutation with no effect:226-226|mutation disrupting interaction strength:227-227|mutation with no effect:228-228|mutation with no effect:229-229|mutation with no effect:230-230|mutation disrupting interaction strength:231-231|mutation with no effect:232-232|mutation disrupting interaction strength:233-233|mutation disrupting interaction strength:234-234|mutation with no effect:235-235|mutation with no effect:236-236|mutation with no effect:237-237|mutation with no effect:238-238|mutation with no effect:239-239|mutation with no effect:240-240|mutation with no 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effect:307-307|mutation with no effect:308-308|mutation with no effect:309-309|mutation with no effect:310-310|mutation with no effect:311-311|mutation with no effect:312-312|mutation with no effect:313-313|mutation with no effect:314-314|mutation with no effect:315-315|mutation with no effect:316-316|mutation with no effect:317-317|mutation with no effect:318-318|mutation with no effect:319-319|mutation with no effect:320-320|mutation with no effect:321-321|mutation with no effect:322-322|mutation with no effect:324-324|mutation with no effect:325-325|mutation with no effect:326-326|mutation with no effect:327-327|mutation with no effect:328-328|mutation with no effect:329-329|mutation with no effect:330-330|mutation with no effect:331-331|mutation with no effect:332-332|mutation with no effect:333-333|mutation with no effect:334-334|mutation with no effect:335-335|mutation with no effect:336-336|mutation with no effect:337-337|mutation with no effect:338-338|mutation with no 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interaction strength:29-29|mutation with no effect:30-30|mutation with no effect:31-31|mutation with no effect:32-32|mutation with no effect:33-33|mutation with no effect:34-34|mutation with no effect:35-35|mutation with no effect:36-36|mutation with no effect:37-37|mutation with no effect:38-38|mutation with no effect:39-39|mutation with no effect:40-40|mutation with no effect:42-42|mutation with no effect:43-43|mutation with no effect:44-44|mutation with no effect:45-45|mutation with no effect:46-46|mutation with no effect:47-47|mutation with no effect:48-48|mutation with no effect:49-49|mutation with no effect:50-50|mutation with no effect:51-51|mutation disrupting interaction strength:52-52|mutation with no effect:53-53|mutation with no effect:54-54|mutation with no effect:55-55|mutation disrupting interaction strength:56-56|mutation with no effect:57-57|mutation disrupting interaction strength:58-58|mutation with no effect:59-59|mutation with no effect:60-60|mutation with no 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effect:289-289|mutation with no effect:290-290|mutation with no effect:291-291|mutation with no effect:292-292|mutation with no effect:293-293|mutation with no effect:294-294|mutation with no effect:295-295|mutation with no effect:296-296|mutation with no effect:297-297|mutation with no effect:298-298|mutation with no effect:299-299|mutation with no effect:300-300|mutation with no effect:301-301|mutation disrupting interaction strength:302-302|mutation with no effect:303-303|mutation with no effect:304-304|mutation with no effect:305-305|mutation with no effect:306-306|mutation with no effect:307-307|mutation disrupting interaction strength:309-309|mutation with no effect:310-310|mutation with no effect:311-311|mutation with no effect:312-312|mutation with no effect:313-313|mutation with no effect:314-314|mutation with no effect:315-315|mutation with no effect:316-316|mutation with no effect:317-317|mutation with no effect:318-318|mutation with no effect:319-319|mutation with no effect:320-320|mutation with no effect:321-321|mutation disrupting interaction strength:322-322|mutation with no effect:323-323|mutation with no effect:324-324|mutation with no effect:325-325|mutation with no effect:327-327|mutation with no effect:329-329|mutation with no effect:330-330|mutation with no effect:331-331|mutation with no effect:332-332|mutation with no effect:333-333|mutation with no effect:334-334|mutation with no effect:335-335|mutation with no effect:336-336|mutation with no effect:337-337|mutation with no effect:338-338|mutation with no effect:339-339|mutation with no effect:340-340|mutation with no effect:341-341|mutation with no effect:1-1|mutation with no effect:2-2|mutation with no effect:3-3|mutation with no effect:4-4|mutation with no effect:5-5|mutation with no effect:6-6|mutation with no effect:7-7|mutation with no effect:8-8|mutation with no effect:10-10|mutation disrupting interaction strength:11-11|mutation with no effect:12-12|mutation disrupting interaction strength:13-13|mutation disrupting interaction strength:14-14|mutation disrupting interaction strength:15-15|mutation with no effect:16-16|mutation disrupting interaction strength:17-17|mutation with no effect:18-18|mutation with no effect:19-19|mutation with no effect:20-20|mutation with no effect:21-21|mutation disrupting interaction strength:22-22|mutation with no effect:23-23|mutation with no effect:24-24|mutation disrupting interaction strength:25-25|mutation disrupting interaction strength:26-26|mutation disrupting interaction strength:27-27|mutation with no effect:29-29|mutation with no effect:30-30|mutation with no effect:31-31|mutation with no effect:32-32|mutation with no effect:33-33|mutation with no effect:34-34|mutation with no effect:35-35|mutation with no effect:36-36|mutation with no effect:37-37|mutation with no effect:39-39|mutation with no effect:40-40|mutation with no effect:41-41|mutation disrupting interaction strength:42-42|mutation with no 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effect:74-74|mutation with no effect:75-75|mutation disrupting interaction strength:76-76|mutation with no effect:77-77|mutation with no effect:78-78|mutation with no effect:79-79|mutation with no effect:80-80|mutation with no effect:81-81|mutation with no effect:82-82|mutation with no effect:83-83|mutation with no effect:84-84|mutation with no effect:85-85|mutation with no effect:86-86|mutation with no effect:87-87|mutation with no effect:88-88|mutation with no effect:89-89|mutation with no effect:90-90|mutation with no effect:91-91|mutation with no effect:92-92|mutation with no effect:94-94|mutation disrupting interaction strength:95-95|mutation with no effect:96-96|mutation with no effect:97-97|mutation with no effect:98-98|mutation disrupting interaction strength:99-99|mutation with no effect:100-100|mutation with no effect:101-101|mutation with no effect:102-102|mutation with no effect:103-103|mutation with no effect:104-104|mutation with no effect:105-105|mutation with no effect:106-106|mutation disrupting interaction strength:108-108|mutation with no effect:109-109|mutation with no effect:110-110|mutation with no effect:111-111|mutation with no effect:112-112|mutation with no effect:113-113|mutation with no effect:114-114|mutation with no effect:115-115|mutation with no effect:116-116|mutation with no effect:117-117|mutation with no effect:118-118|mutation with no effect:119-119|mutation with no effect:120-120|mutation with no effect:121-121|mutation with no effect:122-122|mutation with no effect:123-123|mutation with no effect:124-124|mutation with no effect:125-125|mutation with no effect:126-126|mutation with no effect:127-127|mutation with no effect:128-128|mutation with no effect:129-129|mutation with no effect:130-130|mutation with no effect:131-131|mutation with no effect:133-133|mutation with no effect:134-134|mutation with no effect:135-135|mutation with no effect:136-136|mutation with no effect:137-137|mutation with no effect:138-138|mutation with no effect:139-139|mutation with no effect:140-140|mutation with no effect:141-141|mutation with no effect:142-142|mutation with no effect:143-143|mutation with no effect:144-144|mutation with no effect:145-145|mutation with no effect:146-146|mutation with no effect:147-147|mutation with no effect:148-148|mutation with no effect:149-149|mutation with no effect:150-150|mutation with no effect:151-151|mutation with no effect:152-152|mutation with no effect:153-153|mutation with no effect:154-154|mutation with no effect:155-155|mutation with no effect:156-156|mutation with no effect:157-157|mutation with no effect:159-159|mutation with no effect:160-160|mutation with no effect:161-161|mutation with no effect:162-162|mutation with no effect:163-163|mutation with no effect:164-164|mutation with no effect:165-165|mutation with no effect:166-166|mutation with no effect:167-167|mutation with no effect:168-168|mutation with no effect:169-169|mutation with no effect:170-170|mutation with no effect:171-171|mutation with no effect:172-172|mutation with no effect:173-173|mutation with no effect:174-174|mutation with no effect:175-175|mutation with no effect:176-176|mutation with no effect:177-177|mutation disrupting interaction strength:178-178|mutation with no effect:179-179|mutation with no effect:180-180|mutation with no effect:181-181|mutation with no effect:182-182|mutation with no effect:183-183|mutation disrupting interaction strength:184-184|mutation with no effect:185-185|mutation disrupting interaction strength:186-186|mutation with no effect:187-187|mutation with no effect:188-188|mutation with no effect:189-189|mutation with no effect:190-190|mutation with no effect:191-191|mutation with no effect:192-192|mutation with no effect:193-193|mutation with no effect:194-194|mutation with no effect:195-195|mutation with no effect:196-196|mutation with no effect:197-197|mutation with no effect:198-198|mutation with no effect:199-199|mutation with no effect:200-200|mutation with no effect:201-201|mutation with no effect:202-202|mutation with no effect:203-203|mutation with no effect:204-204|mutation with no effect:205-205|mutation with no effect:206-206|mutation with no effect:207-207|mutation with no effect:208-208|mutation with no effect:209-209|mutation with no effect:210-210|mutation with no effect:211-211|mutation with no effect:212-212 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BXC9 uniprotkb:Q8IWZ6-2 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-20947190 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:q8iwz62(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:sBBS2L1(isoform synonym) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20956063|imex:IM-26519-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N uniprotkb:Q8IWZ6-2(isoform-parent) - - - figure legend:Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/22 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:uWaBZJekKTwYu9wwslWw1euimf09606 rigid:lZNR3pCW99hKG1lQMBTuS1BnvqY false gal4 activation domain:n-n|sufficient binding region:324-721 lexa dna binding domain:c-c|mutation with no effect:326-326|mutation with no effect:327-327|mutation with no effect:328-328|mutation with no effect:329-329|mutation with no effect:330-330|mutation with no effect:331-331|mutation with no effect:332-332|mutation with no effect:333-333|mutation with no effect:334-334|mutation with no effect:335-335|mutation with no effect:336-336|mutation with no effect:337-337|mutation with no effect:338-338|mutation with no effect:339-339|mutation with no effect:340-340|mutation with no effect:341-341|mutation with no effect:342-342|mutation with no effect:343-343|mutation with no effect:344-344|mutation with no effect:345-345|mutation with no 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effect:570-570|mutation with no effect:571-571|mutation with no effect:572-572|mutation with no effect:573-573|mutation with no effect:574-574|mutation with no effect:575-575|mutation with no effect:576-576|mutation with no effect:577-577|mutation with no effect:578-578|mutation with no effect:579-579|mutation with no effect:580-580|mutation with no effect:581-581|mutation with no effect:582-582|mutation with no effect:584-584|mutation with no effect:585-585|mutation with no effect:586-586|mutation with no effect:587-587|mutation with no effect:588-588|mutation with no effect:589-589|mutation with no effect:590-590|mutation with no effect:591-591|mutation with no effect:592-592|mutation with no effect:593-593|mutation with no effect:594-594|mutation with no effect:595-595|mutation with no effect:597-597|mutation with no effect:598-598|mutation with no effect:600-600|mutation with no effect:601-601|mutation with no effect:602-602|mutation with no effect:603-603|mutation with no effect:604-604|mutation with no effect:605-605|mutation with no effect:606-606|mutation with no effect:607-607|mutation with no effect:608-608|mutation with no effect:609-609|mutation with no effect:610-610|mutation with no effect:611-611|mutation with no effect:612-612|mutation with no effect:613-613|mutation with no effect:615-615|mutation with no effect:616-616|mutation with no effect:617-617|mutation with no effect:618-618|mutation with no effect:619-619|mutation with no effect:620-620|mutation with no effect:621-621|mutation with no effect:622-622|mutation with no effect:623-623|mutation with no effect:624-624|mutation with no effect:625-625|mutation with no effect:626-626|mutation with no effect:627-627|mutation with no effect:628-628|mutation with no effect:629-629|mutation with no effect:630-630|mutation with no effect:632-632|mutation with no effect:633-633|mutation with no effect:634-634|mutation with no effect:635-635|mutation with no effect:637-637|mutation with no effect:638-638|mutation with no effect:639-639|mutation with no effect:640-640|mutation with no effect:641-641|mutation with no effect:642-642|mutation with no effect:643-643|mutation with no effect:644-644|mutation with no effect:646-646|mutation with no effect:647-647|mutation with no effect:648-648|mutation with no effect:649-649|mutation with no effect:650-650|mutation with no effect:653-653|mutation with no effect:654-654|mutation with no effect:655-655|mutation with no effect:656-656|mutation with no effect:657-657|mutation with no effect:660-660|mutation with no effect:661-661|mutation with no effect:662-662|mutation with no effect:663-663|mutation with no effect:664-664|mutation with no effect:665-665|mutation with no effect:666-666|mutation with no effect:667-667|mutation with no effect:669-669|mutation with no effect:670-670|mutation with no effect:671-671|mutation with no effect:672-672|mutation disrupting interaction strength:529-529|mutation disrupting interaction strength:466-466|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:616-616|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:376-376|mutation disrupting interaction strength:483-483|mutation disrupting interaction strength:485-485|mutation disrupting interaction strength:490-490|mutation disrupting interaction strength:570-570|mutation disrupting interaction strength:624-624|mutation disrupting interaction strength:472-472|mutation disrupting interaction strength:485-485|mutation disrupting interaction strength:396-396|mutation disrupting interaction strength:442-442|mutation disrupting interaction strength:468-468|mutation disrupting interaction strength:491-491|mutation disrupting interaction strength:493-493|mutation disrupting interaction strength:509-509|mutation disrupting interaction strength:511-511|mutation disrupting interaction strength:458-458|mutation disrupting interaction strength:481-481|mutation disrupting interaction strength:485-485|mutation disrupting interaction strength:561-561|mutation disrupting interaction strength:563-563|mutation disrupting interaction strength:499-499|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:529-529|mutation disrupting interaction strength:548-548|mutation disrupting interaction strength:561-561|mutation disrupting interaction strength:624-624|mutation disrupting interaction strength:449-449|mutation disrupting interaction strength:399-399|mutation disrupting interaction strength:447-447|mutation disrupting interaction strength:466-466|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:624-624|sufficient binding region:326-672 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:A0A0C4DGX9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-20959097|ensembl:ENSP00000337653 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:a0a0c4dgx9_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:hCG_21081(orf name) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20959131|imex:IM-26519-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_001275710.1|refseq:XP_011534734.1|ensembl:ENSG00000165533(gene)|ensembl:ENST00000338104(transcript)|go:"GO:0034464"(BBSome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796 - - - figure legend:Supplementary Data 1, Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/22 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:eqYXkO13bM/IvoDreqimd3AoF909606 rigid:PiOnjKHkyGjhE1GXD9moFguM38g false gal4 activation domain:?-? mutation with no effect:40-40|mutation with no effect:41-41|mutation with no effect:42-42|mutation with no effect:43-43|mutation with no effect:44-44|mutation with no effect:45-45|mutation with no effect:46-46|mutation with no effect:47-47|mutation with no effect:48-48|mutation with no effect:49-49|mutation with no effect:51-51|mutation with no effect:52-52|mutation with no effect:53-53|mutation with no effect:54-54|mutation with no effect:55-55|mutation with no effect:57-57|mutation with no effect:58-58|mutation with no effect:59-59|mutation with no effect:60-60|mutation with no effect:61-61|mutation with no effect:63-63|mutation with no effect:64-64|mutation with no effect:65-65|mutation with no effect:67-67|mutation with no effect:68-68|mutation with no effect:69-69|mutation with no effect:70-70|mutation with no effect:72-72|mutation with no effect:73-73|mutation with no effect:74-74|mutation with no effect:75-75|mutation with no effect:76-76|mutation with no effect:77-77|mutation with no effect:78-78|mutation with no effect:79-79|mutation with no effect:80-80|mutation with no effect:81-81|mutation with no effect:82-82|mutation with no effect:83-83|mutation with no effect:84-84|mutation with no effect:85-85|mutation with no effect:86-86|mutation with no effect:87-87|mutation with no effect:88-88|mutation with no effect:89-89|mutation with no effect:90-90|mutation with no effect:91-91|mutation with no effect:92-92|mutation with no effect:93-93|mutation with no effect:94-94|mutation with no effect:95-95|mutation with no effect:96-96|mutation with no effect:97-97|mutation with no effect:98-98|mutation with no effect:99-99|mutation with no effect:100-100|mutation with no effect:101-101|mutation with no effect:102-102|mutation with no effect:103-103|mutation with no effect:104-104|mutation with no effect:105-105|mutation disrupting interaction strength:106-106|mutation with no effect:107-107|mutation with no effect:108-108|mutation with no effect:109-109|mutation with no effect:110-110|mutation with no effect:111-111|mutation with no effect:112-112|mutation with no effect:113-113|mutation with no effect:114-114|mutation with no effect:115-115|mutation with no effect:116-116|mutation with no effect:117-117|mutation with no effect:118-118|mutation with no effect:119-119|mutation with no effect:120-120|mutation with no effect:121-121|mutation with no effect:122-122|mutation with no effect:123-123|mutation disrupting interaction strength:124-124|mutation with no effect:125-125|mutation with no effect:127-127|mutation with no effect:128-128|mutation with no effect:129-129|mutation with no effect:130-130|mutation with no effect:131-131|mutation with no effect:132-132|mutation with no effect:133-133|mutation with no effect:134-134|mutation with no effect:135-135|mutation with no effect:136-136|mutation with no effect:137-137|mutation with no effect:138-138|mutation with no effect:139-139|mutation with no effect:140-140|mutation with no effect:141-141|mutation disrupting interaction strength:142-142|mutation with no effect:143-143|mutation with no effect:144-144|mutation with no effect:145-145|mutation with no effect:146-146|mutation with no effect:147-147|mutation with no effect:148-148|mutation with no effect:149-149|mutation with no effect:150-150|mutation with no effect:151-151|mutation with no effect:152-152|mutation with no effect:153-153|mutation with no effect:154-154|mutation with no effect:155-155|mutation with no effect:156-156|mutation with no effect:157-157|mutation with no effect:158-158|mutation with no effect:159-159|mutation with no effect:160-160|mutation with no effect:161-161|mutation with no effect:162-162|mutation with no effect:163-163|mutation with no effect:164-164|mutation with no effect:165-165|mutation with no effect:166-166|mutation with no effect:167-167|mutation with no effect:168-168|mutation with no effect:169-169|mutation with no effect:170-170|mutation with no effect:171-171|mutation with no effect:172-172|mutation with no effect:173-173|mutation with no effect:174-174|mutation with no effect:175-175|mutation with no effect:176-176|mutation with no effect:177-177|mutation with no effect:178-178|mutation with no effect:179-179|mutation with no effect:180-180|mutation with no effect:181-181|mutation with no effect:182-182|mutation with no effect:183-183|mutation with no effect:184-184|mutation with no effect:185-185|mutation with no effect:186-186|mutation with no effect:188-188|mutation with no effect:189-189|mutation with no effect:190-190|mutation with no effect:191-191|mutation with no effect:192-192|mutation with no effect:194-194|mutation with no effect:195-195|mutation with no effect:196-196|mutation with no effect:197-197|mutation with no effect:198-198|mutation with no effect:199-199|mutation with no effect:200-200|mutation with no effect:201-201|mutation with no effect:203-203|mutation with no effect:204-204|mutation with no effect:205-205|mutation with no effect:206-206|mutation with no effect:207-207|mutation with no effect:208-208|mutation with no effect:209-209|mutation with no effect:210-210|mutation with no effect:211-211|mutation with no effect:212-212|mutation with no effect:213-213|mutation with no effect:214-214|mutation with no effect:215-215|mutation with no effect:216-216|mutation with no effect:217-217|mutation with no effect:218-218|mutation with no effect:219-219|mutation with no effect:220-220|mutation with no effect:221-221|mutation with no effect:223-223|mutation with no effect:224-224|mutation with no effect:225-225|mutation with no effect:226-226|mutation with no effect:227-227|mutation with no effect:228-228|mutation with no effect:229-229|mutation with no effect:230-230|mutation with no effect:231-231|mutation with no effect:232-232|mutation with no effect:233-233|mutation with no effect:235-235|mutation with no effect:236-236|mutation with no effect:237-237|mutation with no effect:238-238|mutation with no effect:239-239|mutation with no effect:240-240|mutation with no effect:241-241|mutation with no effect:242-242|mutation with no effect:243-243|mutation with no effect:244-244|mutation with no effect:245-245|mutation with no effect:246-246|mutation with no effect:247-247|mutation with no effect:248-248|mutation with no effect:249-249|mutation with no effect:250-250|mutation with no effect:251-251|mutation with no effect:252-252|mutation with no effect:253-253|mutation with no effect:254-254|mutation with no effect:255-255|mutation with no effect:256-256|mutation with no effect:257-257|mutation with no effect:258-258|mutation with no effect:260-260|mutation with no effect:262-262|mutation with no effect:263-263|mutation with no effect:264-264|mutation with no effect:265-265|mutation with no effect:266-266|mutation with no effect:267-267|mutation with no effect:268-268|mutation with no effect:269-269|mutation with no effect:270-270|mutation with no effect:271-271|mutation disrupting interaction strength:17-17|mutation disrupting interaction strength:258-258|mutation disrupting interaction strength:23-23|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:149-149|mutation disrupting interaction strength:17-17|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:34-34|mutation disrupting interaction strength:230-230|mutation disrupting interaction strength:13-13|mutation disrupting interaction strength:16-16|mutation disrupting interaction strength:18-18|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:17-17|mutation disrupting interaction strength:80-80|mutation disrupting interaction strength:118-118|mutation disrupting interaction strength:219-219|mutation disrupting interaction strength:13-13|mutation disrupting interaction strength:19-19|mutation disrupting interaction strength:10-10|mutation disrupting interaction strength:26-26|mutation disrupting interaction strength:31-31|mutation disrupting interaction strength:44-44|mutation disrupting interaction strength:113-113|mutation disrupting interaction strength:23-23|mutation disrupting interaction strength:29-29|mutation disrupting interaction strength:135-135|mutation disrupting interaction strength:151-151|mutation disrupting interaction strength:246-246|mutation disrupting interaction strength:20-20|mutation disrupting interaction strength:23-23|mutation disrupting interaction strength:24-24|mutation disrupting interaction strength:43-43|mutation disrupting interaction strength:95-95|mutation disrupting interaction strength:117-117|mutation disrupting interaction strength:11-11|mutation disrupting interaction strength:39-39|mutation disrupting interaction strength:11-11|mutation disrupting interaction strength:105-105|mutation disrupting interaction strength:184-184|mutation disrupting interaction strength:16-16|mutation disrupting interaction strength:23-23|mutation disrupting interaction strength:27-27|lexa dna binding domain:n-n|mutation with no effect:1-1|mutation with no effect:2-2|mutation with no effect:3-3|mutation with no effect:4-4|mutation with no effect:5-5|mutation with no effect:6-6|mutation with no effect:7-7|mutation with no effect:8-8|mutation with no effect:9-9|mutation with no effect:10-10|mutation with no effect:12-12|mutation disrupting interaction strength:13-13|mutation with no effect:14-14|mutation with no effect:15-15|mutation disrupting interaction strength:16-16|mutation disrupting interaction strength:17-17|mutation with no effect:18-18|mutation with no effect:19-19|mutation with no effect:20-20|mutation with no effect:21-21|mutation with no effect:22-22|mutation disrupting interaction strength:23-23|mutation with no effect:25-25|mutation with no effect:26-26|mutation with no effect:27-27|mutation with no effect:28-28|mutation with no effect:29-29|mutation with no effect:30-30|mutation with no effect:31-31|mutation with no effect:32-32|mutation with no effect:33-33|mutation with no effect:34-34|mutation with no effect:35-35|mutation with no effect:36-36|mutation with no effect:37-37|mutation with no effect:38-38|mutation with no effect:41-41|mutation with no effect:42-42|mutation with no effect:43-43|mutation with no effect:44-44|mutation with no effect:46-46|mutation with no effect:48-48|mutation with no effect:49-49|mutation with no effect:50-50|mutation with no effect:51-51|mutation with no effect:52-52|mutation with no effect:53-53|mutation with no effect:54-54|mutation with no effect:55-55|mutation with no effect:56-56|mutation with no effect:57-57|mutation with no effect:58-58|mutation with no effect:59-59|mutation with no effect:60-60|mutation with no effect:61-61|mutation with no effect:62-62|mutation with no effect:63-63|mutation with no effect:64-64|mutation with no effect:66-66|mutation with no effect:67-67|mutation with no effect:68-68|mutation with no effect:69-69|mutation with no effect:70-70|mutation with no effect:71-71|mutation with no effect:72-72|mutation with no effect:74-74|mutation with no effect:76-76|mutation with no effect:77-77|mutation with no effect:78-78|mutation with no effect:79-79|mutation with no effect:80-80|mutation with no effect:81-81|mutation with no effect:82-82|mutation with no effect:83-83|mutation with no effect:84-84|mutation with no effect:85-85|mutation with no effect:86-86|mutation with no effect:87-87|mutation with no effect:88-88|mutation with no effect:89-89|mutation with no effect:90-90|mutation with no effect:91-91|mutation with no effect:92-92|mutation with no effect:93-93|mutation with no effect:94-94|mutation with no effect:95-95|mutation with no effect:96-96|mutation with no effect:97-97|mutation with no effect:99-99|mutation with no effect:100-100|mutation with no effect:101-101|mutation with no effect:102-102|mutation with no effect:103-103|mutation with no effect:104-104|mutation with no effect:106-106|mutation with no effect:107-107|mutation with no effect:108-108|mutation with no effect:109-109|mutation with no effect:110-110|mutation with no effect:111-111|mutation with no effect:112-112|mutation with no effect:113-113|mutation with no effect:114-114|mutation with no effect:115-115|mutation with no effect:116-116|mutation with no effect:117-117|mutation with no effect:118-118|mutation with no effect:119-119|mutation with no effect:120-120|mutation with no effect:121-121|mutation with no effect:122-122|mutation with no effect:123-123|mutation with no effect:124-124|mutation with no effect:125-125|mutation with no effect:126-126|mutation with no effect:127-127|mutation with no effect:129-129|mutation with no effect:130-130|mutation with no effect:131-131|mutation with no effect:132-132|mutation with no effect:133-133|mutation with no effect:134-134|mutation with no effect:136-136|mutation with no effect:137-137|mutation with no effect:139-139|mutation with no effect:140-140|mutation with no effect:141-141|mutation with no effect:142-142|mutation with no effect:143-143|mutation with no effect:144-144|mutation with no effect:145-145|mutation with no effect:146-146|mutation with no effect:147-147|mutation with no effect:148-148|mutation with no effect:149-149|mutation with no effect:150-150|mutation with no effect:151-151|mutation with no effect:152-152|mutation with no effect:153-153|mutation with no effect:155-155|mutation with no effect:156-156|mutation with no effect:157-157|mutation with no effect:158-158|mutation with no effect:159-159|mutation with no effect:160-160|mutation with no effect:161-161|mutation with no effect:162-162|mutation with no effect:163-163|mutation with no effect:164-164|mutation with no effect:165-165|mutation with no effect:166-166|mutation with no effect:167-167|mutation with no effect:168-168|mutation with no effect:169-169|mutation with no effect:170-170|mutation with no effect:171-171|mutation with no effect:172-172|mutation with no effect:173-173|mutation with no effect:174-174|mutation with no effect:175-175|mutation with no effect:176-176|mutation with no effect:177-177|mutation with no effect:178-178|mutation with no effect:179-179|mutation with no effect:180-180|mutation with no effect:181-181|mutation with no effect:183-183|mutation with no effect:185-185|mutation with no effect:186-186|mutation with no effect:187-187|mutation with no effect:188-188|mutation with no effect:189-189|mutation with no effect:190-190|mutation with no effect:191-191|mutation with no effect:192-192|mutation with no effect:193-193|mutation with no effect:194-194|mutation with no effect:195-195|mutation with no effect:196-196|mutation with no effect:197-197|mutation with no effect:198-198|mutation with no effect:199-199|mutation with no effect:200-200|mutation with no effect:201-201|mutation with no effect:202-202|mutation with no effect:203-203|mutation with no effect:204-204|mutation with no effect:205-205|mutation with no effect:206-206|mutation with no effect:207-207|mutation with no effect:208-208|mutation with no effect:209-209|mutation with no effect:210-210|mutation with no effect:211-211|mutation with no effect:212-212|mutation with no effect:213-213|mutation with no effect:214-214|mutation with no effect:215-215|mutation with no effect:216-216|mutation with no effect:217-217|mutation with no effect:218-218|mutation with no effect:219-219|mutation with no effect:220-220|mutation with no effect:221-221|mutation with no effect:222-222|mutation with no effect:223-223|mutation with no effect:224-224|mutation with no effect:226-226|mutation with no effect:227-227|mutation with no effect:228-228|mutation with no effect:231-231|mutation with no effect:232-232|mutation with no effect:233-233|mutation with no effect:234-234|mutation with no effect:235-235|mutation with no effect:236-236|mutation with no effect:237-237|mutation with no effect:238-238|mutation with no effect:239-239|mutation with no effect:240-240|mutation with no effect:241-241|mutation with no effect:242-242|mutation with no effect:243-243|mutation with no effect:244-244|mutation with no effect:245-245|mutation with no effect:246-246|mutation with no effect:247-247|mutation with no effect:248-248|mutation with no effect:249-249|mutation with no effect:250-250|mutation with no effect:251-251|mutation with no effect:252-252|mutation with no effect:253-253|mutation with no effect:254-254|mutation with no effect:255-255|mutation with no effect:256-256|mutation with no effect:257-257|mutation with no effect:258-258|mutation with no effect:259-259|mutation with no effect:261-261|mutation with no effect:262-262|mutation with no effect:263-263|mutation with no effect:264-264|mutation with no effect:265-265|mutation with no effect:266-266|mutation with no effect:268-268|mutation with no effect:269-269|mutation with no effect:270-270|mutation with no effect:271-271|mutation with no effect:1-1|mutation with no effect:2-2|mutation with no effect:3-3|mutation with no effect:4-4|mutation with no effect:5-5|mutation disrupting interaction strength:6-6|mutation with no effect:7-7|mutation with no effect:8-8|mutation with no effect:9-9|mutation with no effect:10-10|mutation with no effect:11-11|mutation with no effect:12-12|mutation with no effect:13-13|mutation with no effect:14-14|mutation with no effect:15-15|mutation with no effect:16-16|mutation with no effect:17-17|mutation with no effect:18-18|mutation with no effect:20-20|mutation with no effect:21-21|mutation with no effect:22-22|mutation disrupting interaction strength:23-23|mutation with no effect:24-24|mutation with no effect:25-25|mutation with no effect:26-26|mutation with no effect:27-27|mutation with no effect:28-28|mutation with no effect:29-29|mutation with no effect:30-30|mutation disrupting interaction strength:31-31|mutation with no effect:32-32|mutation with no effect:34-34|mutation with no effect:35-35|mutation with no effect:36-36|mutation with no effect:37-37|mutation with no effect:38-38|mutation with no effect:39-39|mutation with no effect:40-40|mutation with no effect:41-41|mutation with no effect:42-42|mutation with no effect:43-43|mutation with no effect:45-45|mutation with no effect:46-46|mutation with no effect:47-47|mutation with no effect:48-48|mutation with no effect:49-49|mutation with no effect:50-50|mutation with no effect:51-51|mutation with no effect:52-52|mutation with no effect:53-53|mutation with no effect:54-54|mutation with no effect:55-55|mutation with no effect:56-56|mutation with no effect:57-57|mutation with no effect:58-58|mutation with no effect:59-59|mutation with no effect:60-60|mutation with no effect:61-61|mutation with no effect:62-62|mutation with no effect:63-63|mutation with no effect:64-64|mutation with no effect:65-65|mutation with no effect:66-66|mutation with no effect:67-67|mutation with no effect:68-68|mutation with no effect:69-69|mutation with no effect:70-70|mutation with no effect:71-71|mutation with no effect:72-72|mutation with no effect:73-73|mutation with no effect:74-74|mutation with no effect:75-75|mutation with no effect:76-76|mutation with no effect:77-77|mutation with no effect:78-78|mutation with no effect:79-79|mutation with no effect:80-80|mutation with no effect:81-81|mutation with no effect:82-82|mutation with no effect:83-83|mutation with no effect:84-84|mutation with no effect:86-86|mutation with no effect:87-87|mutation with no effect:88-88|mutation with no effect:89-89|mutation with no effect:90-90|mutation with no effect:91-91|mutation with no effect:92-92|mutation with no effect:93-93|mutation with no effect:94-94|mutation with no effect:95-95|mutation with no effect:96-96|mutation with no effect:97-97|mutation with no effect:98-98|mutation with no effect:99-99|mutation with no effect:100-100|mutation with no effect:101-101|mutation with no effect:102-102|mutation with no effect:103-103|mutation with no effect:104-104|mutation with no effect:105-105|mutation with no effect:106-106|mutation with no effect:107-107|mutation with no effect:108-108|mutation with no effect:109-109|mutation with no effect:110-110|mutation with no effect:111-111|mutation with no effect:112-112|mutation with no effect:113-113|mutation with no effect:114-114|mutation with no effect:115-115|mutation with no effect:116-116|mutation with no effect:117-117|mutation with no effect:118-118|mutation with no effect:119-119|mutation with no effect:120-120|mutation with no effect:121-121|mutation with no effect:122-122|mutation with no effect:123-123|mutation with no effect:124-124|mutation with no effect:125-125|mutation with no effect:126-126|mutation with no effect:127-127|mutation with no effect:128-128|mutation with no effect:129-129|mutation with no effect:130-130|mutation with no effect:131-131|mutation with no effect:132-132|mutation with no effect:133-133|mutation with no effect:134-134|mutation with no effect:135-135|mutation with no effect:136-136|mutation with no effect:137-137|mutation with no effect:138-138|mutation with no effect:139-139|mutation with no effect:140-140|mutation with no effect:141-141|mutation with no effect:142-142|mutation with no effect:143-143|mutation with no effect:144-144|mutation with no effect:145-145|mutation with no effect:146-146|mutation with no effect:147-147|mutation with no effect:148-148|mutation with no effect:149-149|mutation with no effect:150-150|mutation with no effect:151-151|mutation with no effect:152-152|mutation with no effect:153-153|mutation with no effect:154-154|mutation with no effect:155-155|mutation with no effect:156-156|mutation with no effect:157-157|mutation with no effect:158-158|mutation with no effect:159-159|mutation with no effect:160-160|mutation with no effect:161-161|mutation with no effect:162-162|mutation with no effect:163-163|mutation with no effect:164-164|mutation with no effect:165-165|mutation with no effect:166-166|mutation with no effect:167-167|mutation with no effect:168-168|mutation with no effect:169-169|mutation with no effect:170-170|mutation with no effect:171-171|mutation with no effect:172-172|mutation with no effect:173-173|mutation with no effect:175-175|mutation with no effect:176-176|mutation with no effect:177-177|mutation with no effect:179-179|mutation with no effect:181-181|mutation with no effect:182-182|mutation with no effect:184-184|mutation with no effect:185-185|mutation with no effect:186-186|mutation with no effect:187-187|mutation with no effect:188-188|mutation with no effect:189-189|mutation with no effect:190-190|mutation with no effect:191-191|mutation with no effect:192-192|mutation with no effect:193-193|mutation with no effect:194-194|mutation with no effect:195-195|mutation with no effect:196-196|mutation with no effect:198-198|mutation with no effect:199-199|mutation with no effect:200-200|mutation with no effect:201-201|mutation disrupting interaction strength:202-202|mutation with no effect:203-203|mutation with no effect:204-204|mutation with no effect:205-205|mutation with no effect:206-206|mutation with no effect:207-207|mutation with no effect:208-208|mutation with no effect:209-209|mutation with no effect:210-210|mutation with no effect:211-211|mutation with no effect:212-212|mutation with no effect:213-213|mutation with no effect:214-214|mutation with no effect:215-215|mutation with no effect:216-216|mutation with no effect:217-217|mutation with no effect:219-219|mutation with no effect:220-220|mutation with no effect:221-221|mutation with no effect:222-222|mutation with no effect:224-224|mutation with no effect:225-225|mutation with no effect:226-226|mutation with no effect:227-227|mutation with no effect:228-228|mutation with no effect:229-229|mutation with no effect:230-230|mutation with no effect:231-231|mutation with no effect:232-232|mutation with no effect:233-233|mutation with no effect:234-234|mutation with no effect:235-235|mutation with no effect:236-236|mutation with no effect:237-237|mutation with no effect:238-238|mutation with no effect:240-240|mutation with no effect:241-241|mutation with no effect:242-242|mutation with no effect:243-243|mutation with no effect:245-245|mutation with no effect:246-246|mutation with no effect:247-247|mutation with no effect:248-248|mutation with no effect:250-250|mutation with no effect:251-251|mutation with no effect:252-252|mutation with no effect:253-253|mutation with no effect:254-254|mutation with no effect:255-255|mutation with no effect:256-256|mutation with no effect:257-257|mutation with no effect:258-258|mutation with no effect:259-259|mutation with no effect:260-260|mutation with no effect:261-261|mutation with no effect:263-263|mutation with no effect:264-264|mutation with no effect:266-266|mutation with no effect:267-267|mutation with no effect:268-268|mutation with no effect:270-270|mutation with no effect:271-271|mutation with no effect:1-1|mutation with no effect:2-2|mutation with no effect:3-3|mutation with no effect:5-5|mutation with no effect:7-7|mutation with no effect:8-8|mutation with no effect:9-9|mutation with no effect:10-10|mutation disrupting interaction strength:11-11|mutation with no effect:12-12|mutation with no effect:13-13|mutation with no effect:14-14|mutation with no effect:15-15|mutation disrupting interaction strength:16-16|mutation disrupting interaction strength:17-17|mutation with no effect:18-18|mutation disrupting interaction strength:19-19|mutation with no effect:20-20|mutation with no effect:21-21|mutation with no effect:22-22|mutation disrupting interaction strength:23-23|mutation with no effect:24-24|mutation with no effect:25-25|mutation with no effect:26-26|mutation with no effect:27-27|mutation with no effect:28-28|mutation with no effect:29-29|mutation with no effect:30-30|mutation with no effect:31-31|mutation with no effect:33-33|mutation with no effect:34-34|mutation with no effect:35-35|mutation with no effect:36-36|mutation with no effect:37-37|mutation with no effect:38-38|mutation with no effect:39-39|sufficient binding region:1-271 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NFJ9 uniprotkb:Q3SYG4 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20961546|imex:IM-26519-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/22 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rigid:v4O059J1ifzUKCNAa0cdUdhWfOA false sufficient binding region:413-593|gal4 activation domain:n-n lexa dna binding domain:n-n|mutation with no effect:405-405|mutation with no effect:406-406|mutation with no effect:407-407|mutation with no effect:408-408|mutation with no effect:409-409|mutation with no effect:410-410|mutation with no effect:411-411|mutation with no effect:412-412|mutation with no effect:413-413|mutation with no effect:414-414|mutation with no effect:415-415|mutation with no effect:416-416|mutation with no effect:417-417|mutation with no effect:418-418|mutation with no effect:419-419|mutation with no effect:420-420|mutation with no effect:421-421|mutation with no effect:422-422|mutation with no effect:423-423|mutation with no effect:424-424|mutation with no effect:425-425|mutation with no effect:426-426|mutation with no effect:428-428|mutation with no effect:429-429|mutation with no effect:430-430|mutation with no effect:431-431|mutation with no effect:432-432|mutation with no effect:433-433|mutation with no effect:434-434|mutation with no effect:435-435|mutation with no effect:436-436|mutation with no effect:437-437|mutation with no effect:438-438|mutation with no effect:439-439|mutation with no effect:440-440|mutation with no effect:441-441|mutation with no effect:442-442|mutation with no effect:443-443|mutation with no effect:444-444|mutation with no effect:445-445|mutation with no effect:446-446|mutation with no effect:447-447|mutation with no effect:448-448|mutation with no effect:449-449|mutation with no effect:450-450|mutation with no effect:451-451|mutation with no effect:452-452|mutation with no effect:453-453|mutation with no effect:454-454|mutation with no effect:456-456|mutation with no effect:457-457|mutation with no effect:458-458|mutation with no effect:459-459|mutation with no effect:460-460|mutation with no effect:461-461|mutation with no effect:462-462|mutation with no effect:463-463|mutation with no effect:464-464|mutation with no effect:465-465|mutation with no effect:466-466|mutation with no effect:467-467|mutation with no effect:468-468|mutation with no effect:469-469|mutation with no effect:470-470|mutation with no effect:471-471|mutation with no effect:472-472|mutation with no effect:473-473|mutation with no effect:474-474|mutation with no effect:475-475|mutation with no effect:476-476|mutation with no effect:477-477|mutation with no effect:478-478|mutation with no effect:479-479|mutation with no effect:480-480|mutation with no effect:481-481|mutation with no effect:482-482|mutation with no effect:483-483|mutation with no effect:484-484|mutation with no effect:485-485|mutation with no effect:486-486|mutation with no effect:487-487|mutation with no effect:488-488|mutation with no effect:489-489|mutation with no effect:490-490|mutation with no effect:491-491|mutation with no effect:492-492|mutation with no effect:493-493|mutation with no effect:494-494|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation with no effect:499-499|mutation with no effect:500-500|mutation with no effect:501-501|mutation with no effect:502-502|mutation with no effect:503-503|mutation with no effect:505-505|mutation with no effect:506-506|mutation with no effect:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:511-511|mutation with no effect:512-512|mutation with no effect:513-513|mutation with no 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strength:697-697|mutation disrupting interaction strength:702-702|mutation disrupting interaction strength:507-507|mutation disrupting interaction strength:562-562|mutation disrupting interaction strength:616-616|mutation disrupting interaction strength:618-618|mutation disrupting interaction strength:620-620|mutation disrupting interaction strength:667-667|mutation disrupting interaction strength:804-804|mutation disrupting interaction strength:568-568|mutation disrupting interaction strength:600-600|mutation disrupting interaction strength:654-654|mutation disrupting interaction strength:734-734|mutation disrupting interaction strength:754-754|mutation disrupting interaction strength:506-506|mutation disrupting interaction strength:613-613|mutation disrupting interaction strength:757-757|mutation disrupting interaction strength:570-570|mutation disrupting interaction strength:691-691|mutation disrupting interaction strength:742-742|mutation disrupting interaction strength:791-791|mutation disrupting interaction strength:695-695|mutation disrupting interaction strength:705-705|mutation disrupting interaction strength:545-545|mutation disrupting interaction strength:747-747|mutation disrupting interaction strength:817-817|mutation disrupting interaction strength:482-482|mutation disrupting interaction strength:565-565|mutation disrupting interaction strength:616-616|mutation disrupting interaction strength:674-674|mutation disrupting interaction strength:502-502|mutation disrupting interaction strength:585-585|mutation disrupting interaction strength:597-597|mutation disrupting interaction strength:692-692|mutation disrupting interaction strength:701-701|mutation disrupting interaction strength:554-554|mutation disrupting interaction strength:565-565|mutation disrupting interaction strength:598-598|mutation disrupting interaction strength:634-634|mutation disrupting interaction strength:691-691|mutation disrupting interaction strength:718-718|mutation disrupting interaction strength:721-721|mutation disrupting interaction strength:741-741|mutation disrupting interaction strength:771-771|mutation disrupting interaction strength:833-833|mutation disrupting interaction strength:837-837|mutation disrupting interaction strength:462-462|mutation disrupting interaction strength:521-521|mutation disrupting interaction strength:587-587|mutation disrupting interaction strength:627-627|mutation disrupting interaction strength:651-651|mutation disrupting interaction strength:690-690|mutation disrupting interaction strength:722-722|mutation disrupting interaction strength:775-775|mutation disrupting interaction strength:802-802|mutation disrupting interaction strength:592-592|mutation disrupting interaction strength:604-604|mutation disrupting interaction strength:607-607|mutation disrupting interaction strength:633-633|mutation disrupting interaction strength:670-670|mutation disrupting interaction strength:690-690|mutation disrupting interaction strength:696-696|mutation disrupting interaction strength:837-837|mutation disrupting interaction strength:679-679|mutation disrupting interaction strength:469-469|mutation disrupting interaction strength:677-677|mutation disrupting interaction strength:694-694 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BXC9 uniprotkb:Q3SYG4 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20965843|imex:IM-26519-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/22 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rigid:1+jN59cJlcrlyO00OlDRWUz2KzE false sufficient binding region:324-721|gal4 activation domain:n-n mutation with no effect:503-503|mutation with no effect:505-505|mutation with no effect:506-506|mutation with no effect:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:511-511|mutation with no effect:512-512|mutation with no effect:513-513|mutation with no effect:514-514|mutation with no effect:515-515|mutation with no effect:516-516|mutation with no effect:517-517|mutation with no effect:518-518|mutation with no effect:519-519|mutation with no effect:520-520|mutation with no effect:521-521|mutation with no effect:522-522|mutation with no effect:523-523|mutation with no effect:524-524|mutation with no effect:525-525|mutation with no effect:526-526|mutation with no effect:527-527|mutation with no effect:528-528|mutation with no 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strength:833-833|mutation disrupting interaction strength:462-462|mutation disrupting interaction strength:521-521|mutation disrupting interaction strength:553-553|mutation disrupting interaction strength:587-587|mutation disrupting interaction strength:670-670|mutation disrupting interaction strength:722-722|mutation disrupting interaction strength:775-775|mutation disrupting interaction strength:847-847|mutation disrupting interaction strength:633-633|mutation disrupting interaction strength:690-690|mutation disrupting interaction strength:824-824|mutation disrupting interaction strength:462-462|mutation disrupting interaction strength:581-581|mutation disrupting interaction strength:677-677|mutation disrupting interaction strength:694-694|lexa dna binding domain:n-n|mutation with no effect:405-405|mutation with no effect:406-406|mutation with no effect:407-407|mutation with no effect:408-408|mutation with no effect:409-409|mutation with no effect:410-410|mutation with no effect:411-411|mutation with no effect:412-412|mutation with no effect:413-413|mutation with no effect:414-414|mutation with no effect:415-415|mutation with no effect:416-416|mutation with no effect:417-417|mutation with no effect:418-418|mutation with no effect:419-419|mutation with no effect:420-420|mutation with no effect:421-421|mutation with no effect:422-422|mutation with no effect:423-423|mutation with no effect:424-424|mutation with no effect:425-425|mutation with no effect:426-426|mutation with no effect:428-428|mutation with no effect:429-429|mutation with no effect:430-430|mutation with no effect:431-431|mutation with no effect:432-432|mutation with no effect:433-433|mutation with no effect:434-434|mutation with no effect:435-435|mutation with no effect:436-436|mutation with no effect:437-437|mutation with no effect:438-438|mutation with no effect:439-439|mutation with no effect:440-440|mutation with no effect:441-441|mutation with no effect:442-442|mutation with no effect:443-443|mutation with no effect:444-444|mutation with no effect:445-445|mutation with no effect:446-446|mutation with no effect:447-447|mutation with no effect:448-448|mutation with no effect:449-449|mutation with no effect:450-450|mutation with no effect:451-451|mutation with no effect:452-452|mutation with no effect:453-453|mutation with no effect:454-454|mutation with no effect:456-456|mutation with no effect:457-457|mutation with no effect:458-458|mutation with no effect:459-459|mutation with no effect:460-460|mutation with no effect:461-461|mutation with no effect:462-462|mutation with no effect:463-463|mutation with no effect:464-464|mutation with no effect:465-465|mutation with no effect:466-466|mutation with no effect:467-467|mutation with no effect:468-468|mutation with no effect:469-469|mutation with no effect:470-470|mutation with no effect:471-471|mutation with no effect:472-472|mutation with no effect:473-473|mutation with no effect:474-474|mutation with no effect:475-475|mutation with no effect:476-476|mutation with no effect:477-477|mutation with no effect:478-478|mutation with no effect:479-479|mutation with no effect:480-480|mutation with no effect:481-481|mutation with no effect:482-482|mutation with no effect:483-483|mutation with no effect:484-484|mutation with no effect:485-485|mutation with no effect:486-486|mutation with no effect:487-487|mutation with no effect:488-488|mutation with no effect:489-489|mutation with no effect:490-490|mutation with no effect:491-491|mutation with no effect:492-492|mutation with no effect:493-493|mutation with no effect:494-494|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation with no effect:499-499|mutation with no effect:500-500|mutation with no effect:501-501|mutation with no effect:502-502 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RK4 uniprotkb:Q3SYG4 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20970149|imex:IM-26519-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/22 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rigid:yHkR1jlMmCnjc3rEY3bRuhSYsJE false gal4 activation domain:c-c|sufficient binding region:1-268 mutation with no effect:525-525|mutation with no effect:527-527|mutation with no effect:528-528|mutation with no effect:529-529|mutation with no effect:530-530|mutation with no effect:531-531|mutation with no effect:533-533|mutation with no effect:534-534|mutation with no effect:535-535|mutation with no effect:536-536|mutation with no effect:537-537|mutation with no effect:538-538|mutation with no effect:539-539|mutation with no effect:540-540|mutation with no effect:541-541|mutation with no effect:543-543|mutation with no effect:544-544|mutation with no effect:545-545|mutation with no effect:546-546|mutation with no effect:548-548|mutation with no effect:549-549|mutation with no effect:550-550|mutation with no effect:551-551|mutation with no effect:552-552|mutation with no effect:553-553|mutation with no effect:555-555|mutation with no effect:556-556|mutation with no effect:557-557|mutation with no effect:558-558|mutation with no effect:559-559|mutation with no effect:560-560|mutation with no effect:561-561|mutation with no effect:562-562|mutation with no effect:563-563|mutation with no effect:564-564|mutation with no effect:565-565|mutation with no effect:566-566|mutation with no effect:567-567|mutation with no effect:568-568|mutation with no effect:569-569|mutation with no effect:570-570|mutation with no effect:571-571|mutation with no effect:572-572|mutation with no effect:573-573|mutation with no effect:574-574|mutation with no effect:575-575|mutation with no effect:576-576|mutation with no effect:577-577|mutation with no effect:578-578|mutation with no effect:579-579|mutation with no effect:580-580|mutation with no effect:581-581|mutation with no effect:582-582|mutation with no effect:583-583|mutation with no effect:584-584|mutation with no effect:585-585|mutation with no effect:586-586|mutation with no effect:587-587|mutation with no effect:588-588|mutation with no effect:589-589|mutation with no effect:590-590|mutation with no effect:591-591|mutation with no effect:592-592|mutation with no effect:593-593|mutation with no effect:595-595|mutation with no effect:596-596|mutation with no effect:597-597|mutation with no effect:598-598|mutation with no effect:599-599|mutation with no effect:600-600|mutation with no effect:601-601|mutation with no effect:602-602|mutation with no effect:603-603|mutation with no effect:604-604|mutation with no effect:605-605|mutation with no effect:606-606|mutation with no effect:607-607|mutation with no effect:608-608|mutation with no effect:609-609|mutation with no effect:610-610|mutation with no effect:611-611|mutation with no effect:612-612|mutation with no effect:613-613|mutation with no effect:614-614|mutation with no effect:615-615|mutation with no effect:616-616|mutation with no effect:617-617|mutation with no effect:618-618|mutation with no effect:619-619|mutation with no effect:620-620|mutation with no effect:621-621|mutation with no effect:622-622|mutation with no effect:623-623|mutation with no effect:624-624|mutation with no effect:625-625|mutation with no effect:627-627|mutation with no effect:628-628|mutation with no effect:629-629|mutation with no effect:631-631|mutation with no effect:632-632|mutation with no effect:633-633|mutation with no effect:634-634|mutation with no effect:635-635|mutation with no effect:636-636|mutation with no effect:637-637|mutation with no effect:638-638|mutation with no effect:639-639|mutation with no effect:640-640|mutation with no effect:641-641|mutation with no effect:642-642|mutation with no effect:643-643|mutation with no effect:644-644|mutation with no effect:645-645|mutation with no effect:646-646|mutation disrupting interaction strength:647-647|mutation with no effect:648-648|mutation with no effect:649-649|mutation with no effect:650-650|mutation with no effect:651-651|mutation with no effect:652-652|mutation with no effect:653-653|mutation disrupting interaction strength:654-654|mutation with no effect:655-655|mutation with no effect:656-656|mutation with no effect:657-657|mutation with no effect:658-658|mutation with no effect:659-659|mutation with no effect:660-660|mutation with no effect:662-662|mutation with no effect:663-663|mutation with no effect:664-664|mutation with no effect:665-665|mutation with no effect:666-666|mutation with no effect:667-667|mutation with no effect:668-668|mutation with no effect:669-669|mutation with no effect:670-670|mutation with no effect:671-671|mutation with no effect:672-672|mutation with no effect:673-673|mutation with no effect:674-674|mutation with no effect:675-675|mutation with no effect:676-676|mutation with no effect:677-677|mutation disrupting interaction strength:678-678|mutation with no effect:679-679|mutation with no effect:680-680|mutation with no effect:681-681|mutation with no effect:682-682|mutation with no effect:683-683|mutation with no effect:684-684|mutation with no effect:686-686|mutation with no effect:688-688|mutation with no effect:689-689|mutation disrupting interaction strength:690-690|mutation with no effect:691-691|mutation with no effect:692-692|mutation with no effect:693-693|mutation with no effect:694-694|mutation with no effect:695-695|mutation with no effect:696-696|mutation with no effect:697-697|mutation with no effect:698-698|mutation disrupting interaction strength:699-699|mutation with no effect:700-700|mutation with no effect:701-701|mutation with no effect:702-702|mutation with no effect:703-703|mutation with no effect:705-705|mutation with no effect:706-706|mutation with no effect:707-707|mutation with no effect:708-708|mutation with no effect:709-709|mutation with no effect:710-710|mutation with no effect:711-711|mutation with no effect:712-712|mutation with no effect:713-713|mutation with no effect:714-714|mutation disrupting interaction strength:715-715|mutation with no effect:716-716|mutation with no effect:717-717|mutation with no effect:718-718|mutation with no effect:719-719|mutation with no effect:720-720|mutation disrupting interaction strength:721-721|mutation with no effect:722-722|mutation disrupting interaction strength:723-723|mutation with no effect:724-724|mutation with no effect:725-725|mutation with no effect:726-726|mutation with no effect:727-727|mutation with no effect:729-729|mutation with no effect:730-730|mutation with no effect:731-731|mutation with no effect:732-732|mutation with no effect:733-733|mutation with no effect:734-734|mutation with no effect:735-735|mutation with no effect:736-736|mutation with no effect:737-737|mutation disrupting interaction strength:738-738|mutation disrupting interaction strength:739-739|mutation with no effect:740-740|mutation with no effect:741-741|mutation with no effect:742-742|mutation with no effect:744-744|mutation with no effect:745-745|mutation with no effect:746-746|mutation with no effect:747-747|mutation disrupting interaction strength:748-748|mutation with no effect:749-749|mutation with no effect:750-750|mutation with no effect:751-751|mutation with no effect:752-752|mutation with no effect:753-753|mutation with no effect:754-754|mutation with no effect:755-755|mutation with no effect:756-756|mutation with no effect:757-757|mutation with no effect:758-758|mutation with no effect:759-759|mutation with no effect:760-760|mutation with no effect:761-761|mutation with no effect:762-762|mutation with no effect:763-763|mutation with no effect:764-764|mutation with no effect:765-765|mutation with no effect:766-766|mutation with no effect:767-767|mutation with no effect:768-768|mutation with no effect:769-769|mutation with no effect:770-770|mutation with no effect:771-771|mutation disrupting interaction strength:772-772|mutation with no effect:773-773|mutation with no effect:774-774|mutation with no effect:775-775|mutation with no effect:776-776|mutation with no effect:777-777|mutation with no effect:778-778|mutation with no effect:779-779|mutation with no effect:780-780|mutation with no effect:782-782|mutation with no effect:783-783|mutation with no effect:784-784|mutation disrupting interaction strength:785-785|mutation with no effect:787-787|mutation with no effect:788-788|mutation with no effect:790-790|mutation with no effect:791-791|mutation with no effect:792-792|mutation with no effect:793-793|mutation with no effect:794-794|mutation with no effect:795-795|mutation with no effect:796-796|mutation with no effect:797-797|mutation disrupting interaction strength:798-798|mutation with no effect:799-799|mutation with no effect:800-800|mutation with no effect:801-801|mutation with no effect:802-802|mutation with no effect:804-804|mutation with no effect:805-805|mutation with no effect:806-806|mutation with no effect:807-807|mutation with no effect:808-808|mutation with no effect:811-811|mutation with no effect:812-812|mutation with no effect:813-813|mutation with no effect:814-814|mutation with no effect:815-815|mutation with no effect:816-816|mutation with no effect:817-817|mutation with no effect:818-818|mutation with no effect:819-819|mutation with no effect:820-820|mutation with no effect:822-822|mutation with no effect:823-823|mutation with no effect:824-824|mutation with no effect:825-825|mutation with no effect:826-826|mutation with no effect:827-827|mutation with no effect:828-828|mutation with no effect:829-829|mutation with no effect:830-830|mutation with no effect:831-831|mutation with no effect:832-832|mutation with no effect:833-833|mutation with no effect:834-834|mutation with no effect:835-835|mutation with no effect:836-836|mutation with no effect:837-837|mutation disrupting interaction strength:838-838|mutation with no effect:839-839|mutation with no effect:840-840|mutation with no effect:841-841|mutation with no effect:842-842|mutation with no effect:843-843|mutation with no effect:844-844|mutation with no effect:845-845|mutation with no effect:846-846|mutation with no effect:847-847|mutation with no effect:848-848|mutation with no effect:849-849|mutation with no effect:850-850|mutation with no effect:851-851|mutation with no effect:852-852|mutation with no effect:853-853|mutation with no effect:854-854|mutation with no effect:855-855|mutation with no effect:856-856|mutation with no effect:857-857|mutation with no effect:858-858|mutation with no effect:859-859|mutation with no effect:860-860|mutation with no effect:861-861|mutation with no effect:862-862|mutation with no effect:863-863|mutation with no effect:864-864|mutation with no effect:865-865|mutation with no effect:866-866|mutation with no effect:867-867|mutation with no effect:868-868|mutation with no effect:869-869|mutation with no effect:870-870|mutation with no effect:871-871|mutation with no effect:872-872|mutation with no effect:873-873|mutation with no effect:874-874|mutation with no effect:875-875|mutation with no effect:876-876|mutation with no effect:877-877|mutation with no effect:878-878|mutation with no effect:879-879|mutation with no effect:880-880|mutation with no effect:881-881|mutation with no effect:882-882|mutation with no effect:883-883|mutation with no effect:884-884|mutation with no effect:885-885|mutation with no effect:886-886|mutation with no effect:887-887|mutation with no effect:405-405|mutation with no effect:407-407|mutation with no effect:409-409|mutation with no effect:410-410|mutation with no effect:411-411|mutation with no effect:412-412|mutation with no effect:413-413|mutation with no effect:414-414|mutation with no effect:415-415|mutation with no effect:416-416|mutation with no effect:417-417|mutation with no effect:418-418|mutation with no effect:419-419|mutation with no effect:420-420|mutation with no effect:421-421|mutation with no effect:422-422|mutation with no effect:423-423|mutation with no effect:424-424|mutation with no effect:425-425|mutation with no effect:426-426|mutation with no effect:427-427|mutation with no effect:428-428|mutation with no effect:429-429|mutation with no effect:430-430|mutation with no effect:432-432|mutation with no effect:433-433|mutation with no effect:434-434|mutation with no effect:435-435|mutation with no effect:436-436|mutation with no effect:437-437|mutation with no effect:438-438|mutation with no effect:439-439|mutation with no effect:440-440|mutation with no effect:441-441|mutation with no effect:442-442|mutation with no effect:443-443|mutation with no effect:444-444|mutation with no effect:445-445|mutation with no effect:446-446|mutation with no effect:447-447|mutation with no effect:448-448|mutation with no effect:449-449|mutation with no effect:450-450|mutation with no effect:451-451|mutation with no effect:452-452|mutation with no effect:453-453|mutation with no effect:454-454|mutation with no effect:455-455|mutation with no effect:456-456|mutation with no effect:457-457|mutation with no effect:458-458|mutation with no effect:459-459|mutation with no effect:460-460|mutation with no effect:461-461|mutation with no effect:462-462|mutation with no effect:463-463|mutation with no effect:464-464|mutation disrupting interaction strength:465-465|mutation with no effect:467-467|mutation with no effect:468-468|mutation with no effect:469-469|mutation with no effect:470-470|mutation with no effect:471-471|mutation with no effect:472-472|mutation with no effect:473-473|mutation with no effect:474-474|mutation with no effect:476-476|mutation with no effect:477-477|mutation with no effect:478-478|mutation with no effect:479-479|mutation with no effect:480-480|mutation with no effect:481-481|mutation with no effect:482-482|mutation with no effect:483-483|mutation with no effect:484-484|mutation 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with no effect:461-461|mutation with no effect:462-462|mutation with no effect:463-463|mutation with no effect:464-464|mutation disrupting interaction strength:465-465|mutation with no effect:466-466|mutation with no effect:467-467|mutation with no effect:468-468|mutation with no effect:469-469|mutation with no effect:470-470|mutation with no effect:471-471|mutation with no effect:472-472|mutation with no effect:473-473|mutation with no effect:474-474|mutation with no effect:475-475|mutation with no effect:476-476|mutation with no effect:477-477|mutation with no effect:478-478|mutation with no effect:479-479|mutation with no effect:480-480|mutation with no effect:481-481|mutation with no effect:482-482|mutation with no effect:483-483|mutation with no effect:484-484|mutation with no effect:485-485|mutation with no effect:486-486|mutation with no effect:487-487|mutation with no effect:488-488|mutation with no effect:489-489|mutation with no effect:490-490|mutation with no effect:491-491|mutation with no effect:493-493|mutation with no effect:494-494|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation with no effect:499-499|mutation with no effect:500-500|mutation with no effect:501-501|mutation with no effect:502-502|mutation with no effect:503-503|mutation with no effect:504-504|mutation with no effect:505-505|mutation with no effect:506-506|mutation with no effect:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:511-511|mutation with no effect:512-512|mutation with no effect:513-513|mutation with no effect:514-514|mutation with no effect:515-515|mutation with no effect:516-516|mutation with no effect:517-517|mutation with no effect:518-518|mutation with no effect:519-519|mutation with no effect:520-520|mutation with no effect:521-521|mutation with no effect:522-522|mutation with no effect:523-523|mutation with no effect:524-524 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:Q9BXC9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20982995|imex:IM-26519-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/28 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rigid:1+jN59cJlcrlyO00OlDRWUz2KzE false gal4 activation domain:n-n|sufficient binding region:407-887 mutation with no effect:619-619|mutation with no effect:620-620|mutation with no effect:621-621|mutation with no effect:622-622|mutation with no effect:623-623|mutation with no effect:624-624|mutation with no effect:625-625|mutation with no effect:626-626|mutation with no effect:627-627|mutation with no effect:628-628|mutation with no effect:629-629|mutation with no effect:630-630|mutation with no effect:631-631|mutation with no effect:632-632|mutation with no effect:633-633|mutation with no effect:634-634|mutation with no effect:635-635|mutation with no effect:636-636|mutation with no effect:637-637|mutation with no effect:639-639|mutation with no effect:640-640|mutation with no effect:642-642|mutation with no effect:643-643|mutation with no effect:644-644|mutation with no effect:645-645|mutation with no effect:646-646|mutation with no effect:647-647|mutation with no effect:648-648|mutation with no effect:649-649|mutation with no effect:650-650|mutation with no effect:651-651|mutation with no effect:652-652|mutation with no effect:653-653|mutation with no effect:654-654|mutation with no effect:655-655|mutation with no effect:656-656|mutation with no effect:657-657|mutation with no effect:658-658|mutation with no effect:660-660|mutation with no effect:661-661|mutation with no effect:662-662|mutation with no effect:663-663|mutation with no effect:664-664|mutation with no effect:665-665|mutation with no effect:666-666|mutation with no effect:667-667|mutation with no effect:668-668|mutation with no effect:669-669|mutation with no effect:670-670|mutation with no effect:671-671|mutation with no effect:672-672|mutation with no effect:674-674|mutation with no effect:675-675|mutation with no effect:676-676|mutation with no effect:677-677|mutation with no effect:678-678|mutation with no effect:679-679|mutation with no effect:680-680|mutation with no effect:681-681|mutation with no effect:682-682|mutation with no effect:683-683|mutation with no effect:684-684|mutation with no effect:685-685|mutation with no effect:686-686|mutation with no effect:687-687|mutation with no effect:688-688|mutation with no effect:690-690|mutation with no effect:692-692|mutation with no effect:693-693|mutation with no effect:694-694|mutation with no effect:695-695|mutation with no effect:696-696|mutation with no effect:697-697|mutation with no effect:698-698|mutation with no effect:699-699|mutation with no effect:700-700|mutation with no effect:701-701|mutation with no effect:702-702|mutation with no effect:703-703|mutation with no effect:704-704|mutation with no effect:705-705|mutation with no effect:706-706|mutation with no effect:707-707|mutation with no effect:708-708|mutation with no effect:709-709|mutation with no effect:710-710|mutation with no effect:711-711|mutation with no effect:713-713|mutation with no effect:714-714|mutation with no effect:715-715|mutation with no effect:716-716|mutation with no 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effect:590-590|mutation with no effect:593-593|mutation with no effect:594-594|mutation with no effect:595-595|mutation with no effect:596-596|mutation with no effect:597-597|mutation with no effect:598-598|mutation with no effect:599-599|mutation with no effect:600-600|mutation with no effect:601-601|mutation with no effect:603-603|mutation with no effect:604-604|mutation with no effect:605-605|mutation with no effect:606-606|mutation with no effect:607-607|mutation with no effect:608-608|mutation with no effect:609-609|mutation with no effect:610-610|mutation with no effect:611-611|mutation with no effect:612-612|mutation with no effect:613-613|mutation with no effect:614-614|mutation with no effect:615-615|mutation with no effect:616-616|mutation with no effect:617-617|mutation with no effect:618-618|mutation with no effect:619-619|mutation with no effect:620-620|mutation with no effect:621-621|mutation with no effect:622-622|mutation with no effect:623-623|mutation with no effect:624-624|mutation with no effect:625-625|mutation with no effect:626-626|mutation with no effect:627-627|mutation with no effect:628-628|mutation with no effect:630-630|mutation with no effect:631-631|mutation with no effect:632-632|mutation with no effect:633-633|mutation with no effect:634-634|mutation with no effect:635-635|mutation with no effect:636-636|mutation with no effect:637-637|mutation with no effect:638-638|mutation with no effect:639-639|mutation with no effect:640-640|mutation with no effect:641-641|mutation with no effect:642-642|mutation with no effect:643-643|mutation with no effect:644-644|mutation with no effect:645-645|mutation with no effect:647-647|mutation with no effect:648-648|mutation with no effect:649-649|mutation with no effect:650-650|mutation with no effect:651-651|mutation with no effect:652-652|mutation with no effect:653-653|mutation with no effect:654-654|mutation with no effect:655-655|mutation with no effect:656-656|mutation with no effect:657-657|mutation with no effect:658-658|mutation with no effect:659-659|mutation with no effect:660-660|mutation with no effect:661-661|mutation with no effect:662-662|mutation with no effect:663-663|mutation with no effect:664-664|mutation with no effect:665-665|mutation with no effect:666-666|mutation with no effect:668-668|mutation with no effect:669-669|mutation with no effect:670-670|mutation with no effect:671-671|mutation with no effect:672-672|mutation with no effect:673-673|mutation with no effect:674-674|mutation with no effect:675-675|mutation with no effect:676-676|mutation with no effect:677-677|mutation with no effect:678-678|mutation with no effect:679-679|mutation with no effect:680-680|mutation with no effect:681-681|mutation with no effect:682-682|mutation with no effect:683-683|mutation with no effect:684-684|mutation with no effect:685-685|mutation with no effect:686-686|mutation with no effect:687-687|mutation with no effect:688-688|mutation with no 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strength:481-481|mutation disrupting interaction strength:482-482|mutation disrupting interaction strength:483-483|mutation disrupting interaction strength:484-484|mutation with no effect:485-485|mutation with no effect:486-486|mutation with no effect:487-487|mutation with no effect:488-488|mutation with no effect:489-489|mutation with no effect:490-490|mutation with no effect:491-491|mutation with no effect:492-492|mutation with no effect:493-493|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation with no effect:499-499|mutation with no effect:500-500|mutation disrupting interaction strength:501-501|mutation with no effect:502-502|mutation with no effect:503-503|mutation with no effect:504-504|mutation with no effect:506-506|mutation with no effect:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:511-511|mutation with no effect:512-512|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:514-514|mutation with no effect:515-515|mutation with no effect:516-516|mutation with no effect:517-517|mutation disrupting interaction strength:518-518|mutation with no effect:519-519|mutation with no effect:520-520|mutation with no effect:521-521|mutation with no effect:523-523|mutation with no effect:524-524|mutation with no effect:525-525|mutation with no effect:526-526|mutation with no effect:527-527|mutation with no effect:528-528|mutation with no effect:529-529|mutation with no effect:530-530|mutation with no effect:531-531|mutation with no effect:532-532|mutation disrupting interaction strength:533-533|mutation with no effect:534-534|mutation disrupting interaction strength:535-535|mutation with no effect:536-536|mutation with no effect:537-537|mutation with no effect:538-538|mutation with no effect:539-539|mutation with no effect:540-540|mutation with no effect:541-541|mutation with no effect:542-542|mutation with no effect:543-543|mutation disrupting interaction strength:544-544|mutation with no effect:545-545|mutation disrupting interaction strength:546-546|mutation with no effect:547-547|mutation with no effect:548-548|mutation with no effect:549-549|mutation with no effect:550-550|mutation with no effect:551-551|mutation disrupting interaction strength:552-552|mutation with no effect:554-554|mutation with no effect:555-555|mutation with no effect:556-556|mutation with no effect:557-557|mutation with no effect:558-558|mutation with no effect:559-559|mutation with no effect:560-560|mutation with no effect:561-561|mutation with no effect:562-562|mutation with no effect:563-563|mutation with no effect:564-564|mutation with no effect:565-565|mutation with no effect:566-566|mutation with no effect:567-567|mutation disrupting interaction strength:568-568|mutation with no effect:569-569|mutation with no effect:570-570|mutation with no effect:571-571|mutation with no effect:572-572|mutation with no effect:573-573|mutation with no effect:574-574|mutation with no effect:575-575|mutation with no effect:576-576|mutation with no effect:577-577|mutation with no effect:579-579|mutation with no effect:580-580|mutation with no effect:581-581|mutation with no effect:582-582|mutation with no effect:584-584|mutation with no effect:585-585|mutation with no effect:586-586 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20989536|imex:IM-26519-56 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - caution:"The original sequence reported in the publication beared two variants that differed from the UniProt reference (rs2277598, p.Ile354Thr and rs17852452, p.Ala393Val). Sequence changes in these positions did not affect the interaction, so we decided to nevertheless map the protein to SwissProt entry Q96RK4 and leave mutations in these positions out of the entry." figure legend:Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/29 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false gal4 activation domain:c-c lexa dna binding domain:c-c|mutation with no effect:268-268|mutation with no effect:269-269|mutation with no effect:270-270|mutation with no effect:271-271|mutation with no effect:272-272|mutation with no effect:273-273|mutation with no effect:274-274|mutation with no effect:275-275|mutation with no effect:276-276|mutation with no effect:277-277|mutation with no effect:278-278|mutation with no effect:279-279|mutation with no effect:280-280|mutation with no effect:281-281|mutation with no effect:282-282|mutation with no effect:283-283|mutation with no effect:284-284|mutation with no effect:285-285|mutation with no effect:286-286|mutation with no effect:287-287|mutation with no effect:290-290|mutation with no effect:291-291|mutation with no effect:292-292|mutation with no effect:293-293|mutation with no effect:294-294|mutation with no effect:295-295|mutation with no effect:297-297|mutation with no effect:298-298|mutation with no effect:299-299|mutation with no effect:301-301|mutation with no effect:302-302|mutation with no effect:303-303|mutation with no effect:304-304|mutation with no effect:305-305|mutation with no effect:306-306|mutation with no effect:307-307|mutation with no effect:308-308|mutation with no effect:309-309|mutation with no effect:310-310|mutation with no effect:311-311|mutation with no effect:312-312|mutation with no effect:313-313|mutation with no effect:314-314|mutation with no effect:315-315|mutation with no effect:316-316|mutation with no effect:317-317|mutation with no effect:318-318|mutation with no effect:319-319|mutation with no effect:320-320|mutation with no effect:322-322|mutation with no effect:324-324|mutation with no effect:325-325|mutation with no effect:326-326|mutation with no effect:327-327|mutation with no effect:328-328|mutation with no effect:331-331|mutation with no effect:332-332|mutation with no effect:333-333|mutation with no effect:334-334|mutation with no effect:335-335|mutation with no effect:336-336|mutation with no effect:337-337|mutation with no effect:338-338|mutation with no effect:339-339|mutation with no effect:340-340|mutation disrupting interaction strength:341-341|mutation with no effect:342-342|mutation with no effect:343-343|mutation with no effect:344-344|mutation disrupting interaction strength:346-346|mutation with no effect:348-348|mutation with no effect:349-349|mutation with no effect:350-350|mutation with no effect:351-351|mutation with no effect:352-352|mutation with no effect:353-353|mutation with no effect:355-355|mutation with no effect:356-356|mutation with no effect:358-358|mutation with no effect:359-359|mutation with no effect:361-361|mutation with no effect:363-363|mutation with no effect:365-365|mutation with no effect:366-366|mutation with no effect:367-367|mutation with no effect:368-368|mutation with no effect:369-369|mutation with no effect:370-370|mutation with no effect:371-371|mutation with no effect:372-372|mutation with no effect:373-373|mutation with no effect:374-374|mutation with no effect:375-375|mutation with no effect:376-376|mutation with no effect:377-377|mutation with no effect:378-378|mutation disrupting interaction strength:380-380|mutation with no effect:381-381|mutation with no effect:382-382|mutation with no effect:383-383|mutation with no effect:384-384|mutation with no effect:385-385|mutation with no effect:386-386|mutation with no effect:387-387|mutation with no effect:388-388|mutation with no effect:389-389|mutation with no effect:390-390|mutation with no effect:392-392|mutation with no effect:394-394|mutation with no effect:395-395|mutation with no effect:396-396|mutation with no effect:397-397|mutation with no effect:398-398|mutation with no effect:399-399|mutation with no effect:400-400|mutation with no effect:401-401|mutation with no effect:402-402|mutation with no effect:403-403|mutation with no effect:404-404|mutation with no effect:405-405|mutation with no effect:406-406|mutation with no effect:407-407|mutation with no effect:408-408|mutation with no effect:409-409|mutation with no effect:410-410|mutation with no effect:411-411|mutation with no effect:412-412|mutation with no effect:413-413|mutation with no effect:414-414|mutation with no effect:415-415|mutation with no effect:416-416|mutation with no effect:417-417|mutation with no effect:418-418|mutation with no effect:419-419|mutation with no effect:420-420|mutation with no effect:422-422|mutation with no effect:423-423|mutation disrupting interaction strength:424-424|mutation with no effect:425-425|mutation with no effect:428-428|mutation with no effect:429-429|mutation with no effect:430-430|mutation with no effect:431-431|mutation with no effect:432-432|mutation with no effect:434-434|mutation with no effect:435-435|mutation with no effect:436-436|mutation with no effect:437-437|mutation with no effect:438-438|mutation with no effect:439-439|mutation with no effect:440-440|mutation with no effect:441-441|mutation with no effect:442-442|mutation with no effect:443-443|mutation with no effect:444-444|mutation with no effect:445-445|mutation with no effect:446-446|mutation with no effect:447-447|mutation with no effect:448-448|mutation with no effect:449-449|mutation with no effect:450-450|mutation with no effect:451-451|mutation with no effect:452-452|mutation with no effect:453-453|mutation with no effect:454-454|mutation with no effect:455-455|mutation 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effect:494-494|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation with no effect:499-499|mutation with no effect:500-500|mutation with no effect:501-501|mutation with no effect:502-502|mutation with no effect:503-503|mutation with no effect:505-505|mutation with no effect:506-506|mutation with no effect:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:511-511|mutation with no effect:512-512|mutation with no effect:513-513|mutation with no effect:514-514|mutation with no effect:515-515|mutation with no effect:516-516|mutation with no effect:517-517|mutation with no effect:518-518|mutation with no effect:519-519|mutation with no effect:268-268|mutation with no effect:269-269|mutation with no effect:270-270|mutation with no effect:271-271|mutation with no effect:272-272|mutation with no effect:273-273|mutation with no effect:274-274|mutation with no effect:275-275|mutation with no effect:276-276|mutation with no effect:277-277|mutation with no effect:278-278|mutation with no effect:279-279|mutation with no effect:280-280|mutation with no effect:281-281|mutation with no effect:282-282|mutation with no effect:286-286|mutation with no effect:287-287|mutation with no effect:288-288|mutation with no effect:289-289|mutation with no effect:290-290|mutation with no effect:291-291|mutation with no effect:292-292|mutation with no effect:293-293|mutation with no effect:295-295|mutation with no effect:296-296|mutation with no effect:297-297|mutation with no effect:298-298|mutation with no effect:299-299|mutation with no effect:300-300|mutation with no effect:301-301|mutation with no effect:302-302|mutation with no effect:303-303|mutation with no effect:304-304|mutation with no effect:306-306|mutation with no effect:307-307|mutation with no effect:308-308|mutation with no effect:309-309|mutation with no effect:310-310|mutation with no effect:311-311|mutation with no effect:312-312|mutation with no effect:313-313|mutation with no effect:314-314|mutation with no effect:315-315|mutation with no effect:316-316|mutation with no effect:317-317|mutation with no effect:318-318|mutation with no effect:319-319|mutation with no effect:320-320|mutation with no effect:321-321|mutation with no effect:322-322|mutation with no effect:323-323|mutation with no effect:324-324|mutation with no effect:325-325|mutation with no effect:326-326|mutation with no effect:327-327|mutation with no effect:328-328|mutation with no effect:329-329|mutation with no effect:330-330|mutation with no effect:331-331|mutation with no effect:332-332|mutation with no effect:333-333|mutation with no effect:334-334|mutation with no effect:335-335|mutation with no effect:337-337|mutation with no effect:338-338|mutation with no effect:339-339|mutation with no effect:340-340|mutation with no effect:341-341|mutation disrupting interaction strength:342-342|mutation with no effect:343-343|mutation with no effect:344-344|mutation with no effect:345-345|mutation with no effect:346-346|mutation with no effect:347-347|mutation with no effect:348-348|mutation with no effect:349-349|mutation with no effect:350-350|mutation with no effect:351-351|mutation with no effect:352-352|mutation with no effect:353-353|mutation with no effect:355-355|mutation with no effect:356-356|mutation with no effect:357-357|mutation with no effect:359-359|mutation with no effect:360-360|mutation with no effect:361-361|mutation with no effect:362-362|mutation with no effect:363-363|mutation with no effect:364-364|mutation with no effect:365-365|mutation with no effect:366-366|mutation with no effect:367-367|mutation with no effect:368-368|mutation with no effect:370-370|mutation with no effect:371-371|mutation with no effect:372-372|mutation with no effect:373-373|mutation with no effect:374-374|mutation with no effect:375-375|mutation 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effect:413-413|mutation with no effect:414-414|mutation with no effect:415-415|mutation with no effect:416-416|mutation with no effect:417-417|mutation with no effect:418-418|mutation with no effect:419-419|mutation with no effect:420-420|mutation with no effect:421-421|mutation with no effect:422-422|mutation with no effect:424-424|mutation with no effect:425-425|mutation with no effect:426-426|mutation with no effect:427-427|mutation with no effect:428-428|mutation with no effect:429-429|mutation with no effect:430-430|mutation with no effect:431-431|mutation with no effect:432-432|mutation with no effect:433-433|mutation with no effect:434-434|mutation with no effect:435-435|mutation with no effect:436-436|mutation with no effect:437-437|mutation with no effect:439-439|mutation with no effect:440-440|mutation with no effect:442-442|mutation with no effect:443-443|mutation with no effect:445-445|mutation with no effect:447-447|mutation with no effect:448-448|mutation with no effect:449-449|mutation with no effect:450-450|mutation with no effect:451-451|mutation with no effect:452-452|mutation with no effect:453-453|mutation with no effect:455-455|mutation with no effect:456-456|mutation with no effect:457-457|mutation with no effect:458-458|mutation with no effect:459-459|mutation with no effect:460-460|mutation with no effect:461-461|mutation with no effect:462-462|mutation with no effect:463-463|mutation with no effect:464-464|mutation with no effect:465-465|mutation with no effect:466-466|mutation with no effect:467-467|mutation with no effect:468-468|mutation with no effect:469-469|mutation with no effect:470-470|mutation with no effect:471-471|mutation with no effect:472-472|mutation with no effect:473-473|mutation with no effect:474-474|mutation with no effect:475-475|mutation with no effect:476-476|mutation with no effect:477-477|mutation with no effect:478-478|mutation with no effect:479-479|mutation with no effect:480-480|mutation with no effect:481-481|mutation with no effect:482-482|mutation with no effect:483-483|mutation with no effect:484-484|mutation with no effect:485-485|mutation with no effect:486-486|mutation with no effect:487-487|mutation with no effect:488-488|mutation with no effect:489-489|mutation with no effect:490-490|mutation with no effect:491-491|mutation with no effect:492-492|mutation with no effect:494-494|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation with no effect:499-499|mutation with no effect:500-500|mutation with no effect:501-501|mutation with no effect:502-502|mutation with no effect:503-503|mutation with no effect:504-504|mutation with no effect:505-505|mutation with no effect:506-506|mutation with no effect:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:511-511|mutation with no effect:512-512|mutation with no effect:513-513|mutation with no effect:514-514|mutation with no effect:515-515|mutation with no effect:516-516|mutation with no effect:517-517|mutation with no effect:518-518|mutation with no effect:269-269|mutation with no effect:270-270|mutation with no effect:271-271|mutation with no effect:272-272|mutation with no effect:273-273|mutation with no effect:274-274|mutation with no effect:275-275|mutation with no effect:276-276|mutation with no effect:277-277|mutation with no effect:278-278|mutation with no effect:279-279|mutation with no effect:280-280|mutation with no effect:281-281|mutation with no effect:282-282|mutation with no effect:283-283|mutation with no effect:284-284|mutation with no effect:285-285|mutation with no effect:286-286|mutation with no effect:287-287|mutation with no effect:288-288|mutation with no effect:289-289|mutation with no effect:290-290|mutation with no effect:291-291|mutation with no effect:292-292|mutation with no effect:293-293|mutation with no effect:294-294|mutation with no effect:295-295|mutation with no effect:296-296|mutation with no effect:297-297|mutation with no effect:298-298|mutation with no effect:299-299|mutation with no effect:300-300|mutation with no effect:301-301|mutation with no effect:302-302|mutation with no effect:303-303|mutation with no effect:304-304|mutation with no effect:305-305|mutation with no effect:306-306|mutation with no effect:307-307|mutation with no effect:308-308|mutation with no effect:309-309|mutation with no effect:310-310|mutation with no effect:311-311|mutation with no effect:312-312|mutation with no effect:313-313|mutation with no effect:314-314|mutation with no effect:315-315|mutation with no effect:316-316|mutation with no effect:317-317|mutation with no effect:318-318|mutation with no effect:319-319|mutation with no effect:320-320|mutation with no effect:321-321|mutation with no effect:322-322|mutation with no effect:323-323|mutation with no effect:324-324|mutation with no effect:325-325|mutation with no effect:326-326|mutation with no effect:327-327|mutation with no effect:328-328|mutation with no effect:329-329|mutation with no effect:330-330|mutation with no effect:331-331|mutation with no effect:332-332|mutation with no effect:333-333|mutation with no effect:334-334|mutation with no effect:335-335|mutation with no effect:336-336|mutation with no effect:337-337|mutation disrupting interaction strength:338-338|mutation with no effect:340-340|mutation with no effect:341-341|mutation with no effect:342-342|mutation with no effect:343-343|mutation with no effect:344-344|mutation with no effect:345-345|mutation disrupting interaction strength:346-346|mutation with no effect:347-347|mutation with no effect:348-348|mutation with no effect:349-349|mutation with no effect:350-350|mutation with no effect:351-351|mutation with no effect:353-353|mutation with no effect:356-356|mutation with no effect:357-357|mutation with no effect:358-358|mutation with no effect:359-359|mutation with no effect:360-360|mutation with no effect:361-361|mutation with no effect:362-362|mutation with no effect:364-364|mutation with no effect:365-365|mutation with no effect:366-366|mutation with no effect:367-367|mutation with no effect:368-368|mutation with no effect:369-369|mutation with no effect:370-370|mutation with no effect:371-371|mutation with no effect:372-372|mutation with no effect:373-373|mutation with no effect:374-374|mutation with no effect:375-375|mutation with no effect:376-376|mutation with no effect:377-377|mutation with no effect:378-378|mutation with no effect:379-379|mutation with no effect:380-380|mutation with no effect:381-381|mutation with no effect:382-382|mutation with no effect:383-383|mutation with no effect:384-384|mutation with no effect:385-385|mutation with no effect:386-386|mutation with no effect:388-388|mutation with no effect:389-389|mutation with no effect:390-390|mutation with no effect:391-391|mutation with no effect:392-392|mutation with no effect:394-394|mutation with no effect:395-395|mutation with no effect:396-396|mutation with no effect:398-398|mutation with no effect:400-400|mutation disrupting interaction strength:401-401|mutation with no effect:402-402|mutation with no effect:403-403|mutation with no effect:404-404|mutation with no effect:405-405|mutation with no effect:406-406|mutation with no effect:407-407|mutation with no effect:408-408|mutation with no effect:409-409|mutation with no effect:410-410|mutation with no effect:411-411|mutation with no effect:413-413|mutation with no effect:414-414|mutation with no effect:415-415|mutation with no effect:417-417|mutation with no effect:418-418|mutation with no effect:420-420|mutation with no effect:421-421|mutation with no effect:422-422|mutation with no effect:423-423|mutation with no effect:424-424|mutation with no effect:425-425|mutation with no effect:426-426|mutation with no effect:427-427|mutation with no effect:428-428|mutation with no effect:429-429|mutation with no effect:430-430|mutation with no effect:431-431|mutation with no effect:433-433|mutation with no effect:434-434|mutation with no effect:435-435|mutation with no effect:436-436|mutation with no effect:437-437|mutation with no effect:438-438|mutation with no effect:439-439|mutation with no effect:440-440|mutation with no effect:441-441|mutation with no effect:442-442|mutation with no effect:443-443|mutation with no effect:444-444|mutation with no effect:445-445|mutation with no effect:446-446|mutation with no effect:447-447|mutation with no effect:448-448|mutation with no effect:449-449|mutation with no effect:450-450|mutation with no effect:451-451|mutation with no effect:452-452|mutation with no effect:453-453|mutation with no effect:454-454|mutation with no effect:455-455|mutation with no effect:456-456|mutation with no effect:457-457|mutation with no effect:458-458|mutation with no effect:459-459|mutation with no effect:460-460|mutation with no effect:461-461|mutation with no effect:462-462|mutation with no effect:463-463|mutation with no effect:464-464|mutation with no effect:465-465|mutation with no effect:466-466|mutation with no effect:467-467|mutation with no effect:468-468|mutation with no effect:469-469|mutation with no effect:470-470|mutation with no effect:471-471|mutation with no effect:472-472|mutation with no effect:473-473|mutation with no effect:474-474|mutation with no effect:475-475|mutation with no effect:476-476|mutation with no effect:477-477|mutation with no effect:478-478|mutation with no effect:479-479|mutation with no effect:480-480|mutation with no effect:481-481|mutation with no effect:482-482|mutation with no effect:483-483|mutation with no effect:484-484|mutation with no effect:485-485|mutation with no effect:486-486|mutation with no effect:487-487|mutation with no effect:488-488|mutation with no effect:489-489|mutation with no effect:490-490|mutation with no effect:491-491|mutation with no effect:492-492|mutation with no effect:493-493|mutation with no effect:494-494|mutation with no effect:495-495|mutation with no effect:496-496|mutation with no effect:497-497|mutation with no effect:498-498|mutation with no effect:499-499|mutation with no effect:501-501|mutation with no effect:503-503|mutation with no effect:504-504|mutation with no effect:505-505|mutation with no effect:507-507|mutation with no effect:508-508|mutation with no effect:509-509|mutation with no effect:510-510|mutation with no effect:512-512|mutation with no effect:513-513|mutation with no effect:515-515|mutation with no effect:516-516|mutation with no effect:517-517|mutation with no effect:519-519|mutation disrupting interaction strength:320-320|mutation disrupting interaction strength:341-341|mutation disrupting interaction strength:361-361|mutation disrupting interaction strength:377-377|mutation disrupting interaction strength:309-309|mutation disrupting interaction strength:311-311|mutation disrupting interaction strength:334-334|mutation disrupting interaction strength:341-341|mutation disrupting interaction strength:347-347|mutation disrupting interaction strength:350-350|mutation disrupting interaction strength:377-377|mutation disrupting interaction strength:330-330|mutation disrupting interaction strength:331-331|mutation disrupting interaction strength:332-332|mutation disrupting interaction strength:340-340|mutation disrupting interaction strength:353-353|mutation disrupting interaction strength:363-363|mutation disrupting interaction strength:368-368|mutation disrupting interaction strength:387-387|mutation disrupting interaction strength:312-312|mutation disrupting interaction strength:327-327|mutation disrupting interaction strength:343-343|mutation disrupting interaction strength:395-395|mutation disrupting interaction strength:332-332|mutation disrupting interaction strength:377-377|mutation disrupting interaction strength:278-278|mutation disrupting interaction strength:301-301|mutation disrupting interaction strength:326-326|mutation disrupting interaction strength:372-372|mutation disrupting interaction strength:390-390|mutation disrupting interaction strength:394-394|mutation disrupting interaction strength:306-306|mutation disrupting interaction strength:307-307|mutation disrupting interaction strength:312-312|mutation disrupting interaction strength:314-314|mutation disrupting interaction strength:324-324|mutation disrupting interaction strength:327-327|mutation disrupting interaction strength:343-343|mutation disrupting interaction strength:348-348|mutation disrupting interaction strength:351-351|mutation disrupting interaction strength:367-367|mutation disrupting interaction strength:376-376|mutation disrupting interaction strength:381-381|mutation disrupting interaction strength:382-382|mutation disrupting interaction strength:392-392|mutation disrupting interaction strength:428-428|mutation disrupting interaction strength:292-292|mutation disrupting interaction strength:304-304|mutation disrupting interaction strength:327-327|mutation disrupting interaction strength:338-338|mutation disrupting interaction strength:342-342|mutation disrupting interaction strength:343-343|mutation disrupting interaction strength:348-348|mutation disrupting interaction strength:376-376|mutation disrupting interaction strength:377-377|mutation disrupting interaction strength:394-394|mutation disrupting interaction strength:281-281|mutation disrupting interaction strength:301-301|mutation disrupting interaction strength:310-310|mutation disrupting interaction strength:315-315|mutation disrupting interaction strength:326-326|mutation disrupting interaction strength:372-372|mutation disrupting interaction strength:373-373|mutation disrupting interaction strength:377-377|mutation disrupting interaction strength:424-424|mutation disrupting interaction strength:278-278|mutation disrupting interaction strength:306-306|mutation disrupting interaction strength:312-312|mutation disrupting interaction strength:323-323|mutation disrupting interaction strength:327-327|mutation disrupting interaction strength:335-335|mutation disrupting interaction strength:342-342|sufficient binding region:268-519|mutation disrupting interaction strength:343-343|mutation disrupting interaction strength:345-345|mutation disrupting interaction strength:348-348|mutation disrupting interaction strength:364-364|mutation disrupting interaction strength:391-391|mutation disrupting interaction strength:289-289|mutation disrupting interaction strength:296-296|mutation disrupting interaction strength:323-323|mutation disrupting interaction strength:330-330|mutation disrupting interaction strength:342-342|mutation disrupting interaction strength:345-345|mutation disrupting interaction strength:357-357|mutation disrupting interaction strength:364-364|mutation disrupting interaction strength:379-379|mutation disrupting interaction strength:391-391|mutation disrupting interaction strength:401-401|mutation disrupting interaction strength:421-421|mutation disrupting interaction strength:310-310|mutation disrupting interaction strength:342-342|mutation disrupting interaction strength:332-332|mutation disrupting interaction strength:377-377|mutation disrupting interaction strength:384-384 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:Q8NFJ9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978117|imex:IM-26519-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig. 5Bi, Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/28 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rigid:v4O059J1ifzUKCNAa0cdUdhWfOA false gal4 activation domain:n-n|sufficient binding region:407-887 lexa dna binding domain:n-n|mutation with no effect:480-480|mutation disrupting interaction strength:501-501|mutation disrupting interaction strength:503-503|mutation disrupting interaction strength:503-503|mutation disrupting interaction strength:505-505|mutation with no effect:507-507|mutation with no effect:512-512|mutation disrupting interaction strength:516-516|mutation disrupting interaction strength:517-517|mutation disrupting interaction strength:519-519|mutation disrupting interaction strength:521-521|mutation disrupting interaction strength:523-523|mutation disrupting interaction strength:530-530|mutation disrupting interaction strength:537-537|mutation disrupting interaction strength:539-539|mutation disrupting interaction strength:540-540|mutation disrupting interaction strength:546-546|mutation disrupting interaction strength:548-548|mutation disrupting interaction strength:552-552|mutation with no effect:564-564|mutation disrupting interaction strength:566-566|mutation disrupting interaction strength:568-568|mutation with no effect:574-574 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:Q9BXC9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978207|imex:IM-26519-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/30 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rigid:1+jN59cJlcrlyO00OlDRWUz2KzE false gal4 activation domain:n-n|sufficient binding region:407-887 lexa dna binding domain:c-c|mutation disrupting interaction strength:365-365|mutation disrupting interaction strength:455-455|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:568-568|mutation disrupting interaction strength:688-688 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RK4 uniprotkb:A8MTZ0 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978173|imex:IM-26519-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 - - - figure legend:Fig. S6D, Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/28 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false lexa dna binding domain:c-c|sufficient binding region:269-519 gal4 activation domain:c-c|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:34-34 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978227|imex:IM-26519-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig. S6B, Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/28 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false gal4 activation domain:c-c lexa dna binding domain:c-c|mutation disrupting interaction strength:327-327|mutation disrupting interaction strength:377-377 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWZ6-2 uniprotkb:Q9BXC9 intact:EBI-20947190 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:q8iwz62(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:sBBS2L1(isoform synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978187|imex:IM-26519-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q8IWZ6-2(isoform-parent) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/30 rogid:uWaBZJekKTwYu9wwslWw1euimf09606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rigid:lZNR3pCW99hKG1lQMBTuS1BnvqY false gal4 activation domain:n-n|sufficient binding region:326-672 lexa dna binding domain:c-c|mutation disrupting interaction strength:365-365|mutation disrupting interaction strength:455-455|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:568-568|mutation disrupting interaction strength:688-688 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:Q8N3I7 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978241|imex:IM-26519-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) - - - figure legend:Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/30 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 rigid:TYiegKicFt188nDOwkN78GhbNGg false lexa dna binding domain:c-c gal4 activation domain:c-c|mutation disrupting interaction strength:184-184|mutation with no effect:115-115|mutation disrupting interaction strength:56-56|mutation disrupting interaction strength:13-13 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NFJ9 uniprotkb:Q3SYG4 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978345|imex:IM-26519-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/30 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rigid:v4O059J1ifzUKCNAa0cdUdhWfOA false gal4 activation domain:n-n|sufficient binding region:413-593 lexa dna binding domain:n-n|mutation with no effect:690-690|mutation with no effect:741-741|mutation disrupting interaction strength:745-745 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:A0A0C4DGX9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-20959097|ensembl:ENSP00000337653 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:a0a0c4dgx9_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:hCG_21081(orf name) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978279|imex:IM-26519-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_001275710.1|refseq:XP_011534734.1|ensembl:ENSG00000165533(gene)|ensembl:ENST00000338104(transcript)|go:"GO:0034464"(BBSome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796 - - - figure legend:Fig. 4B, Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/28 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:eqYXkO13bM/IvoDreqimd3AoF909606 rigid:PiOnjKHkyGjhE1GXD9moFguM38g false gal4 activation domain:n-n lexa dna binding domain:n-n|mutation disrupting interaction strength:6-6|mutation disrupting interaction strength:11-11|mutation disrupting interaction strength:13-13|mutation disrupting interaction strength:16-16|mutation disrupting interaction strength:17-17|mutation disrupting interaction strength:18-18|mutation disrupting interaction strength:23-23|mutation disrupting interaction strength:26-26|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:31-31|mutation with no effect:54-54|mutation with no effect:64-64 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BXC9 uniprotkb:Q8IWZ6-2 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-20947190 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:q8iwz62(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:sBBS2L1(isoform synonym) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978259|imex:IM-26519-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N uniprotkb:Q8IWZ6-2(isoform-parent) - - - figure legend:Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/30 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:uWaBZJekKTwYu9wwslWw1euimf09606 rigid:lZNR3pCW99hKG1lQMBTuS1BnvqY false gal4 activation domain:n-n|sufficient binding region:324-721 lexa dna binding domain:c-c|mutation disrupting interaction strength:458-458|mutation disrupting interaction strength:474-474|mutation disrupting interaction strength:523-523|mutation with no effect:556-556|mutation disrupting interaction strength:561-561 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RK4 uniprotkb:Q3SYG4 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978313|imex:IM-26519-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/30 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rigid:yHkR1jlMmCnjc3rEY3bRuhSYsJE false gal4 activation domain:c-c|sufficient binding region:1-268 lexa dna binding domain:n-n|mutation disrupting interaction strength:690-690|mutation with no effect:741-741|mutation disrupting interaction strength:745-745 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BXC9 uniprotkb:Q3SYG4 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0018"(two hybrid) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978329|imex:IM-26519-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig. 6e and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/09/27 2018/11/30 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rigid:1+jN59cJlcrlyO00OlDRWUz2KzE false gal4 activation domain:n-n|sufficient binding region:324-721 lexa dna binding domain:n-n|mutation with no effect:690-690|mutation with no effect:741-741|mutation with no effect:745-745 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:A0A0C4DGX9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-20959097|ensembl:ENSP00000337653 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:a0a0c4dgx9_human(display_long)|uniprotkb:TTC8(gene name)|psi-mi:TTC8(display_short)|uniprotkb:hCG_21081(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978497|imex:IM-26519-55 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_001275710.1|refseq:XP_011534734.1|ensembl:ENSG00000165533(gene)|ensembl:ENST00000338104(transcript)|go:"GO:0034464"(BBSome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796 - - - figure legend:Fig. 5b, Suppl. figure 5b and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/27 2018/11/30 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:eqYXkO13bM/IvoDreqimd3AoF909606 rigid:PiOnjKHkyGjhE1GXD9moFguM38g false tandem tag:n-n protein a tag:n-n|mutation disrupting interaction strength:6-6|mutation disrupting interaction strength:11-11|mutation disrupting interaction strength:13-13|mutation disrupting interaction strength:16-16|mutation disrupting interaction strength:17-17|mutation disrupting interaction strength:18-18|mutation disrupting interaction strength:23-23|mutation disrupting interaction strength:26-26|mutation disrupting interaction strength:27-27|mutation with no effect:54-54 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BXC9 uniprotkb:Q8IWZ6-2 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 intact:EBI-20947190 psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:q8iwz62(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:sBBS2L1(isoform synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978481|imex:IM-26519-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N uniprotkb:Q8IWZ6-2(isoform-parent) - - - figure legend:Fig. 5b, Suppl. figure 5b and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/27 2018/11/30 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rogid:uWaBZJekKTwYu9wwslWw1euimf09606 rigid:lZNR3pCW99hKG1lQMBTuS1BnvqY false tandem tag:n-n|sufficient binding region:324-721 protein a tag:n-n|mutation with no effect:458-458|mutation disrupting interaction strength:523-523|mutation disrupting interaction strength:561-561 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:Q9BXC9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978451|imex:IM-26519-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig. 5b, Suppl. figure 5b and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/27 2018/11/30 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rigid:1+jN59cJlcrlyO00OlDRWUz2KzE false tandem tag:n-n|sufficient binding region:407-887 protein a tag:n-n|mutation with no effect:455-455|mutation with no effect:513-513|mutation disrupting interaction strength:568-568 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RK4 uniprotkb:A8MTZ0 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978421|imex:IM-26519-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 - - - figure legend:Fig. 5b, Suppl. figure 5b and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/27 2018/11/30 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false tandem tag:n-n|sufficient binding region:269-519 protein a tag:n-n|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:34-34 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8MTZ0 uniprotkb:Q96RK4 intact:EBI-2892417|ensembl:ENSP00000436622|ensembl:ENSP00000474675|ensembl:ENSP00000498430|uniprotkb:E9PM41|uniprotkb:E9PRI7|uniprotkb:E9PIY9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbip1_human(display_long)|uniprotkb:BBIP1(gene name)|psi-mi:BBIP1(display_short)|uniprotkb:NCRNA00081(gene name synonym)|uniprotkb:BBIP10(gene name synonym)|uniprotkb:BBSome-interacting protein of 10 kDa(gene name synonym) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978467|imex:IM-26519-53 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214413(gene)|ensembl:ENST00000448814(transcript)|ensembl:ENST00000605742(transcript)|ensembl:ENST00000652043(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0034464"(BBSome)|go:"GO:0042755"(eating behavior)|go:"GO:0060271"(cilium assembly)|go:"GO:0097500"(receptor localization to non-motile cilium)|interpro:IPR028233|rcsb pdb:6XT9|reactome:R-HSA-5620922|refseq:NP_001182234.1|refseq:NP_001182235.1|refseq:NP_001230712.1|refseq:NP_001182233.1|refseq:NP_001182236.1 refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig. 5b, Suppl. figure 5b and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/27 2018/11/30 rogid:B6ZtphzP9bVE4acFyj1m92MOJXc9606 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rigid:/H27UXJ8AzA4vAHuXILLdDgwOJk false tandem tag:n-n protein a tag:n-n|mutation disrupting interaction strength:327-327|mutation disrupting interaction strength:377-377 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG4 uniprotkb:Q8NFJ9 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978367|imex:IM-26519-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig. 5b, Suppl. figure 5b and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/27 2018/11/30 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rigid:v4O059J1ifzUKCNAa0cdUdhWfOA false tandem tag:n-n|sufficient binding region:407-887 protein a tag:n-n|mutation with no effect:480-480|mutation disrupting interaction strength:501-501|mutation disrupting interaction strength:503-503|mutation disrupting interaction strength:503-503|mutation disrupting interaction strength:505-505|mutation with no effect:507-507|mutation with no effect:512-512|mutation disrupting interaction strength:517-517|mutation disrupting interaction strength:519-519|mutation disrupting interaction strength:521-521|mutation disrupting interaction strength:523-523|mutation disrupting interaction strength:530-530|mutation disrupting interaction strength:537-537|mutation disrupting interaction strength:539-539|mutation disrupting interaction strength:540-540|mutation disrupting interaction strength:546-546|mutation with no effect:548-548|mutation disrupting interaction strength:552-552|mutation with no effect:564-564|mutation disrupting interaction strength:566-566|mutation disrupting interaction strength:568-568|mutation with no effect:574-574 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWZ6-2 uniprotkb:Q9BXC9 intact:EBI-20947190 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:q8iwz62(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:sBBS2L1(isoform synonym) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Woodsmith et al. (2017) pubmed:29039417|imex:IM-26519|doi:10.1038/nmeth.4464 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20978435|imex:IM-26519-51 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q8IWZ6-2(isoform-parent) refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig. 5b, Suppl. figure 5b and Supplementary Data 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/09/27 2018/11/30 rogid:uWaBZJekKTwYu9wwslWw1euimf09606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 rigid:lZNR3pCW99hKG1lQMBTuS1BnvqY false tandem tag:n-n|sufficient binding region:326-672 protein a tag:n-n|mutation disrupting interaction strength:455-455|mutation disrupting interaction strength:513-513|mutation disrupting interaction strength:568-568 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)