#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8C6L5	uniprotkb:Q8C6L5	intact:EBI-20649472|uniprotkb:Q3ULW3|ensembl:ENSMUSP00000063331	intact:EBI-20649472|uniprotkb:Q3ULW3|ensembl:ENSMUSP00000063331	psi-mi:cgas_mouse(display_long)|uniprotkb:Cgas(gene name)|psi-mi:Cgas(display_short)|uniprotkb:Mb21d1(gene name synonym)|uniprotkb:Mab-21 domain-containing protein 1(gene name synonym)|uniprotkb:2'3'-cGAMP synthase(gene name synonym)	psi-mi:cgas_mouse(display_long)|uniprotkb:Cgas(gene name)|psi-mi:Cgas(display_short)|uniprotkb:Mb21d1(gene name synonym)|uniprotkb:Mab-21 domain-containing protein 1(gene name synonym)|uniprotkb:2'3'-cGAMP synthase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Andreeva et al. (2017)	pubmed:28902841|imex:IM-26777	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20649515|wwpdb:5N6I|imex:IM-26777-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775562.2|ensembl:ENSMUSG00000032344(gene)|ensembl:ENSMUST00000070742(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035861"(site of double-strand break)|go:"GO:0038001"(paracrine signaling)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0061501"(2',3'-cyclic GMP-AMP synthase activity)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR024810|rcsb pdb:4K8V|rcsb pdb:4K96|rcsb pdb:4K97|rcsb pdb:4K98|rcsb pdb:4K99|rcsb pdb:4K9A|rcsb pdb:4K9B|rcsb pdb:4LEY|rcsb pdb:4LEZ|rcsb pdb:4O6A|rcsb pdb:5N6I|rcsb pdb:5XZB|rcsb pdb:5XZE|rcsb pdb:5XZG|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7A08|rcsb pdb:7BUJ|rcsb pdb:7BUM|rcsb pdb:7BUQ|rcsb pdb:7JO9|rcsb pdb:7JOA	refseq:NP_775562.2|ensembl:ENSMUSG00000032344(gene)|ensembl:ENSMUST00000070742(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035861"(site of double-strand break)|go:"GO:0038001"(paracrine signaling)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0061501"(2',3'-cyclic GMP-AMP synthase activity)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR024810|rcsb pdb:4K8V|rcsb pdb:4K96|rcsb pdb:4K97|rcsb pdb:4K98|rcsb pdb:4K99|rcsb pdb:4K9A|rcsb pdb:4K9B|rcsb pdb:4LEY|rcsb pdb:4LEZ|rcsb pdb:4O6A|rcsb pdb:5N6I|rcsb pdb:5XZB|rcsb pdb:5XZE|rcsb pdb:5XZG|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7A08|rcsb pdb:7BUJ|rcsb pdb:7BUM|rcsb pdb:7BUQ|rcsb pdb:7JO9|rcsb pdb:7JOA	-	-	-	figure legend:Fig 1d-e, Table S3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2018/07/23	2018/07/31	rogid:t6PcThnsVw1f2sek0comkdzOqgQ10090	rogid:t6PcThnsVw1f2sek0comkdzOqgQ10090	rigid:Iw4FGW8wzS21tCs3IdsqJNtX5aA	false	binding-associated region:141-507	binding-associated region:141-507	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q00059-1	uniprotkb:Q8N884-1	intact:EBI-20649527|ensembl:ENSP00000420588	intact:EBI-20649535	psi-mi:q00059-1(display_long)|uniprotkb:Mitochondrial transcription factor 1(gene name synonym)|uniprotkb:Transcription factor 6(gene name synonym)|uniprotkb:Transcription factor 6-like 2(gene name synonym)|uniprotkb:TFAM(gene name)|psi-mi:TFAM(display_short)|uniprotkb:TCF6(gene name synonym)|uniprotkb:TCF6L2(gene name synonym)	psi-mi:q8n884-1(display_long)|uniprotkb:CGAS(gene name)|psi-mi:CGAS(display_short)|uniprotkb:C6orf150(gene name synonym)|uniprotkb:MB21D1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Andreeva et al. (2017)	pubmed:28902841|imex:IM-26777	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-20649542|imex:IM-26777-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1049924(isoform-parent)|ensembl:ENSG00000108064(gene)|ensembl:ENST00000487519(transcript)	uniprotkb:Q8N884-1(isoform-parent)	-	-	-	figure legend:Extended Data Fig 9e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/07/23	2018/07/24	rogid:JqG4yJbWWsYMvex7a6GDIDxiVcs9606	rogid:jHb5dp380QcFfJNq8HAAmrZhjZQ9606	rigid:IQjbpMqcWNnt1sYQrmLIIKKATDM	false	binding-associated region:43-246	flag tag:n-n|ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)