#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881717|imex:IM-26387-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	sufficient binding region:200-376|mutation:191-191|mutation with no effect:150-150	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:O43447	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881739|imex:IM-26387-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-3|comment:MORG1, SKIP, PPIH, FAM164A and FAM50B interacted only with full length constructs of FBP21.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606	rigid:H2mryEu6cHEKQNuo4LjvDtlszbI	false	mutation with no effect:150-150|mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:Q13435	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-749111|uniprotkb:A8K485|uniprotkb:B4DT19|uniprotkb:Q7Z627|uniprotkb:Q969K1|uniprotkb:Q96CM6|uniprotkb:Q9BWD2|intact:EBI-1052093|intact:EBI-2688256|uniprotkb:Q7L4T5|ensembl:ENSP00000318861	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:sf3b2_human(display_long)|uniprotkb:SF3B2(gene name)|psi-mi:SF3B2(display_short)|uniprotkb:SAP145(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 145 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein 145(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881749|imex:IM-26387-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_006833.2|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR006568(PSP, proline-rich)|ensembl:ENSG00000087365(gene)|ensembl:ENST00000322535(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR007180(Protein of unknown function DUF382)|rcsb pdb:2DO5|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y53|mint:Q13435|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:Y9uCV2x4J5kqyxeO8iXjojkXocA9606	rigid:vsWGxxvIf/pO59P55veofsL8Pv0	false	mutation with no effect:150-150|mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:Q13573	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-632715|uniprotkb:Q13483|uniprotkb:Q32N03|uniprotkb:Q5D0D6|uniprotkb:A8K8A9|ensembl:ENSP00000261531	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:snw1_human(display_long)|uniprotkb:Nuclear protein SkiP(gene name synonym)|uniprotkb:Ski-interacting protein(gene name synonym)|uniprotkb:Nuclear receptor coactivator NCoA-62(gene name synonym)|uniprotkb:SKIIP(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:SNW1(gene name)|psi-mi:SNW1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881807|imex:IM-26387-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_036377.1|ensembl:ENSG00000100603(gene)|ensembl:ENST00000261531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048385"(regulation of retinoic acid receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0070564"(positive regulation of vitamin D receptor signaling pathway)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071300"(cellular response to retinoic acid)|interpro:IPR004015(SKIP/SNW)|interpro:IPR017862|mint:Q13573|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-72163|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|dip:DIP-34800N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-5|comment:MORG1, SKIP, PPIH, FAM164A and FAM50B interacted only with full length constructs of FBP21.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:DwdpE5FIS2KfI0GOFt9IbAvjm/Y9606	rigid:zGc5Lk7gNr1xzEt0Q8teata3yws	false	mutation with no effect:150-150|mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRX9	uniprotkb:O75554	intact:EBI-7705033|intact:EBI-28975578|ensembl:ENSP00000402653|intact:MINT-4776445|uniprotkb:B2RAF1|uniprotkb:Q53FT6	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	psi-mi:wdr83_human(display_long)|uniprotkb:WDR83(gene name)|psi-mi:WDR83(display_short)|uniprotkb:MORG1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase organizer 1(gene name synonym)	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881816|imex:IM-26387-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000402653|ensembl:ENSG00000123154(gene)|ensembl:ENST00000418543(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0010008"(endosome membrane)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9BRX9|reactome:R-HSA-5674135|refseq:NP_115708.1|refseq:NP_001093207.1	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	-	comment:mint|comment:homomint|function:"Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing"	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	figure legend:Table 1-6|comment:MORG1, SKIP, PPIH, FAM164A and FAM50B interacted only with full length constructs of FBP21.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:p+W60A6W8VtTfMMqMNjACQY6Wk09606	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rigid:G/PjX6FfxglpMLCnSiGVaUfXKrk	false	-	mutation:191-191|mutation with no effect:150-150	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:Q96GY0	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-5458880|uniprotkb:Q9Y372|ensembl:ENSP00000263849	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:zc21a_human(display_long)|uniprotkb:ZC2HC1A(gene name)|psi-mi:ZC2HC1A(display_short)|uniprotkb:C8orf70(gene name synonym)|uniprotkb:FAM164A(gene name synonym)|uniprotkb:CGI-62(orf name)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881899|imex:IM-26387-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_057094.2|ensembl:ENSG00000104427(gene)|ensembl:ENST00000263849(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR026319	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-7|comment:MORG1, SKIP, PPIH, FAM164A and FAM50B interacted only with full length constructs of FBP21.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:5QYEwHhPJBrdqbU1jKnxdZFYC7c9606	rigid:UnMbkqAeMyIqz1HplaAWvNRmwSU	false	mutation:191-191|mutation with no effect:150-150	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:Q9Y247	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-742802|uniprotkb:Q5T2L6|ensembl:ENSP00000369627|ensembl:ENSP00000496837	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:fa50b_human(display_long)|uniprotkb:Protein XAP-5-like(gene name synonym)|uniprotkb:FAM50B(gene name)|psi-mi:FAM50B(display_short)|uniprotkb:X5L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881908|imex:IM-26387-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_036267.1|ensembl:ENST00000380274(transcript)|ensembl:ENST00000648326(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0030496"(midbody)|go:"GO:0045171"(intercellular bridge)|interpro:IPR007005(XAP5 protein)|mint:Q9Y247|ensembl:ENSG00000145945(gene)|refseq:XP_016866218.1	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-8|comment:MORG1, SKIP, PPIH, FAM164A and FAM50B interacted only with full length constructs of FBP21.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:+GYwKGuchxbVElEibszICsOAgFo9606	rigid:VLqj9+QProoOsuZKH2Q8UAHcWVE	false	mutation:191-191|mutation with no effect:150-150	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:P31483	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881917|imex:IM-26387-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606	rigid:Kq1dtUmKrIIi+rtnLnbTjIXM0ZA	false	sufficient binding region:1-50	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:Q9NWB6	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-2808785|uniprotkb:B4E0Y3|uniprotkb:Q6IQ34|uniprotkb:Q5T257|ensembl:ENSP00000383059	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:argl1_human(display_long)|uniprotkb:ARGLU1(gene name)|psi-mi:ARGLU1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881928|imex:IM-26387-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_060481.3|ensembl:ENSG00000134884(gene)|ensembl:ENST00000400198(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0045296"(cadherin binding)|interpro:IPR033371	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:tZ/PMMjPF72fu4NqFOfhHWB0QWM9606	rigid:6pHAPhjz1FYJMomOI+c5uo61l2M	false	sufficient binding region:1-50|mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:P61978	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-304185|intact:EBI-28971491|ensembl:ENSP00000317788|ensembl:ENSP00000353552|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q59F98|uniprotkb:Q60577|uniprotkb:Q922Y7|uniprotkb:Q96J62|uniprotkb:Q5T6W4|intact:EBI-3440248|uniprotkb:Q6IBN1	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:hnrpk_human(display_long)|uniprotkb:HNRNPK(gene name)|psi-mi:HNRNPK(display_short)|uniprotkb:HNRPK(gene name synonym)|uniprotkb:Transformation up-regulated nuclear protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881935|imex:IM-26387-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	ensembl:ENSG00000165119(gene)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000351839(transcript)|ensembl:ENST00000360384(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0002102"(podosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006396"(RNA processing)|go:"GO:0007165"(signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61978|rcsb pdb:1J5K|rcsb pdb:1KHM|rcsb pdb:1ZZI|rcsb pdb:1ZZJ|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9610379|rcsb pdb:1ZZK|refseq:NP_002131.2|refseq:NP_112552.1|refseq:NP_112553.1|ensembl:ENSP00000317788|ensembl:ENSP00000353552|ensembl:ENST00000376263|ensembl:ENSP00000365439|ensembl:ENST00000376281|ensembl:ENSP00000365458|refseq:NP_001305115.1|refseq:NP_001305116.1|refseq:NP_001305117.1|refseq:XP_016870157.1|refseq:XP_005252017.1|refseq:XP_005252020.1|refseq:XP_005252022.1|dip:DIP-31805N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc9606	rigid:9AusFvc1OQamn0ckWV5mTvQOsY0	false	mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:Q9ULR0	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-2557660|uniprotkb:Q9BT05|uniprotkb:Q96IL2|ensembl:ENSP00000376973	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:isy1_human(display_long)|uniprotkb:ISY1(gene name)|psi-mi:ISY1(display_short)|uniprotkb:KIAA1160(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881944|imex:IM-26387-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_001186398.1|refseq:NP_001191819.1|refseq:NP_065752.1|dip:DIP-56636N|ensembl:ENSG00000240682(gene)|ensembl:ENST00000393295(transcript)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:0071020"(post-spliceosomal complex)|interpro:IPR009360(Isy1-like splicing)|interpro:IPR029012|interpro:IPR037200|mint:Q9ULR0|rcsb pdb:5YZG|rcsb pdb:6FF7|rcsb pdb:6ZYM|rcsb pdb:7A5P|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-72163	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-12|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:t4QKu0uotUIJIzR8DTXWje21U1A9606	rigid:eCi5zLfdp4TDxlCAXZqApHuE1Rs	false	mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:Q9Y2W2	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-714455|ensembl:ENSP00000261167|uniprotkb:Q96AY8	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:wbp11_human(display_long)|uniprotkb:SH3 domain-binding protein SNP70(gene name synonym)|uniprotkb:Npw38-binding protein(gene name synonym)|uniprotkb:WBP11(gene name)|psi-mi:WBP11(display_short)|uniprotkb:NPWBP(gene name synonym)|uniprotkb:SNP70(gene name synonym)|uniprotkb:SIPP1(gene name synonym)|uniprotkb:Splicing factor that interacts with PQBP-1 and PP1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881951|imex:IM-26387-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	rcsb pdb:7ABG|reactome:R-HSA-72163|ensembl:ENSG00000084463(gene)|ensembl:ENST00000261167(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0050699"(WW domain binding)|interpro:IPR019007|mint:Q9Y2W2|rcsb pdb:7ABF|refseq:NP_057396.1	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-13|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:qE03bpSsQiJouJbn6ISt8DnD/pA9606	rigid:3ygS9ZJAmvr9EOjwlev31cymeuI	false	mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:Q15459	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1054743|uniprotkb:E9PAW1|ensembl:ENSP00000215793	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:sf3a1_human(display_long)|uniprotkb:Spliceosome-associated protein 114(gene name synonym)|uniprotkb:SF3a120(gene name synonym)|uniprotkb:SF3A1(gene name)|psi-mi:SF3A1(display_short)|uniprotkb:SAP114(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881957|imex:IM-26387-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_005868.1|ensembl:ENSG00000099995(gene)|ensembl:ENST00000215793(transcript)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|rcsb pdb:2DT6|go:"GO:0071004"(U2-type prespliceosome)|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6QX9|go:"GO:0071005"(U2-type precatalytic spliceosome)|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-72163|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000061(SWAP/Surp)|interpro:IPR000626(Ubiquitin)|interpro:IPR022030|interpro:IPR029071|interpro:IPR035563|interpro:IPR035967|mint:Q15459|rcsb pdb:1ZKH|dip:DIP-29164N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-14|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:YrIs3RwfjUcDsHCJDgTLMnOUJZM9606	rigid:+JIUngXWvKur/uMjSXIr/9EVjhA	false	mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:Q92620	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1043041|uniprotkb:O75212|uniprotkb:Q96HN7|ensembl:ENSP00000268482|uniprotkb:D3DWS7|uniprotkb:B4DVG8	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:prp16_human(display_long)|uniprotkb:DHX38(gene name)|psi-mi:DHX38(display_short)|uniprotkb:DDX38(gene name synonym)|uniprotkb:KIAA0224(gene name synonym)|uniprotkb:PRP16(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DHX38(gene name synonym)|uniprotkb:DEAH box protein 38(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881963|imex:IM-26387-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	ensembl:ENSG00000140829(gene)|ensembl:ENST00000268482(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0016020"(membrane)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q92620|rcsb pdb:5YZG|rcsb pdb:6ZYM|rcsb pdb:7A5P|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_054722.2|refseq:XP_011521786.1|refseq:XP_011521787.1	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-15|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:miHZNGhDUIz9imwhlPz2tIsCNLs9606	rigid:nNbL681BJ2NEoajxvb/YLUeVlcM	false	mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:O43143	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1237044|uniprotkb:Q9NQT7|ensembl:ENSP00000336741	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:dhx15_human(display_long)|uniprotkb:DHX15(gene name)|psi-mi:DHX15(display_short)|uniprotkb:DBP1(gene name synonym)|uniprotkb:DDX15(gene name synonym)|uniprotkb:DEAH box protein 15(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #46(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16881969|imex:IM-26387-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_001349.2|dip:DIP-38211N|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR044756|mint:O43143|rcsb pdb:5XDR|rcsb pdb:6ID1|rcsb pdb:6SH6|rcsb pdb:6SH7|reactome:R-HSA-72163|ensembl:ENSG00000109606(gene)|ensembl:ENST00000336812(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0043279"(response to alkaloid)	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Table 1-16|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/03/21	2018/03/27	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:rOkQ5RG/3gc1/0Qcn5ANS6ImepY9606	rigid:ryNETmEflQNa5RGuaOZiDe6V+/w	false	mutation:191-191	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16882106|imex:IM-26387-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Figure 1|comment:The cross-link between FBP21 K338 and Brr2 K1874 was the predominant site.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/03/28	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	cross linker:338-338|sufficient binding region:200-376|cross linker:286-286|cross linker:274-274|cross linker:284-284|cross linker:286-286|cross linker:338-338|cross linker:250-250|cross linker:270-270|cross linker:274-274|cross linker:284-284|cross linker:286-286|cross linker:338-338|cross linker:365-365|cross linker:338-338	cross linker:1874-1874|cross linker:1874-1874|cross linker:1874-1874|cross linker:1874-1874|cross linker:107-107|cross linker:1567-1567|cross linker:1603-1603|cross linker:1711-1711|cross linker:1841-1841|cross linker:1874-1874|cross linker:2080-2080|cross linker:2087-2087|cross linker:1567-1567|cross linker:1567-1567	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16882181|imex:IM-26387-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	sufficient binding region:276-376|15n label:?-?	sufficient binding region:1840-2136	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16882191|imex:IM-26387-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Figure 2B, 3C, Supp. figure 2/3/4|comment:Binding of FBP21_276-376 and FBP21_326-376 induced similar chemical shift changes.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	sufficient binding region:276-376|mutation with no effect:357-357,359-359	sufficient binding region:1840-2136|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16882228|imex:IM-26387-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Figure 3C, Supp.Fig 7|comment:Binding of peptide 58 to Brr2C-Sec63 induced chemical shift changes that were intermediate between peptide 57 and FBP21276–376 in number and magnitude.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	sufficient binding region:346-365|sufficient binding region:351-370	15n label:?-?|sufficient binding region:1840-2136	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16882210|imex:IM-26387-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Figure 3A, Supp 11 A/C/D|comment:Kd values obtained for the interaction of FBP21_116–376 with Brr2  in both  presence and absence  of SmB-peptide were similar.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	sufficient binding region:276-376|sufficient binding region:200-376|sufficient binding region:326-376|sufficient binding region:116-376	sufficient binding region:1840-2136	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16882249|imex:IM-26387-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Figure 3A-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	mutation decreasing interaction strength:357-357,359-359|sufficient binding region:200-376|mutation decreasing interaction strength:360-360,358-358	sufficient binding region:1840-2136	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17144207|imex:IM-26387-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Supp. Fig 6, Fig. 3A|kinetics:The mutated peptides GKKRR and KRFRK give a Kd of 37 and 27 uM respectively.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	sufficient binding region:346-365|sufficient binding region:351-370|sufficient binding region:356-360|mutation:356-360|mutation:356-360	sufficient binding region:1840-2136	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:P14678-2	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-372475|ensembl:ENSP00000370746|intact:EBI-7175726|intact:MINT-124911|intact:EBI-7176920	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:p14678-2(display_long)|uniprotkb:SNRPB(gene name)|psi-mi:SNRPB(display_short)|uniprotkb:COD(gene name synonym)|uniprotkb:SNRPB1(gene name synonym)|uniprotkb:Sm protein B/B'(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17156429|imex:IM-26387-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	intact:EBI-372458(rsmb_human)|ensembl:ENSG00000125835(gene)|ensembl:ENST00000381342(transcript)|uniprotkb:P14678-2(isoform-parent)	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Supp Fig  11  B/D/EF|comment:Brr2C-Sec63 itself did not interact with the SmB-peptide.|comment:The Kd values obtained in both  presence and absence  of Brr2C-Sec63 were similar.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:16.8x10^-6(molar)	2018/03/21	2018/04/06	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:4YLKg8JREkaZmS2RL+o/Sxtl7rw9606	rigid:T1VN792u5VMYYpkIORZneASKxuI	false	sufficient binding region:116-376	sufficient binding region:210-231	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16882280|imex:IM-26387-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Figure 3B|comment:Full length Brr2 reacted weakly.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/05/01	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	sufficient binding region:357-360	sufficient binding region:395-2129|his tag:?-?|sufficient binding region:1282-2136|binding-associated region:1325-2129	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16882302|imex:IM-26387-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Figure 3B-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/05/01	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	sufficient binding region:116-120	his tag:?-?|sufficient binding region:1282-2136	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-17139373	uniprotkb:O75643	rnacentral:URS00006D8611_4932	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139371|imex:IM-26387-54	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	go:"GO:0004004"	-	-	figure legend:Figure 4A|comment:The unwinding activity of full length and  Brr2NC was unchanged upon addition of FBP21  200–376.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	32p radiolabel:1-1	sufficient binding region:395-1324	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	intact:EBI-17139376	rnacentral:URS00006D8611_4932	rnacentral:URS000070B478_4932	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139371|imex:IM-26387-54	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	go:"GO:0004004"	-	-	figure legend:Figure 4A|comment:The unwinding activity of full length and  Brr2NC was unchanged upon addition of FBP21  200–376.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	-	-	false	32p radiolabel:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75643	rnacentral:URS00006D8611_4932	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139385|imex:IM-26387-56	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	go:"GO:0004004"	-	-	figure legend:Figure 4A-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	32p radiolabel:1-1	sufficient binding region:395-2129	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	intact:EBI-17139376	rnacentral:URS00006D8611_4932	rnacentral:URS000070B478_4932	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139385|imex:IM-26387-56	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	go:"GO:0004004"	-	-	figure legend:Figure 4A-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	-	-	false	32p radiolabel:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75643	rnacentral:URS00006D8611_4932	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139395|imex:IM-26387-58	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	go:"GO:0004004"	-	-	figure legend:Figure 4A-3, 4D, supp fig 10-A|comment:FBP21  200–376 caused the apparent unwinding rate of Brr2_HR to be reduced nearly by half.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	32p radiolabel:1-1	sufficient binding region:395-2129	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	intact:EBI-17139376	rnacentral:URS00006D8611_4932	rnacentral:URS000070B478_4932	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139395|imex:IM-26387-58	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	go:"GO:0004004"	-	-	figure legend:Figure 4A-3, 4D, supp fig 10-A|comment:FBP21  200–376 caused the apparent unwinding rate of Brr2_HR to be reduced nearly by half.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	-	-	false	32p radiolabel:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75554	rnacentral:URS00006D8611_4932	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139395|imex:IM-26387-58	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	go:"GO:0004004"	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	figure legend:Figure 4A-3, 4D, supp fig 10-A|comment:FBP21  200–376 caused the apparent unwinding rate of Brr2_HR to be reduced nearly by half.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	-	false	32p radiolabel:1-1	sufficient binding region:200-376	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75643	rnacentral:URS00006D8611_4932	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139516|imex:IM-26387-68	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	go:"GO:0004004"	-	-	figure legend:Figure  4E/F, supp fig 10-B|comment:FBP21  276–376 reduced the unwinding rate of Brr2-HR approximately two-fold, similar to FBP21 200–376.  However, experiments employing high concentrations of FBP21 276–376 revealed the same reduction in unwinding rate, but no decrease in the unwound fraction.|comment:FBP21  326–376 has no inhibitory effect on Brr2-HR|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	32p radiolabel:1-1	sufficient binding region:395-2129	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	intact:EBI-17139376	rnacentral:URS00006D8611_4932	rnacentral:URS000070B478_4932	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139516|imex:IM-26387-68	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	go:"GO:0004004"	-	-	figure legend:Figure  4E/F, supp fig 10-B|comment:FBP21  276–376 reduced the unwinding rate of Brr2-HR approximately two-fold, similar to FBP21 200–376.  However, experiments employing high concentrations of FBP21 276–376 revealed the same reduction in unwinding rate, but no decrease in the unwound fraction.|comment:FBP21  326–376 has no inhibitory effect on Brr2-HR|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	-	-	false	32p radiolabel:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75554	rnacentral:URS00006D8611_4932	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139516|imex:IM-26387-68	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	go:"GO:0004004"	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	figure legend:Figure  4E/F, supp fig 10-B|comment:FBP21  276–376 reduced the unwinding rate of Brr2-HR approximately two-fold, similar to FBP21 200–376.  However, experiments employing high concentrations of FBP21 276–376 revealed the same reduction in unwinding rate, but no decrease in the unwound fraction.|comment:FBP21  326–376 has no inhibitory effect on Brr2-HR|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/04	-	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	-	false	32p radiolabel:1-1	sufficient binding region:276-376	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P33334	intact:EBI-17139373	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	rnacentral:URS00006D8611_4932	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139533|imex:IM-26387-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	-	go:"GO:0004004"	crc64:8F4F6F89D34D3508	-	figure legend:Figure 4G-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	-	-	false	sufficient binding region:2012..2147-2399..2400	32p radiolabel:1-1	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P33334	uniprotkb:O75643	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139533|imex:IM-26387-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	go:"GO:0004004"	crc64:8F4F6F89D34D3508	-	figure legend:Figure 4G-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	sufficient binding region:2012..2147-2399..2400	sufficient binding region:395-2129	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P33334	intact:EBI-17139376	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	rnacentral:URS000070B478_4932	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139533|imex:IM-26387-70	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	-	go:"GO:0004004"	crc64:8F4F6F89D34D3508	-	figure legend:Figure 4G-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	-	-	false	sufficient binding region:2012..2147-2399..2400	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P33334	intact:EBI-17139373	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	rnacentral:URS00006D8611_4932	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139547|imex:IM-26387-76	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	-	go:"GO:0004004"	crc64:8F4F6F89D34D3508	-	figure legend:Figure 4G-2|comment:The activatory effect of Prp8Jab1_delta_C is completely abolished in presence of FBP21_200–376.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	-	-	false	sufficient binding region:2012..2147-2399..2400	32p radiolabel:1-1	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P33334	uniprotkb:O75643	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139547|imex:IM-26387-76	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	go:"GO:0004004"	crc64:8F4F6F89D34D3508	-	figure legend:Figure 4G-2|comment:The activatory effect of Prp8Jab1_delta_C is completely abolished in presence of FBP21_200–376.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	sufficient binding region:2012..2147-2399..2400	sufficient binding region:395-2129	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P33334	intact:EBI-17139376	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	rnacentral:URS000070B478_4932	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139547|imex:IM-26387-76	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	-	go:"GO:0004004"	crc64:8F4F6F89D34D3508	-	figure legend:Figure 4G-2|comment:The activatory effect of Prp8Jab1_delta_C is completely abolished in presence of FBP21_200–376.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	-	-	false	sufficient binding region:2012..2147-2399..2400	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P33334	uniprotkb:O75554	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139547|imex:IM-26387-76	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	go:"GO:0004004"	crc64:8F4F6F89D34D3508	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	figure legend:Figure 4G-2|comment:The activatory effect of Prp8Jab1_delta_C is completely abolished in presence of FBP21_200–376.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/05	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	-	false	sufficient binding region:2012..2147-2399..2400	sufficient binding region:200-376	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75643	rnacentral:URS00006D8611_4932	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17156455|imex:IM-26387-72	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	go:"GO:0004004"	-	-	figure legend:Supp fig 11 G/H|comment:FBP21_116–376 inhibited the Brr2HR helicase activity to a similar extent as FBP21_200–376.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/06	-	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	32p radiolabel:1-1	sufficient binding region:1840-2136	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	intact:EBI-17139376	rnacentral:URS00006D8611_4932	rnacentral:URS000070B478_4932	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17156455|imex:IM-26387-72	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	go:"GO:0004004"	-	-	figure legend:Supp fig 11 G/H|comment:FBP21_116–376 inhibited the Brr2HR helicase activity to a similar extent as FBP21_200–376.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/06	-	-	-	false	32p radiolabel:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75554	rnacentral:URS00006D8611_4932	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17156455|imex:IM-26387-72	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	go:"GO:0004004"	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	figure legend:Supp fig 11 G/H|comment:FBP21_116–376 inhibited the Brr2HR helicase activity to a similar extent as FBP21_200–376.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/06	-	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	-	false	32p radiolabel:1-1	sufficient binding region:116-376	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	intact:EBI-17139376	rnacentral:URS00006D8611_4932	rnacentral:URS000070B478_4932	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139430|imex:IM-26387-60	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	go:"GO:0004004"	-	-	figure legend:Figure 4B, Supp fig 9.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.78x10^-6(molar)	2018/03/21	2018/04/04	-	-	-	false	32p radiolabel:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75554	rnacentral:URS00006D8611_4932	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139430|imex:IM-26387-60	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	go:"GO:0004004"	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	figure legend:Figure 4B, Supp fig 9.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.78x10^-6(molar)	2018/03/21	2018/04/04	-	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	-	false	32p radiolabel:1-1	necessary binding region:200-276|sufficient binding region:200-376	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O75554	intact:EBI-17139373	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	rnacentral:URS00006D8611_4932	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139448|imex:IM-26387-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0607"(small nuclear rna)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	-	go:"GO:0004004"	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Figure 4B, Supp fig 9.-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.5x10^-6(molar)	2018/03/21	2018/04/04	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	-	-	false	necessary binding region:200-276|sufficient binding region:200-376	32p radiolabel:1-1	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75643	rnacentral:URS00006D8611_4932	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139465|imex:IM-26387-74	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	-	-	figure legend:Figure 4C-2|comment:FBP21  200–376 inhibits RNA binding of Brr2HR when present in high concentrations. Inhibition is reduced when the shorter FBP21 276–376 is used.|kinetic_conditions:"Kd given for the  interaction in the  presence of 5uM FBP21 200-376 (163nM). When the shorter FBP21 276–376 was used, a Kd of 43nM was obtained."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:163.0x10^-9(molar)	2018/03/21	2018/04/04	-	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	32p radiolabel:1-1	sufficient binding region:395-2129	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	intact:EBI-17139376	rnacentral:URS00006D8611_4932	rnacentral:URS000070B478_4932	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139465|imex:IM-26387-74	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	-	-	-	figure legend:Figure 4C-2|comment:FBP21  200–376 inhibits RNA binding of Brr2HR when present in high concentrations. Inhibition is reduced when the shorter FBP21 276–376 is used.|kinetic_conditions:"Kd given for the  interaction in the  presence of 5uM FBP21 200-376 (163nM). When the shorter FBP21 276–376 was used, a Kd of 43nM was obtained."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:163.0x10^-9(molar)	2018/03/21	2018/04/04	-	-	-	false	32p radiolabel:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75554	rnacentral:URS00006D8611_4932	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139465|imex:IM-26387-74	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	-	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	figure legend:Figure 4C-2|comment:FBP21  200–376 inhibits RNA binding of Brr2HR when present in high concentrations. Inhibition is reduced when the shorter FBP21 276–376 is used.|kinetic_conditions:"Kd given for the  interaction in the  presence of 5uM FBP21 200-376 (163nM). When the shorter FBP21 276–376 was used, a Kd of 43nM was obtained."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:163.0x10^-9(molar)	2018/03/21	2018/04/04	-	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	-	false	32p radiolabel:1-1	sufficient binding region:200-376	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75643	rnacentral:URS00006D8611_4932	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139482|imex:IM-26387-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	-	-	figure legend:Figure 4C-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:18.0x10^-9(molar)	2018/03/21	2018/04/04	-	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	32p radiolabel:1-1	sufficient binding region:395-2129	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	intact:EBI-17139376	rnacentral:URS00006D8611_4932	rnacentral:URS000070B478_4932	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139482|imex:IM-26387-64	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	-	-	-	figure legend:Figure 4C-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:18.0x10^-9(molar)	2018/03/21	2018/04/04	-	-	-	false	32p radiolabel:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75643	rnacentral:URS00006D8611_4932	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139500|imex:IM-26387-66	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	-	-	figure legend:Figure 4C-3|comment:FBP21  200–376 inhibits RNA binding of Brr2HR when present in high concentrations. Inhibition is reduced when the shorter FBP21 276–376 is used.|kinetic_conditions:Kd for the  interaction in the  presence of 5uM FBP21 200-376 was 163nM.  When the shorter FBP21 276–376 was used, a Kd of 43nM was obtained.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:43.0x10^-9(molar)	2018/03/21	2018/04/04	-	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	-	false	32p radiolabel:1-1	sufficient binding region:395-2129	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	intact:EBI-17139376	rnacentral:URS00006D8611_4932	rnacentral:URS000070B478_4932	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:u6_snrna(display_short)|psi-mi:EBI-17139376(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139500|imex:IM-26387-66	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0607"(small nuclear rna)	-	-	-	-	-	figure legend:Figure 4C-3|comment:FBP21  200–376 inhibits RNA binding of Brr2HR when present in high concentrations. Inhibition is reduced when the shorter FBP21 276–376 is used.|kinetic_conditions:Kd for the  interaction in the  presence of 5uM FBP21 200-376 was 163nM.  When the shorter FBP21 276–376 was used, a Kd of 43nM was obtained.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:43.0x10^-9(molar)	2018/03/21	2018/04/04	-	-	-	false	32p radiolabel:1-1	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-17139373	uniprotkb:O75554	rnacentral:URS00006D8611_4932	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	psi-mi:u4_snrna(display_short)|psi-mi:EBI-17139373(display_long)	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139500|imex:IM-26387-66	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0607"(small nuclear rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	-	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	figure legend:Figure 4C-3|comment:FBP21  200–376 inhibits RNA binding of Brr2HR when present in high concentrations. Inhibition is reduced when the shorter FBP21 276–376 is used.|kinetic_conditions:Kd for the  interaction in the  presence of 5uM FBP21 200-376 was 163nM.  When the shorter FBP21 276–376 was used, a Kd of 43nM was obtained.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:43.0x10^-9(molar)	2018/03/21	2018/04/04	-	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	-	false	32p radiolabel:1-1	sufficient binding region:276-376	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O75554	uniprotkb:O75643	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139593|imex:IM-26387-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	-	figure legend:Supp figure 1A-E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/30	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:Y8tWt0m4A04WJ+y2aNyniIYil10	false	sufficient binding region:200-376	sufficient binding region:395-2129|sufficient binding region:1282-2136|binding-associated region:1325-2129	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33334	uniprotkb:O75643	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139609|imex:IM-26387-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	crc64:8F4F6F89D34D3508	-	figure legend:Supp figure 1F/G|comment:Size exclusion chromatography revealed that FBP21_276–376 can bind simultaneously with Prp8Jab1_delta_C to Brr2-HR.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/30	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:WfifhB8diU7YffNVuEKwg2+ZN80	false	sufficient binding region:2012..2147-2399..2400	sufficient binding region:395-2129	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33334	uniprotkb:O75554	intact:EBI-465|uniprotkb:D3DLB4|ensemblfungi:YHR165C	intact:EBI-7251981|uniprotkb:B7Z4M2|uniprotkb:Q32P29|intact:MINT-127038|ensembl:ENSP00000368801	psi-mi:prp8_yeast(display_long)|uniprotkb:PRP8(gene name)|psi-mi:PRP8(display_short)|uniprotkb:DBF3(gene name synonym)|uniprotkb:DNA39(gene name synonym)|uniprotkb:RNA8(gene name synonym)|uniprotkb:SLT21(gene name synonym)|uniprotkb:USA2(gene name synonym)|uniprotkb:YHR165C(locus name)	psi-mi:wbp4_human(display_long)|uniprotkb:WBP4(gene name)|psi-mi:WBP4(display_short)|uniprotkb:FBP21(gene name synonym)|uniprotkb:FNBP21(gene name synonym)|uniprotkb:Formin-binding protein 21(gene name synonym)|uniprotkb:WW domain-containing-binding protein 4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Henning et al. (2017)	pubmed:28838205|imex:IM-26387	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-17139609|imex:IM-26387-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012035.1|sgd:S000001208|rcsb pdb:4ILJ|rcsb pdb:5DCA|rcsb pdb:5GAM|rcsb pdb:5GAN|rcsb pdb:5GAO|rcsb pdb:5GAP|rcsb pdb:5GM6|rcsb pdb:5GMK|rcsb pdb:5LJ3|rcsb pdb:5LJ5|rcsb pdb:5LQW|rcsb pdb:5M52|rcsb pdb:5M5P|rcsb pdb:5MPS|rcsb pdb:5MQ0|rcsb pdb:5NRL|rcsb pdb:5QY1|rcsb pdb:5QY2|rcsb pdb:5QY3|rcsb pdb:5QY4|rcsb pdb:5QY5|rcsb pdb:5QY6|rcsb pdb:5QY7|rcsb pdb:5QY8|rcsb pdb:5QY9|rcsb pdb:5QYA|rcsb pdb:5QYB|rcsb pdb:5QYC|rcsb pdb:5QYD|rcsb pdb:5QYE|rcsb pdb:5QYF|rcsb pdb:5QYG|rcsb pdb:5QYH|rcsb pdb:5QYI|rcsb pdb:5QYJ|rcsb pdb:5QYK|rcsb pdb:5QYL|rcsb pdb:5QYM|rcsb pdb:5QYN|rcsb pdb:5QYO|rcsb pdb:5QYP|rcsb pdb:5QYQ|rcsb pdb:5QYR|rcsb pdb:5QYS|rcsb pdb:5QYT|rcsb pdb:5QYU|rcsb pdb:5QYV|rcsb pdb:5QYW|rcsb pdb:5QYX|rcsb pdb:5QYY|rcsb pdb:5QYZ|rcsb pdb:5QZ0|rcsb pdb:5QZ1|rcsb pdb:5QZ2|rcsb pdb:5QZ3|rcsb pdb:5QZ4|rcsb pdb:5QZ5|rcsb pdb:5QZ6|rcsb pdb:5QZ7|rcsb pdb:5QZ8|rcsb pdb:5QZ9|rcsb pdb:5QZA|rcsb pdb:5QZB|rcsb pdb:5QZC|rcsb pdb:5QZD|rcsb pdb:5QZE|rcsb pdb:5QZF|rcsb pdb:5QZG|rcsb pdb:5QZH|rcsb pdb:5QZI|rcsb pdb:5QZJ|rcsb pdb:5QZK|rcsb pdb:5QZL|rcsb pdb:5QZM|rcsb pdb:5QZN|rcsb pdb:5QZO|rcsb pdb:5QZP|rcsb pdb:5R14|rcsb pdb:5R15|rcsb pdb:5R16|rcsb pdb:5R17|rcsb pdb:5R18|rcsb pdb:5R19|rcsb pdb:5R1A|rcsb pdb:5R1B|rcsb pdb:5R1C|rcsb pdb:5R1D|rcsb pdb:5R1E|rcsb pdb:5R1F|rcsb pdb:5R1G|rcsb pdb:5R1H|rcsb pdb:5R1I|rcsb pdb:5R1J|rcsb pdb:5R1K|rcsb pdb:5R1L|rcsb pdb:5R1M|rcsb pdb:5R1N|rcsb pdb:5R1O|rcsb pdb:5R1P|rcsb pdb:5R1Q|rcsb pdb:5R1S|rcsb pdb:5WSG|rcsb pdb:5Y88|rcsb pdb:5YLZ|rcsb pdb:5ZWM|rcsb pdb:5ZWO|rcsb pdb:6BK8|rcsb pdb:6EXN|rcsb pdb:6J6G|rcsb pdb:6J6H|rcsb pdb:6J6N|rcsb pdb:6J6Q|rcsb pdb:6TEO|rcsb pdb:7B9V|rcsb pdb:5QZQ|rcsb pdb:5QZR|rcsb pdb:5QZS|rcsb pdb:5QZT|rcsb pdb:5QZU|rcsb pdb:5QZV|rcsb pdb:5QZW|rcsb pdb:5QZX|rcsb pdb:5QZY|rcsb pdb:5QZZ|rcsb pdb:5R00|rcsb pdb:5R01|rcsb pdb:5R02|rcsb pdb:5R03|rcsb pdb:5R04|rcsb pdb:5R05|rcsb pdb:5R06|rcsb pdb:5R07|rcsb pdb:5R08|rcsb pdb:5R09|rcsb pdb:5R0A|rcsb pdb:5R0B|rcsb pdb:5R0C|rcsb pdb:5R0D|rcsb pdb:5R0E|rcsb pdb:5R0F|rcsb pdb:5R0G|rcsb pdb:5R0H|rcsb pdb:5R0I|rcsb pdb:5R0J|rcsb pdb:5R0K|rcsb pdb:5R0L|rcsb pdb:5R0M|rcsb pdb:5R0N|rcsb pdb:5R0O|rcsb pdb:5R0P|rcsb pdb:5R0Q|rcsb pdb:5R0R|rcsb pdb:5R0S|rcsb pdb:5R0T|rcsb pdb:5R0U|rcsb pdb:5R0V|rcsb pdb:5R0W|rcsb pdb:5R0X|rcsb pdb:5R0Y|rcsb pdb:5R0Z|rcsb pdb:5R10|rcsb pdb:5R11|rcsb pdb:5R12|rcsb pdb:5R13|ensemblfungi:YHR165C(gene)|ensemblfungi:YHR165C_mRNA(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000350"(generation of catalytic spliceosome for second transesterification step)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|rcsb pdb:3SBT|rcsb pdb:3ZEF|rcsb pdb:4BGD|rcsb pdb:4I43|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|rcsb pdb:2OG4|rcsb pdb:3E66|rcsb pdb:3E9O|rcsb pdb:3E9P|rcsb pdb:3JCM|rcsb pdb:3SBG|rcsb pdb:4ILG|rcsb pdb:4ILH|dip:DIP-2427N|mint:P33334	refseq:NP_009118.1|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013085(Zinc finger, U1-C type)|interpro:IPR036020|interpro:IPR036236|interpro:IPR040023|rcsb pdb:2DK1|rcsb pdb:2JXW|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000120688(gene)|ensembl:ENST00000379487(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	-	crc64:8F4F6F89D34D3508	comment:mint|function:A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex	figure legend:Supp figure 1F/G|comment:Size exclusion chromatography revealed that FBP21_276–376 can bind simultaneously with Prp8Jab1_delta_C to Brr2-HR.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/03/21	2018/04/30	rogid:0JoVp7ULlbib7N5+GOPksHStSmY559292	rogid:3NQlL8KXrqNmPB7EE8YfZHP0hQY9606	rigid:WfifhB8diU7YffNVuEKwg2+ZN80	false	sufficient binding region:2012..2147-2399..2400	sufficient binding region:276-376|necessary binding region:276-325	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)