#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97438	uniprotkb:P97438	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	intact:EBI-7091062|ensembl:ENSMUSP00000141891|intact:MINT-4050407|uniprotkb:Q4VQI2	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:kcnk2_mouse(display_long)|uniprotkb:Kcnk2(gene name)|psi-mi:Kcnk2(display_short)|uniprotkb:Outward rectifying potassium channel protein TREK-1(gene name synonym)|uniprotkb:"TREK-1 K(+) channel subunit"(gene name synonym)|uniprotkb:Two pore potassium channel TPKC1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lolicato et al. (2017)	imex:IM-26742|pubmed:28693035	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-20649846|wwpdb:6CQ9|wwpdb:6CQ8|wwpdb:6CQ6|imex:IM-26742-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N	ensembl:ENSMUSG00000037624(gene)|ensembl:ENSMUST00000193319(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007613"(memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0030424"(axon)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0048678"(response to axon injury)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0090102"(cochlea development)|go:"GO:0097449"(astrocyte projection)|go:"GO:1900039"(positive regulation of cellular response to hypoxia)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|mint:P97438|rcsb pdb:6CQ6|rcsb pdb:6CQ8|rcsb pdb:6CQ9|rcsb pdb:6V36|rcsb pdb:6V37|rcsb pdb:6V3C|rcsb pdb:6V3I|rcsb pdb:6W7B|rcsb pdb:6W7C|rcsb pdb:6W7D|rcsb pdb:6W7E|rcsb pdb:6W82|rcsb pdb:6W83|rcsb pdb:6W84|rcsb pdb:6W85|rcsb pdb:6W86|rcsb pdb:6W87|rcsb pdb:6W88|rcsb pdb:6W8A|rcsb pdb:6W8C|rcsb pdb:6W8F|reactome:R-MMU-5576886|reactome:R-MMU-1299503|refseq:NP_034737.2|refseq:NP_001153322.1|dip:DIP-58579N	-	comment:mint	comment:mint	figure legend:Extended Data Fig 1a, b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4922(picpa)|taxid:4922("Pichia pastoris (Yeast)")	-	2018/07/24	2018/07/28	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rogid:njcSGBK1p+GNR86j7GFhMYREcMs10090	rigid:0y8B7w6ddeGrmZfDMw9ghu/rleI	false	binding-associated region:35-339|mutation:99-99,100-100,101-101,103-103,104-104,105-105,107-107,110-110,111-111,112-112,134-134,315-315,321-321	binding-associated region:35-339|mutation:99-99,100-100,101-101,103-103,104-104,105-105,107-107,110-110,111-111,112-112,134-134,315-315,321-321	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)