#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03959	uniprotkb:P03960	intact:EBI-20568442|ensemblbacteria:AAC73792|ensemblbacteria:BAA35356	intact:EBI-1116956|uniprotkb:P78053|uniprotkb:P78145|ensemblbacteria:AAC73791|ensemblbacteria:BAA35354	psi-mi:kdpa_ecoli(display_long)|uniprotkb:ATP phosphohydrolase [potassium-transporting] A chain(gene name synonym)|uniprotkb:Potassium-binding and translocating subunit A(gene name synonym)|uniprotkb:Potassium-translocating ATPase A chain(gene name synonym)|uniprotkb:JW0686(locus name)|uniprotkb:b0698(locus name)|uniprotkb:kdpA(gene name)|psi-mi:kdpA(display_short)	psi-mi:kdpb_ecoli(display_long)|uniprotkb:Potassium-translocating ATPase B chain(gene name synonym)|uniprotkb:ATP phosphohydrolase [potassium-transporting] B chain(gene name synonym)|uniprotkb:Potassium-binding and translocating subunit B(gene name synonym)|uniprotkb:kdpB(gene name)|psi-mi:kdpB(display_short)|uniprotkb:b0697(locus name)|uniprotkb:JW0685(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Huang et al. (2017)	imex:IM-26435|pubmed:28636601	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20568458|imex:IM-26435-1|wwpdb:5mrw	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415226.1|refseq:WP_000741129.1|rcsb pdb:5MRW|interpro:IPR004623(K+ transporting ATPase, A subunit)|rcsb pdb:6HRA|rcsb pdb:6HRB|ensemblbacteria:AAC73792(transcript)|ensemblbacteria:b0698(gene)|ensemblbacteria:BAA35356(gene)|ensemblbacteria:BAA35356(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008556"(P-type potassium transmembrane transporter activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031004"(potassium ion-transporting ATPase complex)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098655"(cation transmembrane transport)|rcsb pdb:7BGY|rcsb pdb:7BH1|rcsb pdb:7BH2|rcsb pdb:7LC3|rcsb pdb:7LC6	rcsb pdb:5MRW|refseq:WP_000087939.1|refseq:NP_415225.1|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR023299|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR018303|interpro:IPR006391(Potassium-translocating P-type ATPase, B subunit)|rcsb pdb:1SVJ|rcsb pdb:1U7Q|rcsb pdb:2A00|rcsb pdb:2A29|interpro:IPR044492|rcsb pdb:6HRA|rcsb pdb:6HRB|ensemblbacteria:AAC73791(transcript)|ensemblbacteria:b0697(gene)|ensemblbacteria:BAA35354(gene)|ensemblbacteria:BAA35354(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0008556"(P-type potassium transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031004"(potassium ion-transporting ATPase complex)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098655"(cation transmembrane transport)|interpro:IPR023298|interpro:IPR036412|rcsb pdb:7BGY|rcsb pdb:7BH1|rcsb pdb:7BH2|rcsb pdb:7LC3|rcsb pdb:7LC6	-	-	-	figure legend:Extended Data Table 1|3d-r-factors:Rworking 0.243 Rfree0.275|3d-resolution:2.9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/23	2018/06/01	rogid:71UB9aKGYG65mm3SBebKo9nJKdU83333	rogid:u594tqs01QwNpp3/5pwpR1XlbVU83333	rigid:IsBPLzofgQC4mR7M6Kmqe6HUkE0	false	mutation:116-116	sufficient binding region:9-682	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03959	uniprotkb:P03961	intact:EBI-20568442|ensemblbacteria:AAC73792|ensemblbacteria:BAA35356	intact:EBI-6997216|ensemblbacteria:AAC73790|ensemblbacteria:BAA35353|intact:MINT-8188885	psi-mi:kdpa_ecoli(display_long)|uniprotkb:ATP phosphohydrolase [potassium-transporting] A chain(gene name synonym)|uniprotkb:Potassium-binding and translocating subunit A(gene name synonym)|uniprotkb:Potassium-translocating ATPase A chain(gene name synonym)|uniprotkb:JW0686(locus name)|uniprotkb:b0698(locus name)|uniprotkb:kdpA(gene name)|psi-mi:kdpA(display_short)	psi-mi:kdpc_ecoli(display_long)|uniprotkb:kdpC(gene name)|psi-mi:kdpC(display_short)|uniprotkb:ATP phosphohydrolase [potassium-transporting] C chain(gene name synonym)|uniprotkb:Potassium-binding and translocating subunit C(gene name synonym)|uniprotkb:Potassium-translocating ATPase C chain(gene name synonym)|uniprotkb:b0696(locus name)|uniprotkb:JW0684(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Huang et al. (2017)	imex:IM-26435|pubmed:28636601	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20568458|imex:IM-26435-1|wwpdb:5mrw	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415226.1|refseq:WP_000741129.1|rcsb pdb:5MRW|interpro:IPR004623(K+ transporting ATPase, A subunit)|rcsb pdb:6HRA|rcsb pdb:6HRB|ensemblbacteria:AAC73792(transcript)|ensemblbacteria:b0698(gene)|ensemblbacteria:BAA35356(gene)|ensemblbacteria:BAA35356(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008556"(P-type potassium transmembrane transporter activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031004"(potassium ion-transporting ATPase complex)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098655"(cation transmembrane transport)|rcsb pdb:7BGY|rcsb pdb:7BH1|rcsb pdb:7BH2|rcsb pdb:7LC3|rcsb pdb:7LC6	rcsb pdb:6HRA|rcsb pdb:6HRB|refseq:WP_001300431.1|ensemblbacteria:AAC73790(transcript)|ensemblbacteria:b0696(gene)|ensemblbacteria:BAA35353(gene)|ensemblbacteria:BAA35353(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008556"(P-type potassium transmembrane transporter activity)|go:"GO:0031004"(potassium ion-transporting ATPase complex)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098655"(cation transmembrane transport)|interpro:IPR003820(K+ transporting ATPase, KdpC subunit)|refseq:NP_415224.1|rcsb pdb:5MRW|rcsb pdb:7BGY|rcsb pdb:7BH1|rcsb pdb:7BH2|rcsb pdb:7LC3|rcsb pdb:7LC6	-	-	comment:mint	figure legend:Extended Data Table 1|3d-r-factors:Rworking 0.243 Rfree0.275|3d-resolution:2.9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/23	2018/06/01	rogid:71UB9aKGYG65mm3SBebKo9nJKdU83333	rogid:Eyn2q+2zUXfBl54YUSxB05PaPwc83333	rigid:IsBPLzofgQC4mR7M6Kmqe6HUkE0	false	mutation:116-116	sufficient binding region:4-190|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03959	uniprotkb:P36937	intact:EBI-20568442|ensemblbacteria:AAC73792|ensemblbacteria:BAA35356	intact:EBI-20568427|uniprotkb:Q2EEQ9|ensemblbacteria:ABD18643|ensemblbacteria:BAA35357	psi-mi:kdpa_ecoli(display_long)|uniprotkb:ATP phosphohydrolase [potassium-transporting] A chain(gene name synonym)|uniprotkb:Potassium-binding and translocating subunit A(gene name synonym)|uniprotkb:Potassium-translocating ATPase A chain(gene name synonym)|uniprotkb:JW0686(locus name)|uniprotkb:b0698(locus name)|uniprotkb:kdpA(gene name)|psi-mi:kdpA(display_short)	psi-mi:kdpf_ecoli(display_long)|uniprotkb:ATP phosphohydrolase [potassium-transporting] F chain(gene name synonym)|uniprotkb:Potassium-binding and translocating subunit F(gene name synonym)|uniprotkb:Potassium-translocating ATPase F chain(gene name synonym)|uniprotkb:JW0687(locus name)|uniprotkb:b4513(locus name)|uniprotkb:kdpF(gene name)|psi-mi:kdpF(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Huang et al. (2017)	imex:IM-26435|pubmed:28636601	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20568458|imex:IM-26435-1|wwpdb:5mrw	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415226.1|refseq:WP_000741129.1|rcsb pdb:5MRW|interpro:IPR004623(K+ transporting ATPase, A subunit)|rcsb pdb:6HRA|rcsb pdb:6HRB|ensemblbacteria:AAC73792(transcript)|ensemblbacteria:b0698(gene)|ensemblbacteria:BAA35356(gene)|ensemblbacteria:BAA35356(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008556"(P-type potassium transmembrane transporter activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031004"(potassium ion-transporting ATPase complex)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098655"(cation transmembrane transport)|rcsb pdb:7BGY|rcsb pdb:7BH1|rcsb pdb:7BH2|rcsb pdb:7LC3|rcsb pdb:7LC6	refseq:WP_001272653.1|refseq:YP_588443.1|rcsb pdb:5MRW|interpro:IPR011726(K+-transporting ATPase, F subunit)|rcsb pdb:6HRA|rcsb pdb:6HRB|ensemblbacteria:ABD18643(transcript)|ensemblbacteria:b4513(gene)|ensemblbacteria:BAA35357(gene)|ensemblbacteria:BAA35357(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008556"(P-type potassium transmembrane transporter activity)|go:"GO:0031004"(potassium ion-transporting ATPase complex)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098655"(cation transmembrane transport)|rcsb pdb:7BGY|rcsb pdb:7BH1|rcsb pdb:7BH2|rcsb pdb:7LC3|rcsb pdb:7LC6	-	-	-	figure legend:Extended Data Table 1|3d-r-factors:Rworking 0.243 Rfree0.275|3d-resolution:2.9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/23	2018/06/01	rogid:71UB9aKGYG65mm3SBebKo9nJKdU83333	rogid:dOx2AtQuuaBc9uGDfHWny87aZPI83333	rigid:IsBPLzofgQC4mR7M6Kmqe6HUkE0	false	mutation:116-116	sufficient binding region:1-27	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15422"	intenz:3.6.3.12	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-20568486|wwpdb:5mrw	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:kdpfabc_ecoli(display_short)|psi-mi:3.6.3.12(display_long)|intact:KdpFABC potassium import complex(complex recommended name)|intact:"kdpA:kdpB:kdpC:kdpF"(complex systematic name)	psi-mi:"MI:0880"(atpase assay)	Huang et al. (2017)	imex:IM-26435|pubmed:28636601	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0882"(atpase reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-20584727|imex:IM-26435-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-20568458(exp-evidence)|complex portal:CPX-3564(complex-primary)|pubmed:21684627(see-also)|evidence ontology:"ECO:0000353"|go:"GO:1903103"("potassium:proton antiporter complex")|go:"GO:0008556"(P-type potassium transmembrane transporter activity)|go:"GO:0006813"(potassium ion transport)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)	go:"GO:0016887"(ATP hydrolysis activity)	-	complex-assembly:Heterotetramer|curated-complex:"A potassium pump that maintains intracellular homeostasis as well as cell shape and turgor under conditions where potassium is limiting. The complex exhibits high selectivity and binding-affinity (Kd = 2uM)4 and is able to maintain cytoplasmic K+ concentrations against gradients up to 10,000-fold. Mutagenesis has been used to establish that K+ is transported through KdpA and that the energy of ATP is harnessed by KdpB.  During catalysis, the KdpFABC complex cycles between two main conformational states, each of which comprises different structural properties together with different binding affinities for both ATP and the transport substrate."|complex-properties:KdpA binds the K+ ion in the middle of the membrane. KdpB has a transmembrane domain and three cytoplasmic domains responsible for nucleotide binding, phosphoenzyme formation and dephosphorylation. The catalytic chaperone KdpC and KdpF both have a single transmembrane helix and the soluble domain of KdpC is periplasmic.	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/23	2018/06/04	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)