#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:G1SGD4 uniprotkb:P54311 intact:EBI-20649573|ensembl:ENSOCUP00000001636 intact:EBI-917779|uniprotkb:Q6Q8B1|uniprotkb:Q9QWG8|ensembl:ENSRNOP00000044340 psi-mi:g1sgd4_rabit(display_long)|uniprotkb:GLP1R(gene name)|psi-mi:GLP1R(display_short) psi-mi:gbb1_rat(display_long)|uniprotkb:Transducin beta chain 1(gene name synonym)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short) psi-mi:"MI:0410"(3D electron microscopy) Zhang et al. (2017) pubmed:28538729|imex:IM-26735 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20649571|wwpdb:5VAI|emdb:EMD-8653|imex:IM-26735-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_002714738.1|ensembl:ENSOCUG00000001898(gene)|ensembl:ENSOCUT00000001897(transcript)|go:"GO:0004967"(glucagon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003290(GPCR, family 2, glucagon receptor-like)|interpro:IPR003292(GPCR, family 2, glucagon-like peptide 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:5VAI rgd:2718|refseq:NP_112249.2|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|ensembl:ENSRNOT00000041789(transcript)|ensembl:ENSRNOG00000016638(gene)|refseq:XP_008762557.1|refseq:XP_006239579.1|refseq:XP_017448634.1|refseq:XP_017448635.1|refseq:XP_017448636.1|refseq:XP_017448637.1|refseq:XP_017448638.1|dip:DIP-37029N|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P54311|rcsb pdb:3SN6|rcsb pdb:5TDH|rcsb pdb:5VAI|rcsb pdb:6CMO|rcsb pdb:6LPB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6WWZ|rcsb pdb:7BW0|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7LJC|rcsb pdb:7LJD|rcsb pdb:7MBX|rcsb pdb:7MBY|reactome:R-RNO-1296041|reactome:R-RNO-202040|reactome:R-RNO-2485179|reactome:R-RNO-381676|reactome:R-RNO-381753|reactome:R-RNO-392170|reactome:R-RNO-392451|reactome:R-RNO-400042|reactome:R-RNO-4086398|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-418597|reactome:R-RNO-420092|reactome:R-RNO-428930|reactome:R-RNO-432040|reactome:R-RNO-456926|reactome:R-RNO-6814122|reactome:R-RNO-8964616|reactome:R-RNO-997272 - - - figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/07/24 2018/07/24 rogid:NnsaBIBvDjFjJajmt+RmnCl6fTo9986 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10116 rigid:rHr8+r75liKQACeNCePiH5GKcl8 false binding-associated region:24-422 his tag:n-n 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G1SGD4 uniprotkb:P63212 intact:EBI-20649573|ensembl:ENSOCUP00000001636 intact:EBI-1036424|uniprotkb:P16874|uniprotkb:Q2KI31|uniprotkb:Q61013|uniprotkb:Q9TS47|ensembl:ENSBTAP00000003959 psi-mi:g1sgd4_rabit(display_long)|uniprotkb:GLP1R(gene name)|psi-mi:GLP1R(display_short) psi-mi:gbg2_bovin(display_long)|uniprotkb:GNG2(gene name)|psi-mi:GNG2(display_short)|uniprotkb:G gamma-I(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Zhang et al. (2017) pubmed:28538729|imex:IM-26735 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20649571|wwpdb:5VAI|emdb:EMD-8653|imex:IM-26735-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_002714738.1|ensembl:ENSOCUG00000001898(gene)|ensembl:ENSOCUT00000001897(transcript)|go:"GO:0004967"(glucagon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003290(GPCR, family 2, glucagon receptor-like)|interpro:IPR003292(GPCR, family 2, glucagon-like peptide 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:5VAI refseq:NP_776497.1|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:1GG2|rcsb pdb:1GP2|rcsb pdb:1OMW|rcsb pdb:1XHM|rcsb pdb:2BCJ|rcsb pdb:3AH8|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3SN6|rcsb pdb:3UZS|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:4PNK|rcsb pdb:5TDH|rcsb pdb:5VAI|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6C2Y|rcsb pdb:6CMO|rcsb pdb:6LPB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6PCV|rcsb pdb:6U7C|rcsb pdb:7BW0|rcsb pdb:7BZ2|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7D68|rcsb pdb:7DHI|rcsb pdb:7DHR|rcsb pdb:7JJO|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:7LJC|rcsb pdb:7LJD|reactome:R-BTA-392170|reactome:R-BTA-416476|reactome:R-BTA-418594|reactome:R-BTA-418597|reactome:R-BTA-428930|reactome:R-BTA-456926|reactome:R-BTA-6814122|reactome:R-BTA-392451|ensembl:ENSBTAG00000003043(gene)|ensembl:ENSBTAT00000003959(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|refseq:XP_005211711.1|refseq:XP_010807541.1|dip:DIP-586N - - - figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/07/24 2018/07/24 rogid:NnsaBIBvDjFjJajmt+RmnCl6fTo9986 rogid:8asTjDtSU6sCPSMwcXMbV340Rt49913 rigid:rHr8+r75liKQACeNCePiH5GKcl8 false binding-associated region:24-422 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G1SGD4 uniprotkb:P01275-PRO_0000011259 intact:EBI-20649573|ensembl:ENSOCUP00000001636 intact:EBI-20649737 psi-mi:g1sgd4_rabit(display_long)|uniprotkb:GLP1R(gene name)|psi-mi:GLP1R(display_short) psi-mi:p01275-pro_0000011259(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short) psi-mi:"MI:0410"(3D electron microscopy) Zhang et al. (2017) pubmed:28538729|imex:IM-26735 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20649571|wwpdb:5VAI|emdb:EMD-8653|imex:IM-26735-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_002714738.1|ensembl:ENSOCUG00000001898(gene)|ensembl:ENSOCUT00000001897(transcript)|go:"GO:0004967"(glucagon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003290(GPCR, family 2, glucagon receptor-like)|interpro:IPR003292(GPCR, family 2, glucagon-like peptide 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:5VAI intact:EBI-7629173(chain-parent) - - chain-seq-start:98|chain-seq-end:128 figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/07/24 2018/07/24 rogid:NnsaBIBvDjFjJajmt+RmnCl6fTo9986 rogid:7kFnkmkSWxlwO79djMEqgtZPa589606 rigid:rHr8+r75liKQACeNCePiH5GKcl8 false binding-associated region:24-422 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G1SGD4 uniprotkb:P63092-2 intact:EBI-20649573|ensembl:ENSOCUP00000001636 intact:EBI-7607528|ensembl:ENSP00000360136|uniprotkb:P04895-2|intact:MINT-4826723 psi-mi:g1sgd4_rabit(display_long)|uniprotkb:GLP1R(gene name)|psi-mi:GLP1R(display_short) psi-mi:p63092-2(display_long)|uniprotkb:GSP(gene name synonym)|uniprotkb:Alpha-S-short(isoform synonym)|uniprotkb:Alpha-S1(isoform synonym)|uniprotkb:GNASs(isoform synonym)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)|uniprotkb:GNAS1(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Zhang et al. (2017) pubmed:28538729|imex:IM-26735 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20649571|wwpdb:5VAI|emdb:EMD-8653|imex:IM-26735-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_002714738.1|ensembl:ENSOCUG00000001898(gene)|ensembl:ENSOCUT00000001897(transcript)|go:"GO:0004967"(glucagon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003290(GPCR, family 2, glucagon receptor-like)|interpro:IPR003292(GPCR, family 2, glucagon-like peptide 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:5VAI ensembl:ENSG00000087460(gene)|ensembl:ENST00000371095(transcript)|intact:EBI-1047114(isoform-parent)|uniprotkb:P63092-2(isoform-parent) - - comment:mint figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/07/24 2018/07/24 rogid:NnsaBIBvDjFjJajmt+RmnCl6fTo9986 rogid:DGFroN8wVqG3lG1L6aRMY5bk+RM9606 rigid:rHr8+r75liKQACeNCePiH5GKcl8 false binding-associated region:24-422 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G1SGD4 uniprotkb:P54311 intact:EBI-20649573|ensembl:ENSOCUP00000001636 intact:EBI-917779|uniprotkb:Q6Q8B1|uniprotkb:Q9QWG8|ensembl:ENSRNOP00000044340 psi-mi:g1sgd4_rabit(display_long)|uniprotkb:GLP1R(gene name)|psi-mi:GLP1R(display_short) psi-mi:gbb1_rat(display_long)|uniprotkb:Transducin beta chain 1(gene name synonym)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short) psi-mi:"MI:0071"(molecular sieving) Zhang et al. (2017) pubmed:28538729|imex:IM-26735 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20649769|imex:IM-26735-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_002714738.1|ensembl:ENSOCUG00000001898(gene)|ensembl:ENSOCUT00000001897(transcript)|go:"GO:0004967"(glucagon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003290(GPCR, family 2, glucagon receptor-like)|interpro:IPR003292(GPCR, family 2, glucagon-like peptide 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:5VAI rgd:2718|refseq:NP_112249.2|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|ensembl:ENSRNOT00000041789(transcript)|ensembl:ENSRNOG00000016638(gene)|refseq:XP_008762557.1|refseq:XP_006239579.1|refseq:XP_017448634.1|refseq:XP_017448635.1|refseq:XP_017448636.1|refseq:XP_017448637.1|refseq:XP_017448638.1|dip:DIP-37029N|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P54311|rcsb pdb:3SN6|rcsb pdb:5TDH|rcsb pdb:5VAI|rcsb pdb:6CMO|rcsb pdb:6LPB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6WWZ|rcsb pdb:7BW0|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7LJC|rcsb pdb:7LJD|rcsb pdb:7MBX|rcsb pdb:7MBY|reactome:R-RNO-1296041|reactome:R-RNO-202040|reactome:R-RNO-2485179|reactome:R-RNO-381676|reactome:R-RNO-381753|reactome:R-RNO-392170|reactome:R-RNO-392451|reactome:R-RNO-400042|reactome:R-RNO-4086398|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-418597|reactome:R-RNO-420092|reactome:R-RNO-428930|reactome:R-RNO-432040|reactome:R-RNO-456926|reactome:R-RNO-6814122|reactome:R-RNO-8964616|reactome:R-RNO-997272 - - - figure legend:Extended Data Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/07/24 2018/07/24 rogid:NnsaBIBvDjFjJajmt+RmnCl6fTo9986 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10116 rigid:M6riudLl3KSooHRfQaEVwS167rA false binding-associated region:24-422 his tag:n-n 1 1 psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:2287"(identification by structure determination) uniprotkb:G1SGD4 uniprotkb:P63212 intact:EBI-20649573|ensembl:ENSOCUP00000001636 intact:EBI-1036424|uniprotkb:P16874|uniprotkb:Q2KI31|uniprotkb:Q61013|uniprotkb:Q9TS47|ensembl:ENSBTAP00000003959 psi-mi:g1sgd4_rabit(display_long)|uniprotkb:GLP1R(gene name)|psi-mi:GLP1R(display_short) psi-mi:gbg2_bovin(display_long)|uniprotkb:GNG2(gene name)|psi-mi:GNG2(display_short)|uniprotkb:G gamma-I(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhang et al. (2017) pubmed:28538729|imex:IM-26735 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20649769|imex:IM-26735-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_002714738.1|ensembl:ENSOCUG00000001898(gene)|ensembl:ENSOCUT00000001897(transcript)|go:"GO:0004967"(glucagon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003290(GPCR, family 2, glucagon receptor-like)|interpro:IPR003292(GPCR, family 2, glucagon-like peptide 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:5VAI refseq:NP_776497.1|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:1GG2|rcsb pdb:1GP2|rcsb pdb:1OMW|rcsb pdb:1XHM|rcsb pdb:2BCJ|rcsb pdb:3AH8|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3SN6|rcsb pdb:3UZS|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:4PNK|rcsb pdb:5TDH|rcsb pdb:5VAI|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6C2Y|rcsb pdb:6CMO|rcsb pdb:6LPB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6PCV|rcsb pdb:6U7C|rcsb pdb:7BW0|rcsb pdb:7BZ2|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7D68|rcsb pdb:7DHI|rcsb pdb:7DHR|rcsb pdb:7JJO|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:7LJC|rcsb pdb:7LJD|reactome:R-BTA-392170|reactome:R-BTA-416476|reactome:R-BTA-418594|reactome:R-BTA-418597|reactome:R-BTA-428930|reactome:R-BTA-456926|reactome:R-BTA-6814122|reactome:R-BTA-392451|ensembl:ENSBTAG00000003043(gene)|ensembl:ENSBTAT00000003959(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|refseq:XP_005211711.1|refseq:XP_010807541.1|dip:DIP-586N - - - figure legend:Extended Data Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/07/24 2018/07/24 rogid:NnsaBIBvDjFjJajmt+RmnCl6fTo9986 rogid:8asTjDtSU6sCPSMwcXMbV340Rt49913 rigid:M6riudLl3KSooHRfQaEVwS167rA false binding-associated region:24-422 - 1 1 psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:2287"(identification by structure determination) uniprotkb:G1SGD4 uniprotkb:P63092-2 intact:EBI-20649573|ensembl:ENSOCUP00000001636 intact:EBI-7607528|ensembl:ENSP00000360136|uniprotkb:P04895-2|intact:MINT-4826723 psi-mi:g1sgd4_rabit(display_long)|uniprotkb:GLP1R(gene name)|psi-mi:GLP1R(display_short) psi-mi:p63092-2(display_long)|uniprotkb:GSP(gene name synonym)|uniprotkb:Alpha-S-short(isoform synonym)|uniprotkb:Alpha-S1(isoform synonym)|uniprotkb:GNASs(isoform synonym)|uniprotkb:GNAS(gene name)|psi-mi:GNAS(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)|uniprotkb:GNAS1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhang et al. (2017) pubmed:28538729|imex:IM-26735 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-20649769|imex:IM-26735-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_002714738.1|ensembl:ENSOCUG00000001898(gene)|ensembl:ENSOCUT00000001897(transcript)|go:"GO:0004967"(glucagon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003290(GPCR, family 2, glucagon receptor-like)|interpro:IPR003292(GPCR, family 2, glucagon-like peptide 1 receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:5VAI ensembl:ENSG00000087460(gene)|ensembl:ENST00000371095(transcript)|intact:EBI-1047114(isoform-parent)|uniprotkb:P63092-2(isoform-parent) - - comment:mint figure legend:Extended Data Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2018/07/24 2018/07/24 rogid:NnsaBIBvDjFjJajmt+RmnCl6fTo9986 rogid:DGFroN8wVqG3lG1L6aRMY5bk+RM9606 rigid:M6riudLl3KSooHRfQaEVwS167rA false binding-associated region:24-422 - 1 1 psi-mi:"MI:2287"(identification by structure determination) psi-mi:"MI:2287"(identification by structure determination)