#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43914	uniprotkb:Q9NZC2	intact:EBI-2214794|uniprotkb:Q6FGA5|uniprotkb:Q9UMT3|uniprotkb:A8K2X0|uniprotkb:F5H389|ensembl:ENSP00000262629	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:tyobp_human(display_long)|uniprotkb:TYROBP(gene name)|psi-mi:TYROBP(display_short)|uniprotkb:DAP12(gene name synonym)|uniprotkb:KARAP(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:1037"(Split renilla luciferase complementation)	Varnum et al. (2017)	imex:IM-26878|pubmed:28490631	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20976040|imex:IM-26878-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166985.1|refseq:NP_003323.1|refseq:NP_937758.1|ensembl:ENSG00000011600(gene)|ensembl:ENST00000262629(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|rcsb pdb:2L34|rcsb pdb:2L35|rcsb pdb:4WO1|rcsb pdb:4WOL|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-391160|reactome:R-HSA-416700|reactome:R-HSA-6798695	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	-	-	figure legend:Fig. 2, 6 Supp. Fig. 1|agonist:TREM2-cross-linked antibody|comment:The TREM2 the Thr66Met mutation did not show enhanced luciferase activity on anti-TREM2 antibody stimulation|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/22	2018/12/19	rogid:mu2fXvaw0UH/mPPCFw8kG4XJkGk9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:C6e5tqPrBu1HwfbyZwF1K8wnQEM	false	renilla-n:c-c	mutation increasing interaction strength:66-66|renilla-c:c-c|mutation with no effect:47-47|mutation with no effect:116-116	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:O43914	uniprotkb:Q9NZC2	intact:EBI-2214794|uniprotkb:Q6FGA5|uniprotkb:Q9UMT3|uniprotkb:A8K2X0|uniprotkb:F5H389|ensembl:ENSP00000262629	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:tyobp_human(display_long)|uniprotkb:TYROBP(gene name)|psi-mi:TYROBP(display_short)|uniprotkb:DAP12(gene name synonym)|uniprotkb:KARAP(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Varnum et al. (2017)	imex:IM-26878|pubmed:28490631	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20976059|imex:IM-26878-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166985.1|refseq:NP_003323.1|refseq:NP_937758.1|ensembl:ENSG00000011600(gene)|ensembl:ENST00000262629(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|rcsb pdb:2L34|rcsb pdb:2L35|rcsb pdb:4WO1|rcsb pdb:4WOL|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-391160|reactome:R-HSA-416700|reactome:R-HSA-6798695	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	-	-	figure legend:Fig. 3|agonist:TREM2-cross-linked antibody|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/22	2018/11/23	rogid:mu2fXvaw0UH/mPPCFw8kG4XJkGk9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:C6e5tqPrBu1HwfbyZwF1K8wnQEM	false	renilla-n:c-c	renilla-c:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43914	uniprotkb:Q9NZC2	intact:EBI-2214794|uniprotkb:Q6FGA5|uniprotkb:Q9UMT3|uniprotkb:A8K2X0|uniprotkb:F5H389|ensembl:ENSP00000262629	intact:EBI-14036387|ensembl:ENSP00000362205|uniprotkb:Q8N5H8|uniprotkb:Q8WYN6	psi-mi:tyobp_human(display_long)|uniprotkb:TYROBP(gene name)|psi-mi:TYROBP(display_short)|uniprotkb:DAP12(gene name synonym)|uniprotkb:KARAP(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym)	psi-mi:trem2_human(display_long)|uniprotkb:TREM2(gene name)|psi-mi:TREM2(display_short)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Varnum et al. (2017)	imex:IM-26878|pubmed:28490631	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20976111|imex:IM-26878-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166985.1|refseq:NP_003323.1|refseq:NP_937758.1|ensembl:ENSG00000011600(gene)|ensembl:ENST00000262629(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|rcsb pdb:2L34|rcsb pdb:2L35|rcsb pdb:4WO1|rcsb pdb:4WOL|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-391160|reactome:R-HSA-416700|reactome:R-HSA-6798695	go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5ELI|rcsb pdb:5UD7|rcsb pdb:5UD8|rcsb pdb:6B8O|rcsb pdb:6XDS|rcsb pdb:6Y6C|rcsb pdb:6YMQ|rcsb pdb:6YYE|rcsb pdb:6Z0G|rcsb pdb:6Z0H|rcsb pdb:6Z0I|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-416700|ensembl:ENSG00000095970(gene)|ensembl:ENST00000373113(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006959"(humoral immune response)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001258750.1|refseq:NP_061838.1	-	-	-	figure legend:Supp. Fig. 3A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2018/11/22	2018/11/23	rogid:mu2fXvaw0UH/mPPCFw8kG4XJkGk9606	rogid:r3VTfI6eQhh+g593pLdAEboUXXI9606	rigid:C6e5tqPrBu1HwfbyZwF1K8wnQEM	false	renilla-n:c-c	mutation with no effect:116-116|mutation with no effect:66-66|renilla-c:c-c|mutation with no effect:47-47	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)