#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9NV88 uniprotkb:Q5TA45 intact:EBI-2866634|uniprotkb:O00224|uniprotkb:Q8TB16|uniprotkb:B7Z6M5|uniprotkb:B7Z560|ensembl:ENSP00000429065 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 psi-mi:int9_human(display_long)|uniprotkb:INTS9(gene name)|psi-mi:INTS9(display_short)|uniprotkb:RC74(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 74 kDa(gene name synonym) psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-20621604|imex:IM-26532-1|wwpdb:5v8w - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138631.1|refseq:NP_060720.2|refseq:NP_001166033.1|ensembl:ENSG00000104299(gene)|ensembl:ENST00000521022(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR022712|interpro:IPR027074|interpro:IPR036866|mint:Q9NV88|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:Supp. Table1|3d-resolution:2.1A|3d-r-factors:Rworking 0.166 Rfree0.22|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2018/07/11 2018/07/11 rogid:ShAqPc3dCrs+ixK2yO7PqGVSI/U9606 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rigid:CcoRB1cxqYT9okWe7q/CHGH6OYc false sufficient binding region:582-658 his tag:n-n|sufficient binding region:491-600 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NV88 uniprotkb:Q5TA45 intact:EBI-2866634|uniprotkb:O00224|uniprotkb:Q8TB16|uniprotkb:B7Z6M5|uniprotkb:B7Z560|ensembl:ENSP00000429065 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 psi-mi:int9_human(display_long)|uniprotkb:INTS9(gene name)|psi-mi:INTS9(display_short)|uniprotkb:RC74(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 74 kDa(gene name synonym) psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:"MI:0018"(two hybrid) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622458|imex:IM-26532-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138631.1|refseq:NP_060720.2|refseq:NP_001166033.1|ensembl:ENSG00000104299(gene)|ensembl:ENST00000521022(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR022712|interpro:IPR027074|interpro:IPR036866|mint:Q9NV88|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:Fig, 4A, 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/07/11 2018/07/13 rogid:ShAqPc3dCrs+ixK2yO7PqGVSI/U9606 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rigid:CcoRB1cxqYT9okWe7q/CHGH6OYc false sufficient binding region:579-658|mutation disrupting interaction strength:633-633,635-635|mutation disrupting interaction strength:644-644,648-648|mutation disrupting interaction strength:644-644|mutation disrupting interaction strength:644-644,648-648,652-652 sufficient binding region:500-600 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NV88 uniprotkb:Q5TA45 intact:EBI-2866634|uniprotkb:O00224|uniprotkb:Q8TB16|uniprotkb:B7Z6M5|uniprotkb:B7Z560|ensembl:ENSP00000429065 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 psi-mi:int9_human(display_long)|uniprotkb:INTS9(gene name)|psi-mi:INTS9(display_short)|uniprotkb:RC74(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 74 kDa(gene name synonym) psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:"MI:0018"(two hybrid) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622771|imex:IM-26532-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138631.1|refseq:NP_060720.2|refseq:NP_001166033.1|ensembl:ENSG00000104299(gene)|ensembl:ENST00000521022(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR022712|interpro:IPR027074|interpro:IPR036866|mint:Q9NV88|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:Fig, 4B, 4D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2018/07/11 2018/07/15 rogid:ShAqPc3dCrs+ixK2yO7PqGVSI/U9606 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rigid:CcoRB1cxqYT9okWe7q/CHGH6OYc false sufficient binding region:579-658 sufficient binding region:500-600|mutation disrupting interaction strength:509-509,511-511|mutation disrupting interaction strength:510-510,512-512|mutation disrupting interaction strength:509-509,511-511,581-581 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NV88 uniprotkb:Q5TA45 intact:EBI-2866634|uniprotkb:O00224|uniprotkb:Q8TB16|uniprotkb:B7Z6M5|uniprotkb:B7Z560|ensembl:ENSP00000429065 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 psi-mi:int9_human(display_long)|uniprotkb:INTS9(gene name)|psi-mi:INTS9(display_short)|uniprotkb:RC74(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 74 kDa(gene name synonym) psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622798|imex:IM-26532-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138631.1|refseq:NP_060720.2|refseq:NP_001166033.1|ensembl:ENSG00000104299(gene)|ensembl:ENST00000521022(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR022712|interpro:IPR027074|interpro:IPR036866|mint:Q9NV88|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:Fig, 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/11 2018/07/15 rogid:ShAqPc3dCrs+ixK2yO7PqGVSI/U9606 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rigid:CcoRB1cxqYT9okWe7q/CHGH6OYc false myc tag:?-?|mutation disrupting interaction strength:633-633,635-635|mutation disrupting interaction strength:644-644|mutation disrupting interaction strength:644-644,648-648|mutation disrupting interaction strength:644-644,648-648,652-652 ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NV88 uniprotkb:Q5TA45 intact:EBI-2866634|uniprotkb:O00224|uniprotkb:Q8TB16|uniprotkb:B7Z6M5|uniprotkb:B7Z560|ensembl:ENSP00000429065 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 psi-mi:int9_human(display_long)|uniprotkb:INTS9(gene name)|psi-mi:INTS9(display_short)|uniprotkb:RC74(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 74 kDa(gene name synonym) psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622812|imex:IM-26532-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138631.1|refseq:NP_060720.2|refseq:NP_001166033.1|ensembl:ENSG00000104299(gene)|ensembl:ENST00000521022(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR022712|interpro:IPR027074|interpro:IPR036866|mint:Q9NV88|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:Fig, 4F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/11 2018/07/15 rogid:ShAqPc3dCrs+ixK2yO7PqGVSI/U9606 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rigid:CcoRB1cxqYT9okWe7q/CHGH6OYc false ha tag:?-? myc tag:?-?|mutation disrupting interaction strength:509-509,511-511|mutation disrupting interaction strength:510-510,512-512|mutation disrupting interaction strength:509-509,511-511,581-581|mutation with no effect:203-203 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5TA45 uniprotkb:Q9NVR2 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 intact:EBI-536703|uniprotkb:Q6IA93|uniprotkb:Q7L538|uniprotkb:Q7L8C8|uniprotkb:Q9H3W8|ensembl:ENSP00000381064 psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:int10_human(display_long)|uniprotkb:INTS10(gene name)|psi-mi:INTS10(display_short)|uniprotkb:C8orf35(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622838|imex:IM-26532-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR026164|mint:Q9NVR2|reactome:R-HSA-6807505|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000104613(gene)|ensembl:ENST00000397977(transcript)|go:"GO:0005634"(nucleus)|refseq:NP_060612.2|dip:DIP-34063N - - - figure legend:Fig, 4G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/11 2018/07/15 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rogid:fGpdHHtp91cTl+TFPeZy7loLAE49606 rigid:XmikQtX1/qebMgnqsVGHhAJlvY8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5TA45 uniprotkb:Q68E01 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57 psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622838|imex:IM-26532-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01 - - - figure legend:Fig, 4G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/11 2018/07/15 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606 rigid:XmikQtX1/qebMgnqsVGHhAJlvY8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5TA45 uniprotkb:Q96HW7 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 intact:EBI-5663129|uniprotkb:Q96GA1|uniprotkb:Q9BRC0|uniprotkb:Q6PJG4|uniprotkb:Q96G32|uniprotkb:Q2YD62|uniprotkb:Q7Z4E7|ensembl:ENSP00000434466 psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:int4_human(display_long)|uniprotkb:MSTP093(orf name)|uniprotkb:INTS4(gene name)|psi-mi:INTS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622838|imex:IM-26532-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_291025.3|ensembl:ENSG00000149262(gene)|ensembl:ENST00000534064(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026003|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:Fig, 4G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/11 2018/07/15 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rogid:uGlRFHMzcYz15rtJ/XSGqTaNSPA9606 rigid:XmikQtX1/qebMgnqsVGHhAJlvY8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5TA45 uniprotkb:Q9NV88 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 intact:EBI-2866634|uniprotkb:O00224|uniprotkb:Q8TB16|uniprotkb:B7Z6M5|uniprotkb:B7Z560|ensembl:ENSP00000429065 psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:int9_human(display_long)|uniprotkb:INTS9(gene name)|psi-mi:INTS9(display_short)|uniprotkb:RC74(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 74 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622838|imex:IM-26532-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_001138631.1|refseq:NP_060720.2|refseq:NP_001166033.1|ensembl:ENSG00000104299(gene)|ensembl:ENST00000521022(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR022712|interpro:IPR027074|interpro:IPR036866|mint:Q9NV88|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:Fig, 4G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/11 2018/07/15 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rogid:ShAqPc3dCrs+ixK2yO7PqGVSI/U9606 rigid:XmikQtX1/qebMgnqsVGHhAJlvY8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5TA45 uniprotkb:Q9NVR2 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 intact:EBI-536703|uniprotkb:Q6IA93|uniprotkb:Q7L538|uniprotkb:Q7L8C8|uniprotkb:Q9H3W8|ensembl:ENSP00000381064 psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:int10_human(display_long)|uniprotkb:INTS10(gene name)|psi-mi:INTS10(display_short)|uniprotkb:C8orf35(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622853|imex:IM-26532-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR026164|mint:Q9NVR2|reactome:R-HSA-6807505|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000104613(gene)|ensembl:ENST00000397977(transcript)|go:"GO:0005634"(nucleus)|refseq:NP_060612.2|dip:DIP-34063N - - - figure legend:Fig, 4G|comment:"No IntS9 was associated with IntS9 (Arg510Pro,Thr512Pro) and a significant reduction in the levels of copurifying IntS3, IntS4, and IntS10 relative to wild-type IntS11 was also observed."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/11 2018/07/15 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rogid:fGpdHHtp91cTl+TFPeZy7loLAE49606 rigid:17IhOiS/o8oJW+hRtS9ZXjOBaZw false flag tag:?-?|mutation:510-510,512-512 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5TA45 uniprotkb:Q68E01 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57 psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622853|imex:IM-26532-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01 - - - figure legend:Fig, 4G|comment:"No IntS9 was associated with IntS9 (Arg510Pro,Thr512Pro) and a significant reduction in the levels of copurifying IntS3, IntS4, and IntS10 relative to wild-type IntS11 was also observed."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/11 2018/07/15 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606 rigid:17IhOiS/o8oJW+hRtS9ZXjOBaZw false flag tag:?-?|mutation:510-510,512-512 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5TA45 uniprotkb:Q96HW7 intact:EBI-748258|uniprotkb:Q5TA46|uniprotkb:Q5TA48|uniprotkb:Q5TA52|uniprotkb:Q5TA53|uniprotkb:Q5TA54|uniprotkb:Q7L3D7|uniprotkb:Q96HY1|uniprotkb:Q9BW36|uniprotkb:Q9H0F9|uniprotkb:Q9H8R5|uniprotkb:Q9HAA6|uniprotkb:Q9NWX9|uniprotkb:B4DM87|uniprotkb:A8K5S2|uniprotkb:B3KPR3|uniprotkb:G3V1S5|ensembl:ENSP00000413493 intact:EBI-5663129|uniprotkb:Q96GA1|uniprotkb:Q9BRC0|uniprotkb:Q6PJG4|uniprotkb:Q96G32|uniprotkb:Q2YD62|uniprotkb:Q7Z4E7|ensembl:ENSP00000434466 psi-mi:int11_human(display_long)|uniprotkb:INTS11(gene name)|psi-mi:INTS11(display_short)|uniprotkb:CPSF3L(gene name synonym)|uniprotkb:Cleavage and polyadenylation-specific factor 3-like protein(gene name synonym)|uniprotkb:Protein related to CPSF subunits of 68 kDa(gene name synonym)|uniprotkb:RC68(gene name synonym) psi-mi:int4_human(display_long)|uniprotkb:MSTP093(orf name)|uniprotkb:INTS4(gene name)|psi-mi:INTS4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (2017) imex:IM-26532|pubmed:28396433 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-20622853|imex:IM-26532-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060341.2|refseq:NP_001243392.1|refseq:NP_001243385.1|refseq:NP_001243389.1|refseq:NP_001243391.1|ensembl:ENSG00000127054(gene)|ensembl:ENST00000435064(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR036866|interpro:IPR041897|mint:Q5TA45|rcsb pdb:5V8W|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 refseq:NP_291025.3|ensembl:ENSG00000149262(gene)|ensembl:ENST00000534064(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026003|rcsb pdb:7BFP|rcsb pdb:7BFQ|rcsb pdb:7CUN|reactome:R-HSA-6807505 - - - figure legend:Fig, 4G|comment:"No IntS9 was associated with IntS9 (Arg510Pro,Thr512Pro) and a significant reduction in the levels of copurifying IntS3, IntS4, and IntS10 relative to wild-type IntS11 was also observed."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2018/07/11 2018/07/15 rogid:fKmUHJl/uR84eTlB28zhADznkXQ9606 rogid:uGlRFHMzcYz15rtJ/XSGqTaNSPA9606 rigid:17IhOiS/o8oJW+hRtS9ZXjOBaZw false flag tag:?-?|mutation:510-510,512-512 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)