#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5T011	uniprotkb:Q96S15	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752607|imex:IM-26279-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Figure 2A/B/F, Extended Data figure 3 A/B,4|comment:In the absence of NPRL3 this entire interaction was not seen, and was substantially diminished in the absence of WDR59, WDR24 and MIOS.|comment:The SZT2–GATOR interaction was not modulated by amino acids, and the stable SOG complex did not dissociate during washes with 1.5 M sodium chloride.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q9NXC5	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752607|imex:IM-26279-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	-	-	-	figure legend:Figure 2A/B/F, Extended Data figure 3 A/B,4|comment:In the absence of NPRL3 this entire interaction was not seen, and was substantially diminished in the absence of WDR59, WDR24 and MIOS.|comment:The SZT2–GATOR interaction was not modulated by amino acids, and the stable SOG complex did not dissociate during washes with 1.5 M sodium chloride.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q8WTW4	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752607|imex:IM-26279-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	-	-	-	figure legend:Figure 2A/B/F, Extended Data figure 3 A/B,4|comment:In the absence of NPRL3 this entire interaction was not seen, and was substantially diminished in the absence of WDR59, WDR24 and MIOS.|comment:The SZT2–GATOR interaction was not modulated by amino acids, and the stable SOG complex did not dissociate during washes with 1.5 M sodium chloride.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q12980	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752607|imex:IM-26279-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Figure 2A/B/F, Extended Data figure 3 A/B,4|comment:In the absence of NPRL3 this entire interaction was not seen, and was substantially diminished in the absence of WDR59, WDR24 and MIOS.|comment:The SZT2–GATOR interaction was not modulated by amino acids, and the stable SOG complex did not dissociate during washes with 1.5 M sodium chloride.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q6PJI9	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752607|imex:IM-26279-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Figure 2A/B/F, Extended Data figure 3 A/B,4|comment:In the absence of NPRL3 this entire interaction was not seen, and was substantially diminished in the absence of WDR59, WDR24 and MIOS.|comment:The SZT2–GATOR interaction was not modulated by amino acids, and the stable SOG complex did not dissociate during washes with 1.5 M sodium chloride.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:P55735	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-1046596|ensembl:ENSP00000312122|uniprotkb:Q5BJF0|uniprotkb:Q9BRM6|uniprotkb:Q9BUG7|uniprotkb:A8MV37|uniprotkb:B4DXJ1	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:sec13_human(display_long)|uniprotkb:SEC13(gene name)|psi-mi:SEC13(display_short)|uniprotkb:D3S1231E(gene name synonym)|uniprotkb:SEC13L1(gene name synonym)|uniprotkb:SEC13R(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)|uniprotkb:SEC13A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752607|imex:IM-26279-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037363|interpro:IPR037596|mint:P55735|rcsb pdb:3BG0|rcsb pdb:3BG1|go:"GO:0006886"(intracellular protein transport)|rcsb pdb:5A9Q|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|reactome:R-HSA-1169408|reactome:R-HSA-141444|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-168333|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025|reactome:R-HSA-983170|ensembl:ENSG00000157020(gene)|ensembl:ENST00000350697(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001129704.1|refseq:NP_899195.1|refseq:XP_016862508.1|refseq:NP_001129498.1|refseq:NP_109598.2|refseq:XP_005265436.1|dip:DIP-39091N	-	-	-	figure legend:Figure 2A/B/F, Extended Data figure 3 A/B,4|comment:In the absence of NPRL3 this entire interaction was not seen, and was substantially diminished in the absence of WDR59, WDR24 and MIOS.|comment:The SZT2–GATOR interaction was not modulated by amino acids, and the stable SOG complex did not dissociate during washes with 1.5 M sodium chloride.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:vaNNziH0RNn0+mHITi5+FST0E0s9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q96EE3	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-922818|uniprotkb:Q8NFU6|uniprotkb:Q96MH3|uniprotkb:Q9C069|uniprotkb:A8K5B1|ensembl:ENSP00000262124	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:seh1_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit SEH1(gene name synonym)|uniprotkb:SEH1L(gene name)|psi-mi:SEH1L(display_short)|uniprotkb:SEC13L(gene name synonym)|uniprotkb:SEH1(gene name synonym)|uniprotkb:SEC13-like protein(gene name synonym)|uniprotkb:GATOR complex protein SEH1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752607|imex:IM-26279-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	refseq:NP_001013455.1|refseq:NP_112493.2|ensembl:ENSP00000262124|ensembl:ENST00000399892|ensembl:ENSP00000382779|ensembl:ENSG00000085415(gene)|ensembl:ENST00000262124(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0035859"(Seh1-associated complex)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0061700"(GATOR2 complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037363|interpro:IPR037597|mint:Q96EE3|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025	-	-	-	figure legend:Figure 2A/B/F, Extended Data figure 3 A/B,4|comment:In the absence of NPRL3 this entire interaction was not seen, and was substantially diminished in the absence of WDR59, WDR24 and MIOS.|comment:The SZT2–GATOR interaction was not modulated by amino acids, and the stable SOG complex did not dissociate during washes with 1.5 M sodium chloride.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:I/aUTa3zTawK6QwtkrUkO8B51W49606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75140-4	uniprotkb:Q5VZM2	intact:EBI-16752659|ensembl:ENSP00000383108|ensembl:ENSP00000494406	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:o75140-4(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752640|imex:IM-26279-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000400249(transcript)|ensembl:ENST00000644331(transcript)|intact:EBI-11102814(isoform-parent)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 2A-2|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:9YQAmgaxfnAXw2We/ejwzUvO/D89606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rigid:vh8STvdX71ufZBkQo9buItHxiWI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75140-4	uniprotkb:Q9HB90	intact:EBI-16752659|ensembl:ENSP00000383108|ensembl:ENSP00000494406	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:o75140-4(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752640|imex:IM-26279-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000400249(transcript)|ensembl:ENST00000644331(transcript)|intact:EBI-11102814(isoform-parent)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 2A-2|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:9YQAmgaxfnAXw2We/ejwzUvO/D89606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rigid:vh8STvdX71ufZBkQo9buItHxiWI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75140-4	uniprotkb:Q96S15	intact:EBI-16752659|ensembl:ENSP00000383108|ensembl:ENSP00000494406	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:o75140-4(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752640|imex:IM-26279-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000400249(transcript)|ensembl:ENST00000644331(transcript)|intact:EBI-11102814(isoform-parent)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 2A-2|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:9YQAmgaxfnAXw2We/ejwzUvO/D89606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:vh8STvdX71ufZBkQo9buItHxiWI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75140-4	uniprotkb:Q9NXC5	intact:EBI-16752659|ensembl:ENSP00000383108|ensembl:ENSP00000494406	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:o75140-4(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752640|imex:IM-26279-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000400249(transcript)|ensembl:ENST00000644331(transcript)|intact:EBI-11102814(isoform-parent)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 2A-2|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:9YQAmgaxfnAXw2We/ejwzUvO/D89606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:vh8STvdX71ufZBkQo9buItHxiWI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75140-4	uniprotkb:Q8WTW4	intact:EBI-16752659|ensembl:ENSP00000383108|ensembl:ENSP00000494406	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	psi-mi:o75140-4(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752640|imex:IM-26279-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000400249(transcript)|ensembl:ENST00000644331(transcript)|intact:EBI-11102814(isoform-parent)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 2A-2|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:9YQAmgaxfnAXw2We/ejwzUvO/D89606	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rigid:vh8STvdX71ufZBkQo9buItHxiWI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75140-4	uniprotkb:Q12980	intact:EBI-16752659|ensembl:ENSP00000383108|ensembl:ENSP00000494406	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:o75140-4(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752640|imex:IM-26279-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000400249(transcript)|ensembl:ENST00000644331(transcript)|intact:EBI-11102814(isoform-parent)	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	isoform-comment:No experimental confirmation available.	-	figure legend:Figure 2A-2|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:9YQAmgaxfnAXw2We/ejwzUvO/D89606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:vh8STvdX71ufZBkQo9buItHxiWI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q8WTW4	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762432|imex:IM-26279-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	-	-	-	figure legend:Figure 2F|comment:Weak interaction  in the absence of WDR59, WDR24 and MIOS.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rigid:MusHJekIuoOHoeeRN6fgvqIPQsY	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q12980	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762432|imex:IM-26279-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Figure 2F|comment:Weak interaction  in the absence of WDR59, WDR24 and MIOS.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:MusHJekIuoOHoeeRN6fgvqIPQsY	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12980	uniprotkb:Q5T011	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762610|imex:IM-26279-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:5YtIubPS0xi//7oDKvcUCg9u3f0	false	-	mutation:1938-1938|necessary binding region:1083-1189|flag tag:n-n|sufficient binding region:935-1734	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q5T011	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762633|imex:IM-26279-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data 4-D|comment:"Deletion of a small portion (amino acids 1,083–1,189) within the GATOR1-binding region (amino acids 935–1,734) created a SZT2 mutant, that had minimal  binding to NPRL3."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:6N0PB6KjNCUVLb1sZ0uW2EVljuE	false	-	sufficient binding region:1190-3432,1-1082|mutation:1938-1938|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q6PJI9	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762716|imex:IM-26279-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Extended Data 3E|comment:"Interaction seen when  cells stably over-expressing   Flag–WDR24 were deprived of amino acids.  The interaction of SESN2 with GATOR2 (WDR24/59/MIOS) was unchanged in the absence of SZT2."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:ZXrWMeFJ6WVnrAuAfW6+87aMcZ0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:P58004	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762716|imex:IM-26279-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	-	-	-	figure legend:Extended Data 3E|comment:"Interaction seen when  cells stably over-expressing   Flag–WDR24 were deprived of amino acids.  The interaction of SESN2 with GATOR2 (WDR24/59/MIOS) was unchanged in the absence of SZT2."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rigid:ZXrWMeFJ6WVnrAuAfW6+87aMcZ0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q9NXC5	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762716|imex:IM-26279-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	-	-	-	figure legend:Extended Data 3E|comment:"Interaction seen when  cells stably over-expressing   Flag–WDR24 were deprived of amino acids.  The interaction of SESN2 with GATOR2 (WDR24/59/MIOS) was unchanged in the absence of SZT2."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:ZXrWMeFJ6WVnrAuAfW6+87aMcZ0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q6PJI9	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762726|imex:IM-26279-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Extended Data 3E-2|comment:Interaction seen when  cells stably over-expressing   Flag–WDR24 were re-stimulated with amino acids after prior deprivation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:OcBIWbvd3ix/OX9vqlZIFDIeasc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q9NXC5	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762726|imex:IM-26279-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	-	-	-	figure legend:Extended Data 3E-2|comment:Interaction seen when  cells stably over-expressing   Flag–WDR24 were re-stimulated with amino acids after prior deprivation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:OcBIWbvd3ix/OX9vqlZIFDIeasc	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q12980	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762737|imex:IM-26279-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Extended Data 3F|comment:SESN2 overexpression did not affect the interaction between SZT2, GATOR1 and GATOR2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:0Md10KnT/kWK9HyHgH5KW7AOpDU	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q6PJI9	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762737|imex:IM-26279-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Extended Data 3F|comment:SESN2 overexpression did not affect the interaction between SZT2, GATOR1 and GATOR2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:0Md10KnT/kWK9HyHgH5KW7AOpDU	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q9NXC5	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762737|imex:IM-26279-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	-	-	-	figure legend:Extended Data 3F|comment:SESN2 overexpression did not affect the interaction between SZT2, GATOR1 and GATOR2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:0Md10KnT/kWK9HyHgH5KW7AOpDU	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q96S15	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762737|imex:IM-26279-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Extended Data 3F|comment:SESN2 overexpression did not affect the interaction between SZT2, GATOR1 and GATOR2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:0Md10KnT/kWK9HyHgH5KW7AOpDU	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58004	uniprotkb:Q5T011	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752682|imex:IM-26279-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Figure 2B-3|comment:SESN2 pulled down GATOR2, GATOR1 and SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:U2D5qzY9P+OIBYy0ZO2iE7KC+Z8	false	-	mutation:1938-1938|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P58004	uniprotkb:Q6PJI9	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752682|imex:IM-26279-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Figure 2B-3|comment:SESN2 pulled down GATOR2, GATOR1 and SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:U2D5qzY9P+OIBYy0ZO2iE7KC+Z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58004	uniprotkb:Q96S15	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752682|imex:IM-26279-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Figure 2B-3|comment:SESN2 pulled down GATOR2, GATOR1 and SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:U2D5qzY9P+OIBYy0ZO2iE7KC+Z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58004	uniprotkb:Q9NXC5	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752682|imex:IM-26279-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	-	-	-	figure legend:Figure 2B-3|comment:SESN2 pulled down GATOR2, GATOR1 and SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:U2D5qzY9P+OIBYy0ZO2iE7KC+Z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58004	uniprotkb:Q8WTW4	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752682|imex:IM-26279-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	-	-	-	figure legend:Figure 2B-3|comment:SESN2 pulled down GATOR2, GATOR1 and SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rigid:U2D5qzY9P+OIBYy0ZO2iE7KC+Z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58004	uniprotkb:Q12980	intact:EBI-3939642|uniprotkb:Q96SI5|uniprotkb:Q5T7D0|ensembl:ENSP00000253063|ensembl:ENSP00000496365	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:sesn2_human(display_long)|uniprotkb:SESN2(gene name)|psi-mi:SESN2(display_short)|uniprotkb:SEST2(gene name synonym)|uniprotkb:Hi95(gene name synonym)|uniprotkb:Hypoxia-induced gene(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752682|imex:IM-26279-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130766(gene)|ensembl:ENSG00000285069(gene)|ensembl:ENST00000253063(transcript)|ensembl:ENST00000645231(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032542"(sulfiredoxin activity)|go:"GO:0032868"(response to insulin)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046323"(glucose import)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901031"(regulation of response to reactive oxygen species)|go:"GO:1902010"(negative regulation of translation in response to endoplasmic reticulum stress)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1990253"(cellular response to leucine starvation)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|interpro:IPR006730("PA26 p53-induced protein (sestrin)")|interpro:IPR029032|mint:P58004|rcsb pdb:5CUF|rcsb pdb:5DJ4|rcsb pdb:5T0N|rcsb pdb:6N0M|reactome:R-HSA-5628897|reactome:R-HSA-9639288|go:"GO:0070728"(leucine binding)|refseq:NP_113647.1|dip:DIP-62044N	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Figure 2B-3|comment:SESN2 pulled down GATOR2, GATOR1 and SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:VXNFyYSRCJ52PWWODX6OVCBjndk9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:U2D5qzY9P+OIBYy0ZO2iE7KC+Z8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q9NXC5	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752694|imex:IM-26279-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	-	-	-	figure legend:Figure 2B/D|comment:Endogenous WDR24 co-immunoprecipitated efficiently with WDR59 and MIOS, but not with NPRL2 or NPRL3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:OcBIWbvd3ix/OX9vqlZIFDIeasc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q6PJI9	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752694|imex:IM-26279-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Figure 2B/D|comment:Endogenous WDR24 co-immunoprecipitated efficiently with WDR59 and MIOS, but not with NPRL2 or NPRL3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:OcBIWbvd3ix/OX9vqlZIFDIeasc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTW4	uniprotkb:Q12980	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752706|imex:IM-26279-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Figure 2B-2|comment:NPRL3 pulled down NPRL2, but not WDR59, WDR24 or MIOS.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/06/21	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:hNwj6WsC7NmtsCg56ujQk5B4vXc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q5T011	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752891|imex:IM-26279-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Figure 2D|comment:"WDR24 pulled down NPRL3 only in SZT2-containing SEC fractions (13-20)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:pIM+q2uh9LSh1fJ6aVCQfeA4oh4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q12980	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752891|imex:IM-26279-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Figure 2D|comment:"WDR24 pulled down NPRL3 only in SZT2-containing SEC fractions (13-20)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:pIM+q2uh9LSh1fJ6aVCQfeA4oh4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q6PJI9	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752891|imex:IM-26279-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Figure 2D|comment:"WDR24 pulled down NPRL3 only in SZT2-containing SEC fractions (13-20)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:pIM+q2uh9LSh1fJ6aVCQfeA4oh4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PJI9	uniprotkb:Q96S15	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752744|imex:IM-26279-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Figure 2C|comment:Interaction  in absence of Flag-SZT2 transfection, higher molecular weight bands, fractions ~13-20.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:lUfh//c4FIC4uBUrv36qTv3d8s4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTW4	uniprotkb:Q12980	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752854|imex:IM-26279-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Figure 2C|comment:"Interaction seen in Flag-SZT2 transfected cells, higher molecular weight fractions only (13-20)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTW4	uniprotkb:Q5T011	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752854|imex:IM-26279-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Figure 2C|comment:"Interaction seen in Flag-SZT2 transfected cells, higher molecular weight fractions only (13-20)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	mutation:1938-1938|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8WTW4	uniprotkb:Q96S15	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752854|imex:IM-26279-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Figure 2C|comment:"Interaction seen in Flag-SZT2 transfected cells, higher molecular weight fractions only (13-20)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTW4	uniprotkb:Q6PJI9	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752854|imex:IM-26279-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Figure 2C|comment:"Interaction seen in Flag-SZT2 transfected cells, higher molecular weight fractions only (13-20)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTW4	uniprotkb:Q12980	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752874|imex:IM-26279-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Figure 2Ci|comment:Interaction seen in non-Flag-SZT2 transfected cells, lower molecular weight bands, fractions ~23-28.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:wh9EnKvcuu4NmOkmrcdrmh/lgTI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTW4	uniprotkb:Q96S15	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752874|imex:IM-26279-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Figure 2Ci|comment:Interaction seen in non-Flag-SZT2 transfected cells, lower molecular weight bands, fractions ~23-28.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:wh9EnKvcuu4NmOkmrcdrmh/lgTI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTW4	uniprotkb:Q6PJI9	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16752874|imex:IM-26279-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Figure 2Ci|comment:Interaction seen in non-Flag-SZT2 transfected cells, lower molecular weight bands, fractions ~23-28.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:wh9EnKvcuu4NmOkmrcdrmh/lgTI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NXC5	uniprotkb:Q8WTW4	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762531|imex:IM-26279-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	-	-	-	figure legend:Extended Data Figure 2 F/G|comment:"Fraction containing (purified)  SOG complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NXC5	uniprotkb:Q12980	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762531|imex:IM-26279-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Extended Data Figure 2 F/G|comment:"Fraction containing (purified)  SOG complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NXC5	uniprotkb:P55735	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	intact:EBI-1046596|ensembl:ENSP00000312122|uniprotkb:Q5BJF0|uniprotkb:Q9BRM6|uniprotkb:Q9BUG7|uniprotkb:A8MV37|uniprotkb:B4DXJ1	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:sec13_human(display_long)|uniprotkb:SEC13(gene name)|psi-mi:SEC13(display_short)|uniprotkb:D3S1231E(gene name synonym)|uniprotkb:SEC13L1(gene name synonym)|uniprotkb:SEC13R(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)|uniprotkb:SEC13A(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762531|imex:IM-26279-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037363|interpro:IPR037596|mint:P55735|rcsb pdb:3BG0|rcsb pdb:3BG1|go:"GO:0006886"(intracellular protein transport)|rcsb pdb:5A9Q|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|reactome:R-HSA-1169408|reactome:R-HSA-141444|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-168333|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025|reactome:R-HSA-983170|ensembl:ENSG00000157020(gene)|ensembl:ENST00000350697(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001129704.1|refseq:NP_899195.1|refseq:XP_016862508.1|refseq:NP_001129498.1|refseq:NP_109598.2|refseq:XP_005265436.1|dip:DIP-39091N	-	-	-	figure legend:Extended Data Figure 2 F/G|comment:"Fraction containing (purified)  SOG complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rogid:vaNNziH0RNn0+mHITi5+FST0E0s9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NXC5	uniprotkb:Q96EE3	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	intact:EBI-922818|uniprotkb:Q8NFU6|uniprotkb:Q96MH3|uniprotkb:Q9C069|uniprotkb:A8K5B1|ensembl:ENSP00000262124	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:seh1_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit SEH1(gene name synonym)|uniprotkb:SEH1L(gene name)|psi-mi:SEH1L(display_short)|uniprotkb:SEC13L(gene name synonym)|uniprotkb:SEH1(gene name synonym)|uniprotkb:SEC13-like protein(gene name synonym)|uniprotkb:GATOR complex protein SEH1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762531|imex:IM-26279-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	refseq:NP_001013455.1|refseq:NP_112493.2|ensembl:ENSP00000262124|ensembl:ENST00000399892|ensembl:ENSP00000382779|ensembl:ENSG00000085415(gene)|ensembl:ENST00000262124(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0035859"(Seh1-associated complex)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0061700"(GATOR2 complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037363|interpro:IPR037597|mint:Q96EE3|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025	-	-	-	figure legend:Extended Data Figure 2 F/G|comment:"Fraction containing (purified)  SOG complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rogid:I/aUTa3zTawK6QwtkrUkO8B51W49606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NXC5	uniprotkb:Q5T011	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762531|imex:IM-26279-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data Figure 2 F/G|comment:"Fraction containing (purified)  SOG complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	-	mutation:1938-1938|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NXC5	uniprotkb:Q96S15	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762531|imex:IM-26279-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Extended Data Figure 2 F/G|comment:"Fraction containing (purified)  SOG complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NXC5	uniprotkb:Q6PJI9	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0071"(molecular sieving)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762531|imex:IM-26279-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Extended Data Figure 2 F/G|comment:"Fraction containing (purified)  SOG complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:WpC6LvIxMS2e6LhTeQ8T/91PTv8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q5T011	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762408|imex:IM-26279-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Figure 2E|comment:The presence of SZT2 was required to bind NPRL2/3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q6PJI9	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0030"(cross-linking study)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762408|imex:IM-26279-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Figure 2E|comment:The presence of SZT2 was required to bind NPRL2/3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q8WTW4	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762408|imex:IM-26279-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	-	-	-	figure legend:Figure 2E|comment:The presence of SZT2 was required to bind NPRL2/3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S15	uniprotkb:Q12980	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762408|imex:IM-26279-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Figure 2E|comment:The presence of SZT2 was required to bind NPRL2/3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PJI9	uniprotkb:Q96S15	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0030"(cross-linking study)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762416|imex:IM-26279-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Figure 2Ei|comment:Interaction in the absence of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:lUfh//c4FIC4uBUrv36qTv3d8s4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T011	uniprotkb:Q96EE3	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-922818|uniprotkb:Q8NFU6|uniprotkb:Q96MH3|uniprotkb:Q9C069|uniprotkb:A8K5B1|ensembl:ENSP00000262124	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:seh1_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit SEH1(gene name synonym)|uniprotkb:SEH1L(gene name)|psi-mi:SEH1L(display_short)|uniprotkb:SEC13L(gene name synonym)|uniprotkb:SEH1(gene name synonym)|uniprotkb:SEC13-like protein(gene name synonym)|uniprotkb:GATOR complex protein SEH1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762489|imex:IM-26279-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	refseq:NP_001013455.1|refseq:NP_112493.2|ensembl:ENSP00000262124|ensembl:ENST00000399892|ensembl:ENSP00000382779|ensembl:ENSG00000085415(gene)|ensembl:ENST00000262124(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0035859"(Seh1-associated complex)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0061700"(GATOR2 complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037363|interpro:IPR037597|mint:Q96EE3|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025	-	-	-	figure legend:Extended Data Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:I/aUTa3zTawK6QwtkrUkO8B51W49606	rigid:gc8d1gysJeO2bQG6pgwa2uAPoWU	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q5T011	uniprotkb:P55735	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-1046596|ensembl:ENSP00000312122|uniprotkb:Q5BJF0|uniprotkb:Q9BRM6|uniprotkb:Q9BUG7|uniprotkb:A8MV37|uniprotkb:B4DXJ1	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:sec13_human(display_long)|uniprotkb:SEC13(gene name)|psi-mi:SEC13(display_short)|uniprotkb:D3S1231E(gene name synonym)|uniprotkb:SEC13L1(gene name synonym)|uniprotkb:SEC13R(gene name synonym)|uniprotkb:SEC13-related protein(gene name synonym)|uniprotkb:SEC13-like protein 1(gene name synonym)|uniprotkb:GATOR complex protein SEC13(gene name synonym)|uniprotkb:SEC13A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762489|imex:IM-26279-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051028"(mRNA transport)|go:"GO:0061700"(GATOR2 complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037363|interpro:IPR037596|mint:P55735|rcsb pdb:3BG0|rcsb pdb:3BG1|go:"GO:0006886"(intracellular protein transport)|rcsb pdb:5A9Q|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|reactome:R-HSA-1169408|reactome:R-HSA-141444|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0031080"(nuclear pore outer ring)|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-168333|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025|reactome:R-HSA-983170|ensembl:ENSG00000157020(gene)|ensembl:ENST00000350697(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001129704.1|refseq:NP_899195.1|refseq:XP_016862508.1|refseq:NP_001129498.1|refseq:NP_109598.2|refseq:XP_005265436.1|dip:DIP-39091N	-	-	-	figure legend:Extended Data Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:vaNNziH0RNn0+mHITi5+FST0E0s9606	rigid:gc8d1gysJeO2bQG6pgwa2uAPoWU	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q5T011	uniprotkb:O75140	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-11102814|uniprotkb:Q5THY9|uniprotkb:Q68DR1|uniprotkb:Q5THZ0|uniprotkb:Q6PEZ1|uniprotkb:Q5THZ1|uniprotkb:Q5THZ3|uniprotkb:Q9UH13|uniprotkb:Q6MZX3|uniprotkb:A6H8V6|uniprotkb:Q5K3V5|uniprotkb:Q9UGV8|uniprotkb:A8MPX9|uniprotkb:B9EGN9|uniprotkb:B4DH93|intact:EBI-28971100|ensembl:ENSP00000371546|ensembl:ENSP00000498382	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:depd5_human(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:DEP domain-containing protein 5(gene name synonym)|uniprotkb:KIAA0645(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762489|imex:IM-26279-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENST00000382111|ensembl:ENSP00000371545|ensembl:ENSP00000371546|ensembl:ENST00000400242|ensembl:ENSP00000383101|ensembl:ENST00000400248|ensembl:ENSP00000383107|ensembl:ENST00000400249|ensembl:ENSP00000383108|ensembl:ENST00000535622|ensembl:ENSP00000440210|ensembl:ENST00000642696|ensembl:ENSP00000495917|ensembl:ENST00000644331|ensembl:ENSP00000494406|ensembl:ENST00000645711|ensembl:ENSP00000493489|ensembl:ENST00000646755|ensembl:ENSP00000496532|ensembl:ENSP00000498382|refseq:NP_001007189.1|refseq:NP_001129501.1|refseq:NP_001229825.1|refseq:NP_001229826.1|refseq:NP_055477.1|refseq:XP_005261919.1|refseq:XP_011528859.1|refseq:XP_011528860.1|refseq:XP_011528861.1|refseq:XP_011528865.1|ensembl:ENSG00000100150(gene)|ensembl:ENST00000382112(transcript)|ensembl:ENST00000651528(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR027244|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:XP_016884598.1|refseq:XP_016884599.1|refseq:XP_016884600.1|dip:DIP-62050N	-	-	-	figure legend:Extended Data Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:V209SbgYwn96oWnCN3HlAx7Ewfo9606	rigid:gc8d1gysJeO2bQG6pgwa2uAPoWU	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q5T011	uniprotkb:Q9NXC5	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762489|imex:IM-26279-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N	-	-	-	figure legend:Extended Data Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606	rigid:gc8d1gysJeO2bQG6pgwa2uAPoWU	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q5T011	uniprotkb:Q8WTW4	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762489|imex:IM-26279-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	-	-	-	figure legend:Extended Data Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rigid:gc8d1gysJeO2bQG6pgwa2uAPoWU	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q5T011	uniprotkb:Q12980	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762489|imex:IM-26279-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Extended Data Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:gc8d1gysJeO2bQG6pgwa2uAPoWU	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q5T011	uniprotkb:Q6PJI9	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762489|imex:IM-26279-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Extended Data Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:gc8d1gysJeO2bQG6pgwa2uAPoWU	false	mutation:1938-1938|flag tag:n-n	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q8WTW4	uniprotkb:Q12980	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762557|imex:IM-26279-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Extended Data Figure 2H|comment:Interaction seen in Sucrose fractions1-5 inclusive, in both the presence and absence of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTW4	uniprotkb:Q5T011	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762557|imex:IM-26279-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data Figure 2H|comment:Interaction seen in Sucrose fractions1-5 inclusive, in both the presence and absence of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8WTW4	uniprotkb:Q96S15	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762557|imex:IM-26279-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Extended Data Figure 2H|comment:Interaction seen in Sucrose fractions1-5 inclusive, in both the presence and absence of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WTW4	uniprotkb:Q6PJI9	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762557|imex:IM-26279-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Extended Data Figure 2H|comment:Interaction seen in Sucrose fractions1-5 inclusive, in both the presence and absence of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:0+FU/IHUEIwfg08Xi7+f8WTJO/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11279	uniprotkb:Q8WTW4	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762578|imex:IM-26279-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	-	-	-	figure legend:Extended Data Figure 2Hi|comment:Interaction seen in Sucrose fractions 7-17 inclusive, in the presence  of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rigid:5PnWdPy8TGHmc0Ba8r0iGzezCR4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11279	uniprotkb:Q12980	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762578|imex:IM-26279-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	-	-	-	figure legend:Extended Data Figure 2Hi|comment:Interaction seen in Sucrose fractions 7-17 inclusive, in the presence  of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:5PnWdPy8TGHmc0Ba8r0iGzezCR4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11279	uniprotkb:Q5T011	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762578|imex:IM-26279-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data Figure 2Hi|comment:Interaction seen in Sucrose fractions 7-17 inclusive, in the presence  of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:5PnWdPy8TGHmc0Ba8r0iGzezCR4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11279	uniprotkb:Q96S15	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762578|imex:IM-26279-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Extended Data Figure 2Hi|comment:Interaction seen in Sucrose fractions 7-17 inclusive, in the presence  of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:5PnWdPy8TGHmc0Ba8r0iGzezCR4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11279	uniprotkb:Q6PJI9	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762578|imex:IM-26279-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Extended Data Figure 2Hi|comment:Interaction seen in Sucrose fractions 7-17 inclusive, in the presence  of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:5PnWdPy8TGHmc0Ba8r0iGzezCR4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11279	uniprotkb:Q5T011	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762588|imex:IM-26279-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data figure 2Hii|comment:Interaction seen in Sucrose fractions 9-17 inclusive, in the absence  of SZT2, and also  fractions 19-21 in presence and absence of SZT2, except for fraction 21 where Lamp1 is not detected in the presence of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:d40xrMchEAr0gHK2wsJ5WrKbjSo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11279	uniprotkb:Q96S15	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762588|imex:IM-26279-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N	-	-	-	figure legend:Extended Data figure 2Hii|comment:Interaction seen in Sucrose fractions 9-17 inclusive, in the absence  of SZT2, and also  fractions 19-21 in presence and absence of SZT2, except for fraction 21 where Lamp1 is not detected in the presence of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606	rigid:d40xrMchEAr0gHK2wsJ5WrKbjSo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11279	uniprotkb:Q6PJI9	intact:EBI-2805407|uniprotkb:B4DWL3|ensembl:ENSP00000333298|uniprotkb:Q9NP13|uniprotkb:Q8WU33|uniprotkb:Q9BRD2|uniprotkb:Q96I40	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:lamp1_human(display_long)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:LAMP1(gene name)|psi-mi:LAMP1(display_short)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762588|imex:IM-26279-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185896(gene)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044754"(autolysosome)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENST00000332556(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P11279|reactome:R-HSA-6798695|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|refseq:NP_005552.3|dip:DIP-44670N	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	-	-	-	figure legend:Extended Data figure 2Hii|comment:Interaction seen in Sucrose fractions 9-17 inclusive, in the absence  of SZT2, and also  fractions 19-21 in presence and absence of SZT2, except for fraction 21 where Lamp1 is not detected in the presence of SZT2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2019/07/08	rogid:dP5MZG0I7/SM0EfCUhsESfQYvYU9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:d40xrMchEAr0gHK2wsJ5WrKbjSo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13473	uniprotkb:Q5T011	intact:EBI-2907154|uniprotkb:A8K4X5|uniprotkb:Q16641|uniprotkb:Q96J30|uniprotkb:Q99534|uniprotkb:Q9UD93|uniprotkb:D3DTF0|intact:EBI-4324646|uniprotkb:Q6Q3G8|ensembl:ENSP00000200639	intact:EBI-10749411|uniprotkb:A0PJK5|uniprotkb:A7E2X4|uniprotkb:O75055|uniprotkb:Q5JUY7|uniprotkb:Q5T012|uniprotkb:Q5XKC7|uniprotkb:Q6ZNI8|uniprotkb:Q6ZT24|uniprotkb:Q7Z636|uniprotkb:Q8NAY9|uniprotkb:Q9H5H7|uniprotkb:Q9UFQ8|ensembl:ENSP00000489255	psi-mi:lamp2_human(display_long)|uniprotkb:LAMP2(gene name)|psi-mi:LAMP2(display_short)|uniprotkb:CD107 antigen-like family member B(gene name synonym)|uniprotkb:LGP-96(gene name synonym)	psi-mi:szt2_human(display_long)|uniprotkb:SZT2(gene name)|psi-mi:SZT2(display_short)|uniprotkb:C1orf84(gene name synonym)|uniprotkb:KIAA0467(gene name synonym)|uniprotkb:Seizure threshold 2 protein homolog(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762658|imex:IM-26279-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002285.1|refseq:NP_054701.1|refseq:NP_001116078.1|ensembl:ENSG00000005893(gene)|ensembl:ENST00000200639(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019899"(enzyme binding)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0061742"(chaperone-mediated autophagy translocation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097637"(integral component of autophagosome membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1990836"(lysosomal matrix)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P13473|rcsb pdb:2MOF|rcsb pdb:2MOM|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-9613829	refseq:NP_056099.3|refseq:XP_006710564.1|ensembl:ENSG00000198198(gene)|ensembl:ENST00000634258(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0007417"(central nervous system development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043473"(pigmentation)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0140007"(KICSTOR complex)|go:"GO:1901668"(regulation of superoxide dismutase activity)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR033228|reactome:R-HSA-9639288	go:"GO:0005764"(lysosome)	-	-	figure legend:Extended Data 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:+s4K/qoL3PBwjATJmFDQtqcl/ZQ9606	rogid:nUjQG/kRgtfmCHpvz+RKyFthpcU9606	rigid:v+P3Cq4po02uPA436goqPQdeqSA	false	-	mutation:1938-1938|flag tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P13473	uniprotkb:Q6PJI9	intact:EBI-2907154|uniprotkb:A8K4X5|uniprotkb:Q16641|uniprotkb:Q96J30|uniprotkb:Q99534|uniprotkb:Q9UD93|uniprotkb:D3DTF0|intact:EBI-4324646|uniprotkb:Q6Q3G8|ensembl:ENSP00000200639	intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7	psi-mi:lamp2_human(display_long)|uniprotkb:LAMP2(gene name)|psi-mi:LAMP2(display_short)|uniprotkb:CD107 antigen-like family member B(gene name synonym)|uniprotkb:LGP-96(gene name synonym)	psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Peng et al. (2017)	imex:IM-26279|pubmed:28199315	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16762658|imex:IM-26279-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002285.1|refseq:NP_054701.1|refseq:NP_001116078.1|ensembl:ENSG00000005893(gene)|ensembl:ENST00000200639(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019899"(enzyme binding)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0061742"(chaperone-mediated autophagy translocation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097637"(integral component of autophagosome membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1990836"(lysosomal matrix)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P13473|rcsb pdb:2MOF|rcsb pdb:2MOM|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-9613829	ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3	go:"GO:0005764"(lysosome)	-	-	figure legend:Extended Data 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2018/02/01	2018/02/06	rogid:+s4K/qoL3PBwjATJmFDQtqcl/ZQ9606	rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606	rigid:v+P3Cq4po02uPA436goqPQdeqSA	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)