#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H7E2-3	uniprotkb:O95985	intact:EBI-10969939|ensembl:ENSP00000367113	intact:EBI-373403|uniprotkb:A0M8Q3|uniprotkb:Q9BUP5|ensembl:ENSP00000349705|ensembl:ENSP00000381773	psi-mi:q9h7e2-3(display_long)|uniprotkb:TDRD3(gene name)|psi-mi:TDRD3(display_short)	psi-mi:top3b_human(display_long)|uniprotkb:TOP3B(gene name)|psi-mi:TOP3B(display_short)|uniprotkb:TOP3B1(gene name synonym)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Goto-Ito et al. (2017)	pubmed:28176834|imex:IM-26467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16745993|imex:IM-26467-1|wwpdb:5gve	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083544(gene)|ensembl:ENST00000377881(transcript)|intact:EBI-3938232(isoform-parent)	refseq:NP_003926.1|refseq:XP_011528784.1|refseq:XP_006724412.1|refseq:XP_006724413.1|refseq:NP_001269041.1|refseq:NP_001269042.1|refseq:XP_005261868.1|ensembl:ENSG00000100038(gene)|ensembl:ENST00000357179(transcript)|ensembl:ENST00000398793(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:O95985|rcsb pdb:5GVC|rcsb pdb:5GVE|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)	-	-	-	3d-resolution:3.61A|3d-r-factors:R working  0.198, R free 0.245|figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/19	2018/01/19	rogid:6yYxColCexsylTmLc/3szVv4MKI9606	rogid:R4lom6gXvFXkkGF+Hj94m9ecsXA9606	rigid:PcCKNPLZNgwbLMywzkGuuFRV0sI	false	sufficient binding region:1-161	sufficient binding region:1-612	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H7E2-3	uniprotkb:O95985	intact:EBI-10969939|ensembl:ENSP00000367113	intact:EBI-373403|uniprotkb:A0M8Q3|uniprotkb:Q9BUP5|ensembl:ENSP00000349705|ensembl:ENSP00000381773	psi-mi:q9h7e2-3(display_long)|uniprotkb:TDRD3(gene name)|psi-mi:TDRD3(display_short)	psi-mi:top3b_human(display_long)|uniprotkb:TOP3B(gene name)|psi-mi:TOP3B(display_short)|uniprotkb:TOP3B1(gene name synonym)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Goto-Ito et al. (2017)	pubmed:28176834|imex:IM-26467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16746066|imex:IM-26467-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083544(gene)|ensembl:ENST00000377881(transcript)|intact:EBI-3938232(isoform-parent)	refseq:NP_003926.1|refseq:XP_011528784.1|refseq:XP_006724412.1|refseq:XP_006724413.1|refseq:NP_001269041.1|refseq:NP_001269042.1|refseq:XP_005261868.1|ensembl:ENSG00000100038(gene)|ensembl:ENST00000357179(transcript)|ensembl:ENST00000398793(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:O95985|rcsb pdb:5GVC|rcsb pdb:5GVE|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)	-	-	-	figure legend:Fig. 3C, 3F, 3G, 4B, 4D, Supp. Figs 5, 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/19	2018/01/19	rogid:6yYxColCexsylTmLc/3szVv4MKI9606	rogid:R4lom6gXvFXkkGF+Hj94m9ecsXA9606	rigid:PcCKNPLZNgwbLMywzkGuuFRV0sI	false	mutation disrupting interaction strength:109-109,111-111|mutation disrupting interaction strength:109-109|mutation with no effect:111-111|mutation disrupting interaction strength:92-92,94-94|necessary binding region:79-92|mutation with no effect:82-82|mutation with no effect:96-96|mutation with no effect:139-139|mutation with no effect:96-96,109-109|mutation with no effect:96-96,139-139|mutation with no effect:79-79|mutation decreasing interaction strength:79-79,82-82|mutation with no effect:80-81|mutation decreasing interaction strength:79-82|mutation decreasing interaction strength:92-92|mutation disrupting interaction strength:94-94|mutation with no effect:96-96|mutation disrupting interaction strength:139-139,141-141|mutation with no effect:141-141|mutation decreasing interaction strength:139-139|sufficient binding region:1-161|mutation with no effect:90-92,80-81|mutation with no effect:109-109|mutation with no effect:111-111|mutation with no effect:111-111,109-109,139-139|mutation with no effect:111-111,96-96|mutation with no effect:96-96,109-109,111-111|mutation with no effect:96-96,109-109,139-139|mutation with no effect:139-139,96-96,111-111|mutation decreasing interaction strength:96-96,109-109,111-111,139-139	mutation with no effect:266-266|sufficient binding region:1-612|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9H7E2-3	uniprotkb:O95985	intact:EBI-10969939|ensembl:ENSP00000367113	intact:EBI-373403|uniprotkb:A0M8Q3|uniprotkb:Q9BUP5|ensembl:ENSP00000349705|ensembl:ENSP00000381773	psi-mi:q9h7e2-3(display_long)|uniprotkb:TDRD3(gene name)|psi-mi:TDRD3(display_short)	psi-mi:top3b_human(display_long)|uniprotkb:TOP3B(gene name)|psi-mi:TOP3B(display_short)|uniprotkb:TOP3B1(gene name synonym)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Goto-Ito et al. (2017)	pubmed:28176834|imex:IM-26467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16747074|imex:IM-26467-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083544(gene)|ensembl:ENST00000377881(transcript)|intact:EBI-3938232(isoform-parent)	refseq:NP_003926.1|refseq:XP_011528784.1|refseq:XP_006724412.1|refseq:XP_006724413.1|refseq:NP_001269041.1|refseq:NP_001269042.1|refseq:XP_005261868.1|ensembl:ENSG00000100038(gene)|ensembl:ENST00000357179(transcript)|ensembl:ENST00000398793(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:O95985|rcsb pdb:5GVC|rcsb pdb:5GVE|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)	-	-	-	figure legend:Supp. Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/19	2018/01/24	rogid:6yYxColCexsylTmLc/3szVv4MKI9606	rogid:R4lom6gXvFXkkGF+Hj94m9ecsXA9606	rigid:PcCKNPLZNgwbLMywzkGuuFRV0sI	false	sufficient binding region:48-171	sufficient binding region:1-612	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H7E2-3	uniprotkb:O95985	intact:EBI-10969939|ensembl:ENSP00000367113	intact:EBI-373403|uniprotkb:A0M8Q3|uniprotkb:Q9BUP5|ensembl:ENSP00000349705|ensembl:ENSP00000381773	psi-mi:q9h7e2-3(display_long)|uniprotkb:TDRD3(gene name)|psi-mi:TDRD3(display_short)	psi-mi:top3b_human(display_long)|uniprotkb:TOP3B(gene name)|psi-mi:TOP3B(display_short)|uniprotkb:TOP3B1(gene name synonym)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym)	psi-mi:"MI:0417"(footprinting)	Goto-Ito et al. (2017)	pubmed:28176834|imex:IM-26467	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-16747093|imex:IM-26467-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083544(gene)|ensembl:ENST00000377881(transcript)|intact:EBI-3938232(isoform-parent)	refseq:NP_003926.1|refseq:XP_011528784.1|refseq:XP_006724412.1|refseq:XP_006724413.1|refseq:NP_001269041.1|refseq:NP_001269042.1|refseq:XP_005261868.1|ensembl:ENSG00000100038(gene)|ensembl:ENST00000357179(transcript)|ensembl:ENST00000398793(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:O95985|rcsb pdb:5GVC|rcsb pdb:5GVE|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)	-	-	-	figure legend:Supp. Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/01/19	2018/01/24	rogid:6yYxColCexsylTmLc/3szVv4MKI9606	rogid:R4lom6gXvFXkkGF+Hj94m9ecsXA9606	rigid:PcCKNPLZNgwbLMywzkGuuFRV0sI	false	sufficient binding region:1-161	sufficient binding region:1-612	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)