#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42684	uniprotkb:P36888	intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20628026|imex:IM-26483-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	crc64:ED93869BC2B14FAA	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/19	rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:ILzNlt7clhfHoNR7ppjnYPWy69U	false	binding-associated region:173-263|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:723-733|phosphorylated residue:726-726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P42684	uniprotkb:P36888	intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20638088|imex:IM-26483-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N|interpro:IPR000980(SH2 motif)	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	crc64:ED93869BC2B14FAA	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/19	rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:ILzNlt7clhfHoNR7ppjnYPWy69U	false	binding-associated region:173-263|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:790-800|phosphorylated residue:793-793	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P46109	uniprotkb:P36888	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20638127|imex:IM-26483-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/19	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:2+WboSvXzsiGOvzhfWY8mDHYZLA	false	binding-associated region:14-102|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:790-800|phosphorylated residue:793-793	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P46109	uniprotkb:P36888	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20638157|imex:IM-26483-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/19	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:2+WboSvXzsiGOvzhfWY8mDHYZLA	false	binding-associated region:14-102|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:723-733|phosphorylated residue:726-726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P46108	uniprotkb:P36888	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639168|imex:IM-26483-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:rT+cmmiJkJW77r5Ka/jxOijtBrM	false	binding-associated region:13-118|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:790-800|phosphorylated residue:793-793	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P46108	uniprotkb:P36888	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639183|imex:IM-26483-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:rT+cmmiJkJW77r5Ka/jxOijtBrM	false	binding-associated region:14-102|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:723-733|phosphorylated residue:726-726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P06241	uniprotkb:P36888	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639198|imex:IM-26483-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:sibvCXaWnjdS57duHrT5aV5OMxw	false	binding-associated region:149-246|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:790-800|phosphorylated residue:793-793	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P06241	uniprotkb:P36888	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639213|imex:IM-26483-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:sibvCXaWnjdS57duHrT5aV5OMxw	false	binding-associated region:173-263|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:723-733|phosphorylated residue:726-726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P00519	uniprotkb:P36888	intact:EBI-375543|uniprotkb:Q13869|uniprotkb:Q13870|uniprotkb:Q16133|uniprotkb:Q45F09|ensembl:ENSP00000323315|uniprotkb:A3KFJ3|uniprotkb:Q17R61|intact:EBI-1550796	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:abl1_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)|uniprotkb:ABL1(gene name)|psi-mi:ABL1(display_short)|uniprotkb:ABL(gene name synonym)|uniprotkb:JTK7(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639282|imex:IM-26483-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005148.2|refseq:NP_009297.2|ensembl:ENSG00000097007(gene)|ensembl:ENST00000318560(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00519|rcsb pdb:1AB2|rcsb pdb:1ABL|rcsb pdb:2HIW|rcsb pdb:2HYY|rcsb pdb:2HZ0|rcsb pdb:2HZ4|rcsb pdb:2HZI|rcsb pdb:2O88|rcsb pdb:2V7A|rcsb pdb:3CS9|rcsb pdb:3EG0|rcsb pdb:3EG1|rcsb pdb:3EG2|rcsb pdb:3EG3|rcsb pdb:3EGU|rcsb pdb:3K2M|rcsb pdb:3PYY|rcsb pdb:3QRI|rcsb pdb:3QRJ|rcsb pdb:3QRK|rcsb pdb:3T04|rcsb pdb:3UE4|rcsb pdb:3UYO|rcsb pdb:4J9B|rcsb pdb:4J9C|rcsb pdb:4J9D|rcsb pdb:1AWO|rcsb pdb:1BBZ|rcsb pdb:1JU5|rcsb pdb:1OPL|rcsb pdb:1ZZP|rcsb pdb:2ABL|rcsb pdb:2E2B|rcsb pdb:2F4J|rcsb pdb:2FO0|rcsb pdb:4J9E|rcsb pdb:2G1T|rcsb pdb:4J9F|rcsb pdb:2G2F|rcsb pdb:2G2H|rcsb pdb:4J9G|rcsb pdb:2G2I|rcsb pdb:4J9H|rcsb pdb:2GQG|rcsb pdb:4J9I|rcsb pdb:4JJB|rcsb pdb:4JJC|rcsb pdb:4JJD|rcsb pdb:4TWP|rcsb pdb:4WA9|rcsb pdb:4XEY|rcsb pdb:4YC8|rcsb pdb:4ZOG|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5HU9|rcsb pdb:5MO4|rcsb pdb:5NP2|rcsb pdb:5OAZ|rcsb pdb:6AMV|rcsb pdb:6AMW|rcsb pdb:6BL8|rcsb pdb:6NPE|rcsb pdb:6NPU|rcsb pdb:6NPV|rcsb pdb:6XR6|rcsb pdb:6XR7|rcsb pdb:6XRG|rcsb pdb:7CC2|rcsb pdb:7DT2|reactome:R-HSA-2029482|reactome:R-HSA-428890|reactome:R-HSA-525793|reactome:R-HSA-5663213|reactome:R-HSA-5685938|reactome:R-HSA-5693565|reactome:R-HSA-69231|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-9664422|reactome:R-HSA-983231|dip:DIP-1042N	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:t7dT+fWrrK2QaWF4U0HQaVgHKUc9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:zRKOh59s8X2Q28n7++GN4Nt74uM	false	binding-associated region:127-217|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:790-800|phosphorylated residue:793-793	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P00519	uniprotkb:P36888	intact:EBI-375543|uniprotkb:Q13869|uniprotkb:Q13870|uniprotkb:Q16133|uniprotkb:Q45F09|ensembl:ENSP00000323315|uniprotkb:A3KFJ3|uniprotkb:Q17R61|intact:EBI-1550796	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:abl1_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)|uniprotkb:ABL1(gene name)|psi-mi:ABL1(display_short)|uniprotkb:ABL(gene name synonym)|uniprotkb:JTK7(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639297|imex:IM-26483-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005148.2|refseq:NP_009297.2|ensembl:ENSG00000097007(gene)|ensembl:ENST00000318560(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00519|rcsb pdb:1AB2|rcsb pdb:1ABL|rcsb pdb:2HIW|rcsb pdb:2HYY|rcsb pdb:2HZ0|rcsb pdb:2HZ4|rcsb pdb:2HZI|rcsb pdb:2O88|rcsb pdb:2V7A|rcsb pdb:3CS9|rcsb pdb:3EG0|rcsb pdb:3EG1|rcsb pdb:3EG2|rcsb pdb:3EG3|rcsb pdb:3EGU|rcsb pdb:3K2M|rcsb pdb:3PYY|rcsb pdb:3QRI|rcsb pdb:3QRJ|rcsb pdb:3QRK|rcsb pdb:3T04|rcsb pdb:3UE4|rcsb pdb:3UYO|rcsb pdb:4J9B|rcsb pdb:4J9C|rcsb pdb:4J9D|rcsb pdb:1AWO|rcsb pdb:1BBZ|rcsb pdb:1JU5|rcsb pdb:1OPL|rcsb pdb:1ZZP|rcsb pdb:2ABL|rcsb pdb:2E2B|rcsb pdb:2F4J|rcsb pdb:2FO0|rcsb pdb:4J9E|rcsb pdb:2G1T|rcsb pdb:4J9F|rcsb pdb:2G2F|rcsb pdb:2G2H|rcsb pdb:4J9G|rcsb pdb:2G2I|rcsb pdb:4J9H|rcsb pdb:2GQG|rcsb pdb:4J9I|rcsb pdb:4JJB|rcsb pdb:4JJC|rcsb pdb:4JJD|rcsb pdb:4TWP|rcsb pdb:4WA9|rcsb pdb:4XEY|rcsb pdb:4YC8|rcsb pdb:4ZOG|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5HU9|rcsb pdb:5MO4|rcsb pdb:5NP2|rcsb pdb:5OAZ|rcsb pdb:6AMV|rcsb pdb:6AMW|rcsb pdb:6BL8|rcsb pdb:6NPE|rcsb pdb:6NPU|rcsb pdb:6NPV|rcsb pdb:6XR6|rcsb pdb:6XR7|rcsb pdb:6XRG|rcsb pdb:7CC2|rcsb pdb:7DT2|reactome:R-HSA-2029482|reactome:R-HSA-428890|reactome:R-HSA-525793|reactome:R-HSA-5663213|reactome:R-HSA-5685938|reactome:R-HSA-5693565|reactome:R-HSA-69231|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-9664422|reactome:R-HSA-983231|dip:DIP-1042N	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:t7dT+fWrrK2QaWF4U0HQaVgHKUc9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:zRKOh59s8X2Q28n7++GN4Nt74uM	false	binding-associated region:127-217|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:723-733|phosphorylated residue:726-726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P06239	uniprotkb:P36888	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639328|imex:IM-26483-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:uIYLGtzJlUbNT2zpA2zojeBXYRc	false	binding-associated region:127-224|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:790-800|phosphorylated residue:793-793	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P06239	uniprotkb:P36888	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639343|imex:IM-26483-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:uIYLGtzJlUbNT2zpA2zojeBXYRc	false	binding-associated region:127-224|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:723-733|phosphorylated residue:726-726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:O14544	uniprotkb:P36888	intact:EBI-3929549|uniprotkb:Q8WUM3|ensembl:ENSP00000381034|ensembl:ENSP00000463395	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:socs6_human(display_long)|uniprotkb:SOCS6(gene name)|psi-mi:SOCS6(display_short)|uniprotkb:CIS4(gene name synonym)|uniprotkb:SOCS4(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 4(gene name synonym)|uniprotkb:Suppressor of cytokine signaling 4(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639405|imex:IM-26483-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR037345|mint:O14544|rcsb pdb:2VIF|reactome:R-HSA-1433559|reactome:R-HSA-8951664|reactome:R-HSA-9706369|interpro:IPR036860|ensembl:ENSG00000170677(gene)|ensembl:ENST00000397942(transcript)|ensembl:ENST00000582322(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028421|interpro:IPR035865|interpro:IPR036036|refseq:NP_004223.2|refseq:XP_005266840.1|refseq:XP_016881575.1|refseq:XP_016881576.1	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:O++hp+HHhT2m2QNupHdNfK5DBqQ9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:LZBaGjYtMAOEb/8Ww1FABRBMzlg	false	binding-associated region:384-491|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:839-849|phosphorylated residue:842-842	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P43405	uniprotkb:P36888	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639451|imex:IM-26483-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/07/23	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:rAVZwku0oi5DG5wB/lFlQ1jFfhQ	false	binding-associated region:168-259|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:839-849|phosphorylated residue:842-842	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P20936	uniprotkb:P36888	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20728909|imex:IM-26483-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/09/05	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:ffvdAmY24k3YxxtRkPy/fdtdWt8	false	binding-associated region:181-272|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:790-800|phosphorylated residue:793-793	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P20936	uniprotkb:P36888	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20728926|imex:IM-26483-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/09/05	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:ffvdAmY24k3YxxtRkPy/fdtdWt8	false	binding-associated region:181-272|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:790-800|phosphorylated residue:726-726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P51451	uniprotkb:P36888	intact:EBI-2105445|uniprotkb:Q96IN1|uniprotkb:Q16291|ensembl:ENSP00000259089	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:blk_human(display_long)|uniprotkb:BLK(gene name)|psi-mi:BLK(display_short)|uniprotkb:B lymphocyte kinase(gene name synonym)|uniprotkb:p55-Blk(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20728991|imex:IM-26483-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001706.2|ensembl:ENSG00000136573(gene)|ensembl:ENST00000259089(transcript)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035853|interpro:IPR036028|interpro:IPR036860|mint:P51451|reactome:R-HSA-8939245|reactome:R-HSA-983695	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/09/05	rogid:z6p1emCKpfhFkpk1GysjT8WEj5g9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:keBTdjobhaBPsN2xA0goOcWNToE	false	binding-associated region:124-220|glutathione s tranferase tag:?-?	binding-associated region:839-849|phosphorylated residue:842-842|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P36888	uniprotkb:Q9HBL0	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	intact:EBI-3389814|uniprotkb:Q6IPI5|ensembl:ENSP00000171887|uniprotkb:Q4ZG71	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:tens1_human(display_long)|uniprotkb:TNS1(gene name)|psi-mi:TNS1(display_short)|uniprotkb:TNS(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20729012|imex:IM-26483-52	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	ensembl:ENSG00000079308(gene)|ensembl:ENST00000171887(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|go:"GO:0003779"(actin binding)|refseq:NP_001294951.1|refseq:NP_072174.3|dip:DIP-60948N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/09/05	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rogid:xyE5fHGhuORnau3rX2Nfpi1LCvg9606	rigid:miqfde584ytC6rewTz7Eup7HTpM	false	biotin tag:n-n|phosphorylated residue:842-842|binding-associated region:839-849	binding-associated region:1463-1572|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07947	uniprotkb:P36888	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0089"(protein array)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-20729029|imex:IM-26483-54	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/07/19	2018/09/05	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:8xQuYjiaPKt1zDSH/TuNTuaqtsc	false	binding-associated region:158-255|glutathione s tranferase tag:?-?	biotin tag:n-n|binding-associated region:723-733|phosphorylated residue:726-726	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P42684	uniprotkb:P36888	intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kazi et al. (2017)	pubmed:28086240|imex:IM-26483	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-20639491|imex:IM-26483-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N	-	crc64:ED93869BC2B14FAA	-	figure legend:f1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2018/07/19	2018/07/23	rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rigid:ILzNlt7clhfHoNR7ppjnYPWy69U	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)