#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86XT9	uniprotkb:Q14627	intact:EBI-20264080|uniprotkb:D5FK14|uniprotkb:Q8WVV8|ensembl:ENSP00000279396|ensembl:ENSP00000388485|ensembl:ENSP00000456960|ensembl:ENSP00000457492|ensembl:ENSP00000459813	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:tm219_human(display_long)|uniprotkb:TMEM219(gene name)|psi-mi:TMEM219(display_short)|uniprotkb:Transmembrane protein 219(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559251|imex:IM-26399-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077082.1|refseq:NP_919256.1|refseq:XP_005255180.1|ensembl:ENSG00000149932(gene)|ensembl:ENST00000279396(transcript)|ensembl:ENST00000414689(transcript)|ensembl:ENST00000561899(transcript)|ensembl:ENST00000566848(transcript)|ensembl:ENST00000570255(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-HSA-6803211	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	-	-	-	figure legend:"(Figure 1A)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/05/02	2018/05/09	rogid:JDeHxM/rrToXnR49YkzrDeu2ono9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:lKrvMctbn4mqqiWcZltUB5YdTjM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q86XT9	uniprotkb:Q14627	intact:EBI-20264080|uniprotkb:D5FK14|uniprotkb:Q8WVV8|ensembl:ENSP00000279396|ensembl:ENSP00000388485|ensembl:ENSP00000456960|ensembl:ENSP00000457492|ensembl:ENSP00000459813	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:tm219_human(display_long)|uniprotkb:TMEM219(gene name)|psi-mi:TMEM219(display_short)|uniprotkb:Transmembrane protein 219(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559281|imex:IM-26399-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077082.1|refseq:NP_919256.1|refseq:XP_005255180.1|ensembl:ENSG00000149932(gene)|ensembl:ENST00000279396(transcript)|ensembl:ENST00000414689(transcript)|ensembl:ENST00000561899(transcript)|ensembl:ENST00000566848(transcript)|ensembl:ENST00000570255(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-HSA-6803211	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	-	-	-	figure legend:Figure 1 A/F, Supp. Fig 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2018/05/02	2018/05/09	rogid:JDeHxM/rrToXnR49YkzrDeu2ono9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:lKrvMctbn4mqqiWcZltUB5YdTjM	false	-	sufficient binding region:26-300..344	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86XT9	uniprotkb:Q14627	intact:EBI-20264080|uniprotkb:D5FK14|uniprotkb:Q8WVV8|ensembl:ENSP00000279396|ensembl:ENSP00000388485|ensembl:ENSP00000456960|ensembl:ENSP00000457492|ensembl:ENSP00000459813	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:tm219_human(display_long)|uniprotkb:TMEM219(gene name)|psi-mi:TMEM219(display_short)|uniprotkb:Transmembrane protein 219(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559370|imex:IM-26399-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077082.1|refseq:NP_919256.1|refseq:XP_005255180.1|ensembl:ENSG00000149932(gene)|ensembl:ENST00000279396(transcript)|ensembl:ENST00000414689(transcript)|ensembl:ENST00000561899(transcript)|ensembl:ENST00000566848(transcript)|ensembl:ENST00000570255(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-HSA-6803211	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	-	-	-	figure legend:Figure 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-1haeo)|taxid:9606(human-transformed normal human airway epithelial cells)	-	2018/05/02	2018/05/09	rogid:JDeHxM/rrToXnR49YkzrDeu2ono9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:lKrvMctbn4mqqiWcZltUB5YdTjM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86XT9	uniprotkb:Q14627	intact:EBI-20264080|uniprotkb:D5FK14|uniprotkb:Q8WVV8|ensembl:ENSP00000279396|ensembl:ENSP00000388485|ensembl:ENSP00000456960|ensembl:ENSP00000457492|ensembl:ENSP00000459813	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:tm219_human(display_long)|uniprotkb:TMEM219(gene name)|psi-mi:TMEM219(display_short)|uniprotkb:Transmembrane protein 219(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559375|imex:IM-26399-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077082.1|refseq:NP_919256.1|refseq:XP_005255180.1|ensembl:ENSG00000149932(gene)|ensembl:ENST00000279396(transcript)|ensembl:ENST00000414689(transcript)|ensembl:ENST00000561899(transcript)|ensembl:ENST00000566848(transcript)|ensembl:ENST00000570255(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-HSA-6803211	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	-	-	-	figure legend:Figure 1Bi|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-1haeo)|taxid:9606(human-transformed normal human airway epithelial cells)	-	2018/05/02	2018/05/09	rogid:JDeHxM/rrToXnR49YkzrDeu2ono9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:lKrvMctbn4mqqiWcZltUB5YdTjM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86XT9	uniprotkb:Q14627	intact:EBI-20264080|uniprotkb:D5FK14|uniprotkb:Q8WVV8|ensembl:ENSP00000279396|ensembl:ENSP00000388485|ensembl:ENSP00000456960|ensembl:ENSP00000457492|ensembl:ENSP00000459813	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:tm219_human(display_long)|uniprotkb:TMEM219(gene name)|psi-mi:TMEM219(display_short)|uniprotkb:Transmembrane protein 219(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559395|imex:IM-26399-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077082.1|refseq:NP_919256.1|refseq:XP_005255180.1|ensembl:ENSG00000149932(gene)|ensembl:ENST00000279396(transcript)|ensembl:ENST00000414689(transcript)|ensembl:ENST00000561899(transcript)|ensembl:ENST00000566848(transcript)|ensembl:ENST00000570255(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-HSA-6803211	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	go:"GO:0009897"(external side of plasma membrane)	-	-	figure legend:Figure 1D, Supp. figure  1B|agonist:rChi3l1 - P36222|agonist:IL-13 -P35225|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-1haeo)|taxid:9606(human-transformed normal human airway epithelial cells)	-	2018/05/02	2018/05/09	rogid:JDeHxM/rrToXnR49YkzrDeu2ono9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:lKrvMctbn4mqqiWcZltUB5YdTjM	false	c-venus:c-c	n-venus:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9D123	uniprotkb:O88786	intact:EBI-20559426|uniprotkb:Q9D6H1|ensembl:ENSMUSP00000032926|ensembl:ENSMUSP00000112485	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	psi-mi:tm219_mouse(display_long)|uniprotkb:Transmembrane protein 219(gene name synonym)|uniprotkb:Tmem219(gene name)|psi-mi:Tmem219(display_short)	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559424|imex:IM-26399-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081103.1|refseq:NP_082665.1|refseq:XP_006508220.1|refseq:XP_006508221.1|ensembl:ENSMUSG00000060538(gene)|ensembl:ENSMUST00000032926(transcript)|ensembl:ENSMUST00000121532(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-MMU-6803211	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	go:"GO:0009279"(cell outer membrane)	-	-	figure legend:Figure 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/02	2018/05/09	rogid:rgFbt9a9EiPitS51BRKTKThxApQ10090	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rigid:ITk3do9LEGeaehwfcIr8OP2Uq88	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P36222	uniprotkb:Q14627	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559520|imex:IM-26399-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	-	-	-	figure legend:Figure 2C|comment:TMEM219 nanodisc showed strong interactions with IL-13Ra2-Chi3l1 complexes.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:288.0x10^-9(molar)	2018/05/02	2018/05/09	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:zmRyAvfYYsfvb0K/eg75IKnpd88	false	his tag:c-c	sufficient binding region:29-331|his tag:c-c|bodipy label:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P36222	uniprotkb:Q86XT9	intact:EBI-6917454|ensembl:ENSP00000255409|uniprotkb:B2R7B0|uniprotkb:P30923|uniprotkb:Q8IVA4|uniprotkb:Q96HI7	intact:EBI-20264080|uniprotkb:D5FK14|uniprotkb:Q8WVV8|ensembl:ENSP00000279396|ensembl:ENSP00000388485|ensembl:ENSP00000456960|ensembl:ENSP00000457492|ensembl:ENSP00000459813	psi-mi:ch3l1_human(display_long)|uniprotkb:CHI3L1(gene name)|psi-mi:CHI3L1(display_short)|uniprotkb:39 kDa synovial protein(gene name synonym)|uniprotkb:Cartilage glycoprotein 39(gene name synonym)|uniprotkb:YKL-40(gene name synonym)	psi-mi:tm219_human(display_long)|uniprotkb:TMEM219(gene name)|psi-mi:TMEM219(display_short)|uniprotkb:Transmembrane protein 219(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559520|imex:IM-26399-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000133048(gene)|ensembl:ENST00000255409(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008061"(chitin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028538|interpro:IPR029070|rcsb pdb:1HJV|rcsb pdb:1HJW|rcsb pdb:1HJX|rcsb pdb:1LA7|rcsb pdb:1NWR|rcsb pdb:1NWS|rcsb pdb:1NWT|reactome:R-HSA-6798695|rcsb pdb:1NWU|refseq:NP_001267.2	refseq:NP_001077082.1|refseq:NP_919256.1|refseq:XP_005255180.1|ensembl:ENSG00000149932(gene)|ensembl:ENST00000279396(transcript)|ensembl:ENST00000414689(transcript)|ensembl:ENST00000561899(transcript)|ensembl:ENST00000566848(transcript)|ensembl:ENST00000570255(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-HSA-6803211	-	-	-	figure legend:Figure 2C|comment:TMEM219 nanodisc showed strong interactions with IL-13Ra2-Chi3l1 complexes.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:288.0x10^-9(molar)	2018/05/02	2018/05/09	rogid:zZfR9p8Rzm74r9jur2r1nUoBR4M9606	rogid:JDeHxM/rrToXnR49YkzrDeu2ono9606	rigid:zmRyAvfYYsfvb0K/eg75IKnpd88	false	his tag:c-c	his tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q86XT9	uniprotkb:Q14627	intact:EBI-20264080|uniprotkb:D5FK14|uniprotkb:Q8WVV8|ensembl:ENSP00000279396|ensembl:ENSP00000388485|ensembl:ENSP00000456960|ensembl:ENSP00000457492|ensembl:ENSP00000459813	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:tm219_human(display_long)|uniprotkb:TMEM219(gene name)|psi-mi:TMEM219(display_short)|uniprotkb:Transmembrane protein 219(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559573|imex:IM-26399-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077082.1|refseq:NP_919256.1|refseq:XP_005255180.1|ensembl:ENSG00000149932(gene)|ensembl:ENST00000279396(transcript)|ensembl:ENST00000414689(transcript)|ensembl:ENST00000561899(transcript)|ensembl:ENST00000566848(transcript)|ensembl:ENST00000570255(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-HSA-6803211	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	-	-	-	figure legend:Supp. figure  1C|agonist:rChi3l1 - P36222|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bronchial_epithelial)|taxid:9606(Homo sapiens)	-	2018/05/02	2018/05/09	rogid:JDeHxM/rrToXnR49YkzrDeu2ono9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:lKrvMctbn4mqqiWcZltUB5YdTjM	false	c-venus:c-c	n-venus:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O88786	uniprotkb:P20109	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	intact:EBI-20559598|ensembl:ENSMUSP00000020650	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:il13_mouse(display_long)|uniprotkb:T-cell activation protein P600(gene name synonym)|uniprotkb:Il13(gene name)|psi-mi:Il13(display_short)|uniprotkb:Il-13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559593|imex:IM-26399-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	refseq:NP_032381.1|ensembl:ENSMUSG00000020383(gene)|ensembl:ENSMUST00000020650(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470	-	-	-	figure legend:Supp. fig 8A|comment:There was  decreased binding between IL-13 and IL-13Ra2 in the lungs from IL-13Tg mice that lacked TMEM219.|agonist:TEM219- Uniprot entry Q9D123|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/02	2018/05/23	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rogid:ziniEN0ZwkLTNwSohCKIEt1YPso10090	rigid:GNYSRFjd3TvW7iyaTUy8AQWAags	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88786	uniprotkb:P20109	intact:EBI-20260800|uniprotkb:A3F812|uniprotkb:Q3V2V5|ensembl:ENSMUSP00000033646|ensembl:ENSMUSP00000108446	intact:EBI-20559598|ensembl:ENSMUSP00000020650	psi-mi:i13r2_mouse(display_long)|uniprotkb:Il13ra2(gene name)|psi-mi:Il13ra2(display_short)	psi-mi:il13_mouse(display_long)|uniprotkb:T-cell activation protein P600(gene name synonym)|uniprotkb:Il13(gene name)|psi-mi:Il13(display_short)|uniprotkb:Il-13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559629|imex:IM-26399-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001292988.1|refseq:NP_032382.1|refseq:XP_006528770.1|refseq:XP_006528771.1|refseq:XP_017173884.1|ensembl:ENSMUSG00000031289(gene)|ensembl:ENSMUST00000033646(transcript)|ensembl:ENSMUST00000112827(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116	refseq:NP_032381.1|ensembl:ENSMUSG00000020383(gene)|ensembl:ENSMUST00000020650(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470	-	-	-	figure legend:Supp. fig 8Ai|comment:There was  decreased binding between IL-13 and IL-13Ra2 in the lungs from IL-13Tg mice that lacked TMEM219.|agonist:TEM219- Uniprot entry Q9D123|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lung)|taxid:10090(Mus musculus)	-	2018/05/02	2018/05/23	rogid:ej6FDiQbxIRW5n9HtOfI5KBXEB410090	rogid:ziniEN0ZwkLTNwSohCKIEt1YPso10090	rigid:GNYSRFjd3TvW7iyaTUy8AQWAags	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14627	uniprotkb:P35225	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559646|imex:IM-26399-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	-	-	-	figure legend:Supp. Fig8 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/02	2018/05/09	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	rigid:wPMlTdJsawR38ioaYml0+k5Ti7c	false	-	sufficient binding region:35-146	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35225	uniprotkb:Q86XT9	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	intact:EBI-20264080|uniprotkb:D5FK14|uniprotkb:Q8WVV8|ensembl:ENSP00000279396|ensembl:ENSP00000388485|ensembl:ENSP00000456960|ensembl:ENSP00000457492|ensembl:ENSP00000459813	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:tm219_human(display_long)|uniprotkb:TMEM219(gene name)|psi-mi:TMEM219(display_short)|uniprotkb:Transmembrane protein 219(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559652|imex:IM-26399-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	refseq:NP_001077082.1|refseq:NP_919256.1|refseq:XP_005255180.1|ensembl:ENSG00000149932(gene)|ensembl:ENST00000279396(transcript)|ensembl:ENST00000414689(transcript)|ensembl:ENST00000561899(transcript)|ensembl:ENST00000566848(transcript)|ensembl:ENST00000570255(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-HSA-6803211	-	-	-	figure legend:Supp. Fig8 B|agonist:TMEM219- Uniprot Q86XT9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/02	2018/05/23	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	rogid:JDeHxM/rrToXnR49YkzrDeu2ono9606	rigid:AwN6c+PifSsGlNUpTj9/Cu//vTk	false	sufficient binding region:35-146	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35225	uniprotkb:Q14627	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559652|imex:IM-26399-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	-	-	-	figure legend:Supp. Fig8 B|agonist:TMEM219- Uniprot Q86XT9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/02	2018/05/23	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rigid:AwN6c+PifSsGlNUpTj9/Cu//vTk	false	sufficient binding region:35-146	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14627	uniprotkb:P35225	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559662|imex:IM-26399-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	-	-	-	figure legend:Supp. Fig8 C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/02	2018/05/09	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	rigid:wPMlTdJsawR38ioaYml0+k5Ti7c	false	-	sufficient binding region:35-146	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14627	uniprotkb:Q86XT9	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-20264080|uniprotkb:D5FK14|uniprotkb:Q8WVV8|ensembl:ENSP00000279396|ensembl:ENSP00000388485|ensembl:ENSP00000456960|ensembl:ENSP00000457492|ensembl:ENSP00000459813	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:tm219_human(display_long)|uniprotkb:TMEM219(gene name)|psi-mi:TMEM219(display_short)|uniprotkb:Transmembrane protein 219(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559668|imex:IM-26399-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	refseq:NP_001077082.1|refseq:NP_919256.1|refseq:XP_005255180.1|ensembl:ENSG00000149932(gene)|ensembl:ENST00000279396(transcript)|ensembl:ENST00000414689(transcript)|ensembl:ENST00000561899(transcript)|ensembl:ENST00000566848(transcript)|ensembl:ENST00000570255(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039493|interpro:IPR039587|reactome:R-HSA-6803211	-	-	-	figure legend:Supp. Fig8 C|agonist:TMEM219- Uniprot Q86XT9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/02	2018/05/23	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:JDeHxM/rrToXnR49YkzrDeu2ono9606	rigid:AwN6c+PifSsGlNUpTj9/Cu//vTk	false	-	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14627	uniprotkb:P35225	intact:EBI-4320063|uniprotkb:A8K7E2|uniprotkb:O00667|ensembl:ENSP00000243213|ensembl:ENSP00000361004	intact:EBI-1647828|uniprotkb:O43644|uniprotkb:Q4VB52|uniprotkb:Q9UDC7|ensembl:ENSP00000304915	psi-mi:i13r2_human(display_long)|uniprotkb:IL13RA2(gene name)|psi-mi:IL13RA2(display_short)|uniprotkb:IL13R(gene name synonym)|uniprotkb:Interleukin-13-binding protein(gene name synonym)	psi-mi:il13_human(display_long)|uniprotkb:IL13(gene name)|psi-mi:IL13(display_short)|uniprotkb:NC30(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2016)	pubmed:27629921|imex:IM-26399	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-20559668|imex:IM-26399-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000631.1|ensembl:ENSG00000123496(gene)|ensembl:ENST00000243213(transcript)|ensembl:ENST00000371936(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043305"(negative regulation of mast cell degranulation)|interpro:IPR003532(Short hematopoietin receptor, family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:3LB6|reactome:R-HSA-6785807|dip:DIP-3340N	refseq:NP_002179.2|dip:DIP-3224N|ensembl:ENSG00000169194(gene)|ensembl:ENST00000304506(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005125"(cytokine activity)|go:"GO:0005144"(interleukin-13 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032723"(positive regulation of connective tissue growth factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0035094"(response to nicotine)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045471"(response to ethanol)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901247"(negative regulation of lung ciliated cell differentiation)|go:"GO:1901251"(positive regulation of lung goblet cell differentiation)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:2000231"(positive regulation of pancreatic stellate cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|interpro:IPR020470|rcsb pdb:1GA3|rcsb pdb:1IJZ|rcsb pdb:1IK0|rcsb pdb:1J9U|rcsb pdb:3BPO|rcsb pdb:3G6D|rcsb pdb:3ITR|rcsb pdb:3ITS|rcsb pdb:3L5W|rcsb pdb:3L5X|rcsb pdb:3LB6|rcsb pdb:4I77|rcsb pdb:4PS4|rcsb pdb:5E4E|rcsb pdb:5L6Y|reactome:R-HSA-6785807|reactome:R-HSA-9012546	-	-	-	figure legend:Supp. Fig8 C|agonist:TMEM219- Uniprot Q86XT9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2018/05/02	2018/05/23	rogid:LItbTlLuFXGhjC4PVCIW9aeBRZk9606	rogid:NORPxfYHTfYxQaFWP3FFlC76bWE9606	rigid:AwN6c+PifSsGlNUpTj9/Cu//vTk	false	-	sufficient binding region:35-146	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)